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    Chemistry

    Click the arrow to open the dropdown
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    read-moreClick the button for full data set
    Also known as: 274693-27-5, Brilinta, Brilique, Azd6140, Azd-6140, Possia
    Molecular Formula
    C23H28F2N6O4S
    Molecular Weight
    522.6  g/mol
    InChI Key
    OEKWJQXRCDYSHL-FNOIDJSQSA-N
    FDA UNII
    GLH0314RVC
    Ticagrelor
    An adenosine triphosphate analogue and reversible P2Y12 PURINORECEPTOR antagonist that inhibits ADP-mediated PLATELET AGGREGATION. It is used for the prevention of THROMBOEMBOLISM by patients with ACUTE CORONARY SYNDROME or a history of MYOCARDIAL INFARCTION.
    Ticagrelor is a P2Y12 Platelet Inhibitor. The mechanism of action of ticagrelor is as a Phenylalanine Hydroxylase Activator, and P2Y12 Receptor Antagonist, and Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A5 Inhibitor, and P-Glycoprotein Inhibitor. The physiologic effect of ticagrelor is by means of Decreased Platelet Aggregation.
    1 2D Structure

    Ticagrelor

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-propylsulfanyltriazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol
    2.1.2 InChI
    InChI=1S/C23H28F2N6O4S/c1-2-7-36-23-27-21(26-15-9-12(15)11-3-4-13(24)14(25)8-11)18-22(28-23)31(30-29-18)16-10-17(35-6-5-32)20(34)19(16)33/h3-4,8,12,15-17,19-20,32-34H,2,5-7,9-10H2,1H3,(H,26,27,28)/t12-,15+,16+,17-,19-,20+/m0/s1
    2.1.3 InChI Key
    OEKWJQXRCDYSHL-FNOIDJSQSA-N
    2.1.4 Canonical SMILES
    CCCSC1=NC(=C2C(=N1)N(N=N2)C3CC(C(C3O)O)OCCO)NC4CC4C5=CC(=C(C=C5)F)F
    2.1.5 Isomeric SMILES
    CCCSC1=NC(=C2C(=N1)N(N=N2)[C@@H]3C[C@@H]([C@H]([C@H]3O)O)OCCO)N[C@@H]4C[C@H]4C5=CC(=C(C=C5)F)F
    2.2 Other Identifiers
    2.2.1 UNII
    GLH0314RVC
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 3-(7-((2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3h-(1-3)-triazolo(4,5-d)pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

    2. Azd 6140

    3. Azd-6140

    4. Azd6140

    5. Brilinta

    6. Brilique

    2.3.2 Depositor-Supplied Synonyms

    1. 274693-27-5

    2. Brilinta

    3. Brilique

    4. Azd6140

    5. Azd-6140

    6. Possia

    7. Ar-c126532xx

    8. Azd 6140

    9. Ticargrelor

    10. [14c]-ticagrelor

    11. Glh0314rvc

    12. (1s,2s,3r,5s)-3-(7-(((1r,2s)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

    13. Chebi:68558

    14. (1s,2s,3r,5s)-3-(7-((1r,2s)-2-(3,4-difluorophenyl)cyclopropylamino)-5-(propylthio)-3h-(1,2,3)triazolo(4,5-d)pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

    15. (1s,2s,3r,5s)-3-[7-[[(1r,2s)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3h-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol

    16. (1s,2s,3r,5s)-3-[7-[[(1r,2s)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-propylsulfanyltriazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

    17. 1,2-cyclopentanediol, 3-(7-(((1r,2s)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3h-1,2,3-triazolo(4,5-d)pyrimidin-3-yl)-5-(2-hydroxyethoxy)-, (1s,2s,3r,5s)-

    18. (1s,2s,3r,5s)-3-(7-((1r,2s)-2-(3,4-difluorophenyl)cyclopropylamino)-5-(propylthio)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

    19. (1s,2s,3r,5s)-3-[7-[(1r,2s)-2-(3,4-difluorophenyl)cyclopropylamino]-5-(propylthio)- 3h-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

    20. Ticagrelor [usan]

    21. Unii-glh0314rvc

    22. Ticagrelor [usan:inn:ban]

    23. C23h28f2n6o4s

    24. Ar-c 126532xx

    25. Brilinta (tn)

    26. (1s,2s,3r,5s)-3-(7-(((1r)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

    27. (1s,2s,3r,5s)-3-(7-{[(1r,2s)-2-(3,4-difluorophenyl)cyclopropyl]amino}-5-(propylsulfanyl)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

    28. (1s,2s,3r,5s)-3-[7-[[(1r,2s)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

    29. (1s,2s,3r,5s)-3-[7-{[(1r,2s)-2-(3,4-difluorophenyl)cyclopropyl]amino}-5-(propylsulfanyl)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

    30. Ticagrelor- Bio-x

    31. Ar-c126532

    32. Ticagrelor [mi]

    33. Ticagrelor [inn]

    34. Ticagrelor [jan]

    35. Ticagrelor [vandf]

    36. Ticagrelor [mart.]

    37. Ticagrelor [usp-rs]

    38. Ticagrelor [who-dd]

    39. Ticagrelor (jan/usan/inn)

    40. Ticagrelor [ema Epar]

    41. Chembl398435

    42. Gtpl1765

    43. Schembl1979652

    44. Ticagrelor [orange Book]

    45. Ammd00027

    46. Hsdb 8306

    47. Ex-a503

    48. Ticagrelor (brilinta,azd6140)

    49. Ticagrelor [ep Monograph]

    50. Dtxsid901009337

    51. Hms3885b03

    52. Bdbm50397205

    53. Mfcd09954148

    54. S4079

    55. Zinc28957444

    56. Akos015900739

    57. Am85693

    58. Ccg-269870

    59. Cs-0619

    60. Db08816

    61. Ex-6274

    62. Ar-c 126532xx;azd6140

    63. Compound 17 [pmid: 17827008]

    64. Ncgc00379052-01

    65. Ncgc00379052-02

    66. Ac-24755

    67. As-19943

    68. Bt164470

    69. Hy-10064

    70. D09017

    71. Ab01565855_02

    72. 693t275

    73. A850981

    74. Q420542

    75. J-016772

    76. J-524969

    77. (1s,2s,3r,5s)-3-(7-(((1s,2s)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

    78. (1s,2s,3r,5s)-3-(7-((1r,2s)-2-(3,4-difluorophenyl)cyclopropylamino)-5-(propylthio)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy) Cyclopentane-1,2-diol

    79. (1s,2s,3r,5s)-3-(7-((1r,2s)-2-(3,4-difluorophenyl)cyclopropylamino)-5-(propylthio)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2 Diol

    80. (1s,2s,3r,5s)-3-[7-[[(1r,2s)-2-(3,4-d1,2-cyclopentanediolifluorophenyl)cyclopropyl]amino]-5-(propylthio)-3h-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol

    81. (1s,2s,3r,5s)-3-[7-[[(1r,2s)-2-(3,4-difluorophenyl)-cyclopropyl]amino]-5-(propylthio)-3h-[1,2,3]-triazolo[4,5-d]pyrimidine-3-yl]-5-(2-hydroxyethoxy) Cyclopentane-1,2-diol

    82. (1s,2s,3r,5s)-3-[7-[[(1r,2s)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-propylsulfanyltriazolo[5,4-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

    83. 1,2-cyclopentanediol,3-[7-[[(1r,2s)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3h-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-,(1s,2s,3r,5s)-

    2.4 Create Date
    2006-10-25
    3 Chemical and Physical Properties
    Molecular Weight 522.6 g/mol
    Molecular Formula C23H28F2N6O4S
    XLogP32
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count12
    Rotatable Bond Count10
    Exact Mass522.18608089 g/mol
    Monoisotopic Mass522.18608089 g/mol
    Topological Polar Surface Area164 Ų
    Heavy Atom Count36
    Formal Charge0
    Complexity736
    Isotope Atom Count0
    Defined Atom Stereocenter Count6
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameBrilinta
    PubMed HealthTicagrelor (By mouth)
    Drug ClassesPlatelet Aggregation Inhibitor
    Drug LabelBRILINTA contains ticagrelor, a cyclopentyltriazolopyrimidine, inhibitor of platelet activation and aggregation mediated by the P2Y12 ADP-receptor. Chemically it is (1S,2S,3R,5S)-3-[7-{[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino}-5-(propylthio)-...
    Active IngredientTicagrelor
    Dosage FormTablet
    RouteOral
    Strength90mg
    Market StatusPrescription
    CompanyAstrazeneca

    2 of 2  
    Drug NameBrilinta
    PubMed HealthTicagrelor (By mouth)
    Drug ClassesPlatelet Aggregation Inhibitor
    Drug LabelBRILINTA contains ticagrelor, a cyclopentyltriazolopyrimidine, inhibitor of platelet activation and aggregation mediated by the P2Y12 ADP-receptor. Chemically it is (1S,2S,3R,5S)-3-[7-{[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino}-5-(propylthio)-...
    Active IngredientTicagrelor
    Dosage FormTablet
    RouteOral
    Strength90mg
    Market StatusPrescription
    CompanyAstrazeneca

    4.2 Therapeutic Uses

    Purinergic P2Y Receptor Antagonists

    National Library of Medicine's Medical Subject Headings. Ticagrelor. Online file (MeSH, 2016). Available from, as of January 20, 2016: https://www.nlm.nih.gov/mesh/2016/mesh_browser/MBrowser.html

    /CLINICAL TRIALS/ ClinicalTrials.gov is a registry and results database of publicly and privately supported clinical studies of human participants conducted around the world. The Web site is maintained by the National Library of Medicine (NLM) and the National Institutes of Health (NIH). Each ClinicalTrials.gov record presents summary information about a study protocol and includes the following: Disease or condition; Intervention (for example, the medical product, behavior, or procedure being studied); Title, description, and design of the study; Requirements for participation (eligibility criteria); Locations where the study is being conducted; Contact information for the study locations; and Links to relevant information on other health Web sites, such as NLM's MedlinePlus for patient health information and PubMed for citations and abstracts for scholarly articles in the field of medicine. Ticagrelor is included in the database.

    NIH/NLM; ClinicalTrials.Gov. Available from, as of March 17, 2016: https://clinicaltrials.gov/ct2/results?term=ticagrelor&Search=Search

    Brilinta is indicated to reduce the rate of cardiovascular death, myocardial infarction, and stroke in patients with acute coronary syndrome (ACS) or a history of myocardial infarction (MI). For at least the first 12 months following ACS, it is superior to clopidogrel. /Included in US product label/

    NIH; DailyMed. Current Medication Information for Brilinta (Ticagrelor) Tablet (Updated: September 2015). Available from, as of January 20, 2016: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f7b3f443-e83d-4bf2-0e96-023448fed9a8

    Brilinta also reduces the rate of stent thrombosis in patients who have been stented for treatment of acute coronary syndrome (ACS). /Included in US product label/

    NIH; DailyMed. Current Medication Information for Brilinta (Ticagrelor) Tablet (Updated: September 2015). Available from, as of January 20, 2016: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f7b3f443-e83d-4bf2-0e96-023448fed9a8

    4.3 Drug Warning

    /BOXED WARNING/ BLEEDING RISK. Brilinta, like other antiplatelet agents, can cause significant, sometimes fatal bleeding. Do not use Brilinta in patients with active pathological bleeding or a history of intracranial hemorrhage. Do not start Brilinta in patients undergoing urgent coronary artery bypass graft surgery (CABG). If possible, manage bleeding without discontinuing Brilinta. Stopping Brilinta increases the risk of subsequent cardiovascular events

    NIH; DailyMed. Current Medication Information for Brilinta (Ticagrelor) Tablet (Updated: September 2015). Available from, as of January 27, 2016: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f7b3f443-e83d-4bf2-0e96-023448fed9a8

    /BOXED WARNING/ ASPIRIN DOSE AND BRILINTA EFFECTIVENESS. Maintenance doses of aspirin above 100 mg reduce the effectiveness of Brilinta and should be avoided.

    NIH; DailyMed. Current Medication Information for Brilinta (Ticagrelor) Tablet (Updated: September 2015). Available from, as of January 27, 2016: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f7b3f443-e83d-4bf2-0e96-023448fed9a8

    In general, treatment with ticagrelor should not be discontinued prematurely because this increases the risk of cardiovascular events. Premature discontinuance of antiplatelet therapy (e.g., P2Y12 adenosine diphosphate (ADP)-receptor antagonists, aspirin) in patients with coronary artery stents has been associated with an increased risk of ischemic cardiovascular events (e.g., stent thrombosis, myocardial infarction (MI), death). If temporary discontinuance of ticagrelor is necessary such as prior to elective surgery or for management of bleeding, the drug should be restarted as soon as possible. Patients should be advised to never stop taking ticagrelor without first consulting the prescribing clinician, even if instructed by another clinician (e.g., dentist) to stop such therapy. Prior to scheduling an invasive procedure, patients should inform clinicians (including dentists) that they are currently taking ticagrelor and clinicians performing the invasive procedure should consult with the prescribing clinician before discontinuing such therapy.

    American Society of Health-System Pharmacists 2015; Drug Information 2015. Bethesda, MD. 2015, p. 1546-7

    Bradyarrhythmias, including ventricular pauses, have occurred in patients receiving ticagrelor. In the The Study of Platelet Inhibition and Patient Outcomes (PLATO) study, Holter monitor-detected ventricular pauses of at least 3 seconds were reported more frequently during the first week of therapy in patients receiving ticagrelor than in those receiving clopidogrel (5.8 versus 3.6%, respectively). There was no difference in the overall risk of clinically important bradycardic effects (e.g., syncope, need for pacemaker insertion) between the treatment groups. Ventricular pauses were mostly asymptomatic and attributed to sinoatrial nodal suppression. Patients with a baseline increased risk of bradycardia (e.g., those with sick sinus syndrome, second- or third-degree AV block, syncope due to bradycardia without a pacemaker) were excluded from the PLATO study; therefore, some clinicians recommend that ticagrelor be used with caution in such patients.

    American Society of Health-System Pharmacists 2015; Drug Information 2015. Bethesda, MD. 2015, p. 1547

    For more Drug Warnings (Complete) data for Ticagrelor (15 total), please visit the HSDB record page.

    4.4 Drug Indication

    Ticagrelor is indicated to reduce the risk of cardiovascular death, myocardial infarction, and stroke in patients with acute coronary syndrome or a history of myocardial infarction. Ticagrelor is also indicated to reduce the risk of a first myocardial infarction or stroke in high risk patients with coronary artery disease.

    FDA Label

    Brilique, co administered with acetylsalicylic acid (ASA), is indicated for the prevention of atherothrombotic events in adult patients with

    - acute coronary syndromes (ACS) or

    - a history of myocardial infarction (MI) and a high risk of developing an atherothrombotic event

    Brilique, co-administered with acetyl salicylic acid (ASA), is indicated for the prevention of atherothrombotic events in adult patients with a history of myocardial infarction (MI occurred at least one year ago) and a high risk of developing an atherothrombotic event.

    Possia, co-administered with acetylsalicylic acid (ASA), is indicated for the prevention of atherothrombotic events in adult patients with acute coronary syndromes (unstable angina, non-ST-elevation myocardial infarction [NSTEMI] or ST-elevation myocardial infarction [STEMI]); including patients managed medically, and those who are managed with percutaneous coronary intervention (PCI) or coronary artery by-pass grafting (CABG).

    Prevention of thromboembolic events

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Ticagrelor is a P2Y12 receptor antagonist that inhibits the formation of thromboses to reduce the risk of myocardial infarction and ischemic stroke. It has a moderate duration of action as it is given twice daily, and a wide therapeutic index as high single doses are well tolerated. Patients should be counselled regarding the risk of bleeding, dyspnea, and bradyarrhythmias.

    5.2 MeSH Pharmacological Classification

    Platelet Aggregation Inhibitors

    Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (See all compounds classified as Platelet Aggregation Inhibitors.)

    Purinergic P2Y Receptor Antagonists

    Compounds that bind to and block the stimulation of PURINERGIC P2Y RECEPTORS. Included under this heading are antagonists for specific P2Y receptor subtypes. (See all compounds classified as Purinergic P2Y Receptor Antagonists.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    TICAGRELOR
    5.3.2 FDA UNII
    GLH0314RVC
    5.3.3 Pharmacological Classes
    Cytochrome P450 3A5 Inhibitors [MoA]; Decreased Platelet Aggregation [PE]; P-Glycoprotein Inhibitors [MoA]; P2Y12 Platelet Inhibitor [EPC]; P2Y12 Receptor Antagonists [MoA]; Phenylalanine Hydroxylase Activators [MoA]; Cytochrome P450 3A4 Inhibitors [MoA]
    5.4 ATC Code

    B01AC24

    B01AC24

    B01AC24

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    B - Blood and blood forming organs

    B01 - Antithrombotic agents

    B01A - Antithrombotic agents

    B01AC - Platelet aggregation inhibitors excl. heparin

    B01AC24 - Ticagrelor

    5.5 Absorption, Distribution and Excretion

    Absorption

    Ticagrelor is 36% orally bioavailable. A single 200mg oral dose of ticagrelor reaches a Cmax of 923ng/mL, with a Tmax of 1.5 hours and an AUC of 6675ng\*h/mL. The active metabolite of ticagrelor reaches a Cmax of 264ng/mL, with a Tmax of 3.0 hours and an AUC of 2538ng\*h/mL.

    Route of Elimination

    A radiolabelled dose of ticagrelor is 57.8% recovered in feces and 26.5% recovered in urine. Less than 1% of the dose is recovered as the unmetabolized parent drug. The active metabolite AC-C124910XX makes up 21.7% of the recovery in the feces. The metabolite AR-C133913XX makes up 9.2% of the recovery in the urine and 2.7% of the recovery in the feces. Other minor metabolites are predominantly recovered in the urine.

    Volume of Distribution

    The steady state volume of distribution of ticagrelor is 88 L.

    Clearance

    The renal clearance of ticagrelor is 0.00584L/h.

    The drug is metabolized principally by cytochrome P-450 (CYP) isoenzyme 3A4 to an active metabolite that has similar antiplatelet activity as the parent drug.Plasma concentrations of ticagrelor and its active metabolite increase in a dose-dependent manner with peak concentrations achieved within approximately 1.5 and 2.5 hours, respectively. Ticagrelor is primarily eliminated in the feces and to a lesser extent in urine; less than 1% of a dose is recovered in urine as the parent drug and active metabolite. ... Both ticagrelor and its active metabolite are extensively (more than 99%) bound to human plasma proteins. Administration with a high-fat meal increases systemic exposure of ticagrelor by 21% and decreases peak plasma concentrations of the active metabolite by 22%, but has no effect on peak plasma concentrations of ticagrelor or on systemic exposure to the active metabolite.

    American Society of Health-System Pharmacists 2015; Drug Information 2015. Bethesda, MD. 2015, p. 1548

    Ticagrelor is rapidly absorbed following oral administration.

    American Society of Health-System Pharmacists 2015; Drug Information 2015. Bethesda, MD. 2015, p. 1548

    The primary route of ticagrelor elimination is hepatic metabolism. When radiolabeled ticagrelor is administered, the mean recovery of radioactivity is approximately 84% (58% in feces, 26% in urine). Recoveries of ticagrelor and the active metabolite in urine were both less than 1% of the dose. The primary route of elimination for the major metabolite of ticagrelor is most likely to be biliary secretion.

    NIH; DailyMed. Current Medication Information for Brilinta (Ticagrelor) Tablet (Updated: September 2015). Available from, as of January 27, 2016: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f7b3f443-e83d-4bf2-0e96-023448fed9a8

    /MILK/ It is not known whether ticagrelor or its active metabolites are excreted in human milk. Ticagrelor is excreted in rat milk.

    NIH; DailyMed. Current Medication Information for Brilinta (Ticagrelor) Tablet (Updated: September 2015). Available from, as of January 27, 2016: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f7b3f443-e83d-4bf2-0e96-023448fed9a8

    For more Absorption, Distribution and Excretion (Complete) data for Ticagrelor (6 total), please visit the HSDB record page.

    5.6 Metabolism/Metabolites

    The complete structure of all ticagrelor metabolites are not well defined. Ticagrelor can be dealkylated at postition 5 of the cyclopentane ring to form the active AR-C124910XX. AR-C124910XX's cyclopentane ring can be further glucuronidated or the alkyl chain attached to the sulfur can be hydroxylated. Ticagrelor can also be glucuronidated or hydroxylated. Ticagrelor can also be N-dealkylated to form AR-C133913XX, which is further glucuronidated or hydroxylated.

    CYP3A4 is the major enzyme responsible for ticagrelor metabolism and the formation of its major active metabolite. Ticagrelor and its major active metabolite are weak P-glycoprotein substrates and inhibitors. The systemic exposure to the active metabolite is approximately 30-40% of the exposure of ticagrelor.

    NIH; DailyMed. Current Medication Information for Brilinta (Ticagrelor) Tablet (Updated: September 2015). Available from, as of January 27, 2016: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f7b3f443-e83d-4bf2-0e96-023448fed9a8

    The drug is metabolized principally by cytochrome P-450 (CYP) isoenzyme 3A4 to an active metabolite that has similar antiplatelet activity as the parent drug.

    American Society of Health-System Pharmacists 2015; Drug Information 2015. Bethesda, MD. 2015, p. 1548

    Ticagrelor is a reversibly binding oral P2Y(12) receptor antagonist in development for the prevention of thrombotic events in patients with acute coronary syndromes. The pharmacokinetics, metabolism, and excretion of ticagrelor were investigated over 168 hr in six healthy male subjects receiving a single oral suspension dose of 200 mg of (14)C-ticagrelor. ... Major circulating components in the plasma and feces were identified as ticagrelor and AR-C124910XX, whereas in urine the major components were metabolite M5 (AR-C133913XX) and its glucuronide conjugate M4. Levels of unchanged ticagrelor and AR-C124910XX were <0.05% in the urine, indicating that renal clearance of ticagrelor and AR-C124910XX is of minor importance. Interindividual variability was small in both urine and fecal extracts with only small quantitative differences. All 10 of the metabolites were fully or partially characterized and a full biotransformation pathway was proposed for ticagrelor, in which oxidative loss of the hydroxyethyl side chain from ticagrelor forms AR-C124910XX and a second oxidative pathway leads to N-dealkylation of ticagrelor, forming AR-C133913XX.

    PMID:20551239 Teng R et al; Drug Metab Dispos 38 (9): 1514-21 (2010)

    5.7 Biological Half-Life

    Ticagrelor has a plasma half life of approximately 8 hours, while the active metabolite has a plasma half life of approximately 12 hours.

    The mean terminal half-lives of ticagrelor and its active metabolite reportedly are about 7 and 9 hours, respectively.

    American Society of Health-System Pharmacists 2015; Drug Information 2015. Bethesda, MD. 2015, p. 1548

    Ticagrelor is a reversibly binding oral P2Y(12) receptor antagonist in development for the prevention of thrombotic events in patients with acute coronary syndromes. The pharmacokinetics, metabolism, and excretion of ticagrelor were investigated over 168 hr in six healthy male subjects receiving a single oral suspension dose of 200 mg of (14)C-ticagrelor. In most subjects, radioactivity was undetectable in plasma after 20 hr and whole blood after 12 hr (half-life values of 6.3 and 4.6 hr, respectively).

    PMID:20551239 Teng R et al; Drug Metab Dispos 38 (9): 1514-21 (2010)

    5.8 Mechanism of Action

    Ticagrelor is a P2Y12 receptor antagonist. The P2Y12 receptor couples with Gi2 and other Gi proteins which inhibit adenylyl cyclase. Gi mediated signalling also activates PI3K, Akt, Rap1b, and potassium channels. The downstream effects of these activities mediate hemostasis and lead to platelet aggregation. Antagonism of the P2Y12 receptor reduces development of occlusive thromboses, which can reduce the risk of myocardial infarction and ischemic stroke.

    Ticagrelor, a cyclopentyltriazolopyrimidine derivative, is a nonthienopyridine, P2Y12 platelet adenosine diphosphate (ADP)-receptor antagonist. In contrast to the thienopyridines (e.g., clopidogrel, prasugrel), ticagrelor binds reversibly to the P2Y12 ADP receptor and does not require hepatic transformation to exert its pharmacologic effect. Ticagrelor exhibits noncompetitive and reversible binding to the P2Y12 platelet ADP receptor, preventing signal transduction of the cyclic adenosine monophosphate (cAMP) pathway. This results in reduced exposure of fibrinogen binding sites to the platelet glycoprotein (GP) IIb/IIIa complex and subsequent inhibition of platelet activation and aggregation. In addition to platelet ADP-receptor blockade, ticagrelor inhibits reuptake of adenosine into erythrocytes, a mechanism that may account for some of the beneficial cardiovascular effects of the drug, while potentially contributing to some of its adverse effects (e.g., dyspnea, ventricular pauses).

    American Society of Health-System Pharmacists 2015; Drug Information 2015. Bethesda, MD. 2015, p. 1547

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    ZHEJIANG AUSUN PHARMACEUTICAL CO., ...

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PU DONG","customer":"ALKEM LABORATORIES","customerCountry":"INDIA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"510","totalValueFC":"51560.5","currency":"USD","unitRateINR":"43324.5","date":"23-Oct-2024","totalValueINR":"4332450","totalValueInUsd":"51560.5","indian_port":"Delhi Air","hs_no":"29339990","bill_no":"6278868","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI - PU DONG","supplierAddress":"NO.2 TONGHAI SI ROAD YANGKOU CHEMIC AL INDUSTRIAL PARK RUDONG COASTAL E CONOMIC DEVELOPMENT ZONE NANTONG JI CHINA","customerAddress":"ALKEM HOUSE, DEVASHISH ADJACENT T"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730053800,"product":"TICAGRELOR API","address":"20TH KM, HOSUR ROAD,","city":"BANGALORE","supplier":"PHARMARESOURCES","supplierCountry":"CHINA","foreign_port":"BEIJING, 11","customer":"BIOCON","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"650","totalValueFC":"3285.7","currency":"USD","unitRateINR":"55217.6","date":"28-Oct-2024","totalValueINR":"276088","totalValueInUsd":"3285.7","indian_port":"Biocon-SEZ","hs_no":"29420090","bill_no":"1014189","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING, 11","supplierAddress":"NO.3, BEIHUAN ROAD, KAIYUAN CITY LI AONING PROVINCE, CHINA Beijing, , C hina CHINA","customerAddress":"20TH KM, HOSUR ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1731522600,"product":"TICAGRELOR FORM-II IN-HOUSE(DR. REDDY'S)","address":"564\/A\/22, ROAD NO.92","city":"HYDERABAD,ANDHRA PRADESH","supplier":"MYLAN LABORATORIES LIMITED FDF UNIT-3","supplierCountry":"INDIA","foreign_port":"WALUJ (AURANGABAD)","customer":"VIATRIS","customerCountry":"INDIA","quantity":"59.93","actualQuantity":"59.934","unit":"KGS","unitRateFc":"2501.8","totalValueFC":"151386.1","currency":"USD","unitRateINR":"213154.5","date":"14-Nov-2024","totalValueINR":"12775201.8","totalValueInUsd":"151386.1","indian_port":"Indore-EPZ\/SEZ","hs_no":"29321990","bill_no":"6674477","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"WALUJ (AURANGABAD)","supplierAddress":"Plot No 11,12 & 13, SEZ Phase II, ISEZ, Sector 3, Pithampur,Dist Dhar SDNF India","customerAddress":"564\/A\/22, ROAD NO.92"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1734287400,"product":"TICAGRELOR PH. EUR","address":"CORPORATE HOUSE, NR. SOLA BRIDGE,,","city":"AHMEDABAD,GUJARAT","supplier":"N\/A","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"INTAS PHARMACEUTICALS","customerCountry":"INDIA","quantity":"51.00","actualQuantity":"51","unit":"KGS","unitRateFc":"650","totalValueFC":"33415.7","currency":"USD","unitRateINR":"55672.5","date":"16-Dec-2024","totalValueINR":"2839298","totalValueInUsd":"33415.7","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29335990","bill_no":"7255640","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"N\/A","customerAddress":"CORPORATE HOUSE, NR. SOLA BRIDGE,,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1736188200,"product":"TICAGRELOR TICAGRELOR","address":"ALKEM HOUSE, DEVASHISH ADJACENT T","city":"MUMBAI,MAHARASHTRA","supplier":"NANTONG CHANYOO PHARMATECH","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"ALKEM LABORATORIES","customerCountry":"INDIA","quantity":"880.00","actualQuantity":"880","unit":"KGS","unitRateFc":"500","totalValueFC":"441892.1","currency":"USD","unitRateINR":"43300","date":"07-Jan-2025","totalValueINR":"38104000","totalValueInUsd":"441892.1","indian_port":"JNPT","hs_no":"29339990","bill_no":"7651026","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"NO.2 TONGHAI SI ROAD YANGKOU CHEMIC AL INDUSTRIAL PARK RUDONG COASTAL E CONOMIC DEVELOPMENT ZONE NANTONG ZO CHINA","customerAddress":"ALKEM HOUSE, DEVASHISH ADJACENT T"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1736879400,"product":"TICAGRELOR TICAGRELOR","address":"ALKEM HOUSE, DEVASHISH ADJACENT T","city":"MUMBAI,MAHARASHTRA","supplier":"NANTONG CHANYOO PHARMATECH","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"ALKEM LABORATORIES","customerCountry":"INDIA","quantity":"108.80","actualQuantity":"108.798","unit":"KGS","unitRateFc":"500","totalValueFC":"54632.9","currency":"USD","unitRateINR":"43300","date":"15-Jan-2025","totalValueINR":"4710953.4","totalValueInUsd":"54632.9","indian_port":"JNPT","hs_no":"29339990","bill_no":"7803840","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"NO.2 TONGHAI SI ROAD YANGKOU CHEMIC AL INDUSTRIAL PARK RUDONG COASTAL E CONOMIC DEVELOPMENT ZONE NANTONG ZO CHINA","customerAddress":"ALKEM HOUSE, DEVASHISH ADJACENT T"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1742236200,"product":"TICAGRELOR-FOR RESEARCH PURPOSE ONLY TICAGRELOR-FOR RESEARCH PURPOSE ONLY","address":"VILLAGE MANPURA,","city":"","supplier":"NANTONG CHANYOO PHARMATECH","supplierCountry":"CHINA","foreign_port":"HANGCHOW (HANGZHOU)","customer":"PINNACLE LIFE SCIENCE","customerCountry":"INDIA","quantity":"1.30","actualQuantity":"1.3","unit":"KGS","unitRateFc":"900","totalValueFC":"1186","currency":"USD","unitRateINR":"79020","date":"18-Mar-2025","totalValueINR":"102726","totalValueInUsd":"1186","indian_port":"Bombay Air","hs_no":"29339990","bill_no":"8958647","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HANGCHOW (HANGZHOU)","supplierAddress":"NO. 2 TONGHAI SI ROAD. YANGKOU CHEMICAL INDUSTRIAL PARK RUDONG COASTAL ECONOMIC DEVELOPMENT ZONE N CN","customerAddress":"VILLAGE MANPURA,"}]
    02-Jan-2021
    31-Mar-2025
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    Drugs in Development

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    Morepen Laboratories Expands Its Domestic Portfolio

    Details:

    Ticapen (ticagrelor) mechanism of action involves inhibiting platelet activation and aggregation by reversibly binding to the P2Y12 receptor, to reduce the risk of stroke and heart attack.


    Lead Product(s): Ticagrelor

    Therapeutic Area: Cardiology/Vascular Diseases Brand Name: Ticapen

    Study Phase: Approved FDFProduct Type: Other Small Molecule

    Sponsor: Inapplicable

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable April 25, 2025

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    01

    Morepen Laboratories

    India
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    Morepen Laboratories

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    Lead Product(s) : Ticagrelor

    Therapeutic Area : Cardiology/Vascular Diseases

    Highest Development Status : Approved FDF

    Partner/Sponsor/Collaborator : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Morepen Laboratories Expands Its Domestic Portfolio

    Details : Ticapen (ticagrelor) mechanism of action involves inhibiting platelet activation and aggregation by reversibly binding to the P2Y12 receptor, to reduce the risk of stroke and heart attack.

    Product Name : Ticapen

    Product Type : Other Small Molecule

    Upfront Cash : Inapplicable

    April 25, 2025

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    University Medical Center Utrecht Study Shows that Crushed Prasugrel Prehospital Fails to Improve STEMI Reperfusion vs. Integral Tablets

    Details:

    The incidence of death, myocardial infarction, or stroke was significantly lower among those who received prasugrel than among those who received ticagrelor, and the incidence of major bleeding was not significantly different between the two groups.


    Lead Product(s): Ticagrelor

    Therapeutic Area: Cardiology/Vascular Diseases Brand Name: Brilique

    Study Phase: Phase IVProduct Type: Other Small Molecule

    Sponsor: Inapplicable

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable October 17, 2020

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    02

    University Medical Center Utrecht

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    University Medical Center Utrecht

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    Lead Product(s) : Ticagrelor

    Therapeutic Area : Cardiology/Vascular Diseases

    Highest Development Status : Phase IV

    Partner/Sponsor/Collaborator : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    University Medical Center Utrecht Study Shows that Crushed Prasugrel Prehospital Fails to Improve ...

    Details : The incidence of death, myocardial infarction, or stroke was significantly lower among those who received prasugrel than among those who received ticagrelor, and the incidence of major bleeding was not significantly different between the two groups.

    Product Name : Brilique

    Product Type : Other Small Molecule

    Upfront Cash : Inapplicable

    October 17, 2020

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    AstraZeneca's BRILINTA Gets FDA Priority Review for the Reduction of Subsequent Stroke Acute Ischemic Stroke Patients

    Details:

    Phase III THALES trial showed aspirin plus BRILINTA 90mg used twice daily for 30 days, resulted in a statistically significant and clinically meaningful reduction in the risk of the primary composite endpoint of stroke and death, compared to aspirin alone.


    Lead Product(s): Ticagrelor,Aspirin

    Therapeutic Area: Cardiology/Vascular Diseases Brand Name: Brilinta

    Study Phase: Phase IIIProduct Type: Other Small Molecule

    Sponsor: Inapplicable

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable September 07, 2020

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    AstraZeneca

    United Kingdom
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    AstraZeneca

    United Kingdom
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    Lead Product(s) : Ticagrelor,Aspirin

    Therapeutic Area : Cardiology/Vascular Diseases

    Highest Development Status : Phase III

    Partner/Sponsor/Collaborator : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    AstraZeneca's BRILINTA Gets FDA Priority Review for the Reduction of Subsequent Stroke Acute Ische...

    Details : Phase III THALES trial showed aspirin plus BRILINTA 90mg used twice daily for 30 days, resulted in a statistically significant and clinically meaningful reduction in the risk of the primary composite endpoint of stroke and death, compared to aspirin alon...

    Product Name : Brilinta

    Product Type : Other Small Molecule

    Upfront Cash : Inapplicable

    September 07, 2020

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    AZ Unveils Detailed Data from THALES Trial

    Details:

    The Phase III THALES results shows that a combination of twice daily Brilinta (ticagrelor) and daily aspirin reduced the rate of stroke and death by 17% after 30 days compared to aspirin alone in patients with acute ischemic stroke or transient ischemic attack.


    Lead Product(s): Ticagrelor,Aspirin

    Therapeutic Area: Cardiology/Vascular Diseases Brand Name: Brilinta

    Study Phase: Phase IIIProduct Type: Other Small Molecule

    Sponsor: Inapplicable

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable July 16, 2020

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    AstraZeneca

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    Lead Product(s) : Ticagrelor,Aspirin

    Therapeutic Area : Cardiology/Vascular Diseases

    Highest Development Status : Phase III

    Partner/Sponsor/Collaborator : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    AZ Unveils Detailed Data from THALES Trial

    Details : The Phase III THALES results shows that a combination of twice daily Brilinta (ticagrelor) and daily aspirin reduced the rate of stroke and death by 17% after 30 days compared to aspirin alone in patients with acute ischemic stroke or transient ischemic ...

    Product Name : Brilinta

    Product Type : Other Small Molecule

    Upfront Cash : Inapplicable

    July 16, 2020

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    Brilinta Approved in the US to Reduce the Risk of Stroke in Patients with an Acute Ischaemic Stroke or High-Risk Transient Ischaemic Attack

    Details:

    The approval by the US FDA was based on positive results from the THALES Phase III trial that showed aspirin plus Brilinta 90mg significantly reduced the rate of the composite of stroke and death compared to aspirin alone in patients with acute ischaemic stroke or TIA.


    Lead Product(s): Ticagrelor,Aspirin

    Therapeutic Area: Cardiology/Vascular Diseases Brand Name: Brilinta

    Study Phase: Approved FDFProduct Type: Other Small Molecule

    Sponsor: Inapplicable

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable June 11, 2020

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    AstraZeneca

    United Kingdom
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    Lead Product(s) : Ticagrelor,Aspirin

    Therapeutic Area : Cardiology/Vascular Diseases

    Highest Development Status : Approved FDF

    Partner/Sponsor/Collaborator : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Brilinta Approved in the US to Reduce the Risk of Stroke in Patients with an Acute Ischaemic Strok...

    Details : The approval by the US FDA was based on positive results from the THALES Phase III trial that showed aspirin plus Brilinta 90mg significantly reduced the rate of the composite of stroke and death compared to aspirin alone in patients with acute ischaemic...

    Product Name : Brilinta

    Product Type : Other Small Molecule

    Upfront Cash : Inapplicable

    June 11, 2020

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    BRILINTA Met Primary Endpoint in the Phase III THALES Trial in Stroke

    Details:

    BRILINTA reduced the risk of the composite of stroke and death after an acute ischemic stroke or transient ischemic attack.


    Lead Product(s): Ticagrelor,Aspirin

    Therapeutic Area: Cardiology/Vascular Diseases Brand Name: Brilinta

    Study Phase: Phase IIIProduct Type: Other Small Molecule

    Sponsor: Inapplicable

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable January 27, 2020

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    AstraZeneca

    United Kingdom
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    Not Confirmed

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    United Kingdom
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    Not Confirmed
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    Lead Product(s) : Ticagrelor,Aspirin

    Therapeutic Area : Cardiology/Vascular Diseases

    Highest Development Status : Phase III

    Partner/Sponsor/Collaborator : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    BRILINTA Met Primary Endpoint in the Phase III THALES Trial in Stroke

    Details : BRILINTA reduced the risk of the composite of stroke and death after an acute ischemic stroke or transient ischemic attack.

    Product Name : Brilinta

    Product Type : Other Small Molecule

    Upfront Cash : Inapplicable

    January 27, 2020

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    BRILINTA Approved in the US to Reduce the Risk of a First Heart Attack or Stroke in High-Risk Patients with Coronary Artery Disease

    Details:

    The approval was based on positive results from the Phase III THEMIS trial. The trial showed a statistically significant reduction in the primary composite endpoint of MACE at 36 months with aspirin + Brilinta 60mg versus aspirin alone in patients with CAD and type-2 diabetes.


    Lead Product(s): Ticagrelor,Aspirin

    Therapeutic Area: Cardiology/Vascular Diseases Brand Name: Brilinta

    Study Phase: Approved FDFProduct Type: Other Small Molecule

    Sponsor: Inapplicable

    Deal Size: Inapplicable Upfront Cash: Inapplicable

    Deal Type: Inapplicable January 06, 2020

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    AstraZeneca

    United Kingdom
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    Lead Product(s) : Ticagrelor,Aspirin

    Therapeutic Area : Cardiology/Vascular Diseases

    Highest Development Status : Approved FDF

    Partner/Sponsor/Collaborator : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    BRILINTA Approved in the US to Reduce the Risk of a First Heart Attack or Stroke in High-Risk Pati...

    Details : The approval was based on positive results from the Phase III THEMIS trial. The trial showed a statistically significant reduction in the primary composite endpoint of MACE at 36 months with aspirin + Brilinta 60mg versus aspirin alone in patients with C...

    Product Name : Brilinta

    Product Type : Other Small Molecule

    Upfront Cash : Inapplicable

    January 06, 2020

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    INTERMEDIATE SUPPLIERS

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    Aarti Pharmalabs

    India
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    Virtual BoothAarti Pharmalabs is a partner of choice for APIs & Intermediates and the largest Indian manufacturer of Xanthine Derivatives.

    2-((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-...

    CAS Number : 376608-65-0

    End Use API : Ticagrelor

    About The Company : Aarti Pharmalab, earlier the pharma division of Aarti Industries, is a leading Indian manufacturer of APIs. It has dedicated facilities to manufacture HPAPIs, c...

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    4,6-dichloro-2-(propyl sulfanyl) pyrimidin-5-amine

    CAS Number : 145783-15-9

    End Use API : Ticagrelor

    About The Company : Aarti Pharmalab, earlier the pharma division of Aarti Industries, is a leading Indian manufacturer of APIs. It has dedicated facilities to manufacture HPAPIs, c...

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    Aarti Pharmalabs

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    Virtual BoothAarti Pharmalabs is a partner of choice for APIs & Intermediates and the largest Indian manufacturer of Xanthine Derivatives.

    (1R,2S)-2-(3,4-difuorophenyl)cyclopropan-1- amine ...

    CAS Number : 376608-71-8

    End Use API : Ticagrelor

    About The Company : Aarti Pharmalab, earlier the pharma division of Aarti Industries, is a leading Indian manufacturer of APIs. It has dedicated facilities to manufacture HPAPIs, c...

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    Aarti Pharmalabs

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    (1R, 2S)-2- (3,4-difuorophenyl) cyclopropanamine, ...

    CAS Number : 1402222-66-5

    End Use API : Ticagrelor

    About The Company : Aarti Pharmalab, earlier the pharma division of Aarti Industries, is a leading Indian manufacturer of APIs. It has dedicated facilities to manufacture HPAPIs, c...

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    05

    Amara Labs

    India
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    4,6-DICHLORO-2-PROPYLTHIOPYRIMIDINE-5-AMINE

    CAS Number : 145783-15-9

    End Use API : Ticagrelor

    About The Company : Amara Labs Pvt Ltd is a WHO-GMP certified manufacturing company wholly owned by a team of technocrats with working experience of more than 20 years in Multi-Nat...

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    Anhui HaiKang Pharmaceutical Co. Lt...

    China
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    Anhui HaiKang Pharmaceutical Co. Lt...

    China
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    2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl...

    CAS Number : 376608-65-0

    End Use API : Ticagrelor

    About The Company : Anhui Haikang Pharmaceutical Co., Ltd. was established in 2009 and located in a High-tech industry park, Anqing City, Anhui Province---a famous historical and c...

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    Anhui HaiKang Pharmaceutical Co. Lt...

    China
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    (1R,2S)-2-(3,4-Difluorophenyl)

    CAS Number : 376608-71-8

    End Use API : Ticagrelor

    About The Company : Anhui Haikang Pharmaceutical Co., Ltd. was established in 2009 and located in a High-tech industry park, Anqing City, Anhui Province---a famous historical and c...

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    Anhui HaiKang Pharmaceutical Co. Lt...

    China
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    Anhui HaiKang Pharmaceutical Co. Lt...

    China
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    4,6-Dichloro-2-(propylthio)pyrimidin-5-amine

    CAS Number : 145783-15-9

    End Use API : Ticagrelor

    About The Company : Anhui Haikang Pharmaceutical Co., Ltd. was established in 2009 and located in a High-tech industry park, Anqing City, Anhui Province---a famous historical and c...

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    Anhui HaiKang Pharmaceutical Co. Lt...

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    N-Propylsulfuric diamide-sodium

    CAS Number : 1642873-03-7

    End Use API : Ticagrelor

    About The Company : Anhui Haikang Pharmaceutical Co., Ltd. was established in 2009 and located in a High-tech industry park, Anqing City, Anhui Province---a famous historical and c...

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    Anhui HaiKang Pharmaceutical Co. Lt...

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    5-(4-bromophenyl)-4,6-dichloropyrimidine

    CAS Number : 146533-41-7

    End Use API : Ticagrelor

    About The Company : Anhui Haikang Pharmaceutical Co., Ltd. was established in 2009 and located in a High-tech industry park, Anqing City, Anhui Province---a famous historical and c...

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    FDF Dossiers

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    Dr. Reddy's Laboratories

    India
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    Regulatory Info : RX

    Registration Country : USA

    TICAGRELOR

    Brand Name : TICAGRELOR

    Dosage Form : TABLET;ORAL

    Dosage Strength : 90MG

    Packaging :

    Approval Date : 2024-10-29

    Application Number : 208541

    Regulatory Info : RX

    Registration Country : USA

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    Dr. Reddy's Laboratories

    India
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    Registration Country : USA

    TICAGRELOR

    Brand Name : TICAGRELOR

    Dosage Form : TABLET;ORAL

    Dosage Strength : 90MG

    Packaging :

    Approval Date :

    Application Number : 208541

    Regulatory Info :

    Registration Country : USA

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    Dr. Reddy's Laboratories

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    Regulatory Info : Lead Market Dossiers- Filed

    Registration Country : India

    Ticagrelor

    Brand Name :

    Dosage Form : Oral Solid Dosage Form

    Dosage Strength : 60MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info : Lead Market Dossiers- Filed

    Registration Country : India

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    Dosage Strength : 90MG

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    Regulatory Info : Lead Market Dossiers- Filed

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    Regulatory Info : EU Dossier Readiness-Q4 2018

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    Ticagrelor

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    Dosage Form : Film Coated Tablet

    Dosage Strength : 90MG

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    Application Number :

    Regulatory Info : EU Dossier Readiness-Q4 2018

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    Regulatory Info : EU Dossier Readiness-Q4 2018

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    Regulatory Info : EU Dossier Readiness-Q1 2020

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    DOSAGE - TABLET;ORAL - 60MG

    USFDA APPLICATION NUMBER - 22433

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    DOSAGE - TABLET;ORAL - 90MG

    USFDA APPLICATION NUMBER - 22433

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    ABOUT THIS PAGE

    Looking for 274693-27-5 / Ticagrelor API manufacturers, exporters & distributors?

    Ticagrelor manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Ticagrelor API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Ticagrelor manufacturer or Ticagrelor supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Ticagrelor manufacturer or Ticagrelor supplier.

    PharmaCompass also assists you with knowing the Ticagrelor API Price utilized in the formulation of products. Ticagrelor API Price is not always fixed or binding as the Ticagrelor Price is obtained through a variety of data sources. The Ticagrelor Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Ticagrelor

    Synonyms

    274693-27-5, Brilinta, Brilique, Azd6140, Azd-6140, Possia

    Cas Number

    274693-27-5

    Unique Ingredient Identifier (UNII)

    GLH0314RVC

    About Ticagrelor

    An adenosine triphosphate analogue and reversible P2Y12 PURINORECEPTOR antagonist that inhibits ADP-mediated PLATELET AGGREGATION. It is used for the prevention of THROMBOEMBOLISM by patients with ACUTE CORONARY SYNDROME or a history of MYOCARDIAL INFARCTION.

    Brilinta Manufacturers

    A Brilinta manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Brilinta, including repackagers and relabelers. The FDA regulates Brilinta manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Brilinta API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Brilinta manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Brilinta Suppliers

    A Brilinta supplier is an individual or a company that provides Brilinta active pharmaceutical ingredient (API) or Brilinta finished formulations upon request. The Brilinta suppliers may include Brilinta API manufacturers, exporters, distributors and traders.

    click here to find a list of Brilinta suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Brilinta USDMF

    A Brilinta DMF (Drug Master File) is a document detailing the whole manufacturing process of Brilinta active pharmaceutical ingredient (API) in detail. Different forms of Brilinta DMFs exist exist since differing nations have different regulations, such as Brilinta USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Brilinta DMF submitted to regulatory agencies in the US is known as a USDMF. Brilinta USDMF includes data on Brilinta's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Brilinta USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Brilinta suppliers with USDMF on PharmaCompass.

    Brilinta KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Brilinta Drug Master File in Korea (Brilinta KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Brilinta. The MFDS reviews the Brilinta KDMF as part of the drug registration process and uses the information provided in the Brilinta KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Brilinta KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Brilinta API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Brilinta suppliers with KDMF on PharmaCompass.

    Brilinta CEP

    A Brilinta CEP of the European Pharmacopoeia monograph is often referred to as a Brilinta Certificate of Suitability (COS). The purpose of a Brilinta CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Brilinta EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Brilinta to their clients by showing that a Brilinta CEP has been issued for it. The manufacturer submits a Brilinta CEP (COS) as part of the market authorization procedure, and it takes on the role of a Brilinta CEP holder for the record. Additionally, the data presented in the Brilinta CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Brilinta DMF.

    A Brilinta CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Brilinta CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Brilinta suppliers with CEP (COS) on PharmaCompass.

    Brilinta WC

    A Brilinta written confirmation (Brilinta WC) is an official document issued by a regulatory agency to a Brilinta manufacturer, verifying that the manufacturing facility of a Brilinta active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Brilinta APIs or Brilinta finished pharmaceutical products to another nation, regulatory agencies frequently require a Brilinta WC (written confirmation) as part of the regulatory process.

    click here to find a list of Brilinta suppliers with Written Confirmation (WC) on PharmaCompass.

    Brilinta NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Brilinta as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Brilinta API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Brilinta as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Brilinta and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Brilinta NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Brilinta suppliers with NDC on PharmaCompass.

    Brilinta GMP

    Brilinta Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Brilinta GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Brilinta GMP manufacturer or Brilinta GMP API supplier for your needs.

    Brilinta CoA

    A Brilinta CoA (Certificate of Analysis) is a formal document that attests to Brilinta's compliance with Brilinta specifications and serves as a tool for batch-level quality control.

    Brilinta CoA mostly includes findings from lab analyses of a specific batch. For each Brilinta CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Brilinta may be tested according to a variety of international standards, such as European Pharmacopoeia (Brilinta EP), Brilinta JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Brilinta USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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