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KER-047, is designed to selectively and potently inhibit ALK2, a TGF-β receptor. KER-047 is being developed for the treatment of functional iron deficiency which is a consequence of elevated ALK2 signaling, including the Company’s initial target, IRIDA.
KER-047, is designed to selectively and potently inhibit activin receptor-like kinase-2, a TGF-β superfamily receptor. KER-047 is being developed for the treatment of functional iron deficiency which is a consequence of elevated ALK2 signaling.
AG-946, is a novel small molecule that activates the enzyme pyruvate kinase which contributes to the production of energy in the RBC. By helping to increase energy, RBC functionality and survival may be improved.
With the acquisition, Novo Nordisk will gain access to Forma’s lead development candidate, etavopivat being developed in SCD to expand presence in sickle cell disease, rare blood disorders and haemoglobinopathies.
Results of post-hoc study analysis showing that ES-SCLC patients who received Cosela (trilaciclib) prior to chemotherapy had a lower incidence of single- and multilineage myelosuppressive events compared to patients receiving placebo.
BCX9930, significantly increased hemoglobin and reduced transfusions in an ongoing dose-ranging trial in treatment-naïve paroxysmal nocturnal hemoglobinuria patients, and in PNH patients with an inadequate response to C5 inhibitors.
Study results demonstrate that nafamostat had similar efficacy as citrate, while providing lower toxicity and lower costs to the hospital over standard citrate anticoagulation.
First patient is enrolled for REDEEM-1 Pivotal Trial of BCX9930 on the basis of results from the previous trial which was safe and generally well-tolerated and, showed increased hemoglobin from baseline with 80 percent of patients being transfusion-free over the same period.
Company received feedback from USFDA regarding IND of Triferic (Ferric Pyrophosphate Citrate), designed for the treatment of iron deficiency anemia and maintenance of hemoglobin in patients receiving infusion therapy in the home setting.
Company enrolled first patient in trial of BCX9930, an oral Factor D inhibitor showed primary endpoint change from baseline in paroxysmal nocturnal hemoglobinuria, as assessed at week 12.
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