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    [{"orgOrder":0,"company":"Orexia Therapeutics","sponsor":"Centessa Pharmaceuticals","pharmaFlowCategory":"D","upfrontCash":"Undisclosed","therapeuticArea":"Sleep","country":"UNITED KINGDOM","productType":"Small molecule","date":"February 2021","year":"2021","type":"Merger","leadProduct":"Undisclosed","moa":"","graph1":"Sleep","graph2":"Preclinical","graph3":"Orexia Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Sleep","amount2New":0,"dosageForm":"Oral","sponsorNew":"Orexia Therapeutics \/ Centessa","highestDevelopmentStatusID":"4","companyTruncated":"Orexia Therapeutics \/ Centessa"},{"orgOrder":0,"company":"Enalare Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","upfrontCash":"Not Applicable","therapeuticArea":"Sleep","country":"","productType":"Small molecule","date":"December 2021","year":"2021","type":"Not Applicable","leadProduct":"ENA-001","moa":"Potassium ion channel","graph1":"Sleep","graph2":"Preclinical","graph3":"Enalare Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Sleep","amount2New":0,"dosageForm":"Inhalation","sponsorNew":"Enalare Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"4","companyTruncated":"Enalare Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Tris Pharma Inc","sponsor":"Not Applicable","pharmaFlowCategory":"DU","upfrontCash":"Not Applicable","therapeuticArea":"Sleep","country":"","productType":"Small molecule","date":"July 2022","year":"2022","type":"Not Applicable","leadProduct":"Sodium Oxybate","moa":"GABA B receptor","graph1":"Sleep","graph2":"Preclinical","graph3":"Tris Pharma Inc","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Sleep","amount2New":0,"dosageForm":"","sponsorNew":"Tris Pharma Inc \/ Not Applicable","highestDevelopmentStatusID":"4","companyTruncated":"Tris Pharma Inc \/ Not Applicable"},{"orgOrder":0,"company":"Eagle Pharmaceuticals","sponsor":"Enalare Therapeutics","pharmaFlowCategory":"DU","upfrontCash":"Not Applicable","therapeuticArea":"Sleep","country":"","productType":"Small molecule","date":"October 2022","year":"2022","type":"Not Applicable","leadProduct":"ENA-001","moa":"Potassium ion channel","graph1":"Sleep","graph2":"Preclinical","graph3":"Eagle Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Sleep","amount2New":0,"dosageForm":"Injectable\/Injection","sponsorNew":"Eagle Pharmaceuticals \/ Enalare Therapeutics","highestDevelopmentStatusID":"4","companyTruncated":"Eagle Pharmaceuticals \/ Enalare Therapeutics"},{"orgOrder":0,"company":"Enalare Therapeutics","sponsor":"National Institutes of Health","pharmaFlowCategory":"DU","upfrontCash":"Not Applicable","therapeuticArea":"Sleep","country":"","productType":"Small molecule","date":"October 2022","year":"2022","type":"Not Applicable","leadProduct":"ENA-001","moa":"Potassium ion channel","graph1":"Sleep","graph2":"Preclinical","graph3":"Enalare Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Sleep","amount2New":0,"dosageForm":"","sponsorNew":"Enalare Therapeutics \/ National Institutes of Health","highestDevelopmentStatusID":"4","companyTruncated":"Enalare Therapeutics \/ National Institutes of Health"},{"orgOrder":0,"company":"F. Hoffmann-La Roche","sponsor":"PsychoGenics","pharmaFlowCategory":"D","upfrontCash":"Undisclosed","therapeuticArea":"Sleep","country":"","productType":"Undisclosed","date":"December 2023","year":"2023","type":"Licensing Agreement","leadProduct":"RO7117997","moa":"","graph1":"Sleep","graph2":"Preclinical","graph3":"F. Hoffmann-La Roche","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Sleep","amount2New":0,"dosageForm":"","sponsorNew":"F. Hoffmann-La Roche \/ PsychoGenics","highestDevelopmentStatusID":"4","companyTruncated":"F. Hoffmann-La Roche \/ PsychoGenics"},{"orgOrder":0,"company":"NLS Pharmaceutics","sponsor":"Aexon Labs","pharmaFlowCategory":"D","upfrontCash":"Undisclosed","therapeuticArea":"Sleep","country":"","productType":"Undisclosed","date":"December 2023","year":"2023","type":"Agreement","leadProduct":"Undisclosed","moa":"","graph1":"Sleep","graph2":"Preclinical","graph3":"NLS Pharmaceutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Sleep","amount2New":0,"dosageForm":"","sponsorNew":"NLS Pharmaceutics \/ Aexon Labs","highestDevelopmentStatusID":"4","companyTruncated":"NLS Pharmaceutics \/ Aexon Labs"},{"orgOrder":0,"company":"Aexon Labs","sponsor":"NLS Pharmaceutics","pharmaFlowCategory":"D","upfrontCash":"Undisclosed","therapeuticArea":"Sleep","country":"","productType":"Undisclosed","date":"March 2024","year":"2024","type":"Licensing Agreement","leadProduct":"AEX-2","moa":"","graph1":"Sleep","graph2":"Preclinical","graph3":"Aexon Labs","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Sleep","amount2New":0,"dosageForm":"","sponsorNew":"Aexon Labs \/ NLS Pharmaceutics","highestDevelopmentStatusID":"4","companyTruncated":"Aexon Labs \/ NLS Pharmaceutics"},{"orgOrder":0,"company":"Bioprojet Pharma","sponsor":"Harmony Biosciences","pharmaFlowCategory":"D","upfrontCash":"$25.5 million","therapeuticArea":"Sleep","country":"","productType":"Small molecule","date":"April 2024","year":"2024","type":"Licensing Agreement","leadProduct":"TPM-1116","moa":"","graph1":"Sleep","graph2":"Preclinical","graph3":"Bioprojet Pharma","amount2":0.39000000000000001,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Sleep","amount2New":0.39000000000000001,"dosageForm":"","sponsorNew":"Bioprojet Pharma \/ Harmony Biosciences","highestDevelopmentStatusID":"4","companyTruncated":"Bioprojet Pharma \/ Harmony Biosciences"}]

    Find Clinical Drug Development Pipelines & Deals | PipelineProspector

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                            01

                            NLS Pharmaceutics

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                            Aquaexpo 2024
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                            NLS Pharmaceutics

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                            Lead Product(s) : Mazindol

                            Therapeutic Area : Sleep

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            NLS Pharmaceutics Reports Positive KO-874 Study on Mazindol for Narcoleptic-like Model

                            Details : The Company's lead candidate, Quilience®, is a proprietary extended-release formulation of Mazindol (Mazindol ER) and is being developed for the treatment of orexin-B-saporin induced narcolepsy.

                            Brand Name : Quilience

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            May 28, 2024

                            Lead Product(s) : Mazindol

                            Therapeutic Area : Sleep

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Bioprojet Pharma

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                            Aquaexpo 2024
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                            Bioprojet Pharma

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                            Lead Product(s) : TPM-1116

                            Therapeutic Area : Sleep

                            Study Phase : Preclinical

                            Sponsor : Harmony Biosciences

                            Deal Size : $393.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Harmony Enters Agreement to Develop Oral Orexin-2 Agonist TPM-1116

                            Details : Through the Licensing Agreement, Bioprojet will develop, manufacture, and commercialize TPM-1116, a selective oral orexin-2 receptor agonist for narcolepsy and other sleep/wake disorders.

                            Brand Name : TPM-1116

                            Molecule Type : Small molecule

                            Upfront Cash : $25.5 million

                            April 11, 2024

                            Lead Product(s) : TPM-1116

                            Therapeutic Area : Sleep

                            Highest Development Status : Preclinical

                            Sponsor : Harmony Biosciences

                            Deal Size : $393.0 million

                            Deal Type : Licensing Agreement

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                            03

                            Aexon Labs

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                            Aquaexpo 2024
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                            Lead Product(s) : AEX-2

                            Therapeutic Area : Sleep

                            Study Phase : Preclinical

                            Sponsor : NLS Pharmaceutics

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            NLS Pharmaceutics Secures Exclusive Global License for Dual Orexin Agonist Platform

                            Details : The agreement grants NLS global rights to next-gen oral OX1R/OX2R agonists, including AEX-2, tailored for narcolepsy, idiopathic hypersomnia, Parkinson's disease, dementia with Lewy bodies.

                            Brand Name : AEX-2

                            Molecule Type : Undisclosed

                            Upfront Cash : Undisclosed

                            March 20, 2024

                            Lead Product(s) : AEX-2

                            Therapeutic Area : Sleep

                            Highest Development Status : Preclinical

                            Sponsor : NLS Pharmaceutics

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            04

                            F. Hoffmann-La Roche

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                            Aquaexpo 2024
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                            F. Hoffmann-La Roche

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                            Aquaexpo 2024
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                            Lead Product(s) : RO7117997

                            Therapeutic Area : Sleep

                            Study Phase : Preclinical

                            Sponsor : PsychoGenics

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            PsychoGenics Announces Exclusive Global License for an IND-Ready ENT1 Inhibitor for the Treatment of Neuropsyc...

                            Details : Under the agreement, Roche obtains global development, manufacturing, and commercialization rights to RO7117997, an IND-ready ENT1 inhibitor discovered using the PsychoGenics’ AI-enabled phenotypic screening platforms.

                            Brand Name : RO7117997

                            Molecule Type : Undisclosed

                            Upfront Cash : Undisclosed

                            December 01, 2023

                            Lead Product(s) : RO7117997

                            Therapeutic Area : Sleep

                            Highest Development Status : Preclinical

                            Sponsor : PsychoGenics

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            05

                            NLS Pharmaceutics

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                            Aquaexpo 2024
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                            NLS Pharmaceutics

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Sleep

                            Study Phase : Preclinical

                            Sponsor : Aexon Labs

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            NLS Pharmaceutics Announces Exclusive Option Agreement to Develop and Commercialize Next Generation Dual Orexi...

                            Details : Under the agreement, NLS may acquire development and commercialization rights to Aexon Labs' dual orexin receptor agonists platform for the treatment of narcolepsy and idiopathic hypersomnia, as well as neuro-degenerative disorders.

                            Brand Name : Undisclosed

                            Molecule Type : Undisclosed

                            Upfront Cash : Undisclosed

                            December 01, 2023

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Sleep

                            Highest Development Status : Preclinical

                            Sponsor : Aexon Labs

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            06

                            Eagle Pharmaceuticals

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                            Aquaexpo 2024
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                            Eagle Pharmaceuticals

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                            Lead Product(s) : ENA-001

                            Therapeutic Area : Sleep

                            Study Phase : Preclinical

                            Sponsor : Enalare Therapeutics

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Eagle Pharmaceuticals and Enalare Therapeutics Announce FDA Orphan Drug Designation for ENA-001 for the Treatm...

                            Details : ENA-001, is a one-of-a-kind new chemical entity (NCE) designed as an agnostic respiratory stimulant. The compound has a novel mechanism of action that affects ventilation via the peripheral chemoreceptor pathways in the carotid body.

                            Brand Name : ENA-001

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            October 03, 2022

                            Lead Product(s) : ENA-001

                            Therapeutic Area : Sleep

                            Highest Development Status : Preclinical

                            Sponsor : Enalare Therapeutics

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Enalare Therapeutics

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                            Aquaexpo 2024
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                            Enalare Therapeutics

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                            Aquaexpo 2024
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                            Lead Product(s) : ENA-001

                            Therapeutic Area : Sleep

                            Study Phase : Preclinical

                            Sponsor : National Institutes of Health

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Enalare Therapeutics Receives Orphan Drug Designation From the U.S. FDA on ENA-001 for the Treatment of Apnea ...

                            Details : Enalare's lead compound, ENA-001, is a one-of-a-kind new chemical entity (NCE) designed as an agnostic respiratory stimulant. The compound has a novel mechanism of action that affects ventilation via the peripheral chemoreceptor pathways in the carotid b...

                            Brand Name : ENA-001

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            October 03, 2022

                            Lead Product(s) : ENA-001

                            Therapeutic Area : Sleep

                            Highest Development Status : Preclinical

                            Sponsor : National Institutes of Health

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Tris Pharma Inc

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                            Aquaexpo 2024
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                            Tris Pharma Inc

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                            Lead Product(s) : Sodium Oxybate

                            Therapeutic Area : Sleep

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Tris Pharma Announces Development of a Very Low Sodium and Once-Nightly Oxybate Formulation

                            Details : In a human clinical study, Tris established about 100% bioavailability for one dose of its formulation against two doses of XYREM at 4.5 gm each, equivalent to the 9.0 gm maximum dose of sodium oxybate.

                            Brand Name : Undisclosed

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            July 27, 2022

                            Lead Product(s) : Sodium Oxybate

                            Therapeutic Area : Sleep

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            RespireRx Pharmaceuticals

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                            Aquaexpo 2024
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                            RespireRx Pharmaceuticals

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                            Lead Product(s) : Tetrahydrocannabinol

                            Therapeutic Area : Sleep

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            RespireRx Pharmaceuticals Inc. Announces Patent Filings Claiming Novel Lipid Based Formulations for Insoluble ...

                            Details : Provisional patent application describing novel lipid based formulation technology (LFT) that may be used to improve the solubility and bioavailability of poorly soluble drugs particularly cannabinoids Dronabinol that is formulated as a sesame oil emulsi...

                            Brand Name : Undisclosed

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            March 23, 2022

                            Lead Product(s) : Tetrahydrocannabinol

                            Therapeutic Area : Sleep

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            10

                            KemPharm

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                            Aquaexpo 2024
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                            KemPharm

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                            Lead Product(s) : Dexmethylphenidate

                            Therapeutic Area : Sleep

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            KemPharm Completes KP1077 Pre-IND Meeting Process with FDA

                            Details : The successful completion of the pre-IND meeting process with the FDA for KP1077 affirms company's plan to submit the IND application by mid-year 2022 and to initiate a Phase 2 trial of KP1077 for Idiopathic Hypersomnia.

                            Brand Name : KP1077

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            February 23, 2022

                            Lead Product(s) : Dexmethylphenidate

                            Therapeutic Area : Sleep

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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