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            The net proceeds will be used to fund the clinical development of the company's lead product Tonmya (cyclobenzaprine HCl). Currently, it is being evaluated for treating patients with fibromyalgia.

            Lead Product(s): Cyclobenzaprine

            Therapeutic Area: Musculoskeletal Product Name: Tonmya

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Dawson James Securities

            Deal Size: $4.0 million Upfront Cash: Undisclosed

            Deal Type: Public Offering June 27, 2024

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            Tonmya (cyclobenzaprine HCl) is a sublingual product candidate & a 5-HT2 receptor inhibitor. It is being evaluated for the treatment of patients with fibromyalgia.

            Lead Product(s): Cyclobenzaprine

            Therapeutic Area: Musculoskeletal Product Name: Tonmya

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 20, 2024

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            The net proceeds will be used to fund the clinical development of the company's lead product Tonmya (cyclobenzaprine HCl). Currently, it is being evaluated for treating patients with fibromyalgia.

            Lead Product(s): Cyclobenzaprine

            Therapeutic Area: Musculoskeletal Product Name: Tonmya

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Dawson James Securities

            Deal Size: $4.0 million Upfront Cash: Undisclosed

            Deal Type: Public Offering June 13, 2024

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            The net proceeds will be used to fund the clinical development of the company's lead product Tonmya (cyclobenzaprine HCl). Currently, it is being evaluated for treating patients with fibromyalgia.

            Lead Product(s): Cyclobenzaprine

            Therapeutic Area: Musculoskeletal Product Name: Tonmya

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Dawson James Securities, Inc

            Deal Size: $4.0 million Upfront Cash: Undisclosed

            Deal Type: Public Offering June 12, 2024

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            The partnership aims to cover AVT03, a clinical-stage biosimilar candidate referencing the Prolia®/Xgeva® (denosumab) medicines for osteoporosis and cancer-related bone loss respectively.

            Lead Product(s): Denosumab

            Therapeutic Area: Musculoskeletal Product Name: AVT03

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: STADA Arzneimittel

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Partnership June 11, 2024

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            The net proceeds will be used to fund the clinical development of the company's lead product Tonmya (cyclobenzaprine HCl). Currently, it is being evaluated for treating patients with fibromyalgia.

            Lead Product(s): Cyclobenzaprine

            Therapeutic Area: Musculoskeletal Product Name: Tonmya

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Dawson James Securities

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Public Offering June 11, 2024

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            HLX14 (denosumab-biosimilar) is a fully human recombinant anti-RANKL monoclonal antibody, which is approved for the treatment of postmenopausal women with osteoporosis at high risk for fracture.

            Lead Product(s): Denosumab

            Therapeutic Area: Musculoskeletal Product Name: HLX14

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Organon

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable May 24, 2024

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            Sanofi receives exclusive rights to commercialize FTX-1821 (losmapimod), an oral small molecule being investigated for the treatment of facioscapulohumeral muscular dystrophy (FSHD), in all territories outside the US.

            Lead Product(s): Losmapimod

            Therapeutic Area: Musculoskeletal Product Name: FTX-1821

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Sanofi

            Deal Size: $1,055.0 million Upfront Cash: $80.0 million

            Deal Type: Collaboration May 13, 2024

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            ReNu, a cryopreserved amniotic suspension allograft (ASA), for the management of symptoms associated with knee osteoarthritis (OA) achieved its primary endpoint upon the analysis of positive top line data.

            Lead Product(s): Amniotic Suspension Allograft

            Therapeutic Area: Musculoskeletal Product Name: ReNu

            Highest Development Status: Preclinical Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable May 02, 2024

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            NPJ5008 (dantrolene sodium hemiheptahydrate) is a RYR1 inhibitor, small molecule drug candidate. It is being evaluated for the treatment of malignant hyperthermia.

            Lead Product(s): Dantrolene

            Therapeutic Area: Musculoskeletal Product Name: NPJ5008

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable March 26, 2024

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