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Find Novel Musculoskeletal Drugs in Preclinical Development
KMN-159 is a potent, stable, and a highly selective EP4 receptor agonist that stimulates osteogenic activity. It is being evaluated for the treatment of osteoporosis.
The grant will be used to explore Cayman’s patented small molecule bone repair agent KMN-159 as the active pharmaceutical ingredient (API) in a drug-device combination to improve the mechanical anchorage of dental titanium implants into the jawbone.
AlzeCure's ACD137 is a potent and selective negative allosteric modulator of TrkA, which is currently being evaluated for the treatment of osteoarthritis pain.
Telomir-1 is the first novel small molecule, which is proposed to be dosed orally, to lengthen the DNA’s protective telomere caps in order to potentially reverse age-related conditions.
OA-201 consists of a natural metabolite, formulated as an injectable small molecule product. It is being developed for the treatment of symptomatic osteoarthritis pain.
SAT-3247 is a small molecule designed to inhibit AAK1, a protein kinase member of the notch pathway. It is being developed for the treatment of facioscapulohumeral muscular dystrophy.
ACD137 is being developed within the TrkA-NAM project in AlzeCure's Painless platform. It is being evaluated in preclinical studies for the treatment of severe pain & osteoarthritis.
The collaboration aims to further the development of Vaxxinity’s active immunotherapies to prevent and mitigate muscle and bone wasting and to assess its effects on undisclosed proteins through in vitro and in vivo experiments, and animal models established by UCF.
Under the agreement, Ascendia will provide services to support the clinical development of OA-201, a novel, injectable small molecule therapeutic for the treatment of symptomatic osteoarthritis pain.
The funding will be used to accelerate new therapies for FSHD and to assess skeletal muscle torque as a functional outcome measure in the TIC-DUX4 mouse model of FSHD.
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Cayman Pharma is Europe's most reliable and versatile source for Prostaglandin APIs//FDA approved. 
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