Continuous processing, or flow chemistry, has been used for decades in the chemical industry. However, the pharmaceutical industry has relied on batch processing to manufacture drug products for decades. Recently, continuous flow chemistry (e.g. the use of micro flow reactors) has been gaining interest in the pharmaceutical and fine chemical industries due to the inherent increased safety, improved product quality and cost efficiency, and overall production flexibility. Many contract manufacturing organizations (CMOs) offer continuous flow chemistry, but few have the technical capabilities to develop active pharmaceutical ingredients (API) which help customers take full advantage of the technology.  Find globally leading, cGMP compliant Contract Manufacturing Organizations (CMO) and Contract Manufacturing Development Organizations (CDMO) which use advanced continuous flow chemistry techniques to manufacture APIs and fine chemical intermediates by using our free-access database on PharmaCompass. Flow technology was introduced to the pharmaceutical manufacturing in the early 2000s and is now becoming a preferred option for many new chemical entities (NCEs) which are being developed.

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Continuous flow reactor at industrial scale in our plant in Spain. Medichem can provide scale up services from R&D to industrial scale.

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Our continuous flow processing capabilities offer unique advantages compared with batch processes, resulting in faster, safer and more robust material production with higher selectivity of desired products.

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Your GMP “One-Stop-Shop”, Angelini Fine Chemicals is a Contract Development and Manufacturing Organization (CDMO), which is fully dedicated to third party manufacturing of APIs, IMs and NCEs for the pharmaceutical and small molecule biotech industry.

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DOTTIKON has more than 40 years of experience in continuous reactions using micro and tubular flow reactors. For fast hazardous reactions in particular continuous processing enables the reduction of critical volumes while at the same time increasing the h

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State-of-the-art analytical equipment and a small Pilot Plant to support the development programmes. The R&D Department is approved by the Department of Scientific and Industrial Research (DSIR), Ministry of Science and Technology, Govt. Of India.

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Procos S.p.A. is specialized in the development, scale-up and production of Active Pharmaceutical Ingredients (APIs), advanced intermediates and related services for the pharmaceutical industry. Our core business sectors include custom synthesis and Generic API manufacturing.

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Design of a novel synthetic pathway accompanied by supply of a few grams, provision of pilot batches following development of the industrial procedure and GMP production of several tons of product along with regulatory file drafting.

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Servier brings 60 years of experience in process development, intermediates, APIs and high-potency APIs. Our full cGMP?/?FDA-approved chemistry network includes R&D, production and supply chain expertise with full regulatory support.

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Special technologies and manufacturing processes including full scale cryogenics, phosgenation, hazardous reactions, isolation technology, micro-reactors, and spray drying

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Dalton Pharma Services is an ideal contract partner for your API Process Development. We are FDA registered and Health Canada approved, and provide integrated process development, API manufacturing and finished dose manufacturing at a single location.

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Grace Albany Fine Chemicals' site is designed to meet customers' highest quality, regulatory, and confidentiality expectations for the manufacture of fine chemicals and intermediates.

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In the area of fully synthetic organic chemicals, Olon S.p.A. has a wide range of advanced and sophisticated technologies such as organo-metallic chemistry, low temperature reactions, photo-chemistry, etc. that consent to obtain very complex APIs and building blocks.

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Farmhispania Group develops and manufactures a diverse range of API’s, advanced intermediates and building blocks. Furthermore, Farmhispania Group provides PR&D and manufacturing services to support clinical trials and commercial supply.

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Queenborough facility of Aesica offers both finished dose and API services and has successfully expanded the customer portfolio and offers a broad range of technologies.

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Continuous-flow technology involves the continuous introduction of a stream of chemical reactants into a tube reactor or a microreactor to yield a desired reaction product on a continuous basis.