[{"orgOrder":0,"company":"Valbiotis","sponsor":"Nestle Health Sciences SA","pharmaFlowCategory":"D","upfrontCash":"$5.1 million","therapeuticArea":"Endocrinology","country":"FRANCE","productType":"Undisclosed","date":"February 2020","year":"2020","type":"Partnership","leadProduct":"TOTUM-63","moa":"","graph1":"Endocrinology","graph2":"Phase II\/ Phase III","graph3":"Valbiotis","amount2":0.070000000000000007,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Endocrinology","amount2New":0.070000000000000007,"dosageForm":"Capsule","sponsorNew":"Valbiotis \/ Nestle Health Science","highestDevelopmentStatusID":"9","companyTruncated":"Valbiotis \/ Nestle Health Science"},{"orgOrder":0,"company":"Valbiotis","sponsor":"Not Applicable","pharmaFlowCategory":"DU","upfrontCash":"Not Applicable","therapeuticArea":"Endocrinology","country":"","productType":"Large molecule","date":"July 2020","year":"2020","type":"Not Applicable","leadProduct":"Totum-63","moa":"","graph1":"Endocrinology","graph2":"Phase II\/ Phase III","graph3":"Valbiotis","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Valbiotis \/ Not Applicable","highestDevelopmentStatusID":"9","companyTruncated":"Valbiotis \/ Not Applicable"},{"orgOrder":0,"company":"Valbiotis","sponsor":"Not Applicable","pharmaFlowCategory":"DU","upfrontCash":"Not Applicable","therapeuticArea":"Endocrinology","country":"","productType":"Large molecule","date":"September 2020","year":"2020","type":"Not Applicable","leadProduct":"Totum-63","moa":"","graph1":"Endocrinology","graph2":"Phase II\/ Phase III","graph3":"Valbiotis","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Valbiotis \/ Not Applicable","highestDevelopmentStatusID":"9","companyTruncated":"Valbiotis \/ Not Applicable"},{"orgOrder":0,"company":"ChromaDex, Inc","sponsor":"Not Applicable","pharmaFlowCategory":"DU","upfrontCash":"Not Applicable","therapeuticArea":"Endocrinology","country":"","productType":"Small molecule","date":"November 2020","year":"2020","type":"Not Applicable","leadProduct":"Nicotinamide Riboside Chloride","moa":"","graph1":"Endocrinology","graph2":"Phase II\/ Phase III","graph3":"ChromaDex, Inc","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"ChromaDex, Inc \/ Not Applicable","highestDevelopmentStatusID":"9","companyTruncated":"ChromaDex, Inc \/ Not Applicable"},{"orgOrder":0,"company":"Valbiotis","sponsor":"INAF","pharmaFlowCategory":"DU","upfrontCash":"Not Applicable","therapeuticArea":"Endocrinology","country":"","productType":"Large molecule","date":"April 2022","year":"2022","type":"Not Applicable","leadProduct":"Totum-63","moa":"","graph1":"Endocrinology","graph2":"Phase II\/ Phase III","graph3":"Valbiotis","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Valbiotis \/ INAF","highestDevelopmentStatusID":"9","companyTruncated":"Valbiotis \/ INAF"},{"orgOrder":0,"company":"Valbiotis","sponsor":"Nestle Health Sciences SA","pharmaFlowCategory":"DU","upfrontCash":"Not Applicable","therapeuticArea":"Endocrinology","country":"","productType":"Small molecule","date":"May 2023","year":"2023","type":"Not Applicable","leadProduct":"TOTUM\u202263","moa":"","graph1":"Endocrinology","graph2":"Phase II\/ Phase III","graph3":"Valbiotis","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Valbiotis \/ Nestle Health Sciences SA","highestDevelopmentStatusID":"9","companyTruncated":"Valbiotis \/ Nestle Health Sciences SA"}]

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                          Top Deals by Deal Size (USD bn)

                          01

                          Aquaexpo 2024
                          Not Confirmed
                          Aquaexpo 2024
                          Not Confirmed

                          Details : Through the acquisition, AstraZeneca leverages the AZP-3601 (neboparatide), peptide agonist of the PTH1 receptor. Currently, being evaluated for the treatment of Chronic Hypoparathyroidism.

                          Brand Name : AZP-3601

                          Molecule Type : Peptide

                          Upfront Cash : $800.0 million

                          July 15, 2024

                          Lead Product(s) : Eneboparatide

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : AstraZeneca

                          Deal Size : $1,050.0 million

                          Deal Type : Acquisition

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                          02

                          Aquaexpo 2024
                          Not Confirmed
                          Aquaexpo 2024
                          Not Confirmed

                          Details : TOTUM•63 is a unique and patented combination of 5 plant extracts that targets the pathophysiological mechanisms of type 2 diabetes. TOTUM•63 benefits from intellectual property validated by patents in the world's leading markets.

                          Brand Name : TOTUM•63

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          May 22, 2023

                          Lead Product(s) : TOTUM•63

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Nestle Health Sciences SA

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          Aquaexpo 2024
                          Not Confirmed
                          Aquaexpo 2024
                          Not Confirmed

                          Details : TOTUM-63 is a unique and patented combination of 5 plant extracts that targets the pathophysiological mechanisms of type 2 diabetes, has already been shown to be safe and effective in healthy volunteers in a Phase I/II clinical study.

                          Brand Name : Totum-63

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          April 29, 2022

                          Lead Product(s) : Totum-63

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : INAF

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          Aquaexpo 2024
                          Not Confirmed
                          Aquaexpo 2024
                          Not Confirmed

                          Details : ChromaDex has invested over $35 million in investigating and marketing NR as Niagen, which has received regulatory acceptance in the United States, Canada, the European Union, and Australia.

                          Brand Name : Niagen

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          November 17, 2020

                          Lead Product(s) : Nicotinamide Riboside Chloride

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          Aquaexpo 2024
                          Not Confirmed
                          Aquaexpo 2024
                          Not Confirmed

                          Details : EASD has selected the positive results of the international Phase II clinical study on TOTUM-63 in prediabetes to be presented next September in its 56th annual meeting. These results were selected by the American Diabetes Association last June 2020.

                          Brand Name : Totum-63

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          September 21, 2020

                          Lead Product(s) : Totum-63

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          Aquaexpo 2024
                          Not Confirmed
                          Aquaexpo 2024
                          Not Confirmed

                          Details : The REVERSE-IT study will include 600 patients with fasting hyperglycemia ranging from prediabetes to untreated early stage Type 2 Diabetes. The study should confirm the efficacy of TOTUM-63 - at a dose of 5g/day for 6 months.

                          Brand Name : Totum-63

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          July 15, 2020

                          Lead Product(s) : Totum-63

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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