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Exosome Product","moa":"Undisclosed","graph1":"Musculoskeletal","graph2":"Phase I","graph3":"Rion","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Injection","sponsorNew":"Rion \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Rion \/ Undisclosed"},{"orgOrder":0,"company":"Aberystwyth University","sponsor":"Phytoquest Ltd | Gateway Health Alliance | Welsh Government","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"UNITED KINGDOM","productType":"Dietary Supplement","year":"2023","type":"Inapplicable","leadProduct":"Q-Actin","moa":"Undisclosed","graph1":"Musculoskeletal","graph2":"Phase I","graph3":"Aberystwyth University","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Aberystwyth University \/ Phytoquest Ltd | Gateway Health Alliance | Welsh Government","highestDevelopmentStatusID":"6","companyTruncated":"Aberystwyth University \/ Phytoquest Ltd | Gateway Health Alliance | Welsh Government"},{"orgOrder":0,"company":"EMO Biomedicine","sponsor":"Genuine Research Center, Egypt","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"TAIWAN","productType":"Plant Extract\/Herbal","year":"2017","type":"Inapplicable","leadProduct":"Regstem","moa":"Undisclosed","graph1":"Musculoskeletal","graph2":"Phase I","graph3":"EMO Biomedicine","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Injection","sponsorNew":"EMO Biomedicine \/ Genuine Research Center, Egypt","highestDevelopmentStatusID":"6","companyTruncated":"EMO Biomedicine \/ Genuine Research Center, Egypt"},{"orgOrder":0,"company":"Pfizer Inc","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Undisclosed","year":"2011","type":"Inapplicable","leadProduct":"RN564","moa":"Undisclosed","graph1":"Musculoskeletal","graph2":"Phase I","graph3":"Pfizer Inc","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Pfizer Inc \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Pfizer Inc \/ Undisclosed"},{"orgOrder":0,"company":"ARMGO Pharma","sponsor":"National Institute of Neurological Disorders and Stroke | National Institute of Nursing Research | Celerion","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Miscellaneous","year":"2019","type":"Inapplicable","leadProduct":"ARM210","moa":"Undisclosed","graph1":"Musculoskeletal","graph2":"Phase I","graph3":"ARMGO 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PHARMACEUTICALS \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"SHENZHEN SALUBRIS PHARMACEUTICALS \/ Undisclosed"},{"orgOrder":0,"company":"Sanofi","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"FRANCE","productType":"Undisclosed","year":"2024","type":"Inapplicable","leadProduct":"SAR446959","moa":"Undisclosed","graph1":"Musculoskeletal","graph2":"Phase I","graph3":"Sanofi","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Injection","sponsorNew":"Sanofi \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Sanofi \/ Undisclosed"},{"orgOrder":0,"company":"Jiangsu Hengrui Medicine","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"CHINA","productType":"Antibody, 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Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Jiangsu Hengrui Medicine \/ Undisclosed"},{"orgOrder":0,"company":"Suzhou Suncadia Biopharmaceuticals Co., Ltd.","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"CHINA","productType":"Antibody, Unconjugated","year":"2023","type":"Inapplicable","leadProduct":"SHR-2017","moa":"Undisclosed","graph1":"Musculoskeletal","graph2":"Phase I","graph3":"Suzhou Suncadia Biopharmaceuticals Co., Ltd.","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Injection","sponsorNew":"Suzhou Suncadia Biopharmaceuticals Co., Ltd. \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Suzhou Suncadia Biopharmaceuticals Co., Ltd. \/ Undisclosed"},{"orgOrder":0,"company":"Arugula Sciences","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Cell & 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Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"General Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"StemMedical A\/S","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"DENMARK","productType":"Undisclosed","year":"2023","type":"Inapplicable","leadProduct":"STEM-OA","moa":"Undisclosed","graph1":"Musculoskeletal","graph2":"Phase I","graph3":"StemMedical A\/S","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"StemMedical A\/S \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"StemMedical A\/S \/ Undisclosed"},{"orgOrder":0,"company":"Jacksonville University","sponsor":"Specnova, inc","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Undisclosed","year":"2018","type":"Inapplicable","leadProduct":"Tart Cherry","moa":"Undisclosed","graph1":"Musculoskeletal","graph2":"Phase I","graph3":"Jacksonville University","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Jacksonville University \/ Specnova, inc","highestDevelopmentStatusID":"6","companyTruncated":"Jacksonville University \/ Specnova, inc"},{"orgOrder":0,"company":"QuadMedicine","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Undisclosed","year":"2024","type":"Inapplicable","leadProduct":"Teriq Patch","moa":"Undisclosed","graph1":"Musculoskeletal","graph2":"Phase I","graph3":"QuadMedicine","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Patch","sponsorNew":"QuadMedicine \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"QuadMedicine \/ Undisclosed"},{"orgOrder":0,"company":"Prof. Dr. med. Frank Christoph Mooren","sponsor":"Heel | University of Giessen","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"","productType":"Plant Extract\/Herbal","year":"2013","type":"Inapplicable","leadProduct":"Traumeel","moa":"Undisclosed","graph1":"Musculoskeletal","graph2":"Phase I","graph3":"Prof. Dr. med. Frank Christoph Mooren","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Prof. Dr. med. Frank Christoph Mooren \/ Heel | University of Giessen","highestDevelopmentStatusID":"6","companyTruncated":"Prof. Dr. med. Frank Christoph Mooren \/ Heel | University of Giessen"},{"orgOrder":0,"company":"Prof. Dr. med. Frank Christoph Mooren","sponsor":"Heel | University of Giessen","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"","productType":"Plant Extract\/Herbal","year":"2013","type":"Inapplicable","leadProduct":"Traumeel","moa":"Undisclosed","graph1":"Musculoskeletal","graph2":"Phase I","graph3":"Prof. Dr. med. Frank Christoph Mooren","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Prof. Dr. med. Frank Christoph Mooren \/ Heel | University of Giessen","highestDevelopmentStatusID":"6","companyTruncated":"Prof. Dr. med. Frank Christoph Mooren \/ Heel | University of Giessen"},{"orgOrder":0,"company":"University of Florida","sponsor":"Restem","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2021","type":"Inapplicable","leadProduct":"Umbilical Cord Lining Stem Cell","moa":"Undisclosed","graph1":"Musculoskeletal","graph2":"Phase I","graph3":"University of Florida","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Infusion","sponsorNew":"University of Florida \/ Restem","highestDevelopmentStatusID":"6","companyTruncated":"University of Florida \/ Restem"},{"orgOrder":0,"company":"Wuhan Union Hospital","sponsor":"Wuhan Hamilton Biotechnology Co., Ltd | Hamilton Company","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"CHINA","productType":"Cell & Gene Therapy","year":"2024","type":"Inapplicable","leadProduct":"Umbilical Cord Mesenchymal 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Pharmaceuticals","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Miscellaneous","year":"2013","type":"Inapplicable","leadProduct":"2MD","moa":"Vitamin D receptor","graph1":"Musculoskeletal","graph2":"Phase I","graph3":"Deltanoid Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Deltanoid Pharmaceuticals \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Deltanoid Pharmaceuticals \/ Undisclosed"},{"orgOrder":0,"company":"Swiss Federal Institute of Technology","sponsor":"Royal DSM","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"SWITZERLAND","productType":"Vitamins\/Minerals\/Inorganic Salts","year":"2010","type":"Inapplicable","leadProduct":"Vitamin D","moa":"Vitamin D receptor","graph1":"Musculoskeletal","graph2":"Phase I","graph3":"Swiss Federal Institute of Technology","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Swiss Federal Institute of Technology \/ Royal DSM","highestDevelopmentStatusID":"6","companyTruncated":"Swiss Federal Institute of Technology \/ Royal DSM"},{"orgOrder":0,"company":"NYU Langone Health","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Miscellaneous","year":"2018","type":"Inapplicable","leadProduct":"Chloroethane","moa":"Voltage-gated sodium channels","graph1":"Musculoskeletal","graph2":"Phase I","graph3":"NYU Langone Health","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Injection","sponsorNew":"NYU Langone Health \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"NYU Langone Health \/ 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BioMed","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"CHINA","productType":"Cell & Gene Therapy","year":"2025","type":"Inapplicable","leadProduct":"BBM-A101","moa":"IL-1RA","graph1":"Musculoskeletal","graph2":"Phase I","graph3":"Belief BioMed","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Injection","sponsorNew":"Belief BioMed \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Belief BioMed \/ Undisclosed"},{"orgOrder":0,"company":"Epirium","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Miscellaneous","year":"2025","type":"Inapplicable","leadProduct":"MF-300","moa":"15-PGDH","graph1":"Musculoskeletal","graph2":"Phase I","graph3":"Epirium","amount2":0,"highestDevelopmentShortName":"Ph 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                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : SAR446959

                          Therapeutic Area : Musculoskeletal

                          Study Phase : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : SAR446959 is a drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Osteoarthritis.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          November 26, 2024

                          Lead Product(s) : SAR446959

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          02

                          Lead Product(s) : GZ389988

                          Therapeutic Area : Musculoskeletal

                          Study Phase : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : GZ389988 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Osteoarthritis.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          April 23, 2015

                          Lead Product(s) : GZ389988

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          03

                          Details : ABT-981 is a Antibody drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Osteoarthritis.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          August 20, 2012

                          Lead Product(s) : ABT-981

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Abbvie Company Banner

                          04

                          Lead Product(s) : SAR113945

                          Therapeutic Area : Musculoskeletal

                          Study Phase : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : SAR113945 is a drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Osteoarthritis, Knee.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          January 18, 2012

                          Lead Product(s) : SAR113945

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          05

                          Lead Product(s) : SAR113945

                          Therapeutic Area : Musculoskeletal

                          Study Phase : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : SAR113945 is a drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Osteoarthritis, Knee.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          November 02, 2011

                          Lead Product(s) : SAR113945

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          06

                          Lead Product(s) : SAR113945

                          Therapeutic Area : Musculoskeletal

                          Study Phase : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : SAR113945 is a drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Osteoarthritis.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          April 29, 2010

                          Lead Product(s) : SAR113945

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          07

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : MF-300 is a a first-in-class, oral 15-PGDH enzyme inhibitor, which is being evaluated for the treatment of sarcopenia.

                          Product Name : MF-300

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          September 24, 2025

                          Lead Product(s) : MF-300

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Nuwacell Biotechnologies

                          Country arrow
                          OTS 2025
                          Not Confirmed

                          Nuwacell Biotechnologies

                          Country arrow
                          OTS 2025
                          Not Confirmed

                          Details : NCR100 is a drug candidate, which is currently being evaluated in Phase I clinical studies for the treatment of Osteoarthritis, Knee.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          August 24, 2025

                          Lead Product(s) : NCR100

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : GC012F is a Cell and Gene Therapy drug candidate, which is currently being evaluated in Phase I clinical studies for the treatment of Myositis.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          July 25, 2025

                          Lead Product(s) : GC012F

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I

                          Sponsor : AstraZeneca | Daishi Tian

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : MF-300 is a first-in-class, oral 15-PGDH enzyme inhibitor, which is being evaluated for the treatment of sarcopenia.

                          Product Name : MF-300

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          July 21, 2025

                          Lead Product(s) : MF-300

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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