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Find Clinical Drug Development Pipelines & Deals | PipelineProspector
BIIB110 (ALG-801) is a novel, next-generation ligand trap, which selectively sequesters a subset of TGF-beta family, including growth differentiation factors and activins. It is being evaluated for treatment of muscle wasting, metabolic disorders, and neuromuscular diseases.
PCRX-201 (enekinragene inzadenovec), the high-capacity adenoviral gene therapy vector codes for IL-1Ra expression, a cytokine inhibitor that plays a central role in blocking inflammation and catabolic processes associated with pain and disease progression in osteoarthritis.
NVG-2089 is a novel, recombinant, non-immunosuppressive immunomodulator designed to target type II Fc receptors and trigger an endogenous regulatory mechanism. It is being developed for the treatment of inflammatory myopathies and severe dermatologic autoimmune disease.
AVT03 (denosumab) is a human monoclonal antibody and a biosimilar candidate to Prolia & Xgeva. It is a RANK ligand inhibitor, which is being evaluated in phase 1 trials for bone loss in adult men.
Allocetra is being developed as a universal, off-the-shelf cell therapy designed to reprogram macrophages into their homeostatic state. It is under phase 1/2 clinical development for the treatment of moderate to severe knee osteoarthritis.
GNSC-001 (sc-rAAV2.5IL-1Ra) is a genetic medicine – a recombinant adeno-associated viral vector expressing an optimized form of IL-1Ra, a naturally occurring protein that blocks IL-1 signaling. It is under phase 1 clinical development for the treatment of Knee Osteoarthritis.
Trichomylin softgels, a first-in-class drug product candidate formulated with a proprietary fixed-dose cannabinoid combination, has been specifically designed for the management of chronic pain.
4P004, a GLP1 analog, is a novel first-in-class drug candidate addressing a high unmet medical need. The purpose is to potentially change the natural course of osteoarthritis to prevent long-term disability.
RJx-01, a novel combination drug comprising galantamine and metformin, demonstrated positive results in 42 elderly male subjects with disuse-induced muscle atrophy.
TST002 (blosozumab) is a humanized anti-sclerostin mAb for osteoporosis and other bone loss diseases. It has a dual effect possessing both anabolic and anti-resorptive effects, which stimulates bone formation and inhibits bone absorption, enhancing bone mineral density.
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