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                          01

                          26th North American ISSX
                          Not Confirmed
                          26th North American ISSX
                          Not Confirmed

                          Lead Product(s) : CYT-108

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I

                          Partner/Sponsor/Collaborator : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : CYT-108 is a recombinant variant of the endogenous alpha-2-macroglobulin (A2M) blood serum protein, targeting proteases responsible for cartilage degradation in osteoarthritis.

                          Product Name : CYT-108

                          Product Type : Small molecule

                          Upfront Cash : Not Applicable

                          July 15, 2024

                          Lead Product(s) : CYT-108

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I

                          Partner/Sponsor/Collaborator : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          26th North American ISSX
                          Not Confirmed
                          26th North American ISSX
                          Not Confirmed

                          Lead Product(s) : KYV-101

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I

                          Partner/Sponsor/Collaborator : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : KYV-101 is an autologous, fully human CD19 CAR T-cell product candidate. It is being evaluated for the treatment of treatment-refractory stiff-person syndrome.

                          Product Name : KYV-101

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          June 20, 2024

                          Lead Product(s) : KYV-101

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I

                          Partner/Sponsor/Collaborator : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          26th North American ISSX
                          Not Confirmed
                          26th North American ISSX
                          Not Confirmed