Rochem International Inc Rochem International Inc

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            Rona licensed Sanofi’s siRNA platform to enable discovery programs in expanded therapeutic areas including neuro and muscular diseases, for which Sanofi has an exclusive option to acquire neuro and muscular disease candidates for ex-China territories.

            Lead Product(s): siRNA Therapeutic

            Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Rona Therapeutics

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Licensing Agreement July 25, 2022

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            Details:

            bbHEP01 is a encapsulated allogeneic txHepatocytes for the treatment of acute liver failure, expected to enter clinical development in 2025 and generate initial clinical data in 2026.

            Lead Product(s): Allogeneic Induced Hepatocyte-like Cell

            Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: bbHEP01

            Highest Development Status: Preclinical Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable November 08, 2023

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            Under the collaboration, Merck will assess Quris-AI platform’s ability to effectively identify liver toxicity risks in a selection of drug candidates.

            Lead Product(s): Undisclosed

            Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Undisclosed

            Partner/Sponsor/Collaborator: Merck Group

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Expanded Collaboration September 28, 2023

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            Tramontane Therapeutics

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            Kriya acquires a portfolio of Fibroblast Growth Factor 21 (FGF21) assets including Tramontane’s lead program, an adeno-associated virus (AAV) vector designed to express a steady level of the native FGF21 protein, for treating people with NASH.

            Lead Product(s): AAV Gene Therapy

            Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Kriya Therapeutics

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Acquisition September 06, 2023

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            Under the agreement, GENFIT will advance Celloram’s first-in-class inflammasome inhibitor, CLM-022, a triterpenoid derivative that targets the inflammasome machinery, in liver disease indications.

            Lead Product(s): CLM-022

            Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: CLM-022

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Genfit

            Deal Size: $175.5 million Upfront Cash: Undisclosed

            Deal Type: Licensing Agreement July 31, 2023

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            OnKai

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            Details:

            Under the partnership, OnKai will apply its AI, models for enrollment and execution of clinical trials in underserved communities, starting with Galmed's innovative Primary Sclerosing Cholangitis clinical program evaluating Aramchol (arachidyl amido cholanoic acid).

            Lead Product(s): Aramchol

            Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: Aramchol

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Galmed Pharmaceuticals

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Partnership July 10, 2023

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            CM5480 is a selective oral CRAC channel inhibitor and restored the expression of SOCE-associated regulatory factor in acinar cells, which being developed for Chronic Pancreatitis (CP).

            Lead Product(s): CM5480

            Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: CM5480

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 06, 2023

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            MN-001 (tipelukast) is a novel, orally administered, small molecule compound which reduces triglycerides (TG) in the blood. It has being investigated for the treatment or maintainence of type 2 diabetes and hypertriglyceridemia.

            Lead Product(s): Tipelukast

            Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: MN-001

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable January 10, 2023

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            The OLX702A program is based on compelling human genetic evidence which suggests that knockdown of this target may reduce liver fat, inflammation, and fibrosis and protect against liver-related mortality.

            Lead Product(s): OLX702A

            Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: OLX702A

            Highest Development Status: Preclinical Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable November 10, 2022

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            ACMSD is a key enzyme involved in the de novo synthesis of NAD+, which is critical to mitochondrial function via maintenance of cellular redox state. TLC-065, is being advanced for the treatment of a range of metabolic and inflammatory liver and kidney disorders.

            Lead Product(s): TLC-065

            Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: TLC-065

            Highest Development Status: Preclinical Product Type: Undisclosed

            Partner/Sponsor/Collaborator: OrsoBio

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Acquisition November 02, 2022

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