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Sciences","sponsor":"GSK","pharmaFlowCategory":"D","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"","productType":"Large molecule","year":"2024","type":"Collaboration","leadProduct":"Undisclosed","moa":"","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Preclinical","graph3":"Wave Life Sciences","amount2":3.3100000000000001,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Hepatology","amount2New":3.3100000000000001,"dosageForm":"","sponsorNew":"Wave Life Sciences \/ GSK","highestDevelopmentStatusID":"4","companyTruncated":"Wave Life Sciences \/ GSK"},{"orgOrder":0,"company":"ProQR Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"","productType":"Large molecule","year":"2024","type":"Not Applicable","leadProduct":"AX-0810","moa":"","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Preclinical","graph3":"ProQR Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"","sponsorNew":"ProQR Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"4","companyTruncated":"ProQR Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"CytoDyn","sponsor":"SMC Laboratories","pharmaFlowCategory":"DU","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"","productType":"Large molecule","year":"2024","type":"Not Applicable","leadProduct":"Leronlimab","moa":"","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Preclinical","graph3":"CytoDyn","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"","sponsorNew":"CytoDyn \/ SMC Laboratories","highestDevelopmentStatusID":"4","companyTruncated":"CytoDyn \/ SMC Laboratories"}]

Find Clinical Drug Development Pipelines & Deals | PipelineProspector

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : siRNA Therapeutic

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Study Phase : Preclinical

                          Sponsor : Rona Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

                          Details : Rona licensed Sanofi’s siRNA platform to enable discovery programs in expanded therapeutic areas including neuro and muscular diseases, for which Sanofi has an exclusive option to acquire neuro and muscular disease candidates for ex-China territories.

                          Brand Name : Undisclosed

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          July 25, 2022

                          Lead Product(s) : siRNA Therapeutic

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Preclinical

                          Sponsor : Rona Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

                          Sanofi Company Banner

                          02

                          Saudi International Expo
                          Not Confirmed
                          Saudi International Expo
                          Not Confirmed

                          Details : PRO-140 (leronlimab) a monocloncal antibody works by blocking the activity of CCR5 receptor. It is currently in preclinical in combination with Resmetirom for the treatment of liver fibrosis.

                          Brand Name : PRO-140

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          June 27, 2024

                          Lead Product(s) : Leronlimab,Resmetirom

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Preclinical

                          Sponsor : SMC Laboratories

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          Saudi International Expo
                          Not Confirmed
                          Saudi International Expo
                          Not Confirmed

                          Details : AX-0810 is an editing oligonucleotide development program targeting SLC10A1 RNA, providing a controlled approach aimed at reducing bile acids concentration in the liver for cholestatic diseases.

                          Brand Name : AX-0810

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          May 08, 2024

                          Lead Product(s) : AX-0810

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Preclinical

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          Saudi International Expo
                          Not Confirmed
                          Saudi International Expo
                          Not Confirmed

                          Details : GSK selected two programs utilizing Wave's GalNAc-siRNA format for hepatology, advancing to development candidates after target validation.

                          Brand Name : Undisclosed

                          Molecule Type : Large molecule

                          Upfront Cash : $12.0 million

                          April 23, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Preclinical

                          Sponsor : GSK

                          Deal Size : $3,312.0 million

                          Deal Type : Collaboration

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                          05

                          Saudi International Expo
                          Not Confirmed
                          Saudi International Expo
                          Not Confirmed

                          Details : The collaboration focuses on developing Oxy210 (oxysterol), a small-molecule antifibrotic, evaluated in preclinical studies for non-alcoholic steatohepatitis and pulmonary fibrosis.

                          Brand Name : Oxy210

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          February 26, 2024

                          Lead Product(s) : Oxysterol

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Preclinical

                          Sponsor : MAX BioPharma

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          06

                          Saudi International Expo
                          Not Confirmed
                          Saudi International Expo
                          Not Confirmed

                          Details : OCE-205 is a therapeutic peptide with a differentiated mechanism of action. It is being evaluated in preclinical studies for the treatment of Ascites due to all etiologies except cancer.

                          Brand Name : OCE-205

                          Molecule Type : Peptide

                          Upfront Cash : Not Applicable

                          December 20, 2023

                          Lead Product(s) : OCE-205

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Preclinical

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          Saudi International Expo
                          Not Confirmed
                          Saudi International Expo
                          Not Confirmed

                          Details : bbHEP01 is a encapsulated allogeneic txHepatocytes for the treatment of acute liver failure, expected to enter clinical development in 2025 and generate initial clinical data in 2026.

                          Brand Name : bbHEP01

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          November 08, 2023

                          Lead Product(s) : Allogeneic Induced Hepatocyte-like Cell

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Preclinical

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Saudi International Expo
                          Not Confirmed
                          Saudi International Expo
                          Not Confirmed

                          Details : Under the collaboration, Merck will assess Quris-AI platform’s ability to effectively identify liver toxicity risks in a selection of drug candidates.

                          Brand Name : Undisclosed

                          Molecule Type : Undisclosed

                          Upfront Cash : Undisclosed

                          September 28, 2023

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Preclinical

                          Sponsor : Merck Group

                          Deal Size : Undisclosed

                          Deal Type : Expanded Collaboration

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                          09

                          Tramontane Therapeutics

                          Country arrow
                          Saudi International Expo
                          Not Confirmed

                          Tramontane Therapeutics

                          Country arrow
                          Saudi International Expo
                          Not Confirmed

                          Details : Kriya acquires a portfolio of Fibroblast Growth Factor 21 (FGF21) assets including Tramontane’s lead program, an adeno-associated virus (AAV) vector designed to express a steady level of the native FGF21 protein, for treating people with NASH.

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          September 06, 2023

                          Lead Product(s) : AAV Gene Therapy

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Preclinical

                          Sponsor : Kriya Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Acquisition

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                          10

                          Saudi International Expo
                          Not Confirmed
                          Saudi International Expo
                          Not Confirmed

                          Details : Under the agreement, GENFIT will advance Celloram’s first-in-class inflammasome inhibitor, CLM-022, a triterpenoid derivative that targets the inflammasome machinery, in liver disease indications.

                          Brand Name : CLM-022

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          July 31, 2023

                          Lead Product(s) : CLM-022

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Preclinical

                          Sponsor : Genfit

                          Deal Size : $175.5 million

                          Deal Type : Licensing Agreement

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