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    Looking for Low Temperature / Cryogenic conditions? Find API Manufacturing & other pharma service details on PharmaCompass.

    Cryogenic Reactions
    Polpharma is a Polish CDMO of APIs and a significant European API producer, delivering products to companies worldwide.
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    01 Overview (20)

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    01 Polpharma (1)

    02 PMC Isochem (1)

    03 Minakem (1)

    04 Neuland Laboratories (1)

    05 Axplora (1)

    06 Norchim (1)

    07 Alven Laboratories (1)

    08 Anacipher (1)

    09 Bellen Chemistry (1)

    10 Bioindustria L.I.M. Spa (1)

    11 CARBOGEN AMCIS AG (1)

    12 DOTTIKON EXCLUSIVE SYNTHESIS AG (1)

    13 Evotec (1)

    14 Farmhispania (1)

    15 Grace (1)

    16 Olon S.p.A (1)

    17 Recipharm AB (1)

    18 ScinoPharm Taiwan, Ltd (1)

    19 Siegfried AG (1)

    20 ZCL Chemicals Limited (1)

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    10 Switzerland (3)

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    Polpharma

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    CRYOGENIC REACTIONS

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    Polpharma API is a contract development and manufacturing organization (CDMO) that has experience in cryogenic reactions for pilot and commercial scale with operational temperatures down to -80 °C.

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    Cryogenic Reactions

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    PMC Isochem

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    CRYOGENIC REACTIONS

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    PMC Isochem offers cGMP cryogenic reactions. It works on both rapid evaluation and process development for scale-up of cryogenic reactions.

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    PMC Isochem Cryogenic Reactions

    CPhI North America

    Booth #1256

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    Minakem

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    LOW TEMPERATURE CHEMISTRY

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    Minakem is a leader in certain technologies such as low-temperature chemistry, flow reactions, hazardous chemistry and HPAPIs (high-potency active pharmaceutical ingredients), including cytotoxic molecules.

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    Low Temperature Chemistry

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    Neuland Laboratories

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    CRYOGENIC REACTIONS

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    Neuland's manufacturing capabilities include cryogenic reactions, heterocyclic compounds, chiral compounds, cyanation, hydrogenation, bromination, carbohydrate chemistry, steroidal bile acids & vitamin D derivatives, etc.

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    CPhI North America

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    Axplora

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    CRYOGENIC CHEMISTRY

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    Axplora's Chasse-sur-Rhône site in France offers CDMO services for APIs from process development, clinical supply to commercial manufacturing. It also provides low-temperature reactions, industrial chromatography, and high-pressure hydrogenation.

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    CRYOGENIC CHEMISTRY

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    Norchim

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    CRYOGENIC REACTION

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    Cryogenic reactors up to 1200 L

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    ZCL Chemicals Limited

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    CRYOGENIC REACTION CAPABILITIES

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    Four multi-purpose cGMP manufacturing plants have reaction capacity of 214 KL with 72 reactors - 34 Stainless Steel reactors, 37 Glass Lined reactors. Our cryogenic reaction is carried out by one Cryogenic reactor, ranging from 100 L to 8,000 L.

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    Alven Laboratories

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    PERFORMING A VARIABILITY OF REACTIONS (-50°C)

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    Alven's facility has all relevant infrastructure to perform a variability of reactions and production conditions, including Temperature range -50 °C to 200 °C.

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    Recipharm AB

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    LOW TEMPERATURE REACTIONS

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    Recipharm's multi-purpose plant can manufacture several API products at a time, including generic & hormonal APIs. The facility is equipped to handle low temperature (–80 degrees Celsius), high temperature (150 degrees Celsius) & high pressure reactions.

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    DOTTIKON EXCLUSIVE SYNTHESIS AG

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    LOW-TEMPERATURE PROCESSES

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    DOTTIKON has know-how and low-temperature equipment (glass and Hastelloy) on all scales for batch-wise as well as continuous processing: Research & Development up to 0.5 l and down to –80 °C, Small-scale & Pilot up to 160 l and down to –80 °C, Production

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    Bioindustria L.I.M. Spa

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    TEMPERATURE CAPABILITIES (-100°C TO +170°C)

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    Biondustria L.I.M has temperature capabilities from -100°C to +170°C.

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    ScinoPharm Taiwan, Ltd

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    LOW TEMPERATURE ASYMMETRIC SYNTHESIS

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    ScinoPharm's core competency will be to specialize in producing international cGMP-quality Active Pharmaceutical Ingredients through organic synthesis.

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    Anacipher

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      CRYOGENIC REACTION FACILITIES

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      Synthetic Labs are supported by expert team of scientist in handling mg to Kg scale Reactions, adequate Utility Services, hygienic Environment, cryogenic & High pressure Reaction Facilities and separate Laboratories for CRAMS and Generic Research.

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      Farmhispania

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      TEMPERATURE RANGE FROM -70 TO 200 ºC

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      Farmhispania Groups equipment includes: vessels from 5 to 1000 L, temperature range from -70 to 200 ºC, filtration equipment, centrifuges and a wide range of handling equipment to mill, dry and lyophilise the bulk product.

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      Grace

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        LOW TEMPERATURE (-80º C) MANUFACTURING CAPABILITIES

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        Grace Albany Fine Chemicals' site is designed to meet customers' highest quality, regulatory, and confidentiality expectations for the manufacture of fine chemicals and intermediates.

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        Siegfried AG

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        CRYOGENIC REACTIONS

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        Special technologies and manufacturing processes including full scale cryogenics, phosgenation, hazardous reactions, isolation technology, micro-reactors, and spray drying, and having 800 liters hastelloy C22 reactor for cryogenic reactions, and temperature range -100°C to 250°C.

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        Olon S.p.A

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        LOW TEMPERATURE REACTIONS

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        In the area of fully synthetic organic chemicals, Olon S.p.A. has a wide range of advanced and sophisticated technologies such as organo-metallic chemistry, low temperature reactions, photo-chemistry, etc. that consent to obtain very complex APIs and building blocks.

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        CARBOGEN AMCIS AG

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        TEMPERATURE RANGE FROM -80°C TO +250 °C

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        Large-scale production capacities (upto 4’500 L, with a temperature range from -80°C to +250 °C) allow the efficient production of early-phase APIs and large-scale intermediates under nonGMP conditions at the CARBOGEN AMCIS Swiss’ facilities.

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        Evotec

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        CRYOGENIC CAPABILITY UPTO –80°C

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        Our key aspects of Evotec’s pilot plant offering is Cryogenic capability to –80°C and  up to +160°C

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        Bellen Chemistry

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          CRYOGENIC REACTIONS

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          Bellen Chemistry's manufacturing plant in Shandong, China, utilize cryogenic reactors with an operating range down to -78 °C & hydrogenators ranging from 100L to 2000L that operate up to 50 bar. Their current reactor volume is ~100m3.

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