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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : YCT529

                          Therapeutic Area : Obstetrics/Gynecology (Women’s Health)

                          Study Phase : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : YCT-529 is a retinoic acid receptor-alpha (RAR-alpha) inhibitor that prevents sperm production by blocking access to vitamin A. It is under phase 1 clinical development for male contraception.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          December 20, 2023

                          Lead Product(s) : YCT529

                          Therapeutic Area : Obstetrics/Gynecology (Women’s Health)

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Quotient

                          02

                          Details : Under the license agreement with Douglas, Dare will be responsible for advancing the development of R-131-2 (Lopinavir/Ritonavir) in the U.S. for the treatment for cervical intraepithelial neoplasia.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          September 27, 2023

                          Lead Product(s) : Lopinavir,Ritonavir

                          Therapeutic Area : Obstetrics/Gynecology (Women’s Health)

                          Highest Development Status : Phase I

                          Sponsor : Daré Bioscience

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

                          Douglas CDMO

                          04

                          Lead Product(s) : Prasterone

                          Therapeutic Area : Obstetrics/Gynecology (Women’s Health)

                          Study Phase : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Hormone

                          Upfront Cash : Inapplicable

                          July 29, 2021

                          Lead Product(s) : Prasterone

                          Therapeutic Area : Obstetrics/Gynecology (Women’s Health)

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Company Banner

                          05

                          Details : Alora® (Estradiol transdermal system) used for Treatment of Moderate to Severe Vasomotor Symptoms due to Menopause, Vulvar and Vaginal Atrophy due to Menopause, Hypoestrogenism Primary Ovarian Failure and Postmenopausal Osteoporosis.

                          Product Name : Alora

                          Product Type : Hormone

                          Upfront Cash : Undisclosed

                          March 16, 2021

                          Lead Product(s) : Estradiol

                          Therapeutic Area : Obstetrics/Gynecology (Women’s Health)

                          Highest Development Status : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : Undisclosed

                          Deal Type : Divestment

                          Abbvie Company Banner

                          06

                          Details : Avion Pharmaceuticals gets exclusive rights to relaunch Cenestin® in the USA. Cenestin® is the only plant-derived mixture of nine conjugated estrogens indicated for treatment of moderate to severe symptoms of vasomotor, and vulvar and vaginal atrophy d...

                          Product Name : Cenestin

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          December 11, 2020

                          Lead Product(s) : Conjugated Estrogens

                          Therapeutic Area : Obstetrics/Gynecology (Women’s Health)

                          Highest Development Status : Approved FDF

                          Sponsor : Avion Pharmaceuticals

                          Deal Size : Undisclosed

                          Deal Type : Partnership

                          Aspen API Comapny Banner

                          07

                          Lead Product(s) : Progesterone

                          Therapeutic Area : Obstetrics/Gynecology (Women’s Health)

                          Study Phase : Approved FDF

                          Sponsor : Effik

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Enviero is first-of-its-kind, a green-chemistry progesterone that represents a step change in progesterone API synthesis, is manufactured via a proprietary biocatalytic process based on plant sterols that reduce waste, greenhouse gas emissions and use of...

                          Product Name : Estima

                          Product Type : Hormone

                          Upfront Cash : Inapplicable

                          November 18, 2020

                          Lead Product(s) : Progesterone

                          Therapeutic Area : Obstetrics/Gynecology (Women’s Health)

                          Highest Development Status : Approved FDF

                          Sponsor : Effik

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Pfizer centreOne

                          08

                          Details : Vectura will support the development of a single use device/formulation combination for evaluation in Phase I of inhaled oxytocin, and then expedite technical transfer to a commercial manufacturer to advance to Phase III and commercial launch.

                          Product Name : Undisclosed

                          Product Type : Hormone

                          Upfront Cash : Undisclosed

                          September 14, 2020

                          Lead Product(s) : Oxytocin

                          Therapeutic Area : Obstetrics/Gynecology (Women’s Health)

                          Highest Development Status : Preclinical

                          Sponsor : Monash University

                          Deal Size : Undisclosed

                          Deal Type : Agreement

                          Skyepharma Company Banner

                          10

                          Lead Product(s) : Estriol

                          Therapeutic Area : Obstetrics/Gynecology (Women’s Health)

                          Study Phase : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          November 12, 2019

                          Lead Product(s) : Estriol

                          Therapeutic Area : Obstetrics/Gynecology (Women’s Health)

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Aspen API Comapny Banner