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Mass spectrometry is a powerful analytical technique used to quantify known materials, to identify unknown compounds within a sample, and to elucidate the structure and chemical properties of different molecules. The complete process involves the conversion of the sample into gaseous ions, with or without fragmentation, which are then characterized by their mass to charge ratios (m/z) and relative abundances. This technique basically studies the effect of ionizing energy on molecules. It depends upon chemical reactions in the gas phase in which sample molecules are consumed during the formation of ionic and neutral species. The first step in the mass spectrometric analysis of compounds is the production of gas phase ions of the compound, basically by electron ionization. This molecular ion undergoes fragmentation. Each primary product ion derived from the molecular ion, in turn, undergoes fragmentation, and so on. The ions are separated in the mass spectrometer according to their mass-to-charge ratio, and are detected in proportion to their abundance. A mass spectrum of the molecule is thus produced. It displays the result in the form of a plot of ion abundance versus mass-to-charge ratio. Ions provide information concerning the nature and the structure of their precursor molecule. In the spectrum of a pure compound, the molecular ion, if present, appears at the highest value of m/z (followed by ions containing heavier isotopes) and gives the molecular mass of the compound. Mass spectrometry (MS) analysis of proteins measures the mass-to-charge ratio of ions to identify and quantify molecules in simple and complex mixtures. MS has become invaluable across a broad range of fields and applications, including proteomics. The development of high-throughput and quantitative MS proteomics workflows within the last two decades has expanded the scope of what we know about protein structure, function, modification and global protein dynamics. This overview outlines the role of mass spectrometry in the field of proteomics, reviews MS methodology and instrumentation, and touches on sample preparation and liquid chromatography–based separation prior to MS analysis.

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KriSan Biotech

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Mass Spectrometry

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We provide ultra-high resolution mass spectrometry with our industry-leading expertise, the resulting data and scientific interpretation are unmatched in the contract preclinical research industry for large and small molecule analyse

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Pharma Service: Analytical

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Sub Category: Mass spectrometry and LC / MS

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Mass Spectrometry & LC / MS

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Bachem offers spectroscopic methods such as Electrospray Mass Spectrometry (ESI-MS Iontrap & TOF), Matrix Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-TOF-MS), Infrared Spectroscopy (IR), UV/VIS Spectroscopy, NMR Spectroscopy etc

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Pharma Service: Analytical

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Sub Category: Mass spectrometry and LC / MS

Virtual BoothEurope's most reliable and versatile source for Prostaglandin APIs// FDA Inspected 2017

Mass Spectrometry: LC-MS, High Resolution Acc...

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Our scientists perform routine quality control testing on thousands of our catalog products each year, giving them unparalleled expertise in developing and validating methods to analyze, quantify, and purify small molecules.

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Pharma Service: Analytical

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Sub Category: Mass spectrometry and LC / MS

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Mass Spectrometry & Electrospray Interfaces

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Your GMP “One-Stop-Shop”, Angelini Fine Chemicals is a Contract Development and Manufacturing Organization (CDMO), which is fully dedicated to third party manufacturing of APIs, IMs and NCEs for the pharmaceutical and small molecule biotech industry.

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Pharma Service: Analytical

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Sub Category: Mass spectrometry and LC / MS

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Mass Spectrometry Analysis - LC/MS 

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We offer full compound certification and recertification services, which includes a comprehensive Certificate of Analysis, along with all supporting documentation.

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Pharma Service: Analytical

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LC-MS Method Development

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We undertake development of critical parameters or methods, such as analytical method to determine impurities, which don't have chromophores and hence don't have detection, Chiral method development, LC-MS suitable method development.

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Sub Category: Mass spectrometry and LC / MS

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HPLC / MS / UV / GC

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Crystec is an established pharmaceutical R&D company with the capacity to rapidly progress products from concept to clinical production. The company operates across three key sites (as listed below), and each incorporates characterisation and analytical suites which include - HPLC/MS/UV/GC

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Sub Category: Mass spectrometry and LC / MS

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Analytical Development (LC-MS)

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Procos S.p.A. is specialized in the development, scale-up and production of Active Pharmaceutical Ingredients (APIs), advanced intermediates and related services for the pharmaceutical industry. Our core business sectors include custom synthesis and Generic API manufacturing.

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Sub Category: Mass spectrometry and LC / MS

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LC / MS, IR Techniques of Product Analysis

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Acceleration Laboratory Services is the foremost Contract Solutions Provider for the pharmaceutical research. The ultimate goal for our associates is to deliver superior solutions to our clients, on time, and on point, while maintaining a fun and empowering work environment.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Mass spectrometry and LC / MS

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Mass Spectroscopy

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Through a cooperative agreement with local universities such as Clark University in Worcester, MA, PCI also provides advanced non-GMP testing techniques including: Mass Spectroscopy.

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Pharma Service: Analytical

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Sub Category: Mass spectrometry and LC / MS

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LC-MS-MS (Waters)

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Neuland has a separate, specially equipped R&D Centre located at Bonthapally. Custom Synthesis is another area where Neuland has been concentrating and is taking up several projects. We work in close association with clients, under strict confidentiality, to bring products early to markets.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Mass spectrometry and LC / MS

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Thermo Finnigan Surveyor MSQ Plus Mass Spectr...

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KriSan Biotech has dedicated analytical team that provides full analytical services for process development, GLP studies and CGMP manufacturing.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Mass spectrometry and LC / MS

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Detection of Non-Chromophoric Molecules by LC...

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Thanks to its innovative techniques (HPLC, SFC or combined preparative HPLC/SFC), DIVERCHIM proposes to its customers to isolate, purify and characterize process impurities as well as reference compounds.

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Pharma Service: Analytical

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Sub Category: Mass spectrometry and LC / MS

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Identification of Degradant Products & Impuri...

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Pharmavize operates an audited 1,600-m2 GMP facility serving clients from all over the world. We are thoroughly familiar with the European and American regulatory frameworks and guarantee compliance with all applicable guidelines and directives.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Mass spectrometry and LC / MS

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LC-MS/MS

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Aizant's GLP certified bioanalytical laboratory is equipped with state-of-the art Liquid Chromatography and Tandem Mass Spectrometry (LC-MS/MS) instruments with a capacity of 4000 samples per week. We validate our analytical methods as per global regulatory requirements.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Mass spectrometry and LC / MS

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Mass Spectroscopy

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M2M Pharmaceuticals Ltd, a Contract Research Organization (CRO) supports early stage product development for pharmaceutical, food and biotech companies with various services in Method Development and Validation, Physico-Chemical Analysis, Formulation and Quality/Regulatory support.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Mass spectrometry and LC / MS

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Mass Spectrometry and LC/MS

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DPT’s provides reliable and accurate analytical testing services for Light Microscopy, Mass spectrometry and LC / MS, Particle size, Physical Characterization, etc

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Mass spectrometry and LC / MS

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ICP-MS

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Megsan Labs is an USFDA inspected leading analytical testing laboratory, we focused and committed to deliver testing services to our costumers with excellence in quality, compliance and promptness

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Mass spectrometry and LC / MS

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Mass Spectrometry and LC/MS

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Our LC/MS/MS bioanalytic services include Bioanalytical method development and validation, Nonclinical and cGLP/cGMP clinical sample analysis, Non-GLP discovery support, TK/PK sample analysis, Dried blood spot analysis, 96-well sample processing and analysis

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Mass spectrometry and LC / MS

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Thermo IRIS ICP-MS

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Analytical Services Laboratory is equipped with modern analytical testing instrumentation

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Pharma Service: Analytical

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Sub Category: Mass spectrometry and LC / MS

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LC-MS & LC-MS/MS – UPLC-PDA & ELSD

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GVK BIO offers a broad range of analytical services for complex research needs. We perform method development, validate and transfer Good Manufacturing Practice (cGMP) compliant methods for a broad spectrum of pharma compounds.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Mass spectrometry and LC / MS

Mass spectrometry is a powerful analytical technique used to quantify known materials, to identify unknown compounds within a sample, and to elucidate the structure and chemical properties of different molecules. The complete process involves the conversion of the sample into gaseous ions, with or without fragmentation, which are then characterized by their mass to charge ratios (m/z) and relative abundances. This technique basically studies the effect of ionizing energy on molecules. It depends upon chemical reactions in the gas phase in which sample molecules are consumed during the formation of ionic and neutral species. The first step in the mass spectrometric analysis of compounds is the production of gas phase ions of the compound, basically by electron ionization. This molecular ion undergoes fragmentation. Each primary product ion derived from the molecular ion, in turn, undergoes fragmentation, and so on. The ions are separated in the mass spectrometer according to their mass-to-charge ratio, and are detected in proportion to their abundance. A mass spectrum of the molecule is thus produced. It displays the result in the form of a plot of ion abundance versus mass-to-charge ratio. Ions provide information concerning the nature and the structure of their precursor molecule. In the spectrum of a pure compound, the molecular ion, if present, appears at the highest value of m/z (followed by ions containing heavier isotopes) and gives the molecular mass of the compound. Mass spectrometry (MS) analysis of proteins measures the mass-to-charge ratio of ions to identify and quantify molecules in simple and complex mixtures. MS has become invaluable across a broad range of fields and applications, including proteomics. The development of high-throughput and quantitative MS proteomics workflows within the last two decades has expanded the scope of what we know about protein structure, function, modification and global protein dynamics. This overview outlines the role of mass spectrometry in the field of proteomics, reviews MS methodology and instrumentation, and touches on sample preparation and liquid chromatography–based separation prior to MS analysis.

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