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Mass Spectrometry & Electrospray Interfaces

Analytical >> Analytical Testing Services >> Mass spectrometry and LC / MS

Your GMP “One-Stop-Shop”, Angelini Fine Chemicals is a Contract Development and Manufacturing Organization (CDMO), which is fully dedicated to third party manufacturing of APIs, IMs and NCEs for the pharmaceutical and small molecule biotech industry.

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Mass Spectrometry

Analytical >> Analytical Testing Services >> Mass spectrometry and LC / MS

Specializes in method development, validation & transfer, cGMP batch release testing, impurity characterization & identification, drug substance & product stability & comparability studies, protein/peptide crystallization & solid state characterization.

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Chromatographic Techniques for NCEs & Peptide Analysis

Analytical >> Analytical Testing Services >> Mass spectrometry and LC / MS

Bachem is committed to using synthesis and purification strategies that yield products of the quality and purity you require. Our standard analytical package typically includes mass spectrometric analysis and determination of purity (by RP-HPLC).

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Mass Spectrometry Analysis - LC/MS 

Analytical >> Analytical Testing Services >> Mass spectrometry and LC / MS

We offer full compound certification and recertification services, which includes a comprehensive Certificate of Analysis, along with all supporting documentation.

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LC-MS Method Development

Analytical >> Analytical Testing Services >> Mass spectrometry and LC / MS

We undertake development of critical parameters or methods, such as analytical method to determine impurities, which don't have chromophores and hence don't have detection, Chiral method development, LC-MS suitable method development.

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Mass Spectrometry: LC-MS, High Resolution Accurate Mass

Analytical >> Analytical Testing Services >> Mass spectrometry and LC / MS

Our scientists perform routine quality control testing on thousands of our catalog products each year, giving them unparalleled expertise in developing and validating methods to analyze, quantify, and purify small molecules.

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Analytical Development (LC-MS)

Analytical >> Analytical Testing Services >> Mass spectrometry and LC / MS

Procos S.p.A. is specialized in the development, scale-up and production of Active Pharmaceutical Ingredients (APIs), advanced intermediates and related services for the pharmaceutical industry. Our core business sectors include custom synthesis and Generic API manufacturing.

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HPLC / MS / UV / GC

Analytical >> Analytical Testing Services >> Mass spectrometry and LC / MS

Crystec is an established pharmaceutical R&D company with the capacity to rapidly progress products from concept to clinical production. The company operates across three key sites (as listed below), and each incorporates characterisation and analytical suites which include - HPLC/MS/UV/GC

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LC / MS, IR Techniques of Product Analysis

Analytical >> Analytical Testing Services >> Mass spectrometry and LC / MS

Acceleration Laboratory Services is the foremost Contract Solutions Provider for the pharmaceutical research. The ultimate goal for our associates is to deliver superior solutions to our clients, on time, and on point, while maintaining a fun and empowering work environment.

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Mass Spectroscopy

Analytical >> Analytical Testing Services >> Mass spectrometry and LC / MS

Through a cooperative agreement with local universities such as Clark University in Worcester, MA, PCI also provides advanced non-GMP testing techniques including: Mass Spectroscopy.

Mass spectrometry is a powerful analytical technique used to quantify known materials, to identify unknown compounds within a sample, and to elucidate the structure and chemical properties of different molecules. The complete process involves the conversion of the sample into gaseous ions, with or without fragmentation, which are then characterized by their mass to charge ratios (m/z) and relative abundances. This technique basically studies the effect of ionizing energy on molecules. It depends upon chemical reactions in the gas phase in which sample molecules are consumed during the formation of ionic and neutral species. The first step in the mass spectrometric analysis of compounds is the production of gas phase ions of the compound, basically by electron ionization. This molecular ion undergoes fragmentation. Each primary product ion derived from the molecular ion, in turn, undergoes fragmentation, and so on. The ions are separated in the mass spectrometer according to their mass-to-charge ratio, and are detected in proportion to their abundance. A mass spectrum of the molecule is thus produced. It displays the result in the form of a plot of ion abundance versus mass-to-charge ratio. Ions provide information concerning the nature and the structure of their precursor molecule. In the spectrum of a pure compound, the molecular ion, if present, appears at the highest value of m/z (followed by ions containing heavier isotopes) and gives the molecular mass of the compound. Mass spectrometry (MS) analysis of proteins measures the mass-to-charge ratio of ions to identify and quantify molecules in simple and complex mixtures. MS has become invaluable across a broad range of fields and applications, including proteomics. The development of high-throughput and quantitative MS proteomics workflows within the last two decades has expanded the scope of what we know about protein structure, function, modification and global protein dynamics. This overview outlines the role of mass spectrometry in the field of proteomics, reviews MS methodology and instrumentation, and touches on sample preparation and liquid chromatography–based separation prior to MS analysis.

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