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Differential scanning calorimetry (DSC) is used to measure Specific Heat Capacity, Heat of Transition, and the Temperature of Phase Changes and Melting Points, instruments are equipped for rapid assessment of large sample batches. DSC also measures the rate of heat flow, and compares differences between the heat flow rate of the test sample and known reference materials. The difference determines variations in material composition, crystallinity and oxidation. Differential scanning calorimetry thermal analysis provides test data for a wide range of materials. Materials analyzed by DSC include polymers, plastics, composites, laminates, adhesives, food, coatings, pharmaceuticals, organic materials, rubber, petroleum, chemicals, explosives, biological samples and more. DSC instruments can output a heat capacity signal directly in a single experiment by dividing the absolute heat flow by the measured heating rate. Monitoring the heat-capacity signal as a function of the applied experimental conditions (such as a heating ramp) can determine how the heat capacity of the sample changes as it undergoes a phase change or a chemical reaction. Direct heat capacity measurements can also be obtained at isothermal temperatures with a high level of accuracy. DSC thermal analysis contains following servces Thermal Phase Change, Thermal Glass Transition, Temperature (Tg), Crystalline Melt Temperature, Endothermic Effects, Exothermic Effects, Thermal Stability, Thermal Formulation Stability, Oxidative Stability Studies, Transition Phenomena, Solid State Structure, Analysis of a Diverse Range of Materials. A temperature program is applied to a sample and an inert reference material in the DSC cell and the sensors measure the temperature difference between them. When the sample undergoes a thermal process that evolves heat, such as crystallization, the DSC plot shows an increase in heat flow. This is indicative of an exothermic event because the temperature registered by the sample sensor is higher than that sensed for the reference. If the sample undergoes a thermal event that causes it to absorb more heat than the reference does (such as melting), the DSC plot shows a decrease in heat flow. This is called an endotherm and, in this case, the temperature sensor measures a lower temperature for the sample compared to the reference. A typical DSC scan involves heating the sample at a controlled steady rate, such as 10°C per minute, and monitoring the heat flow to characterize the phase transitions and/or cure reactions as a function of increasing temperature. More involved studies utilize multiple heating and/or cooling ramps, as well as isothermal hold segments. EAG Laboratories also offers a temperature modulation technique (Modulated DSC), which is capable of measuring weak transitions and separating overlapping thermal events. DSC Service provders also features some DSC instruments that measure absolute heat flow because correction factors for cell resistance and capacitance have been applied.

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Virtual BoothDevelopment, production, marketing of APIs, Intermediates & specialities// FDA inspected.

Thermal Analysis – DSC, Calorimetry

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Our analytical centre provides these methods & equipment: Analytical methods and equipment are validated; LCMS, GCMS, HPLC, TLC; UV/VIS and IR spectrometry; Capillary electrophoresis; Thermal analysis – DSC, Calorimetry; NMR (400 MHz) + xRAY; PSD analysis

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: DSC

Virtual BoothA partner for the pharma and biotech industries to improve patient outcomes & quality of life

Thermal Analysis & Calorimetry

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AMRI monitors thermochemical events and weight loss as a function of temperature to achieve insight into solid form characteristics, mechanisms of polymorphic transformations and solid state degradation pathways.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: DSC

Virtual BoothCDMO (API & HPAPI)/ Generics/ Security of supply/ Regulatory submission expertise/ Track record performance/ FDA & GMP

Differential Scanning Calorimetry (DSC)

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Minakem's Solid Form Laboratory capturing a growing need from our clients to manage in-house polymorph characterization and control, crystalization conditions, filtration, drying and particle size reduction to add further value in process developemt and scale-up.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: DSC

Virtual BoothCommitted to providing Highly Customized Solutions for all your Development Programs.

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Zach has over 30 years of experience in multi-step syntheses involving complex reactions.We have dedicated R&D and analytical development teams on each site, and state-of-the art analytical equipment.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: DSC

Virtual BoothA leading provider of Contract Development and Manufacturing services in softgel advanced technologies for the global market.

DSC, MDSC Capabilities

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Our analytical instrumentation capabilities include DSC, MDSC & TGA capabilities, automated dissolution system, HPLC with with UV, PDA, FL, RI Detectors, Gas chromatography, Disintegration studies, infrared apparatus among others.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: DSC

Virtual BoothGMP APIs & Flow Chemistry from a Leader in the Healthcare & Wellbeing market in the Pharma & Mass-market sectors

DSC (Polymorphism & Purity Studies)

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Your GMP “One-Stop-Shop”, Angelini Fine Chemicals is a Contract Development and Manufacturing Organization (CDMO), which is fully dedicated to third party manufacturing of APIs, IMs and NCEs for the pharmaceutical and small molecule biotech industry.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: DSC

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Full Polymer Characterization by DSC

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The Mithra CDMO open platform is accessible to partners willing to leverage our technological know-how and capabilities across the drug life-cycle from proof of concept to commercialization.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: DSC

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Differential Scanning Calorimetry (DSC)

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Arbro offers pharmaceutical testing and research services to support the development, approval, and manufacture of pharmaceutical raw materials and finished products. Arbro is listed on a number of leading pharmaceutical manufacturer’s licenses as the contract analytical testing site.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: DSC

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Thermal Analysis: DSC (Differential Scanning ...

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Our dedicated team of scientists have their core training in the area of preformulation and have expertise in the complete pharmaceutical profiling of molecules.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: DSC

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Differential Scanning Calorimetry

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Through a cooperative agreement with local universities such as Clark University in Worcester, MA, PCI also provides advanced non-GMP testing techniques including: Differential Scanning Calorimetry.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: DSC

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Differential Scanning Calorimetry

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KriSan Biotech has dedicated analytical team that provides full analytical services for process development, GLP studies and CGMP manufacturing.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: DSC

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DSC (Perkin Elmer)

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Neuland has a separate, specially equipped R&D Centre located at Bonthapally. Custom Synthesis is another area where Neuland has been concentrating and is taking up several projects. We work in close association with clients, under strict confidentiality, to bring products early to markets.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: DSC

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Compatibility Studies by DSC

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Whether it is a New Chemical Entity or a mature API, Galenix can help with the characterization and the building up of the Drug Master File (DMF) which is deemed necessary for the final registration process.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: DSC

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Differential Scanning Calorimetry

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M2M Pharmaceuticals Ltd, a Contract Research Organization (CRO) supports early stage product development for pharmaceutical, food and biotech companies with various services in Method Development and Validation, Physico-Chemical Analysis, Formulation and Quality/Regulatory support.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: DSC

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Megsan Labs is an USFDA inspected leading analytical testing laboratory, we focused and committed to deliver testing services to our costumers with excellence in quality, compliance and promptness

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: DSC

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GVK BIO offers a broad range of analytical services for complex research needs. We perform method development, validate and transfer Good Manufacturing Practice (cGMP) compliant methods for a broad spectrum of pharma compounds.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: DSC

Differential scanning calorimetry (DSC) is used to measure Specific Heat Capacity, Heat of Transition, and the Temperature of Phase Changes and Melting Points, instruments are equipped for rapid assessment of large sample batches. DSC also measures the rate of heat flow, and compares differences between the heat flow rate of the test sample and known reference materials. The difference determines variations in material composition, crystallinity and oxidation. Differential scanning calorimetry thermal analysis provides test data for a wide range of materials. Materials analyzed by DSC include polymers, plastics, composites, laminates, adhesives, food, coatings, pharmaceuticals, organic materials, rubber, petroleum, chemicals, explosives, biological samples and more. DSC instruments can output a heat capacity signal directly in a single experiment by dividing the absolute heat flow by the measured heating rate. Monitoring the heat-capacity signal as a function of the applied experimental conditions (such as a heating ramp) can determine how the heat capacity of the sample changes as it undergoes a phase change or a chemical reaction. Direct heat capacity measurements can also be obtained at isothermal temperatures with a high level of accuracy. DSC thermal analysis contains following servces Thermal Phase Change, Thermal Glass Transition, Temperature (Tg), Crystalline Melt Temperature, Endothermic Effects, Exothermic Effects, Thermal Stability, Thermal Formulation Stability, Oxidative Stability Studies, Transition Phenomena, Solid State Structure, Analysis of a Diverse Range of Materials. A temperature program is applied to a sample and an inert reference material in the DSC cell and the sensors measure the temperature difference between them. When the sample undergoes a thermal process that evolves heat, such as crystallization, the DSC plot shows an increase in heat flow. This is indicative of an exothermic event because the temperature registered by the sample sensor is higher than that sensed for the reference. If the sample undergoes a thermal event that causes it to absorb more heat than the reference does (such as melting), the DSC plot shows a decrease in heat flow. This is called an endotherm and, in this case, the temperature sensor measures a lower temperature for the sample compared to the reference. A typical DSC scan involves heating the sample at a controlled steady rate, such as 10°C per minute, and monitoring the heat flow to characterize the phase transitions and/or cure reactions as a function of increasing temperature. More involved studies utilize multiple heating and/or cooling ramps, as well as isothermal hold segments. EAG Laboratories also offers a temperature modulation technique (Modulated DSC), which is capable of measuring weak transitions and separating overlapping thermal events. DSC Service provders also features some DSC instruments that measure absolute heat flow because correction factors for cell resistance and capacitance have been applied.

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