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Nuclear Magnetic Resonance (NMR) spectroscopy is an analytical chemistry technique used in quality control and reserach for determining the content and purity of a sample as well as its molecular structure. For example, NMR can quantitatively analyze mixtures containing known compounds. For unknown compounds, NMR can either be used to match against spectral libraries or to infer the basic structure directly. In the solid state, anisotropic spin interactions such as the chemical shift anisotropy or dipolar couplings contain unique spatial and dynamic information. However, these interactions lead to broad and overlapping spectral lines, which obscure the familiar isotropic chemical information known from solution-state NMR spectroscopy. In order to obtain high-resolution, it is necessary to remove the broadening due to this anisotropic interactions. The most convenient way to achieve this goal is rapid sample rotation at the so-called “magic” angle (MAS) relative to the static magnetic field, and at spinning speeds up to 35 kHz the anisotropic spin interactions are mostly refocused and the isotropic chemical shift information is regained. However one would like to access the spatial and dynamic information inhered to the anisotropic interactions. This can be achieved by combining fast MAS with appropriate recoupling techniques, based on the irradiation of sample rotation-synchronized radio frequency impulses. In this way, new solid-state NMR experiments can be designed which access spatial information, such as local proximities, as well as molecular dynamics. A particularly successful experimental solid-state method is ¹H double-quantum NMR spectroscopy under fast MAS in solids. This method is based on the indirect observation of double-quantum (DQ) coherences, which are correlated non-equilibrium states involving two dipolar coupled nuclear spins. Since the efficiency of DQ excitation strongly depends on the dipolar coupling between the two spins, these DQ experiments can be used to determine the dipolar coupling constant. In rigid samples, the dipolar coupling can be used to determine the distance between the coupled spins, and hence elucidate, e.g. the nature of hydrogen-bonded intermolecular bridges, whereas in mobile systems with known chemical structure the anisotropy of the molecular dynamics, as described by a local order parameter, can be probed.

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Aizant Drug Research Solutions Pvt. Ltd.

Arbro Pharmaceuticals Pvt. Ltd

Arevipharma GmbH

Bachem AG

CARBOGEN AMCIS AG

CLEARSYNTH LABS LIMITED

Cayman Chemical Company Inc

ChemCon GmbH

Chemtos

Crystec Pharma

Dishman Carbogen Amcis

Diverchim S.A.

Farmak A.S

GVK Biosciences

Grace

KriSan Biotech

M2M Pharmaceuticals Ltd

Neuland Laboratories Inc

PCI Synthesis

PROCOS S.p.A.

Temad Co

ZACH SYSTEM SA

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Virtual BoothDevelopment, production, marketing of APIs, Intermediates & specialities// FDA inspected.

NMR (400 Mhz) + Xray

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Our analytical centre provides these methods & equipment: Analytical methods and equipment are validated; LCMS, GCMS, HPLC, TLC; UV/VIS and IR spectrometry; Capillary electrophoresis; Thermal analysis – DSC, Calorimetry; NMR (400 MHz) + xRAY; PSD analysis

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Solid State NMR

Virtual BoothSpecializes in development of innovative, efficient manufacturing processes & reliable production of peptide-based APIs

NMR Spectroscopy

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Bachem offers spectroscopic methods such as Electrospray Mass Spectrometry (ESI-MS Iontrap & TOF), Matrix Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-TOF-MS), Infrared Spectroscopy (IR), UV/VIS Spectroscopy, NMR Spectroscopy etc

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Solid State NMR

Virtual BoothWe think of World Class Quality.

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Temad utilizes Analytical Chemistry experts & various analytical equipment including HPLC, GC, FTIR, XRD, NMR 500 Hz, for Method development, validation, separation of active ingredients & impurities to conduct precise analyses according to BP, EP, USP.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Solid State NMR

Virtual BoothEurope's most reliable and versatile source for Prostaglandin APIs// FDA Inspected 2017

NMR (1H, 13C, 19F, 2D)

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Our scientists perform routine quality control testing on thousands of our catalog products each year, giving them unparalleled expertise in developing and validating methods to analyze, quantify, and purify small molecules.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Solid State NMR

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Content & Purity Testing

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Dishman's anlaytical services support offers various spectroscopy services to determine the content & purity of a sample with NMR 400 MHz, FTIR, ICP, CHN, XRD, UV-Spectrophotomtry, Polarimetry.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Solid State NMR

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Analysis of Highly Potent APIs Using NMR

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Carbogen Amcis SAS offers customized chromatography solutions for the separation and purification of active pharmaceutical intermediates (APIs) and intermediates, including highly active APIs.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Solid State NMR

Virtual BoothCommitted to providing Highly Customized Solutions for all your Development Programs.

NMR [400 MHz]

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Zach System's in-house development of new analytical methods validation and transfer of analytical methods.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Solid State NMR

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Analytical Development (NMR)

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Procos S.p.A. is specialized in the development, scale-up and production of Active Pharmaceutical Ingredients (APIs), advanced intermediates and related services for the pharmaceutical industry. Our core business sectors include custom synthesis and Generic API manufacturing.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Solid State NMR

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31P NMR, 19F NMR Techniques of Product Analys...

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Chemtos' other analysis that are available upon request include 31P NMR; 19F NMR

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Solid State NMR

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NMR & DSC / TGA / DMA ACI / NGI

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Crystec is an established pharmaceutical R&D company with the capacity to rapidly progress products from concept to clinical production.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Solid State NMR

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NMR Analysis/IR Analysis

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CLEARSYNTH team has extensive experience in developing, optimizing and validating methods. Our reliable analytical methods and techniques ensure that the quality of the products that we have produced is of the highest standards.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Solid State NMR

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Nuclear Magnetic Resonance (NMR)

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Arbro offers pharmaceutical testing and research services to support the development, approval, and manufacture of pharmaceutical raw materials and finished products. Arbro is listed on a number of leading pharmaceutical manufacturer’s licenses as the contract analytical testing site.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Solid State NMR

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Molecular Spectroscopy - NMR Spectroscopy

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NMR spectroscopy - special pulse technologies, multidimensional NMR for structure elucidation, 500 MHz-NMR spectrometer, 1H-, 13C-, 15N- und 31P-NMR spectroscopy.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Solid State NMR

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Nuclear Magnetic Resonance Spectroscopy

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Through a cooperative agreement with local universities such as Clark University in Worcester, MA, PCI also provides advanced non-GMP testing techniques including: Nuclear Magnetic Resonance Spectroscopy.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Solid State NMR

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300 MHz FT NMR (Bruker)

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Neuland has a separate, specially equipped R&D Centre located at Bonthapally. Custom Synthesis is another area where Neuland has been concentrating and is taking up several projects. We work in close association with clients, under strict confidentiality, to bring products early to markets.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Solid State NMR

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cGMP NMR: Answer to cGMP Needs

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Thanks to its innovative techniques (HPLC, SFC or combined preparative HPLC/SFC), DIVERCHIM proposes to its customers to isolate, purify and characterize process impurities as well as reference compounds.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Solid State NMR

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Varian Inova NMR Systems, 300 & 400 MHz

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KriSan Biotech has dedicated analytical team that provides full analytical services for process development, GLP studies and CGMP manufacturing.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Solid State NMR

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NMR (Nuclear Magnetic Resonance)

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Analytical research and development (AR&D) offers standalone services and supports our formulation development activities.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Solid State NMR

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Grace Albany Fine Chemicals' site is designed to meet customers' highest quality, regulatory, and confidentiality expectations for the manufacture of fine chemicals and intermediates.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Solid State NMR

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NMR Analysis

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M2M Pharmaceuticals Ltd, a Contract Research Organization (CRO) supports early stage product development for pharmaceutical, food and biotech companies with various services in Method Development and Validation, Physico-Chemical Analysis, Formulation and Quality/Regulatory support.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Solid State NMR

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Chemcon's analytic machines are regularly calibrated and qulified. Our analytical suite is state-of-the-art and is being extended continuously.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Solid State NMR

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NMR (300, 400 & 500 MHz)

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GVK BIO offers a broad range of analytical services for complex research needs. We perform method development, validate and transfer Good Manufacturing Practice (cGMP) compliant methods for a broad spectrum of pharma compounds.

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Pharma Service: Analytical

Category: Analytical Testing Services

Sub Category: Solid State NMR

Nuclear Magnetic Resonance (NMR) spectroscopy is an analytical chemistry technique used in quality control and reserach for determining the content and purity of a sample as well as its molecular structure. For example, NMR can quantitatively analyze mixtures containing known compounds. For unknown compounds, NMR can either be used to match against spectral libraries or to infer the basic structure directly. In the solid state, anisotropic spin interactions such as the chemical shift anisotropy or dipolar couplings contain unique spatial and dynamic information. However, these interactions lead to broad and overlapping spectral lines, which obscure the familiar isotropic chemical information known from solution-state NMR spectroscopy. In order to obtain high-resolution, it is necessary to remove the broadening due to this anisotropic interactions. The most convenient way to achieve this goal is rapid sample rotation at the so-called “magic” angle (MAS) relative to the static magnetic field, and at spinning speeds up to 35 kHz the anisotropic spin interactions are mostly refocused and the isotropic chemical shift information is regained. However one would like to access the spatial and dynamic information inhered to the anisotropic interactions. This can be achieved by combining fast MAS with appropriate recoupling techniques, based on the irradiation of sample rotation-synchronized radio frequency impulses. In this way, new solid-state NMR experiments can be designed which access spatial information, such as local proximities, as well as molecular dynamics. A particularly successful experimental solid-state method is ¹H double-quantum NMR spectroscopy under fast MAS in solids. This method is based on the indirect observation of double-quantum (DQ) coherences, which are correlated non-equilibrium states involving two dipolar coupled nuclear spins. Since the efficiency of DQ excitation strongly depends on the dipolar coupling between the two spins, these DQ experiments can be used to determine the dipolar coupling constant. In rigid samples, the dipolar coupling can be used to determine the distance between the coupled spins, and hence elucidate, e.g. the nature of hydrogen-bonded intermolecular bridges, whereas in mobile systems with known chemical structure the anisotropy of the molecular dynamics, as described by a local order parameter, can be probed.

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