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NMR (400 Mhz) + Xray

Analytical >> Analytical Testing Services >> Solid state NMR

Our analytical centre provides these methods & equipment: Analytical methods and equipment are validated; LCMS, GCMS, HPLC, TLC; UV/VIS and IR spectrometry; Capillary electrophoresis; Thermal analysis – DSC, Calorimetry; NMR (400 MHz) + xRAY; PSD analysis

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NMR Spectroscopy (1H & 13C NMR) for Peptide Analysis

Analytical >> Analytical Testing Services >> Solid state NMR

Bachem is committed to using synthesis and purification strategies that yield products of the quality and purity you require. Our standard analytical package typically includes mass spectrometric analysis and determination of purity (by RP-HPLC).

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Determine the Content & Purity of a Sample

Analytical >> Analytical Testing Services >> Solid state NMR

Dishman strives to provide a comprehensive portfolio of analytical services to facilitate this work. Analytical services support both process control and material characterisation for laboratory and production chemistry from initial raw material release to release of the final APIs.

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cGMP NMR: Answer to cGMP Needs

Analytical >> Analytical Testing Services >> Solid state NMR

Thanks to its innovative techniques (HPLC, SFC or combined preparative HPLC/SFC), DIVERCHIM proposes to its customers to isolate, purify and characterize process impurities as well as reference compounds.

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Varian Inova NMR Systems, 300 & 400 MHz

Analytical >> Analytical Testing Services >> Solid state NMR

KriSan Biotech has dedicated analytical team that provides full analytical services for process development, GLP studies and CGMP manufacturing.

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NMR (Nuclear Magnetic Resonance)

Analytical >> Analytical Testing Services >> Solid state NMR

Analytical research and development (AR&D) offers standalone services and supports our formulation development activities.

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Molecular Spectroscopy - NMR Spectroscopy

Analytical >> Analytical Testing Services >> Solid state NMR

NMR spectroscopy - special pulse technologies, multidimensional NMR for structure elucidation, 500 MHz-NMR spectrometer, 1H-, 13C-, 15N- und 31P-NMR spectroscopy.

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NMR & DSC / TGA / DMA ACI / NGI

Analytical >> Analytical Testing Services >> Solid state NMR

Crystec is an established pharmaceutical R&D company with the capacity to rapidly progress products from concept to clinical production.

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300 MHz FT NMR (Bruker)

Analytical >> Analytical Testing Services >> Solid state NMR

Neuland has a separate, specially equipped R&D Centre located at Bonthapally. Custom Synthesis is another area where Neuland has been concentrating and is taking up several projects. We work in close association with clients, under strict confidentiality, to bring products early to markets.

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Analysis of Highly Potent APIs Using NMR

Analytical >> Analytical Testing Services >> Solid state NMR

Carbogen Amcis SAS offers customized chromatography solutions for the separation and purification of active pharmaceutical intermediates (APIs) and intermediates, including highly active APIs.

Nuclear Magnetic Resonance (NMR) spectroscopy is an analytical chemistry technique used in quality control and reserach for determining the content and purity of a sample as well as its molecular structure. For example, NMR can quantitatively analyze mixtures containing known compounds. For unknown compounds, NMR can either be used to match against spectral libraries or to infer the basic structure directly. In the solid state, anisotropic spin interactions such as the chemical shift anisotropy or dipolar couplings contain unique spatial and dynamic information. However, these interactions lead to broad and overlapping spectral lines, which obscure the familiar isotropic chemical information known from solution-state NMR spectroscopy. In order to obtain high-resolution, it is necessary to remove the broadening due to this anisotropic interactions. The most convenient way to achieve this goal is rapid sample rotation at the so-called “magic” angle (MAS) relative to the static magnetic field, and at spinning speeds up to 35 kHz the anisotropic spin interactions are mostly refocused and the isotropic chemical shift information is regained. However one would like to access the spatial and dynamic information inhered to the anisotropic interactions. This can be achieved by combining fast MAS with appropriate recoupling techniques, based on the irradiation of sample rotation-synchronized radio frequency impulses. In this way, new solid-state NMR experiments can be designed which access spatial information, such as local proximities, as well as molecular dynamics. A particularly successful experimental solid-state method is ¹H double-quantum NMR spectroscopy under fast MAS in solids. This method is based on the indirect observation of double-quantum (DQ) coherences, which are correlated non-equilibrium states involving two dipolar coupled nuclear spins. Since the efficiency of DQ excitation strongly depends on the dipolar coupling between the two spins, these DQ experiments can be used to determine the dipolar coupling constant. In rigid samples, the dipolar coupling can be used to determine the distance between the coupled spins, and hence elucidate, e.g. the nature of hydrogen-bonded intermolecular bridges, whereas in mobile systems with known chemical structure the anisotropy of the molecular dynamics, as described by a local order parameter, can be probed.

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