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NMR (400 Mhz) + Xray

Analytical >> Analytical Testing Services >> Solid state NMR

Our analytical centre provides these methods & equipment: Analytical methods and equipment are validated; LCMS, GCMS, HPLC, TLC; UV/VIS and IR spectrometry; Capillary electrophoresis; Thermal analysis – DSC, Calorimetry; NMR (400 MHz) + xRAY; PSD analysis

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NMR Spectroscopy (1H & 13C NMR) for Peptide Analysis

Analytical >> Analytical Testing Services >> Solid state NMR

Bachem is committed to using synthesis and purification strategies that yield products of the quality and purity you require. Our standard analytical package typically includes mass spectrometric analysis and determination of purity (by RP-HPLC).

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Determine the Content & Purity of a Sample

Analytical >> Analytical Testing Services >> Solid state NMR

Dishman strives to provide a comprehensive portfolio of analytical services to facilitate this work. Analytical services support both process control and material characterisation for laboratory and production chemistry from initial raw material release to release of the final APIs.

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Analytical Development (NMR)

Analytical >> Analytical Testing Services >> Solid state NMR

Procos S.p.A. is specialized in the development, scale-up and production of Active Pharmaceutical Ingredients (APIs), advanced intermediates and related services for the pharmaceutical industry. Our core business sectors include custom synthesis and Generic API manufacturing.

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NMR (1H, 13C, 19F, 2D)

Analytical >> Analytical Testing Services >> Solid state NMR

Our scientists perform routine quality control testing on thousands of our catalog products each year, giving them unparalleled expertise in developing and validating methods to analyze, quantify, and purify small molecules.

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NMR & DSC / TGA / DMA ACI / NGI

Analytical >> Analytical Testing Services >> Solid state NMR

Crystec is an established pharmaceutical R&D company with the capacity to rapidly progress products from concept to clinical production.

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NMR Analysis/IR Analysis

Analytical >> Analytical Testing Services >> Solid state NMR

CLEARSYNTH team has extensive experience in developing, optimizing and validating methods. Our reliable analytical methods and techniques ensure that the quality of the products that we have produced is of the highest standards.

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Nuclear Magnetic Resonance (NMR)

Analytical >> Analytical Testing Services >> Solid state NMR

Arbro offers pharmaceutical testing and research services to support the development, approval, and manufacture of pharmaceutical raw materials and finished products. Arbro is listed on a number of leading pharmaceutical manufacturer’s licenses as the contract analytical testing site.

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NMR (400 MHz, quantitative, multinuclear, multidimensional)

Analytical >> Analytical Testing Services >> Solid state NMR

All analytic machines at ChemCon are regularly calibrated and qulified. Our analytical suite is state-of-the-art and is beeing extended continuously.

Nuclear Magnetic Resonance (NMR) spectroscopy is an analytical chemistry technique used in quality control and reserach for determining the content and purity of a sample as well as its molecular structure. For example, NMR can quantitatively analyze mixtures containing known compounds. For unknown compounds, NMR can either be used to match against spectral libraries or to infer the basic structure directly. In the solid state, anisotropic spin interactions such as the chemical shift anisotropy or dipolar couplings contain unique spatial and dynamic information. However, these interactions lead to broad and overlapping spectral lines, which obscure the familiar isotropic chemical information known from solution-state NMR spectroscopy. In order to obtain high-resolution, it is necessary to remove the broadening due to this anisotropic interactions. The most convenient way to achieve this goal is rapid sample rotation at the so-called “magic” angle (MAS) relative to the static magnetic field, and at spinning speeds up to 35 kHz the anisotropic spin interactions are mostly refocused and the isotropic chemical shift information is regained. However one would like to access the spatial and dynamic information inhered to the anisotropic interactions. This can be achieved by combining fast MAS with appropriate recoupling techniques, based on the irradiation of sample rotation-synchronized radio frequency impulses. In this way, new solid-state NMR experiments can be designed which access spatial information, such as local proximities, as well as molecular dynamics. A particularly successful experimental solid-state method is ¹H double-quantum NMR spectroscopy under fast MAS in solids. This method is based on the indirect observation of double-quantum (DQ) coherences, which are correlated non-equilibrium states involving two dipolar coupled nuclear spins. Since the efficiency of DQ excitation strongly depends on the dipolar coupling between the two spins, these DQ experiments can be used to determine the dipolar coupling constant. In rigid samples, the dipolar coupling can be used to determine the distance between the coupled spins, and hence elucidate, e.g. the nature of hydrogen-bonded intermolecular bridges, whereas in mobile systems with known chemical structure the anisotropy of the molecular dynamics, as described by a local order parameter, can be probed.

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