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Extract\/Herbal","year":"2024","type":"Inapplicable","leadProduct":"Traumeel","moa":"Undisclosed","graph1":"Orthopedics\/Orthopedic Surgery","graph2":"Phase III","graph3":"Heel","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Orthopedics","amount2New":0,"dosageForm":"Gel","sponsorNew":"Heel \/ Undisclosed","highestDevelopmentStatusID":"10","companyTruncated":"Heel \/ Undisclosed"},{"orgOrder":0,"company":"Heel","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Orthopedics\/Orthopedic Surgery","country":"GERMANY","productType":"Plant Extract\/Herbal","year":"2010","type":"Inapplicable","leadProduct":"Traumeel","moa":"Undisclosed","graph1":"Orthopedics\/Orthopedic Surgery","graph2":"Phase III","graph3":"Heel","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Orthopedics","amount2New":0,"dosageForm":"Ointment","sponsorNew":"Heel \/ Undisclosed","highestDevelopmentStatusID":"10","companyTruncated":"Heel \/ Undisclosed"},{"orgOrder":0,"company":"McMaster University","sponsor":"Canadian Institutes of Health Research | McMaster Surgical Associates | Hamilton Health Sciences","pharmaFlowCategory":"DU","therapeuticArea":"Orthopedics\/Orthopedic Surgery","country":"CANADA","productType":"Vitamins\/Minerals\/Inorganic Salts","year":"2013","type":"Inapplicable","leadProduct":"Vitamin D","moa":"Vitamin D receptor","graph1":"Orthopedics\/Orthopedic Surgery","graph2":"Phase III","graph3":"McMaster University","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Orthopedics","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"McMaster University \/ Canadian Institutes of Health Research | McMaster Surgical Associates | Hamilton Health Sciences","highestDevelopmentStatusID":"10","companyTruncated":"McMaster University \/ Canadian Institutes of Health Research | McMaster Surgical Associates | Hamilton Health Sciences"},{"orgOrder":0,"company":"University of Miami","sponsor":"Arthrex","pharmaFlowCategory":"DU","therapeuticArea":"Orthopedics\/Orthopedic Surgery","country":"U.S.A","productType":"Undisclosed","year":"2021","type":"Inapplicable","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Orthopedics\/Orthopedic Surgery","graph2":"Phase III","graph3":"University of Miami","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Orthopedics","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"University of Miami \/ Arthrex","highestDevelopmentStatusID":"10","companyTruncated":"University of Miami \/ Arthrex"}]

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                          Top Deals by Deal Size (USD bn)

                          01

                          COMPAMED
                          Not Confirmed
                          COMPAMED
                          Not Confirmed

                          Details : The combined company will focus on the development of OrthoCellix’s NeoCart technology for the treatment of knee articular cartilage defects and plans to initiate a Phase 3 trial for NeoCart.

                          Product Name : NeoCart

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Undisclosed

                          June 23, 2025

                          Lead Product(s) : NeoCart,Autologous Cartilagenous Tissue

                          Therapeutic Area : Orthopedics/Orthopedic Surgery

                          Highest Development Status : Phase III

                          Sponsor : Carisma Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Merger

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                          02

                          COMPAMED
                          Not Confirmed
                          COMPAMED
                          Not Confirmed

                          Details : AGA111 is a recombinant human bone morphogenic protein 6 (rhBMP6) product in clinical development to promote bone fusion & functional outcomes in patients undergoing spinal fusion procedures.

                          Product Name : Undisclosed

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          March 18, 2025

                          Lead Product(s) : AGA111

                          Therapeutic Area : Orthopedics/Orthopedic Surgery

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          COMPAMED
                          Not Confirmed
                          COMPAMED
                          Not Confirmed

                          Lead Product(s) : Esflurbiprofen

                          Therapeutic Area : Orthopedics/Orthopedic Surgery

                          Study Phase : Phase III

                          Sponsor : CRM Biometrics | SocraTec R&D GmbH | SocraMetrics GmbH | HWI Pharma Services | Clinsearch GmbH

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Esflurbiprofen is a Other Small Molecule drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Ankle Injuries.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          March 10, 2025

                          Lead Product(s) : Esflurbiprofen

                          Therapeutic Area : Orthopedics/Orthopedic Surgery

                          Highest Development Status : Phase III

                          Sponsor : CRM Biometrics | SocraTec R&D GmbH | SocraMetrics GmbH | HWI Pharma Services | Clinsearch GmbH

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          COMPAMED
                          Not Confirmed
                          COMPAMED
                          Not Confirmed

                          Details : SB-01 is a 7-amino acid synthetic peptide that binds to and antagonizes TGF-Beta activity. It is being developed for chronic low back pain in degenerative disc disease.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          September 24, 2024

                          Lead Product(s) : SB-01

                          Therapeutic Area : Orthopedics/Orthopedic Surgery

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          COMPAMED
                          Not Confirmed
                          COMPAMED
                          Not Confirmed

                          Details : Spine BioPharma acquired the right to develop and commercialize SB-01, excluding Korea. It is being evaluated for the treatment of pain-related disability, associated with Degenerative Disc Disease.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Undisclosed

                          July 10, 2024

                          Lead Product(s) : SB-01

                          Therapeutic Area : Orthopedics/Orthopedic Surgery

                          Highest Development Status : Phase III

                          Sponsor : Spine BioPharma

                          Deal Size : $155.0 million

                          Deal Type : Agreement

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                          06

                          COMPAMED
                          Not Confirmed
                          COMPAMED
                          Not Confirmed

                          Details : Rexlemestrocel-L is a Cell and Gene Therapy drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Intervertebral Disc Degeneration.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          March 22, 2024

                          Lead Product(s) : Rexlemestrocel-L

                          Therapeutic Area : Orthopedics/Orthopedic Surgery

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          COMPAMED
                          Not Confirmed
                          COMPAMED
                          Not Confirmed

                          Details : Traumeel is a Plant Extract/Herbal drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Ankle Injuries.

                          Product Name : Undisclosed

                          Product Type : Plant Extract/Herbal

                          Upfront Cash : Inapplicable

                          January 05, 2024

                          Lead Product(s) : Traumeel

                          Therapeutic Area : Orthopedics/Orthopedic Surgery

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          COMPAMED
                          Not Confirmed
                          COMPAMED
                          Not Confirmed

                          Details : AGA111 is a Protein drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Intervertebral Disc Degeneration.

                          Product Name : Undisclosed

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          November 03, 2023

                          Lead Product(s) : AGA111

                          Therapeutic Area : Orthopedics/Orthopedic Surgery

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          COMPAMED
                          Not Confirmed
                          COMPAMED
                          Not Confirmed

                          Details : Hyalofast is a highly differentiated, single-stage, bone preserving, hyaluronic acid matrix, which is intended to support the entrapment of mesenchymal stem cells obtained from autologous bone marrow aspirate concentrate for the repair of chondral and os...

                          Product Name : Hyalofast

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          May 30, 2023

                          Lead Product(s) : Hyaluronic Acid

                          Therapeutic Area : Orthopedics/Orthopedic Surgery

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          Nantes University Hospital

                          Country arrow
                          COMPAMED
                          Not Confirmed

                          Nantes University Hospital

                          Country arrow
                          COMPAMED
                          Not Confirmed

                          Details : Oxygen is a Other Small Molecule drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Ankle Fractures.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          January 11, 2022

                          Lead Product(s) : Oxygen

                          Therapeutic Area : Orthopedics/Orthopedic Surgery

                          Highest Development Status : Phase III

                          Sponsor : Radiometer Medical ApS

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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