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Find Clinical Drug Development Pipelines & Deals | PipelineProspector
Imcivree (setmelanotide), has shown significant potential to transform the care of individuals living with the onset of extreme weight gain from hypothalamic obesity.
Setmelanotide, an MC4R agonist marketed as IMCIVREE®, previously received Breakthrough Designation while being developed for Bardet-Biedl syndrome and proopiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1) and leptin receptor (LEPR) deficiencies.
ALT-801 (pemvidutide) is a GLP-1/glucagon dual receptor agonist that is being developed for the treatment of obesity and non-alcoholic steatohepatitis (NASH).
APH-012 is a glucose formulation designed to be released at discrete parts of the small intestine to restore endogenous nutrient-sensing signaling pathways and stimulate the release of the broad spectrum of enteric hormones that control multiple homeostatic functions.
XW003 is a novel, biased long-lasting GLP-1 peptide analogue optimized for improved biological activity and once weekly dosing. GLP-1 analogs are effective tools in managing type 2 diabetes, obesity, and have demonstrated clinical potential as a treatment for NASH.
Imcivree (setmelanotide) is a MC4R agonist. The MC4R is part of the key biological pathway that regulates hunger, caloric intake and energy expenditure. Variants in genes may impair the function of the MC4R pathway, potentially leading to hyperphagia and obesity.
Mazdutide (IBI362) is a long-acting synthetic peptide related to mammalian OXM, which uses a fatty acid side chain to prolong the duration of action and allow once-weekly administration.In higher-dose cohorts, mazdutide up-titrated to 10 mg and 9 mg were both well tolerated.
Pemvidutide (ALT-801) is novel, investigational, peptide-based GLP-1/glucagon dual receptor agonist in development for treatment of obesity and NASH. Activation of GLP-1 and glucagon receptors.
The financing will further support clinical advancement of lead candidate HU6, a first-in-class Controlled Metabolic Accelerator (CMA) designed to treat cardio-metabolic disease by addressing obesity, a primary driver of disease.
At Week 24, each dose of IBI362 (mazdutide) showed significant efficacy on body weight loss compared with placebo in a dose-dependent manner and brought multiple cardio-metabolic benefits to participants.
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