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II","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Intramuscular Injection","sponsorNew":"AEON Biopharma \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"AEON Biopharma \/ Inapplicable"},{"orgOrder":0,"company":"AEON Biopharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Protein","year":"2022","type":"Inapplicable","leadProduct":"Prabotulinumtoxin A","moa":"ACh receptor","graph1":"Musculoskeletal","graph2":"Phase II","graph3":"AEON Biopharma","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Intramuscular Injection","sponsorNew":"AEON Biopharma \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"AEON Biopharma \/ Inapplicable"},{"orgOrder":0,"company":"AEON Biopharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Protein","year":"2024","type":"Inapplicable","leadProduct":"Prabotulinumtoxin A","moa":"ACh receptor","graph1":"Musculoskeletal","graph2":"Phase II","graph3":"AEON Biopharma","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Intramuscular Injection","sponsorNew":"AEON Biopharma \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"AEON Biopharma \/ Inapplicable"},{"orgOrder":0,"company":"AEON Biopharma","sponsor":"PPD","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Protein","year":"2024","type":"Inapplicable","leadProduct":"Prabotulinumtoxin A","moa":"ACh receptor","graph1":"Musculoskeletal","graph2":"Phase II","graph3":"AEON Biopharma","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Intramuscular Injection","sponsorNew":"AEON Biopharma \/ PPD","highestDevelopmentStatusID":"8","companyTruncated":"AEON Biopharma \/ PPD"},{"orgOrder":0,"company":"AEON Biopharma","sponsor":"Priveterra Acquisition Corp.","pharmaFlowCategory":"D","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Protein","year":"2022","type":"Merger","leadProduct":"Prabotulinumtoxin A","moa":"ACh receptor","graph1":"Musculoskeletal","graph2":"Phase II","graph3":"AEON Biopharma","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Intramuscular Injection","sponsorNew":"AEON Biopharma \/ Priveterra Acquisition Corp.","highestDevelopmentStatusID":"8","companyTruncated":"AEON Biopharma \/ Priveterra Acquisition Corp."},{"orgOrder":0,"company":"AEON Biopharma","sponsor":"Undisclosed","pharmaFlowCategory":"D","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Protein","year":"2022","type":"Financing","leadProduct":"Prabotulinumtoxin A","moa":"ACh receptor","graph1":"Musculoskeletal","graph2":"Phase II","graph3":"AEON Biopharma","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Intramuscular Injection","sponsorNew":"AEON Biopharma \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"AEON Biopharma \/ Undisclosed"},{"orgOrder":0,"company":"4Moving Biotech","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"FRANCE","productType":"Peptide","year":"2025","type":"Inapplicable","leadProduct":"Liraglutide","moa":"GLP-1 receptor","graph1":"Musculoskeletal","graph2":"Phase II","graph3":"4Moving Biotech","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Intra-articular Injection","sponsorNew":"4Moving Biotech \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"4Moving Biotech \/ Inapplicable"},{"orgOrder":0,"company":"Pacira BioSciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Cell and Gene therapy","year":"2025","type":"Inapplicable","leadProduct":"Enekinragene Inzadenovec","moa":"IL-1 receptor","graph1":"Musculoskeletal","graph2":"Phase II","graph3":"Pacira BioSciences","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Intra-articular Injection","sponsorNew":"Pacira BioSciences \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Pacira BioSciences \/ Inapplicable"},{"orgOrder":0,"company":"Pacira BioSciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Cell and Gene therapy","year":"2025","type":"Inapplicable","leadProduct":"Enekinragene Inzadenovec","moa":"IL-1 receptor","graph1":"Musculoskeletal","graph2":"Phase II","graph3":"Pacira BioSciences","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Intra-articular Injection","sponsorNew":"Pacira BioSciences \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Pacira BioSciences \/ Inapplicable"},{"orgOrder":0,"company":"TNF Pharmaceuticals","sponsor":"Renova Health","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Isomyosamine","moa":"TNF-alpha receptor","graph1":"Musculoskeletal","graph2":"Phase II","graph3":"TNF Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"TNF Pharmaceuticals \/ Renova Health","highestDevelopmentStatusID":"8","companyTruncated":"TNF Pharmaceuticals \/ Renova Health"},{"orgOrder":0,"company":"OrthoTrophix","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Peptide","year":"2025","type":"Inapplicable","leadProduct":"Dentonin","moa":"Integrin","graph1":"Musculoskeletal","graph2":"Phase II","graph3":"OrthoTrophix","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Intra-articular Injection","sponsorNew":"OrthoTrophix \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"OrthoTrophix \/ Inapplicable"},{"orgOrder":0,"company":"Avicanna","sponsor":"University Health Network","pharmaFlowCategory":"D","therapeuticArea":"Musculoskeletal","country":"CANADA","productType":"Controlled Substance","year":"2025","type":"Agreement","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Musculoskeletal","graph2":"Phase II","graph3":"Avicanna","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Oral","sponsorNew":"Avicanna \/ University Health Network","highestDevelopmentStatusID":"8","companyTruncated":"Avicanna \/ University Health Network"}]

    Find Musculoskeletal Drugs in Phase II Clinical Development

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                            01

                            Avicanna

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                            Avicanna

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Musculoskeletal

                            Study Phase : Phase II

                            Sponsor : University Health Network

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Avicanna Announces Sponsorship of Pilot Phase II Clinical Study Osteoarthritis Pain

                            Details : The primary objective of the RCT is to evaluate oral cannabinoids for improving pain interference in patients with hip and/or knee osteoarthritis.

                            Product Name : Undisclosed

                            Product Type : Controlled Substance

                            Upfront Cash : Undisclosed

                            May 20, 2025

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Musculoskeletal

                            Highest Development Status : Phase II

                            Sponsor : University Health Network

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            02

                            OrthoTrophix

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                            OrthoTrophix

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                            Lead Product(s) : Dentonin

                            Therapeutic Area : Musculoskeletal

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            OrthoTrophix Starts Phase 2b TPX-100 Trial for Knee Osteoarthritis Patients

                            Details : TPX-100 is being developed as a potential disease-modifying osteoarthritis drug (DMOAD), a class of therapies that aim not only to alleviate symptoms but to slow or halt disease progression.

                            Product Name : TPX-100

                            Product Type : Peptide

                            Upfront Cash : Inapplicable

                            May 12, 2025

                            Lead Product(s) : Dentonin

                            Therapeutic Area : Musculoskeletal

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            TNF Pharmaceuticals

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                            TNF Pharmaceuticals

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                            Lead Product(s) : Isomyosamine

                            Therapeutic Area : Musculoskeletal

                            Study Phase : Phase II

                            Sponsor : Renova Health

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            TNF & Renova Show Targeting Potential for Inflammation with GLP-1 Therapy

                            Details : The study series is expected to evaluate the impact of the Company’s novel oral TNF-alpha inhibitor, MYMD-1 (isomyosamine), in preserving lean muscle mass during and after GLP-1 treatment.

                            Product Name : MYMD-1

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            May 08, 2025

                            Lead Product(s) : Isomyosamine

                            Therapeutic Area : Musculoskeletal

                            Highest Development Status : Phase II

                            Sponsor : Renova Health

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Pacira BioSciences

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                            Pacira BioSciences

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                            Lead Product(s) : Enekinragene Inzadenovec

                            Therapeutic Area : Musculoskeletal

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Pacira to Present 104-Week Data on PCRX-201 in Knee Osteoarthritis

                            Details : PCRX-201 (enekinragene inzadenovec) is an IL-1 receptor inhibitor gene therapy candidate, which is currently being evaluated for the treatment of osteoarthritis of the knee.

                            Product Name : PCRX-201

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            April 22, 2025

                            Lead Product(s) : Enekinragene Inzadenovec

                            Therapeutic Area : Musculoskeletal

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Pacira BioSciences

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                            Pacira BioSciences

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                            Lead Product(s) : Enekinragene Inzadenovec

                            Therapeutic Area : Musculoskeletal

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Pacira Doses First Patient in Phase 2 Study of PCRX-201 for Knee Osteoarthritis

                            Details : Pacira’s novel product candidate PCRX-201 (enekinragene inzadenovec), features an innovative design based on the company’s proprietary high-capacity adenovirus vector platform.

                            Product Name : PCRX-201

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            April 03, 2025

                            Lead Product(s) : Enekinragene Inzadenovec

                            Therapeutic Area : Musculoskeletal

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            4Moving Biotech

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                            4Moving Biotech

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                            Lead Product(s) : Liraglutide

                            Therapeutic Area : Musculoskeletal

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            4Moving Biotech Starts Phase 2a Knee Osteoarthritis Trial in Canada

                            Details : 4P004 is a GLP-1 analog, tailored for intra-articular use in knee osteoarthritis. It was developed to exploit the analgesic, anti-inflammatory, anti-catabolic, and anabolic benefits of GLP-1.

                            Product Name : 4P004

                            Product Type : Peptide

                            Upfront Cash : Inapplicable

                            March 27, 2025

                            Lead Product(s) : Liraglutide

                            Therapeutic Area : Musculoskeletal

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Antibe Therapeutics

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                            Antibe Therapeutics

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                            Lead Product(s) : Otenaproxesul

                            Therapeutic Area : Musculoskeletal

                            Study Phase : Phase II

                            Sponsor : Taro Pharmaceutical Industries

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Sun Pharma Subsidiary Taro Acquires Antibe Therapeutics

                            Details : Through the acquisition, Taro will leverage Antibe pipeline, including ATB-346 (otenaproxesul), a novel NSAID. It is being evaluated for the treatment of Osteoarthritis.

                            Product Name : ATB-346

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            January 16, 2025

                            Lead Product(s) : Otenaproxesul

                            Therapeutic Area : Musculoskeletal

                            Highest Development Status : Phase II

                            Sponsor : Taro Pharmaceutical Industries

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

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                            08

                            TNF Pharmaceuticals

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                            EPS
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                            TNF Pharmaceuticals

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                            Lead Product(s) : Isomyosamine

                            Therapeutic Area : Musculoskeletal

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            TNF Pharmaceuticals Announces Positive Clinical Data Supporting Clinical Trial Expansion

                            Details : MYMD-1 (isomyosamine) is a TNF-alpha inhibitor drug, currently being investigated in patients with sarcopenia/frailty.

                            Product Name : MYMD-1

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            January 15, 2025

                            Lead Product(s) : Isomyosamine

                            Therapeutic Area : Musculoskeletal

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            AEON Biopharma

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                            AEON Biopharma

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                            Lead Product(s) : Prabotulinumtoxin A

                            Therapeutic Area : Musculoskeletal

                            Study Phase : Phase II

                            Sponsor : Aegis Capital

                            Deal Size : $20.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            AEON Biopharma, Inc. Announces Closing of $20.0 Million Underwritten Public Offering

                            Details : The net proceeds will be used to advance the clinical development of company's lead product ABP-450 (Prabotulinumtoxin A). It is being evaluated for the treatment of Cervical dystonia.

                            Product Name : ABP-450

                            Product Type : Protein

                            Upfront Cash : Undisclosed

                            January 07, 2025

                            Lead Product(s) : Prabotulinumtoxin A

                            Therapeutic Area : Musculoskeletal

                            Highest Development Status : Phase II

                            Sponsor : Aegis Capital

                            Deal Size : $20.0 million

                            Deal Type : Public Offering

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                            10

                            AEON Biopharma

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                            AEON Biopharma

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                            Lead Product(s) : Prabotulinumtoxin A

                            Therapeutic Area : Musculoskeletal

                            Study Phase : Phase II

                            Sponsor : Aegis Capital

                            Deal Size : $20.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            AEON Biopharma Announces $20M Underwritten Public Offering Pricing

                            Details : The net proceeds will be used to advance the clinical development of company's lead product ABP-450 (Prabotulinumtoxin A). It is being evaluated for the treatment of Cervical dystonia.

                            Product Name : ABP-450

                            Product Type : Protein

                            Upfront Cash : Undisclosed

                            January 06, 2025

                            Lead Product(s) : Prabotulinumtoxin A

                            Therapeutic Area : Musculoskeletal

                            Highest Development Status : Phase II

                            Sponsor : Aegis Capital

                            Deal Size : $20.0 million

                            Deal Type : Public Offering

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