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Therapeutics \/ AstraZeneca","highestDevelopmentStatusID":"1","companyTruncated":"Quell Ther.."},{"orgOrder":0,"company":"KayoThera","sponsor":"NIH NIDDK","pharmaFlowCategory":"D","amount":"Undisclosed","upfrontCash":"Undisclosed","newsHeadline":"KayoThera, Inc. Strengthens Financial Position with $5.2 Million in Grant and Expanded Series A Funding, Bringing Total Financial Support to $14 Million","therapeuticArea":"Endocrinology","highestDevelopmentStatus":"Undisclosed","country":"","productType":"Small molecule","productStatus":"New Molecular Entity","date":"July 2023","year":"2023","type":"Funding","leadProduct":"Undisclosed","moa":"","url1":"","url2":"","graph1":"Endocrinology","graph2":"Undisclosed","graph3":"KayoThera","amount2":0,"therapeuticAreaNew":"Endocrinology","highestDevelopmentStatusNew":"Undisclosed","highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Endocrinology","productSubType":"","amount2New":0,"dosageForm":"","sponsorNew":"KayoThera \/ NIH NIDDK","highestDevelopmentStatusID":"1","companyTruncated":"KayoThera .."},{"orgOrder":0,"company":"Undisclosed","sponsor":"BIOSYENT PHARMA INC","pharmaFlowCategory":"D","amount":"Undisclosed","upfrontCash":"Undisclosed","newsHeadline":"BioSyent In-Licenses Endocrinology Product for Canada","therapeuticArea":"Endocrinology","highestDevelopmentStatus":"Undisclosed","country":"","productType":"Undisclosed","productStatus":"New Molecular Entity","date":"June 2024","year":"2024","type":"Licensing Agreement","leadProduct":"Undisclosed","moa":"","url1":"","url2":"","graph1":"Endocrinology","graph2":"Undisclosed","graph3":"Undisclosed","amount2":0,"therapeuticAreaNew":"Endocrinology","highestDevelopmentStatusNew":"Undisclosed","highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Endocrinology","productSubType":"","amount2New":0,"dosageForm":"","sponsorNew":"Undisclosed \/ BIOSYENT PHARMA INC","highestDevelopmentStatusID":"1","companyTruncated":"Undisclose.."}]

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                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : Insulin Glargine,Lixisenatide

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Undisclosed

                          Partner/Sponsor/Collaborator : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : Participants were randomized to switch from their prior insulin to either Soliqua once daily or premixed insulin twice daily, with starting doses determined and adjusted weekly. Any metformin or SGLT-2i t...

                          Product Name : Soliqua

                          Product Type : Peptide

                          Upfront Cash : Not Applicable

                          June 28, 2021

                          Lead Product(s) : Insulin Glargine,Lixisenatide

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Undisclosed

                          Partner/Sponsor/Collaborator : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Sanofi Company Banner

                          02

                          Undisclosed

                          Country arrow
                          26th North American ISSX
                          Not Confirmed

                          Undisclosed

                          Country arrow
                          26th North American ISSX
                          Not Confirmed

                          Details : Under the licensing agreement, BioSyent aims to market, sell & distribute a new endocrinology product in Canada. BioSyent and its European partner will seek Health Canada approval by the end of 2024.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          June 12, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Undisclosed

                          Partner/Sponsor/Collaborator : BIOSYENT PHARMA INC

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          03

                          26th North American ISSX
                          Not Confirmed
                          26th North American ISSX
                          Not Confirmed

                          Details : The net funding will support the advancement of KayoThera’s pipeline of first-in-class antagonists of the retinoid pathway as novel oral therapies for Type 2 Diabetes.

                          Product Name : Undisclosed

                          Product Type : Small molecule

                          Upfront Cash : Undisclosed

                          July 19, 2023

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Undisclosed

                          Partner/Sponsor/Collaborator : NIH NIDDK

                          Deal Size : Undisclosed

                          Deal Type : Funding

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                          04

                          26th North American ISSX
                          Not Confirmed
                          26th North American ISSX
                          Not Confirmed

                          Details : The collaboration aims to focus on the type 1 diabetes and inflammatory bowel disease using Quell’s proprietary toolbox of Treg cell engineering modules, including its innovative Foxp3 Phenotype Lock, t...

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : $85.0 million

                          June 09, 2023

                          Lead Product(s) : Treg-based Cell Therapy

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Undisclosed

                          Partner/Sponsor/Collaborator : AstraZeneca

                          Deal Size : $2,085.0 million

                          Deal Type : Collaboration

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                          05

                          26th North American ISSX
                          Not Confirmed
                          26th North American ISSX
                          Not Confirmed

                          Lead Product(s) : Bioprinted-based Tissue Therapy

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Undisclosed

                          Partner/Sponsor/Collaborator : Novo Nordisk

                          Deal Size : $2,675.0 million

                          Deal Type : Collaboration

                          Details : Under the terms of the agreement, Novo Nordisk will receive an exclusive, worldwide licence to use Aspect’s bioprinting technology to develop bioprinted tissue therapeutics including up to four products...

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : $75.0 million

                          April 12, 2023

                          Lead Product(s) : Bioprinted-based Tissue Therapy

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Undisclosed

                          Partner/Sponsor/Collaborator : Novo Nordisk

                          Deal Size : $2,675.0 million

                          Deal Type : Collaboration

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