What is Custom Synthesis and API Manufacturing? API custom synthesis CMOs offer development and/or manufacturing of early or advanced intermediates and active pharmaceutical ingredients. We can deliver one or all building blocks along your synthetic pathway including biocatalytic steps up to the final API. All compounds can be tailored to meet your particular requirements of API Custom synthesis, with target compound synthesis & API organic synthesis requirements based on a predefined process or ‘from scratch’. Custom APIs CMOs provide services for: APIs High-potency APIs (HAPIs) Early and late stage/advanced intermediates (IMs). The Custom APIs CMOs are able to provide a complete solution during the entire molecule lifecycle — from the preclinical stage up to the market (non-GMP and GMP). The Custom Drug Manufacturing services are offered as a complete package or on a modular basis. The top API manufacturers CMOs with GMP certified custom manufacturing services include: Process development and optimization for APIs and IMs Up-scaling Process validation Development and validation of analytical methods Synthesis of impurities, reference standards, etc. Salt screening, co-crystal screening, polymorphism studies Stability studies according to ICH guidelines Sourcing of raw materials or IMs Production and supply of APIs and IMs Technical transfer to another manufacturer/manufacturing site All top API manufacturers CMOs offer Multistep API Synthesis services on an exclusive basis and all information is treated strictly confidential. In working with Custom manufacturing services customers and Custom API services providers partners, the best custom manufacturing service providers believe in full transparency and open communication. Custom manufacturing services are directly involved in discussions with Custom manufacturing service providers partners and are always fully aware of the activities and progress. The custom synthetic APIs have to gain access to Custom API CMOs in an integrated, global network of Custom API CMO partners and pool of Custom CMOs, as well as the knowledge gained from our years of experience and that of our industry-leading partners. Phosgenation services for Small molecule APIs & Pharma chemicals The specialist teams of Phosgenation services cover all stages of the pharmaceutical value chain and are able to provide complete solutions to meet the specific needs of each customer. As well as custom synthesis and API manufacturing, API manufacturers CMOs offer a range of complementary services. With Custom API synthesis, 4 cGMP plants regularly inspected by the FDA for commercial production supported by three ISO 9001 sites in France and North America, CMO services customers have access to a powerful industrial network of facilities with a high level of Quality, cGMP Custom API Manufacturing Safety and Environmental compliance. Top API manufacturers CMOs like PCAS invests on an ongoing basis in its production sites with API route scouting services in order to provide pharmaceutical laboratories with state of the art equipment combined with cutting-edge technology in organic chemistry associated with proprietary Custom API manufacturing technology for unique biocatalytic routes. API custom synthesis services companies and Route scouting CMOs conduct GMP manufacturing of APIs or Intermediates from kilos to multi-tons quantities . The range of scale and seamless collaboration within our manufacturing sites allow PCAS to accommodate most of the projects regardless size and complexity. Where to Find the Best custom API manufacturing services Top Custom API CMOs are the requirement for GMP “One-Stop-Shop”, custom API services are needed for a Contract Development and Manufacturing Organization (CDMO), which is fully dedicated to third party manufacturing of APIs, IMs and NCEs for the pharmaceutical and small molecule biotech industry. Top Organic Synthesis CMOs and custom API service providers offers an end-to-end partnership for custom API development, scale-up and manufacturing with a flexible multipurpose EU GMP Pilot Plant, from grams to tonnes, with a client centric approach. Custom GMP manufacturing services range from developing new synthesis routes to optimising and validating industrial manufacturing processes// development of analytical methods to validation// preparation of documentation required for clinical trials. Best GMP certified custom manufacturing service providers are a specialized Pharma company focusing on the niche therapeutic areas of CNS, ARVs and Controlled substances having tremendous future growth potential from Custom synthesis CMOs. By virtue of this niche focus Organic Synthesis CMOs have registered an impressive growth over the years. The pharmaceutical contract manufacturing industry will continue to achieve consolidation via mergers and acquisitions (M&A). Consolidation of API custom synthesis CMOs is expected to peak in the next five years, cGMP custom API CMOs, as more CMOs strive to provide a one-stop-shop, Custom synthesis of API & intermediates offering services from APIs to finished doses. Excess capacity is also the driver of the recent M&A activities. Top API custom synthesis CMOs offer Affordability is no longer the main parameter in selecting CMOs for partnership, as sponsor companies will increasingly emphasize quality, compliance with regulatory demands and service requirements. Technological advances will also stimulate that market from 2015 to 2025. Also custom API synthesis CMOs invest in custom API CMOs for single-use technologies for biopharmaceutical manufacturing and continuous manufacturing processes. CMOs will also invest heavily to expand their capacities in HPAPIs.” Along with prediction of the overall world market for outsourced drug production, the new report gives revenue forecasting of 11 world-level submarkets to 2025: Active pharmaceutical ingredients (APIs), with sub forecasts for custom synthetic APIs for generic APIs, high potency active pharma ingredients (HPAPIs) and other products Finished dosage formulations (FDFs), with sub forecasts for solid dose forms, injectable dosages, and other agents GMP certified custom manufacturing Other applications of outsourced Custom CMOs production Clinical manufacturing Custom synthesis APIs Commercial manufacturing & Custom API manufacturing requirements In 2015 Custom API services providers had projects account for most CMO revenue. However, improved funding for early-stage projects in the US and EU will drive demand for clinical trial material manufacturing towards the middle of the forecast period. The growing R&D pipeline of novel antibody-drug conjugates (ADCs) will also create more opportunities for CMOs offering specialised manufacturing technologies, further stimulating the market. Global top Custom APIs CMOs reports new study also discusses regulatory developments and demand for pharma contract manufacturing services in leading and emerging national markets along with custom API synthesis services. Custom Drug Manufacturing Custom CMOs work analyses the US, Japan, Germany, France, Italy, Spain, the UK, China, India, Brazil, Russia and South Korea, with revenue forecasting to 2025. Developed markets account for the greatest demand for outsourced drug manufacturing. The US and EU accounted for 63.9% of CMO revenues in 2013. And concerns with regulatory compliance led some Western companies to seek outsourcing partners closer to home custom API manufacturing. Custom Synthesis and Contract Manufacturing Custom GMP synthesis offers Emerging national markets, however, will still generate much business from pharma companies wanting custom medicine production. That Custom APIs investigation provides quantitative and qualitative analyses of Custom synthesis APIs the pharma contract manufacturing market for the period 2015 to 2025. Best custom manufacturing service providers also shows interviews with companies. Pharmaceutical Contract Manufacturing offers Custom GMP manufacturing: World Industry and Market Outlook 2015-2025 adds to the reports portfolio of market analysis on pharmaceutical outsourcing and other Small Molecule Synthesis healthcare industries. Search for contract manufacturing organizations (CMOs) for custom API synthesis & manufacturing services from Custom API services providers. Search for cGMP custom API CMOs, custom API synthesis services and custom API manufacturing service providers CMOs. Find capabilities like multistep API organic synthesis. Contract API Manufacturing // API Custom Synthesis & Manufacturing Services|CMOs With technology racing onward, drugs are becoming more complex than ever before – along with their active ingredients and the processes that produce them. To some extent, the challenges of commercial API manufacturing vary, based on scale. A large-scale CMO might not necessarily be suited to working in an early stage of development. Applying later-stage standards early on, for example, could waste time and money custom API synthesis– ultimately derailing the project timeline and budget. At the same time, consideration must always be given to later-stage manufacturing processes & requirements during earlier phases of the project to maximize efficiency and minimize cost & time-to-market, Contract Chemistry. It requires striking a balance – maximizing early-stage success while minimizing challenges in the future. Scale-Up Gradually to Identify & Solve New Challenges at Each Stage Many aspects of early-stage production, such as handling and storing raw materials, only become challenging when production is scaled up. Issues with heat generation and dissipation also tend to come to the forefront when production is dramatically increased custom API manufacturing service providers. In addition, larger volumes often mean longer reaction times. This can be problematic for certain processes. To detect and resolve these potential issues, production is scaled gradually, going from micro or milligram scale to gram scale, then pilot scale to full production. Lifecycle Management Key to Successful Process Scale-Up When preparing to scale up drug production, it’s important to partner with a CMO well-versed in lifecycle management. A contract firm that has the extensive expertise needed to work comfortably at all scales can improve many aspects of the scale-up process in custom API manufacturing services measurable ways, making it smoother, faster, and easier overall. The issues that arise when shifting from one scale to another can be unpredictable, and because of this,planning and forecasting should be done as early in the R&D process as possible. The more experienced the transfer team, the more streamlined and simplified the technology transfer can be. Several techniques are currently used to make production more efficient. Scouting alternate synthetic routes to a molecule has become standard, and helps control costs by accelerating production. This can also reduce time spent on regulatory compliance, as there are less steps to document, and less analysis to be made throughout the process. How to find the right supplier for Custom Synthesis? What are Custom API CMOs? What is a Custom API CMO and how can I find the best solution provider for my project? Custom synthesis means the exclusive synthesis of compounds on behalf of the customer, i.e., you can order a specific molecule that is only synthesized on your request on the scale, with the purity and with the specification or methods you require. There is a big difference between the conditions used for small-scale custom synthesis of entirely new molecules and those used for standard multi ton per annum manufacturing multistep API organic synthesis, just as strictly regulated cGMP syntheses are different from those performed for R&D purposes. Active pharmaceutical ingredients custom synthesis Learn more about the market of custom synthesis services, the different kinds Active ingredients custom synthesis of service providers (e.g., CROS and CMOs) and how you can find the best provider for your projects. A Contract Research Organization (CRO) enables the outsourcing of a broad variety of research activities from custom synthesis of small molecules to clinical trials of a new drug, which helps to enliven the commercial research culture toward an international, innovation-based (drug) industry [1]. CROs, with their new epistemic skills and capacities, are both manifestations of the changes in commercial research cultures as well as the vehicles to achieve them. In contrast to Contract Manufacturing Organizations (CMOs), which produce ten to thousands of tons of fine chemicals on multi-purpose plants, CROs have a lab bench or patient population as their working base. However there is an custom API synthesis & manufacturing services API custom synthesis services, interface when it comes to the pilot plant, which is needed at a certain stage in both industries. Medical or pharmaceutical CROs are active in the clinical part of drug development, operating in the sphere of physicians, hospitals, and patients, but also dealing with medical devices, diagnostics, and drug administration. Conversely, chemical CROs mainly focus on only two aspects of the value chain, namely the small-scale preparation of active ingredients of new drugs and the design and basic development of the manufacturing process. As a result, Medical CROs attract more attention, and the general public considers the outsourcing of pharmaceutical development to predominantly include tasks such as lead identification, compound screening, lead optimization, or clinical trials. Therefore, the market for contract businesses offering custom synthesis and research services is rather small compared to that of Medical CROs.

Wavelength Pharmaceuticals

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Wavelength Pharmaceuticals offers custom API manufacturing services ranging from lab-scale to multi-ton commercial manufacturing with cGMP scale up. Their CDMO services include production of cytotoxics, steroids & highly potent APIs (HPAPIs).

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PMC Isochem

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PMC Isochem offers custom synthesis and manufacturing of cGMP intermediates, active pharmaceutical ingredients (APIs) & excipients such as Vitamin E TPGS and polyamino acids for drug delivery solutions.

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Minakem

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Minakem offers contract development & manufacturing of highly potent APIs (HPAPI). Their core capabilities include complex multi-step API process development & cGMP custom synthesis of high-potency APIs (HPAPIs) from kilo-lab to commercial manufacturing.

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ChemWerth Inc

Virtual Booth Generic API development & supply// Non-infringement patent strategies development// Regulatory support.

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Working on an Exclusive Basis with a number of domestic & international cGMP manufacturers, ChemWerth can offer custom manufacturing in supplying those difficult to produce generics and new pharmaceuticals in a time frame that enables quick market entry.

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Farmak A.S

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Farmak's analytical centre provides these methods & equipment: Analytical methods and equipment are validated; LCMS, GCMS, HPLC, TLC; UV/VIS and IR spectrometry; Capillary electrophoresis; Thermal analysis – DSC, Calorimetry; NMR (400 MHz) + xRAY; & more.

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AMRI

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AMRI provides custom synthesis and drug substance manufacturing services at a small and large scale for all phases of discovery, contract development, and manufacturing.

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Phyton Biotech LLC

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Phyton is capable of developing custom product manufacturing stratergies to meet the needs of clients across the pharmaceutical, traditional Chinese medicine (TCM), cosmetic, agricultural and food ingredient industries.

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PHARMASYNTHESE

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Pharmasynthese research and development laboratory offers a variety of CDMO services such as new molecule synthesis, process development, process industrialization and scale-up, process optimization and troubleshooting, and custom manufacturing.

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Inabata France S.A.S

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LEBSA

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LEBSA offers an end-to-end partnership for custom API development, scale-up and manufacturing with a flexible multipurpose EU GMP Pilot Plant, from grams to tones, with a client centric approach.

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SANOFI Active Ingredient Solutions

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SAIS is a cGMP compliant custom API manufacturing CMO service provider. They offer custom synthesis services, custom API manufacturing services, multistep API organic synthesis and other API manufacturing complex long organic synthesis services.

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Cayman Chemical Company Inc

Virtual Booth Europe's most reliable and versatile source for Prostaglandin APIs// FDA Inspected 2017

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Cayman's chemists brings unmatched experience to solving difficult synthetic routes & performing complex, multistep syntheses & specialize in the production of eicosanoids (prostaglandins & leukotrienes), fatty acids, cannabinoids, & complex heterocycles.

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ScinoPharm Taiwan, Ltd

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Supply of gram quantities for use as building blocks, drug screening, purity standards, etc. ScinoPharm can undertake cGMP manufacturing, including pre-clinical and clinical manufacturing, as well as launch and post-launch supply requirements.

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Inke S.A

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High added value active substances with complex synthesis processes, mainly for use in respiratory and CNS therapies

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ZACH System SA

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Zach has over 30 years of experience in multi-step syntheses involving complex reactions.We have dedicated R&D and analytical development teams on each site, and state-of-the art analytical equipment.

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Angelini Pharmaceuticals ACRAF

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Your GMP “One-Stop-Shop”, Angelini Fine Chemicals is a contract development and manufacturing organization (CDMO), which is fully dedicated to third party manufacturing of APIs, IMs and NCEs for the small molecule biotech and pharmaceutical industry.

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Fermion Oy

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Fermion is a contract manufacturing supplier of APIs, HPAPIs & advanced intermediates with best-in-class facilities and high level of automation. Fermion delivers cost-efficient synthesis, process development & life-cycle management solutions.

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CBL- Chemical and Biopharmaceutical Laboratories

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CBL is a global peptide manufacturing company which offers custom GMP peptide synthesis and manufacturing. They have state-of-the-art facilities for peptide synthesis, setting new standards for GMP synthesis at both small & large scale.

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Menadiona

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Menadiona offers custom & contract manufacturing services through their fine chemical division. They specialize in manufacturing active ingredients (APIs) & key intermediates for the pharmaceutical, veterinary, plant health and nutraceutical industries.

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Quality Chemicals

Virtual Booth Your first choice for high purity mineral salts.

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Quality Chemicals offers custom purification & synthesis for various products. They can customise products such as reagents, inorganic salts, organic salts, solvents, solutions and mixtures.

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DOTTIKON EXCLUSIVE SYNTHESIS AG

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DOTTIKON provides chemical custom manufacturing services to scale up from grams to multi-tons, including routefinding, process design, process development, small-scale and pilot production, manufacturing, qualification and validation.

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