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with Argenx","therapeuticArea":"Immunology","highestDevelopmentStatus":"Discovery Platform","country":"PORTUGAL","productType":"Large molecule","productStatus":"New Molecular Entity","date":"April 2021","url1":"","url2":"","graph1":"Large molecule","graph2":"FairJourney Biologics"},{"company":"Nanna Therapeutics","sponsor":"Astellas Pharma","pharmaFlowCategory":"D","amount":"$98.5 million","upfrontCash":"$17.0 million","newsHeadline":"Astellas Announces Acquisition of Nanna","therapeuticArea":"Immunology","highestDevelopmentStatus":"Discovery Platform","country":"UNITED KINGDOM","productType":"Undisclosed","productStatus":"New Molecular Entity","date":"April 2020","url1":"","url2":"","graph1":"Undisclosed","graph2":"Nanna Therapeutics"},{"company":"Mestag Therapeutics","sponsor":"Janssen Pharmaceutical","pharmaFlowCategory":"D","amount":"Undisclosed","upfrontCash":"Undisclosed","newsHeadline":"Mestag Therapeutics Announces Collaboration with 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into Strategic Collaboration to Discover and Develop Novel Lysosomal Targeting Chimera (LYTAC) Degraders","therapeuticArea":"Immunology","highestDevelopmentStatus":"Discovery Platform","country":"U.S.A","productType":"Undisclosed","productStatus":"Undisclosed","date":"August 2021","url1":"","url2":"","graph1":"Undisclosed","graph2":"Lycia Therapeutics"},{"company":"GlycoEra","sponsor":"5AM Ventures","pharmaFlowCategory":"D","amount":"$49.0 million","upfrontCash":"Undisclosed","newsHeadline":"GlycoEra AG Raises CHF 45 Million (US$ 49 Million) Series A Financing to Develop Novel Biologics Based on Innovative Glycoengineering Platform","therapeuticArea":"Immunology","highestDevelopmentStatus":"Discovery Platform","country":"SWITZERLAND","productType":"Large molecule","productStatus":"New Molecular Entity","date":"November 2021","url1":"","url2":"","graph1":"Large molecule","graph2":"GlycoEra"},{"company":"MabGenesis","sponsor":"Boehringer Ingelheim 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molecule","graph2":"Seismic Therapeutic"},{"company":"Modulus Discovery","sponsor":"Green Coinvest Investment Limited","pharmaFlowCategory":"D","amount":"$20.4 million","upfrontCash":"Undisclosed","newsHeadline":"Modulus Discovery Closes $20.4M USD Series C","therapeuticArea":"Immunology","highestDevelopmentStatus":"Discovery Platform","country":"U.S.A","productType":"Small molecule","productStatus":"Undisclosed","date":"March 2022","url1":"","url2":"","graph1":"Small molecule","graph2":"Modulus Discovery"},{"company":"TRexBio","sponsor":"Polaris Partners","pharmaFlowCategory":"D","amount":"$26.0 million","upfrontCash":"Undisclosed","newsHeadline":"TRexBio Completes $26 Million Series A Extension Led by Polaris Partners to Advance Treatments for Immune-Mediated Diseases","therapeuticArea":"Immunology","highestDevelopmentStatus":"Discovery Platform","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"March 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Details:
Proceeds from the financing will be used to expand the company’s unique discovery platform that maps human tissue regulatory T cell (Treg) behavior to dysregulation in diseases, including its lead asset TRB-051.
Lead Product(s):
TRB-051
Therapeutic Area: Immunology
Product Name: TRB-051
Highest Development Status: Discovery Platform
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Polaris Partners
Deal Size: $26.0 million
Upfront Cash: Undisclosed
Deal Type: Series A Financing
March 08, 2022
Details:
Modulus will use the proceeds to further its portfolio of R&D programs driven by its proprietary computational drug discovery platform and globally networked operational model including lead asset MOD-A.
Lead Product(s):
MOD-A
Therapeutic Area: Immunology
Product Name: MOD-A
Highest Development Status: Discovery Platform
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Green Coinvest Investment Limited
Deal Size: $20.4 million
Upfront Cash: Undisclosed
Deal Type: Series C Financing
March 01, 2022
Details:
The Series A financing will support Seismic Therapeutic’s further advancement toward the clinic of its first two lead drug programs, one targeting Ig (immunoglobulin)-mediated autoimmunity and the other targeting cell-mediated autoimmunity.
Lead Product(s):
Undisclosed
Therapeutic Area: Immunology
Product Name: Undisclosed
Highest Development Status: Discovery Platform
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Lightspeed Venture Partners
Deal Size: $101.0 million
Upfront Cash: Undisclosed
Deal Type: Series A Financing
February 09, 2022
Details:
Under the agreement, MabGenesis will apply its unique platform to the discovery of first-in-class candidate antibodies against targets of interest selected by Boehringer Ingelheim.
Lead Product(s):
Monoclonal Antibody
Therapeutic Area: Immunology
Product Name: Undisclosed
Highest Development Status: Discovery Platform
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Boehringer Ingelheim GmbH
Deal Size: Undisclosed
Upfront Cash: Undisclosed
Deal Type: Collaboration
January 18, 2022
Details:
The proceeds will be used to support the growth of the company and to demonstrate the breadth and value of its CustomGlycan Platform technology in developing assets that can unlock unique biological activities for therapeutic targets in several disease indications.
Lead Product(s):
Glycoengineered Therapeutics
Therapeutic Area: Immunology
Product Name: Undisclosed
Highest Development Status: Discovery Platform
Product Type: Large molecule
Partner/Sponsor/Collaborator:
5AM Ventures
Deal Size: $49.0 million
Upfront Cash: Undisclosed
Deal Type: Series A Financing
November 05, 2021
Details:
Under the terms of the agreement, the companies will utilize Lycia's LYTAC platform to discover and develop novel degraders for up to five targets that aim to address key unmet medical needs in Lilly's therapeutic areas of focus, including immunology and pain.
Lead Product(s):
LYTAC-based Therapeutics
Therapeutic Area: Immunology
Product Name: Undisclosed
Highest Development Status: Discovery Platform
Product Type: Undisclosed
Partner/Sponsor/Collaborator:
Eli Lilly
Deal Size: $1,635.0 million
Upfront Cash: $35.0 million
Deal Type: Collaboration
August 25, 2021
Details:
The in-licensed candidate targets a critical immunological kinase that historically has proven difficult to target due to the need for a combination of potency, selectivity, and overall drug-like properties.
Lead Product(s):
Undisclosed
Therapeutic Area: Immunology
Product Name: Undisclosed
Highest Development Status: Discovery Platform
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Bristol Myers Squibb
Deal Size: $1,200.0 million
Upfront Cash: $50.0 million
Deal Type: Collaboration
August 18, 2021
Details:
The objective of the collaboration is to identify new therapeutic product concepts for immune diseases where an AI and ML based approach can be applied to generate compelling evidence for the role of G-protein coupled receptors (GPCRs) in relevant immunomodulatory pathways.
Lead Product(s):
Undisclosed
Therapeutic Area: Immunology
Product Name: Undisclosed
Highest Development Status: Discovery Platform
Product Type: Undisclosed
Partner/Sponsor/Collaborator:
Sosei Heptares
Deal Size: Undisclosed
Upfront Cash: Undisclosed
Deal Type: Collaboration
July 06, 2021
Details:
Proceeds from the financing will be used to advance the development of therapeutic candidates to treat autoimmune diseases, severe allergies, cancer and infectious diseases.
Lead Product(s):
Undisclosed
Therapeutic Area: Immunology
Product Name: Undisclosed
Highest Development Status: Discovery Platform
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Alta Partners
Deal Size: $70.0 million
Upfront Cash: Undisclosed
Deal Type: Series A Financing
June 23, 2021
Details:
Mestag will interrogate fibroblast subpopulations across diseases and their interactions with key aspects of the immune system. Janssen gets an option to an exclusive license to develop and commercialize therapeutics directed against up to two targets.
Lead Product(s):
Undisclosed
Therapeutic Area: Immunology
Product Name: Undisclosed
Highest Development Status: Discovery Platform
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Janssen Pharmaceutical
Deal Size: Undisclosed
Upfront Cash: Undisclosed
Deal Type: Collaboration
May 18, 2021
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