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The osmotic concentration of a solution can be obtained by measuring the extent of the freezing-point depression. osmometer is composed of a sample cell for a fixed volume of sample solution and a cell holder, a cooling unit and bath with a temperature regulator, and a thermistor for detecting temperature. Osmolality measurements using a osmometer, are regularly carried out in the pharmaceutical industry and research labs to establish the isotonicity of intravenous solutions, injections, nasal a