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The osmotic concentration of a solution can be obtained by measuring the extent of the freezing-point depression. osmometer is composed of a sample cell for a fixed volume of sample solution and a cell holder, a cooling unit and bath with a temperature regulator, and a thermistor for detecting temperature. Osmolality measurements using a osmometer, are regularly carried out in the pharmaceutical industry and research labs to establish the isotonicity of intravenous solutions, injections, nasal and eye drops. Preparations which are hypertonic or hypotonic can cause severe irritation when injected into the bloodstream or tissue or when applied to mucous membranes like cornea and wounds. Osmosis is defined as the passage of solvent into a solution through a semi permeable membrane. This process eventually leads to equilibrium and the tendency of the solvent to move from one side of the membrane to the other can be measured by the closely related colligative property called osmotic pressure. Osmotic pressure is classically expressed in terms of atmospheres, but in clinical practice, it is expressed in terms of osmols (Osm) or miliosmols (mOsm). Osmolarity is used more frequently than osmolality in the labelling of parenteral solutions in, pharmaceutical manufacturing, hospitals and pharmacies. But osmolarity cannot be measured and must be calculated experimentally by determining the osmolality of a solution. For near ideal solutions, osmolarity is different from osmolality only by 1 or 2% , but as you go towards more concentrated solutions of polyvalent electrolytes together with buffers, preservatives and other ions these differences become larger. An osmole is a unit of measurement that defines the concentration of a compound that contributes to osmotic pressure of a solution. It is commonly expressed in concentration unit of moles/liter (osmomolarity) or in moles/kg (osmomolality). Measurements of osmotic pressure are relevant to biological fluids such as blood and urine. For accuracy in the preparation and labelling of parenteral solutions osmolality should be measured carefully with the vapour pressure or freezing point based osmometer rather than being calculated based on the concentrations of ingredients added. The osmolality of blood, measured using osmometer, ranges from 250 to 350 mOsm/kg and the normal osmolarity of body fluids given in medical books ranges from 275 to 295 mOsm/kg, but normal values usually fall in an even narrower range of 286±4 mOsm/kg. Parenteral preparations are developed to closely match the values to reduce the irritation caused by them Osmolality measurement using osmometer is a pharmacopoeia requirement for numerous products. The United States Pharmacopoeia (USP) gives the option of using either vapour pressure based osmometer or a cryoscopic (depression increasing point based) osmometer for the measurement of osmolarity whereas the Indian Pharmacopoeia (IP) describes the cryoscopic osmometer for the measurement of osmolarity.

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Osmolarity for Peptide Analysis

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Over the years, Bachem has gathered an extensive know-how not only in the synthesis of active pharmaceutical ingredients, peptides as well as small molecules, but also in the analysis of these compounds.

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Osmolality

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R.D. Laboratories’ osmometer determines the concentration of a solution by determining the solution’s freezing point, which is directly correlated to the level of the concentration.

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Osmolarity Measurement

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Arbro has recently installed a osmometer based on freezing point depression in our state of the art testing lab in New Delhi.

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Determination of Osmolality

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Jubilant HollisterStier’s innovative microbiological and analytical labs are operated by experienced professionals using the most current equipment and procedures to ensure seamless technical transfer of analytical methods for our clients.

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Osmometer

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GVK BIO offers a broad range of analytical services for complex research needs. We perform method development, validate and transfer Good Manufacturing Practice (cGMP) compliant methods for a broad spectrum of pharma compounds.

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Osmometer - Measuring Osmotic Strength of a S...

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Cebiphar offers its expertise and technical platform to the pharmaceutical industry. At Cebiphar we provide physicochemical, pharmacotechnical & microbiological testings according to GMP quality standards.

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Sub Category: Osmotic Strength / Osmometer

The osmotic concentration of a solution can be obtained by measuring the extent of the freezing-point depression. osmometer is composed of a sample cell for a fixed volume of sample solution and a cell holder, a cooling unit and bath with a temperature regulator, and a thermistor for detecting temperature. Osmolality measurements using a osmometer, are regularly carried out in the pharmaceutical industry and research labs to establish the isotonicity of intravenous solutions, injections, nasal and eye drops. Preparations which are hypertonic or hypotonic can cause severe irritation when injected into the bloodstream or tissue or when applied to mucous membranes like cornea and wounds. Osmosis is defined as the passage of solvent into a solution through a semi permeable membrane. This process eventually leads to equilibrium and the tendency of the solvent to move from one side of the membrane to the other can be measured by the closely related colligative property called osmotic pressure. Osmotic pressure is classically expressed in terms of atmospheres, but in clinical practice, it is expressed in terms of osmols (Osm) or miliosmols (mOsm). Osmolarity is used more frequently than osmolality in the labelling of parenteral solutions in, pharmaceutical manufacturing, hospitals and pharmacies. But osmolarity cannot be measured and must be calculated experimentally by determining the osmolality of a solution. For near ideal solutions, osmolarity is different from osmolality only by 1 or 2% , but as you go towards more concentrated solutions of polyvalent electrolytes together with buffers, preservatives and other ions these differences become larger. An osmole is a unit of measurement that defines the concentration of a compound that contributes to osmotic pressure of a solution. It is commonly expressed in concentration unit of moles/liter (osmomolarity) or in moles/kg (osmomolality). Measurements of osmotic pressure are relevant to biological fluids such as blood and urine. For accuracy in the preparation and labelling of parenteral solutions osmolality should be measured carefully with the vapour pressure or freezing point based osmometer rather than being calculated based on the concentrations of ingredients added. The osmolality of blood, measured using osmometer, ranges from 250 to 350 mOsm/kg and the normal osmolarity of body fluids given in medical books ranges from 275 to 295 mOsm/kg, but normal values usually fall in an even narrower range of 286±4 mOsm/kg. Parenteral preparations are developed to closely match the values to reduce the irritation caused by them Osmolality measurement using osmometer is a pharmacopoeia requirement for numerous products. The United States Pharmacopoeia (USP) gives the option of using either vapour pressure based osmometer or a cryoscopic (depression increasing point based) osmometer for the measurement of osmolarity whereas the Indian Pharmacopoeia (IP) describes the cryoscopic osmometer for the measurement of osmolarity.

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