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Details:
The company will use the proceeds from the offering for the development of clinical pipeline including ALPN-303 and for other general and corporate purpose.
Lead Product(s):
ALPN-303
Therapeutic Area: Immunology
Product Name: ALPN-303
Highest Development Status: Phase I
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Morgan Stanley
Deal Size: $100.0 million
Upfront Cash: Undisclosed
Deal Type: Public Offering
September 20, 2022
Details:
The acquisition provides Gilead with MiroBio’s proprietary discovery platform and entire portfolio of immune inhibitory receptor agonists. MiroBio’s lead MB272, is a selective agonist of immune inhibitory receptor B and T-Lymphocyte Attenuator.
Lead Product(s):
MB272
Therapeutic Area: Immunology
Product Name: MB272
Highest Development Status: Phase I
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Gilead Sciences
Deal Size: $405.0 million
Upfront Cash: $405.0 million
Deal Type: Acquisition
September 20, 2022
Details:
THB001, is a highly selective, oral small-molecule inhibitor of KIT, a cell surface receptor that serves as the master regulator of mast cell function and survival.
Lead Product(s):
THB001
Therapeutic Area: Immunology
Product Name: THB001
Highest Development Status: Phase I
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Morgan Stanley
Deal Size: $10.9 million
Upfront Cash: Undisclosed
Deal Type: Public Offering
September 14, 2022
Details:
The new data continue to support the favorable safety profile of DSG3-CAART (Desmoglein 3 Chimeric Auto Antibody Receptor T Cells), with no dose-limiting toxicities, and one grade 1 cytokine release syndrome through cohort A5, at a dose of up to 7.5 billion DSG3-CAART cells.
Lead Product(s):
Desmoglein 3 Chimeric Auto Antibody Receptor T-cell Therapy
Therapeutic Area: Immunology
Product Name: DSG3-CAART
Highest Development Status: Phase I
Product Type: Cell and Gene therapy
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
September 10, 2022
Details:
OX640 is nasal adrenaline rescue medication based on the amorphOX® drug delivery platform is a unique and innovative new product to be used for the emergency treatment of allergic reactions.
Lead Product(s):
Epinephrine
Therapeutic Area: Immunology
Product Name: OX640
Highest Development Status: Phase I
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
September 01, 2022
Details:
DSG3-CAART (Desmoglein 3 Chimeric Auto Antibody Receptor T Cells), is being developed to treat mucosal pemphigus vulgaris, a blistering skin disease that affects mucous membranes.
Lead Product(s):
Desmoglein 3 Chimeric Auto Antibody Receptor T Cells
Therapeutic Area: Immunology
Product Name: DSG3-CAART
Highest Development Status: Phase I
Product Type: Cell and Gene therapy
Partner/Sponsor/Collaborator:
University of Pennsylvania
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
August 29, 2022
Details:
IBI311 is a monoclonal antibody targeting IGF-1R developed by Innovent for the treatment of active TAO. By blocking the binding of IGF-1 and IGF-2 to IGF-1R, IBI311 inhibits IGF-1R signaling pathway activation and reduces the expression of downstream inflammatory factors.
Lead Product(s):
IBI311
Therapeutic Area: Immunology
Product Name: IBI311
Highest Development Status: Phase I
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
August 18, 2022
Details:
Under the terms of the agreement, Horizon will fund development through completion of the two Phase 2 trials of ADX-914, with Q32 being operationally responsible for the conduct of all program-related activities.
Lead Product(s):
ADX-914
Therapeutic Area: Immunology
Product Name: ADX-914
Highest Development Status: Phase I
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Horizon Therapeutics
Deal Size: $645.0 million
Upfront Cash: $55.0 million
Deal Type: Collaboration
August 15, 2022
Details:
The programme includes upstream and downstream process, analytical method, and formulation development with a view to support commercial manufacturing of ALPN 303.
Lead Product(s):
ALPN-303
Therapeutic Area: Immunology
Product Name: ALPN-303
Highest Development Status: Phase I
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Alpine Immune Sciences
Deal Size: Undisclosed
Upfront Cash: Undisclosed
Deal Type: Expanded Collaboration
August 10, 2022
Details:
The acquisition will provide Gilead, MiroBio’s proprietary discovery platform and entire portfolio of immune inhibitory receptor agonists. MiroBio’s lead investigational antibody, MB272, is a selective agonist of immune inhibitory receptor B- and T-Lymphocyte Attenuator.
Lead Product(s):
MB272
Therapeutic Area: Immunology
Product Name: MB272
Highest Development Status: Phase I
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Gilead Sciences
Deal Size: $405.0 million
Upfront Cash: $405.0 million
Deal Type: Acquisition
August 04, 2022
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