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II","graph3":"Nuwacell Biotechnologies","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Nuwacell Biotechnologies \/ Undisclosed","highestDevelopmentStatusID":"7","companyTruncated":"Nuwacell Biotechnologies \/ Undisclosed"},{"orgOrder":0,"company":"BIONCaRT GmbH","sponsor":"KKS Netzwerk | Fraunhofer Institute for Cell Therapy and Immunology IZI | Polski Bank Komorek Macierzystych JSC","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"","productType":"Cell and Gene therapy","year":"2025","type":"Inapplicable","leadProduct":"BP CC 001","moa":"Undisclosed","graph1":"Musculoskeletal","graph2":"Phase I\/ Phase II","graph3":"BIONCaRT GmbH","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"BIONCaRT GmbH \/ KKS Netzwerk | Fraunhofer Institute for Cell Therapy and Immunology IZI | Polski Bank Komorek Macierzystych JSC","highestDevelopmentStatusID":"7","companyTruncated":"BIONCaRT GmbH \/ KKS Netzwerk | Fraunhofer Institute for Cell Therapy and Immunology IZI | Polski Bank Komorek Macierzystych JSC"}]

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                          Top Deals by Deal Size (USD bn)

                          01

                          Synartro AB

                          Country arrow
                          BIOHK2025
                          Not Confirmed

                          Synartro AB

                          Country arrow
                          BIOHK2025
                          Not Confirmed

                          Details : SYN321 (Diclofenac) is a Other Small Molecule drug candidate, which is currently being evaluated in Phase I/ Phase II clinical studies for the treatment of Osteoarthritis, Knee.

                          Product Name : SYN321

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          May 25, 2025

                          Lead Product(s) : Diclofenac

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : CTC Clinical Trial Consultants

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          BIONCaRT GmbH

                          Country arrow
                          BIOHK2025
                          Not Confirmed

                          BIONCaRT GmbH

                          Country arrow
                          BIOHK2025
                          Not Confirmed

                          Lead Product(s) : BP CC 001

                          Therapeutic Area : Musculoskeletal

                          Study Phase : Phase I/ Phase II

                          Sponsor : KKS Netzwerk | Fraunhofer Institute for Cell Therapy and Immunology IZI | Polski Bank Komorek Macierzystych JSC

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : BP CC 001 is a Cell and Gene therapy drug candidate, which is currently being evaluated in Phase I/ Phase II clinical studies for the treatment of Cartilage Diseases.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          May 21, 2025

                          Lead Product(s) : BP CC 001

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : KKS Netzwerk | Fraunhofer Institute for Cell Therapy and Immunology IZI | Polski Bank Komorek Macierzystych JSC

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          BIOHK2025
                          Not Confirmed
                          BIOHK2025
                          Not Confirmed

                          Details : CABA-201 (resecabtagene autoleucel) is a 4-1BB-containing fully human CD19-CAR T cell investigational therapy for patients with myositis.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          May 15, 2025

                          Lead Product(s) : Resecabtagene Autoleucel

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          blank

                          04

                          BIOHK2025
                          Not Confirmed
                          BIOHK2025
                          Not Confirmed

                          Details : The partnership aims to advance the clinical development of EPI-321, which is being evaluated in ther early-stage clinical trial studies for the treatment of FSHD.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          April 23, 2025

                          Lead Product(s) : EPI-321

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Springbok Analytics

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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                          05

                          BIOHK2025
                          Not Confirmed
                          BIOHK2025
                          Not Confirmed

                          Details : Allocetra-OTS, fundamental approach centered on restoring macrophage homeostasis, currently being investigated for knee osteoarthritis.

                          Product Name : Allocetra-OTS

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          April 21, 2025

                          Lead Product(s) : Allocetra-OTS

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          BIOHK2025
                          Not Confirmed
                          BIOHK2025
                          Not Confirmed

                          Details : EPI-321, a first-in-class epigenetic therapy for the treatment of facioscapulohumeral muscular dystrophy (FSHD), a genetic neuromuscular disease.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          April 03, 2025

                          Lead Product(s) : EPI-321

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          BIOHK2025
                          Not Confirmed
                          BIOHK2025
                          Not Confirmed

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          April 02, 2025

                          Lead Product(s) : EPI-321

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          BIOHK2025
                          Not Confirmed
                          BIOHK2025
                          Not Confirmed

                          Details : Allocetra is being developed as a universal, off-the-shelf cell therapy designed to reprogram macrophages into their homeostatic state in patients with knee osteoarthritis.

                          Product Name : Allocetra

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          March 03, 2025

                          Lead Product(s) : Allocetra

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          BIOHK2025
                          Not Confirmed
                          BIOHK2025
                          Not Confirmed

                          Details : NVD-003 is an autologous cell-based therapy which is is made from a patient's own adipose stem cells. It is being evaluated for the treatment of congenital pseudarthrosis of tibia.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          January 28, 2025

                          Lead Product(s) : NVD-003

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          BIOHK2025
                          Not Confirmed
                          BIOHK2025
                          Not Confirmed

                          Details : The financing aims to advance the clinical development of IMM01-STEM, which is being evaluated for the treatment of age-related muscle atrophy.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          January 11, 2025

                          Lead Product(s) : IMM01-STEM

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Remiges Ventures

                          Deal Size : $25.0 million

                          Deal Type : Series A Financing

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