Lead Product(s) : GP1681,Inapplicable
Therapeutic Area : Pharmacology/Toxicology
Study Phase : Phase I/ Phase II
Sponsor : CytoAgents
Deal Size : Undisclosed
Deal Type : Collaboration
Quotient Sciences and CytoAgents Accelerate Potential Treatment for COVID-19 Cytokine Storm
Details : The collaboration aims to focus on the development of GP1681 (CTO1681), which is a small molecule inhibitor of cytokine release targeting the NF-kB signaling pathway via the activation of the EP4 receptor. It is under development for treatment of cytokin...
Product Name : Undisclosed
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
April 28, 2020
Lead Product(s) : GP1681,Inapplicable
Therapeutic Area : Pharmacology/Toxicology
Highest Development Status : Phase I/ Phase II
Sponsor : CytoAgents
Deal Size : Undisclosed
Deal Type : Collaboration
Lead Product(s) : CTO1681,Inapplicable
Therapeutic Area : Pharmacology/Toxicology
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
CytoAgents Completes Phase 1B Cohort 1 for Cytokine Release Syndrome
Details : CTO1681 is a GPCR agonist, small molecule drug candiate, which is being evaluated for the treatment of cytokine release syndrome.
Product Name : Undisclosed
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
April 24, 2025
Lead Product(s) : CTO1681,Inapplicable
Therapeutic Area : Pharmacology/Toxicology
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : CTO1681,Inapplicable
Therapeutic Area : Pharmacology/Toxicology
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : CTO1681 cell therapy, prevents and treats Cytokine Release Syndrome by targeting the NF-kB signaling pathway via the activation of the EP4 receptor, which reduces NF-kB signaling.
Product Name : Undisclosed
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
October 17, 2023
Lead Product(s) : CTO1681,Inapplicable
Therapeutic Area : Pharmacology/Toxicology
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : CTO1681,Inapplicable
Therapeutic Area : Pharmacology/Toxicology
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Undisclosed
Product Name : Undisclosed
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
June 15, 2023
Lead Product(s) : CTO1681,Inapplicable
Therapeutic Area : Pharmacology/Toxicology
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Lenzilumab,Inapplicable
Therapeutic Area : Pharmacology/Toxicology
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : The patent covers the use of lenzilumab to prevent or treat cytokine release syndrome (CRS), neurotoxicity and otherwise inhibit or reduce incidence or severity of CAR-T-related toxicities in patients undergoing CAR-T cell therapy.
Product Name : Humaneered
Product Type : Antibody
Upfront Cash : Inapplicable
December 28, 2020
Lead Product(s) : Lenzilumab,Inapplicable
Therapeutic Area : Pharmacology/Toxicology
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Nivolumab,Tumor Infiltrating Lymphocytes,Interferon Alpha
Therapeutic Area : Pharmacology/Toxicology
Study Phase : Phase I/ Phase II
Sponsor : Bristol Myers Squibb
Deal Size : Inapplicable
Deal Type : Inapplicable
TIL and Anti-PD1 in Metastatic Melanoma
Details : Undisclosed
Product Name : Undisclosed
Product Type : Antibody
Upfront Cash : Inapplicable
August 20, 2018
Lead Product(s) : Nivolumab,Tumor Infiltrating Lymphocytes,Interferon Alpha
Therapeutic Area : Pharmacology/Toxicology
Highest Development Status : Phase I/ Phase II
Sponsor : Bristol Myers Squibb
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Human Umbilical Cord Mesenchymal Stem Cell,Inapplicable
Therapeutic Area : Pharmacology/Toxicology
Study Phase : Phase I/ Phase II
Sponsor : Ivy Institute of Stem Cells Co. Ltd
Deal Size : Inapplicable
Deal Type : Inapplicable
Human Umbilical-Cord-Derived Mesenchymal Stem Cell Therapy in Paraquat Poisoning Induced Lung Injury
Details : Undisclosed
Product Name : Undisclosed
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
May 15, 2015
Lead Product(s) : Human Umbilical Cord Mesenchymal Stem Cell,Inapplicable
Therapeutic Area : Pharmacology/Toxicology
Highest Development Status : Phase I/ Phase II
Sponsor : Ivy Institute of Stem Cells Co. Ltd
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Anhydrous Selenite,Inapplicable
Therapeutic Area : Pharmacology/Toxicology
Study Phase : Phase I/ Phase II
Sponsor : University of Chicago | University of Calgary | University of Alberta | Gabrail Cancer Center Research | Wagner College, Staten Island, NY, USA | `Applied Speciation and Consulting LLC
Deal Size : Inapplicable
Deal Type : Inapplicable
Selenium and Arsenic Pharmacodynamics
Details : Undisclosed
Product Name : Undisclosed
Product Type : Vitamins/Minerals/Inorganic Salts
Upfront Cash : Inapplicable
March 03, 2015
Lead Product(s) : Anhydrous Selenite,Inapplicable
Therapeutic Area : Pharmacology/Toxicology
Highest Development Status : Phase I/ Phase II
Sponsor : University of Chicago | University of Calgary | University of Alberta | Gabrail Cancer Center Research | Wagner College, Staten Island, NY, USA | `Applied Speciation and Consulting LLC
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Cyclosporine,Mycophenolic Acid,Tacrolimus,Mycophenolic Mofetil,Mycophenolate Mofetil Hydrochloride,Sirolimus
Therapeutic Area : Pharmacology/Toxicology
Study Phase : Phase I/ Phase II
Sponsor : F. Hoffmann-La Roche | Pfizer Inc | Sanofi
Deal Size : Inapplicable
Deal Type : Inapplicable
Calcineurin Inhibitor Sparing After Kidney Transplantation
Details : Undisclosed
Product Name : Undisclosed
Product Type : Peptide
Upfront Cash : Inapplicable
February 04, 2010
Lead Product(s) : Cyclosporine,Mycophenolic Acid,Tacrolimus,Mycophenolic Mofetil,Mycophenolate Mofetil Hydrochloride,Sirolimus
Therapeutic Area : Pharmacology/Toxicology
Highest Development Status : Phase I/ Phase II
Sponsor : F. Hoffmann-La Roche | Pfizer Inc | Sanofi
Deal Size : Inapplicable
Deal Type : Inapplicable