[{"orgOrder":0,"company":"CytoAgents","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Pharmacology\/Toxicology","country":"U.S.A","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"CTO1681","moa":"||GPCR","graph1":"Pharmacology\/Toxicology","graph2":"Phase I\/ Phase II","graph3":"CytoAgents","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Toxicology","amount2New":0,"dosageForm":"Oral","sponsorNew":"CytoAgents \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"CytoAgents \/ Inapplicable"},{"orgOrder":0,"company":"CytoAgents","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Pharmacology\/Toxicology","country":"U.S.A","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"CTO1681","moa":"||GPCR","graph1":"Pharmacology\/Toxicology","graph2":"Phase I\/ Phase II","graph3":"CytoAgents","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Toxicology","amount2New":0,"dosageForm":"Oral","sponsorNew":"CytoAgents \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"CytoAgents \/ Inapplicable"},{"orgOrder":0,"company":"CytoAgents","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Pharmacology\/Toxicology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"CTO1681","moa":"||EP4 receptor","graph1":"Pharmacology\/Toxicology","graph2":"Phase I\/ Phase II","graph3":"CytoAgents","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Toxicology","amount2New":0,"dosageForm":"Oral","sponsorNew":"CytoAgents \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"CytoAgents \/ Inapplicable"},{"orgOrder":0,"company":"Quotient Sciences","sponsor":"CytoAgents","pharmaFlowCategory":"D","therapeuticArea":"Pharmacology\/Toxicology","country":"UNITED KINGDOM","productType":"Other Small Molecule","year":"2020","type":"Collaboration","leadProduct":"GP1681","moa":"||GPCR","graph1":"Pharmacology\/Toxicology","graph2":"Phase I\/ Phase II","graph3":"Quotient Sciences","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Toxicology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Quotient Sciences \/ CytoAgents","highestDevelopmentStatusID":"7","companyTruncated":"Quotient Sciences \/ CytoAgents"},{"orgOrder":0,"company":"CytoAgents","sponsor":"TFS Health Science","pharmaFlowCategory":"DU","therapeuticArea":"Pharmacology\/Toxicology","country":"U.S.A","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"CTO1681","moa":"||GPCR","graph1":"Pharmacology\/Toxicology","graph2":"Phase I\/ Phase II","graph3":"CytoAgents","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Toxicology","amount2New":0,"dosageForm":"Oral","sponsorNew":"CytoAgents \/ TFS Health Science","highestDevelopmentStatusID":"7","companyTruncated":"CytoAgents \/ TFS Health Science"}]

Find Clinical Drug Development Pipelines & Deals | PipelineProspector

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                          01

                          Lead Product(s) : GP1681,Inapplicable

                          Therapeutic Area : Pharmacology/Toxicology

                          Study Phase : Phase I/ Phase II

                          Sponsor : CytoAgents

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

                          Details : The collaboration aims to focus on the development of GP1681 (CTO1681), which is a small molecule inhibitor of cytokine release targeting the NF-kB signaling pathway via the activation of the EP4 receptor. It is under development for treatment of cytokin...

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          April 28, 2020

                          Lead Product(s) : GP1681,Inapplicable

                          Therapeutic Area : Pharmacology/Toxicology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : CytoAgents

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

                          Quotient

                          02

                          EPSC
                          Not Confirmed
                          EPSC
                          Not Confirmed

                          Details : CTO1681 is a GPCR agonist, small molecule drug candiate, which is being evaluated for the treatment of cytokine release syndrome.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          April 24, 2025

                          Lead Product(s) : CTO1681,Inapplicable

                          Therapeutic Area : Pharmacology/Toxicology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          EPSC
                          Not Confirmed
                          EPSC
                          Not Confirmed

                          Details : CTO1681 cell therapy, prevents and treats Cytokine Release Syndrome by targeting the NF-kB signaling pathway via the activation of the EP4 receptor, which reduces NF-kB signaling.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          October 17, 2023

                          Lead Product(s) : CTO1681,Inapplicable

                          Therapeutic Area : Pharmacology/Toxicology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          EPSC
                          Not Confirmed
                          EPSC
                          Not Confirmed

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          June 15, 2023

                          Lead Product(s) : CTO1681,Inapplicable

                          Therapeutic Area : Pharmacology/Toxicology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          EPSC
                          Not Confirmed
                          EPSC
                          Not Confirmed

                          Details : The patent covers the use of lenzilumab to prevent or treat cytokine release syndrome (CRS), neurotoxicity and otherwise inhibit or reduce incidence or severity of CAR-T-related toxicities in patients undergoing CAR-T cell therapy.

                          Product Name : Humaneered

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          December 28, 2020

                          Lead Product(s) : Lenzilumab,Inapplicable

                          Therapeutic Area : Pharmacology/Toxicology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Leiden University

                          Country arrow
                          EPSC
                          Not Confirmed

                          Leiden University

                          Country arrow
                          EPSC
                          Not Confirmed

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          August 20, 2018

                          Lead Product(s) : Nivolumab,Tumor Infiltrating Lymphocytes,Interferon Alpha

                          Therapeutic Area : Pharmacology/Toxicology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Bristol Myers Squibb

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Affiliated Hospital to Academy of Military Medical Sciences

                          Country arrow
                          EPSC
                          Not Confirmed

                          Affiliated Hospital to Academy of Military Medical Sciences

                          Country arrow
                          EPSC
                          Not Confirmed

                          Lead Product(s) : Human Umbilical Cord Mesenchymal Stem Cell,Inapplicable

                          Therapeutic Area : Pharmacology/Toxicology

                          Study Phase : Phase I/ Phase II

                          Sponsor : Ivy Institute of Stem Cells Co. Ltd

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          May 15, 2015

                          Lead Product(s) : Human Umbilical Cord Mesenchymal Stem Cell,Inapplicable

                          Therapeutic Area : Pharmacology/Toxicology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Ivy Institute of Stem Cells Co. Ltd

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          University of Saskatchewan

                          Country arrow
                          EPSC
                          Not Confirmed

                          University of Saskatchewan

                          Country arrow
                          EPSC
                          Not Confirmed

                          Lead Product(s) : Anhydrous Selenite,Inapplicable

                          Therapeutic Area : Pharmacology/Toxicology

                          Study Phase : Phase I/ Phase II

                          Sponsor : University of Chicago | University of Calgary | University of Alberta | Gabrail Cancer Center Research | Wagner College, Staten Island, NY, USA | `Applied Speciation and Consulting LLC

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Vitamins/Minerals/Inorganic Salts

                          Upfront Cash : Inapplicable

                          March 03, 2015

                          Lead Product(s) : Anhydrous Selenite,Inapplicable

                          Therapeutic Area : Pharmacology/Toxicology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : University of Chicago | University of Calgary | University of Alberta | Gabrail Cancer Center Research | Wagner College, Staten Island, NY, USA | `Applied Speciation and Consulting LLC

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          University of Minnesota

                          Country arrow
                          EPSC
                          Not Confirmed

                          University of Minnesota

                          Country arrow
                          EPSC
                          Not Confirmed

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Peptide

                          Upfront Cash : Inapplicable

                          February 04, 2010

                          Lead Product(s) : Cyclosporine,Mycophenolic Acid,Tacrolimus,Mycophenolic Mofetil,Mycophenolate Mofetil Hydrochloride,Sirolimus

                          Therapeutic Area : Pharmacology/Toxicology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : F. Hoffmann-La Roche | Pfizer Inc | Sanofi

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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