Immunology | Preclinical Developments

Cellect Biotechnology

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ISRAEL Israel

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Cellect Biotechnology's ApoGraft™ to Empower Cellular Treatment of COVID-19 Related Pulmonary Diseases

Lead Product(s): ApoGraft treated stem cells

Therapeutic Area: Immunology

Highest Development Status: Preclinical Product Type: Large molecule

Partner/Sponsor/Collaborator: Undisclosed

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Agreement May 21, 2020

Details:

Cellect Biotechnology has signed a development agreement with an international consortium to examine the therapeutic effects of ApoGraft treated stem cells on the reduction of pulmonary manifestations caused by COVID-19.

CytoAgents

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United States

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CytoAgents Receives NIH Funding to Accelerate Treatment for Cytokine Storm

Lead Product(s): GP1681

Therapeutic Area: Immunology

Highest Development Status: Preclinical Product Type: Small molecule

Partner/Sponsor/Collaborator: National Institutes of Health

Deal Size: $1.6 million Upfront Cash: Undisclosed

Deal Type: Funding May 13, 2020

Details:

The Phase II SBIR grant is non-dilutive funding from the National Institute of Allergy and Infectious Diseases of the NIH and will advance the research of GP1681.

Singota Solutions

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United States

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Singota Solutions Collaborates with Noveome Biotherapeutics

Lead Product(s): ST266

Therapeutic Area: Immunology

Highest Development Status: Preclinical Product Type: Large molecule

Partner/Sponsor/Collaborator: Noveome Biotherapeutics

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Collaboration May 12, 2020

Details:

Under the terms of the collaboration, Singota will manufacture Noveome’s ST266 to be used for IV infusion in Phase I and II clinical trials.

Noveome Biotherapeutics

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United States

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Noveome Biotherapeutics Receives $4 Million Grant From Commonwealth of Pennsylvania

Lead Product(s): ST266

Therapeutic Area: Immunology

Highest Development Status: Preclinical Product Type: Large molecule

Partner/Sponsor/Collaborator: Commonwealth of Pennsylvania

Deal Size: $4.0 million Upfront Cash: Undisclosed

Deal Type: Funding May 07, 2020

Details:

Funding enables existing clinical trial of its lead product candidate, ST266, to proceed as company joins global response with covid-19 program.

ProThera Biologics

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ProThera Biologics and Takeda Enter Licensing Agreement to Develop Novel Plasma-Derived Therapy Based on Inter-alpha Inhibitor Proteins

Lead Product(s): Plasma-derived Inter-alpha Inhibitor Proteins therapy

Therapeutic Area: Immunology

Highest Development Status: Preclinical Product Type: Large molecule

Partner/Sponsor/Collaborator: Takeda Pharmaceutical

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Licensing Agreement April 23, 2020

Details:

As part of the agreement, ProThera and Takeda will work together on IND-enabling activities, with development led by Takeda's dedicated Plasma Derived Therapies R&D organization.

Hoth Therapeutics

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Hoth Therapeutics Announces Top Line Preclinical Data from Cutaneous Lupus Erythematosus (CLE) Study

Lead Product(s): Anandamide

Therapeutic Area: Immunology

Highest Development Status: Preclinical Product Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable April 21, 2020

Details:

The study conducted in partnership with Zylö Therapeutics confirmed mice treated with Anandamide (AEA)-loaded particles experienced lesions that regressed in size and severity.

twoXAR Pharmaceutical

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twoXAR Pharmaceuticals Presents Preclinical Data Demonstrating Positive Safety and Tolerability of Two Novel Lupus Drug Leads

Lead Product(s): TXR-711

Therapeutic Area: Immunology

Highest Development Status: Preclinical Product Type: Undisclosed

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable April 21, 2020

Details:

TXR-711 and TXR-712, demonstrated significant efficacy and excellent tolerability in preclinical studies.

Immutep

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Immutep Advances Cell Line Development for IMP761

Lead Product(s): IMP761

Therapeutic Area: Immunology

Highest Development Status: Preclinical Product Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable April 15, 2020

Details:

Using its STEP®-mAb technology, Batavia Biosciences has developed a pharmaceutical-grade, stable CHO cell line that produces significantly high product yields of IMP761.

Incyte Corporation

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Novartis, Incyte to test Jakavi for coronavirus-linked cytokine storm

Lead Product(s): Ruxolitinib

Therapeutic Area: Immunology

Highest Development Status: Preclinical Product Type: Small molecule

Partner/Sponsor/Collaborator: Novartis Pharmaceuticals Corporation

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Collaboration April 02, 2020

Details:

Novartis plans to initiate a Phase III clinical trial in collaboration with Incyte to evaluate the use of Jakavi for treatment of severe immune overreaction called cytokine storm in COVID-19.