IOL Chemicals IOL Chemicals

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2020","url1":"","url2":"","graph1":"Large molecule","graph2":"Pluri"},{"orgOrder":0,"company":"Liverpool School of Tropical Medicine","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Researchers at LSTM Demonstrate a Novel Way to Treat Snakebite","therapeuticArea":"Trauma (Emergency, Injury, Surgery)","highestDevelopmentStatus":"Preclinical","country":"","productType":"Small molecule","productStatus":"Approved","date":"May 2020","url1":"","url2":"","graph1":"Small molecule","graph2":"Liverpool School of Tropical Medicine"},{"orgOrder":0,"company":"Histogen","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Histogen Publishes Preclinical Data on its HST 004 Spinal Disc Program","therapeuticArea":"Trauma (Emergency, Injury, Surgery)","highestDevelopmentStatus":"Preclinical","country":"U.S.A","productType":"Large 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Announces NeuroPharm Inc. 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Find Drugs for Trauma (Emergency, Injury, Surgery) in Preclinical Development

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            Details:

            Under the terms of the agreement, Vectura will undertake formulation screening studies, manufacturing process optimisation studies and stability assessments, as well as manufacturing a laboratory-scale batch of IHL-216A (Cannabidiol) to support toxicological studies.

            Lead Product(s): Cannabidiol,Isoflurane

            Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: IHL-216A

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Incannex Healthcare

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Agreement June 22, 2021

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            Details:

            The proceeds will advance the development activities of the Company's assets, with a particular focus on progressing towards the clinical phase, including ExoPTEN, targeted at acute Spinal Cord Injury is being developed using ExoTherapy Technology and Platform.

            Lead Product(s): ExoPTEN

            Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: ExoPTEN

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Undisclosed

            Deal Size: $1.4 million Upfront Cash: Undisclosed

            Deal Type: Private Placement January 05, 2024

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            Under the agreement, the testing will focus on Halberd's patent-pending nasal spray designed to mitigate the effects of Traumatic Brain Injury (TBI), when administered shortly after sustaining head trauma.

            Lead Product(s): Undisclosed

            Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Undisclosed

            Partner/Sponsor/Collaborator: Mississippi State University

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Partnership November 15, 2023

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            Transpose RT cell therapy platform consists of a processing unit, a set of disposables, and Matrase™, a proprietary enzyme mixture, which is investigated for treatment of Partial-Thickness Rotator Cuff Tears.

            Lead Product(s): Transpose RT Cell Therapy

            Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable November 13, 2023

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            ExoPTEN is being developed to be a minimally invasive ExoTherapy for spinal cord injuries (SCI), yielding neuron regeneration and rewiring in traumatically damaged spinal cord.

            Lead Product(s): Biologically-guided Exosome Therapy

            Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: ExoTherapy

            Highest Development Status: Preclinical Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable October 30, 2023

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            Details:

            NurExone is in the process of developing the ExoPTEN product specifically for acute spinal cord injuries. This collaborative effort opens the possibility for the company to expand its focus to chronic spine injuries by developing Exo Therpies.

            Lead Product(s): ExoTherapy

            Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Israeli Shekels

            Deal Size: $0.2 million Upfront Cash: Undisclosed

            Deal Type: Funding October 11, 2023

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            Details:

            Through the agreement, Oragenics acquire Odyssey’s assets including drug candidates, ONP-002 for treating mild traumatic brain injury, and for treating Niemann Pick Disease Type C, as well as Odyssey’s proprietary powder formulation and its nasal delivery device.

            Lead Product(s): ONP-002

            Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: ONP-002

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Oragenics

            Deal Size: $1.0 million Upfront Cash: Undisclosed

            Deal Type: Acquisition October 05, 2023

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            Details:

            ExoPTEN is being developed to be a minimally invasive ExoTherapy for spinal cord injuries (SCI), yielding neuron regeneration and rewiring in traumatically damaged spinal cord.

            Lead Product(s): Exosome

            Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: ExoPTEN

            Highest Development Status: Preclinical Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 22, 2023

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            Details:

            The funds will support preclinical study of ALPHA-1062, an inactive galantamine prodrug and a new generation acetylcholinesterase inhibitor being developed for Alzheimer’s disease, to reduce blast mild Traumatic Brain Injury induced functional deficit and brain abnormalities.

            Lead Product(s): Galantamine Prodrug

            Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: ALPHA-1062

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: AMRMC

            Deal Size: $0.7 million Upfront Cash: Undisclosed

            Deal Type: Funding June 07, 2023

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            Details:

            The research collaboration with CSIRO will help to develop formulations of its small molecule FAK inhibitors, including AMP945 that could be applied topically to wounds and burns to aid healing and reduce scarring.

            Lead Product(s): AMP945

            Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: AMP945

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: CSIRO

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Collaboration May 23, 2023

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