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            Details:

            The active substance of Ranivisio is ranibizumab, a monoclonal antibody fragment (ATC code: S01LA04) which modulates angiogenesis by inhibiting vascular endothelial growth factor A. Ranivisio is a biosimilar medicinal product.

            Lead Product(s): Ranibizumab

            Therapeutic Area: Ophthalmology Product Name: Ranivisio

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 23, 2022

            Details:

            Under the exclusive agreement, MS Pharma will be responsible for the registration and commercialization of FYB201/CHS-201 (Ranibizumab), in the Middle East and North African countries. MS Pharma will start the registration procedures in MENA immediately.

            Lead Product(s): Ranibizumab

            Therapeutic Area: Ophthalmology Product Name: CHS-201

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: MS Pharma

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Licensing Agreement December 14, 2021

            Details:

            CHS-201 (ranibizumab), trade name Lucentis® among others is a monoclonal anti-angiogenic antibody fragment (Fab) that has been approved to treat the "wet" type of age-related macular degeneration a common form of age-related vision loss.

            Lead Product(s): Ranibizumab

            Therapeutic Area: Ophthalmology Product Name: CHS-201

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable August 06, 2021

            Details:

            The company will present patient-reported outcomes for AGN-190584, an investigational therapy for the treatment of presbyopia. Recently the company submitted an NDA to the U.S. Food and Drug Administration based on data from the Phase 3 GEMINI 1 and GEMINI 2 clinical trials.

            Lead Product(s): Pilocarpine Hydrochloride

            Therapeutic Area: Ophthalmology Product Name: AGN-190584

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: AbbVie Inc

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable April 27, 2021

            Abbvie CB

            BIO Asia-Taiwan

            Not Confirmed

            envelop Contact Supplier

            Details:

            Allergan has submitted a New Drug Application to the U.S. Food and Drug Administration for investigational AGN-190584 (pilocarpine 1.25%) ophthalmic solution for the treatment of presbyopia. The FDA is expected to act on the NDA by the end of 2021.

            Lead Product(s): Pilocarpine Hydrochloride

            Therapeutic Area: Ophthalmology Product Name: AGN-190584

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: AbbVie Inc

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable February 25, 2021

            Abbvie CB

            BIO Asia-Taiwan

            Not Confirmed

            envelop Contact Supplier

            Details:

            Data presented at the meeting will include an analysis examining the safety and efficacy of DURYSTA™ and a second analysis of data from the Phase 3 ARTEMIS studies that identify different characteristics of glaucoma patients who may respond after being treated with DURYSTA™.

            Lead Product(s): Pilocarpine Hydrochloride

            Therapeutic Area: Ophthalmology Product Name: AGN-190584

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable November 06, 2020

            Abbvie CB

            BIO Asia-Taiwan

            Not Confirmed

            envelop Contact Supplier

            Details:

            Phase 3 GEMINI 1 and 2 studies evaluating AGN-190584 (pilocarpine 1.25%) ophthalmic solution met the primary endpoint, reaching statistical significance in improvement in near vision.

            Lead Product(s): Pilocarpine Hydrochloride

            Therapeutic Area: Ophthalmology Product Name: AGN-190584

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: AbbVie Inc

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable October 28, 2020

            Abbvie CB

            BIO Asia-Taiwan

            Not Confirmed

            envelop Contact Supplier

            Details:

            Allergan, an AbbVie has informed Molecular Partners of their intent to withdraw application filings with both the EMA and the Japanese Regulatory Agency (PMDA) for abicipar pegol, a novel DARPin therapeutic for patients with neovascular (wet) age-related macular degeneration.

            Lead Product(s): Abicipar Pegol

            Therapeutic Area: Ophthalmology Product Name: Abicipar

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable July 20, 2020

            Abbvie CB

            BIO Asia-Taiwan

            Not Confirmed

            envelop Contact Supplier

            Details:

            A New Drug Application (NDA) for Bimatoprost SR is currently under review with the U.S. Food and Drug Administration, and if approved, has the potential to be the first and only biodegradable.

            Lead Product(s): Bimatoprost

            Therapeutic Area: Ophthalmology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable February 25, 2020

            Abbvie CB

            BIO Asia-Taiwan

            Not Confirmed

            envelop Contact Supplier

            Details:

            MTP-131 (elamipretide) is an investigational mitochondrial-targeting peptide agent, which is being evaluated for the treatment of dry age-related macular degeneration.

            Lead Product(s): Elamipretide

            Therapeutic Area: Ophthalmology Product Name: Bendavia

            Highest Development Status: Preclinical Product Type: Peptide

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 05, 2024

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