Seqens Seqens

X
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Technologies","sponsor":"Spinnaker Biosciences","pharmaFlowCategory":"D","amount":"Undisclosed","upfrontCash":"Undisclosed","newsHeadline":"TruTag Technologies and Spinnaker Biosciences Partner on a New Targeted, Controlled Release Therapy for Age-Related Macular Degeneration","therapeuticArea":"Ophthalmology","highestDevelopmentStatus":"Preclinical","country":"U.S.A","productType":"Large molecule","productStatus":"Biosimilar","date":"December 2023","url1":"","url2":"","graph1":"Large molecule","graph2":"Trutag Technologies"},{"orgOrder":0,"company":"Chromocell Corporation","sponsor":"Alliance Global Partners","pharmaFlowCategory":"D","amount":"$6.6 million","upfrontCash":"Undisclosed","newsHeadline":"Chromocell Therapeutics Announces Pricing of Upsized $6.6 Initial Public Offering","therapeuticArea":"Ophthalmology","highestDevelopmentStatus":"Preclinical","country":"U.S.A","productType":"Small molecule","productStatus":"New Molecular Entity","date":"February 2024","url1":"","url2":"","graph1":"Small molecule","graph2":"Chromocell Corporation"},{"orgOrder":0,"company":"PulseSight Therapeutics","sponsor":"Pureos Bioventures","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"PulseSight Therapeutics Launches to Advance Non-viral Gene Therapies with Disruptive Minimally-Invasive Delivery Technology for Severe Retinal Diseases","therapeuticArea":"Ophthalmology","highestDevelopmentStatus":"Preclinical","country":"FRANCE","productType":"Cell and Gene therapy","productStatus":"New Molecular Entity","date":"February 2024","url1":"","url2":"","graph1":"Cell and Gene therapy","graph2":"PulseSight Therapeutics"}]

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            PST-809, is a potential first-in-class therapy for wet age-related macular degeneration that comprises a dual-gene plasmid encoding for anti-VEGF, aflibercept, together with decorin.

            Lead Product(s): PST-809

            Therapeutic Area: Ophthalmology Product Name: PST-809

            Highest Development Status: Preclinical Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Pureos Bioventures

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable February 27, 2024

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            Chromocell intends to use the net proceeds from the proposed offering to support the development of CC8464, which is being evaluated for treating eye pain.

            Lead Product(s): CC8464

            Therapeutic Area: Ophthalmology Product Name: CC8464

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Alliance Global Partners

            Deal Size: $6.6 million Upfront Cash: Undisclosed

            Deal Type: Public Offering February 21, 2024

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            Chromocell intends to use the net proceeds from the proposed offering to support the development of CC8464, which is being evaluated for treating eye pain.

            Lead Product(s): CC8464

            Therapeutic Area: Ophthalmology Product Name: CC8464

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Alliance Global Partners

            Deal Size: $6.6 million Upfront Cash: Undisclosed

            Deal Type: Public Offering February 16, 2024

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            Eyconis

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            The newly formed Eyconis has exclusive rights to develop and commercialize TransCon RBZ (ranibizumab) ophthalmology products globally, which are used for the treatment of wet age-related macular degeneration (AMD).

            Lead Product(s): Ranibizumab

            Therapeutic Area: Ophthalmology Product Name: TransCon RBZ

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Ascendis Pharma

            Deal Size: $248.0 million Upfront Cash: Undisclosed

            Deal Type: Licensing Agreement January 29, 2024

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            Under the agreement, TruTag will supply its advanced nano-porous silica particles to support commercialization of Spinnaker's new therapy, a combination product that involves the loading of the biosimilar Ranibizumab into pSi particles, for age-related macular degeneration.

            Lead Product(s): Silicon Oxide Loaded Ranibizumab

            Therapeutic Area: Ophthalmology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Spinnaker Biosciences

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Partnership December 20, 2023

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            RetinalGeniX Technologies

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            Avania will provide guidance for the Company’s interactions with the FDA for the development of RTG-2023 for the treatment of dry age-related macular degeneration and RTG-2024 for the treatment of Alzheimer’s syndrome dementia.

            Lead Product(s): RTG-2023

            Therapeutic Area: Ophthalmology Product Name: RTG-2023

            Highest Development Status: Preclinical Product Type: Undisclosed

            Partner/Sponsor/Collaborator: Avania

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Agreement November 08, 2023

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            Under the agreement, BioCryst to develop its investigational plasma kallikrein inhibitor, avoralstat, with Clearside’s SCS Microinjector® to deliver avoralstat directly to the back of the eye through the suprachoroidal space to treat patients with diabetic macular edema (DME).