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Find Clinical Drug Development Pipelines & Deals | PipelineProspector
HG004 is an ophthalmic injection intended for the treatment of RPE65 gene mutation-related retinopathy. Based on direct preclinical comparative studies of HG004 and AAV2 in retinal function, HG004 is at least 10 times more efficient at transducing retinal pigment epithelium.
ACI’s rBV-Sf9-AAV platform is based on single use technology, utilizes suspension cell culture free of fetal bovine serum and uses non-animal derived material throughout the manufacturing process.
Under the terms of the agreement, Titan Pharmaceuticals has granted an exclusive license to Ocular Therapeutix pertaining to certain patent applications for ophthalmic uses in both humans and nonhuman animals.
CT1812 is an experimental oral sigma-2 (σ-2) receptor modulator currently in Phase 2 clinical trials for both Alzheimer's disease and dementia with Lewy bodies (DLB).
By utilizing MRI’s internal pro-forma revenue projections for 2023 & 2024 and comparable market transactions, MRI’s drug development pipeline including MAN-01 and companion diagnostics, are estimated to achieve a net present value.
Under the terms of the agreement, Boehringer Ingelheim will receive an exclusive, worldwide license to develop SZN-413 and other Fzd4-specific Wnt-modulating molecules for all purposes, including as a treatment for retinal diseases.
SZN-413, a bi-specific antibody that targets FZD4 and LRP5, induced Wnt signaling and upregulated blood-retinal barrier gene expression in retinal ECs. SZN-413 reduced the pathologic neovascularization area size compared to vehicle and comparable to the positive control.
Under the Agreement, Celregen will have the exclusive right to develop, manufacture and commercialize CLS001 for bullous keratopathy in the Greater China region, including Mainland China, Hong Kong, Macau and Taiwan.
The OK-101 drug candidate displays potent anti-inflammatory activity in animal models of DED. OK-101 also reduces Corneal Neuropathic Pain (CNP) in a ciliary nerve ligation animal model of CNP.
The new data showing extended dose intervals, together with data previously presented, showing LTB4 inhibition by PAS-nomacopan may also reduce risk of sight-threatening CNV, suggest PAS-rVA576(nomacopan) may be a potential novel and effective treatment option for GA.
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