Quotient Sciences Translational Pharmaceuticals Quotient Sciences Translational Pharmaceuticals

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Meeting","therapeuticArea":"Ophthalmology","highestDevelopmentStatus":"Preclinical","country":"U.S.A","productType":"Small molecule","productStatus":"New Molecular Entity","date":"April 2022","url1":"","url2":"","graph1":"Small molecule","graph2":"CalciMedica"},{"orgOrder":0,"company":"Ocugen","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Ocugen, Inc. to Present Preclinical Results at The Association for Research in Vision and Ophthalmology (ARVO) 2022 Annual Meeting","therapeuticArea":"Ophthalmology","highestDevelopmentStatus":"Preclinical","country":"U.S.A","productType":"Cell and Gene therapy","productStatus":"New Molecular Entity","date":"April 2022","url1":"","url2":"","graph1":"Cell and Gene therapy","graph2":"Ocugen"},{"orgOrder":0,"company":"Abeona Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Abeona 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            Under the collaboration, the partners will advance CDR-Life’s preclinical antibody fragment-based therapeutic including CDR202, targeting a key pathway in geographic atrophy (GA).

            Lead Product(s): CDR202

            Therapeutic Area: Ophthalmology Product Name: CDR202

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Boehringer Ingelheim GmbH

            Deal Size: $487.7 million Upfront Cash: Undisclosed

            Deal Type: Collaboration August 02, 2023

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            The net proceeds from the financing will support the clinical translation of Kriya’s broad pipeline of gene therapies and continued scaling of its engineering, computational and manufacturing platforms.

            Lead Product(s): Gene Therapy

            Therapeutic Area: Ophthalmology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Patient Square Capital

            Deal Size: $430.0 million Upfront Cash: Undisclosed

            Deal Type: Series C Financing July 26, 2023

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            The collaboration aims to develop the P2X7 receptor antagonist programme. Orally available antagonists of the P2X7 receptor represent a novel approach for the treatment of both early-stage DR and dry-AMD.

            Lead Product(s): Undisclosed

            Therapeutic Area: Ophthalmology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Golgi Neurosciences

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Collaboration July 25, 2023

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            BNS Ophthalmics

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            BNSO will develop, manufacture and commercialize a range of innovative ophthalmic pharmaceutical products developed by BioNanoSim, including BNSO-1, a Tacrolimus ocular emulsion developed by its proprietary nano-technology platform to address serious ophthalmic unmet needs.

            Lead Product(s): Tacrolimus

            Therapeutic Area: Ophthalmology Product Name: BNSO-1

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: BioNanoSim

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Agreement May 30, 2023

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            Forge will help to advance Life Bio’s partial epigenetic reprogramming platform to address aging-related diseases, including its lead program targeting ophthalmic indications by providing cGMP manufacturing and development services for its novel AAV gene therapy platform.

            Lead Product(s): Undisclosed

            Therapeutic Area: Ophthalmology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Life Biosciences

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Partnership May 08, 2023

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            OCU410ST (AAV5-hRORA) is an adeno-associated virus serotype 5 capsid protein containing gene construct encoding human retinoic acid receptor-related orphan receptor alpha, for the treatment of ABCA4-associated retinopathies.

            Lead Product(s): OCU410ST

            Therapeutic Area: Ophthalmology Product Name: OCU410ST

            Highest Development Status: Preclinical Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable April 27, 2023

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            Under the agreement, Aevitas’ transgene encoding sCFH, a shortened and optimized form of a natural inhibitor of the inflammatory complement pathway, will be combined with 4DMT’s proprietary retinotropic R100 vector to form 4D-175 for treatment of GA secondary to AMD.

            Lead Product(s): 4D-175

            Therapeutic Area: Ophthalmology Product Name: 4D-175

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: 4D Molecular Therapeutics

            Deal Size: $140.0 million Upfront Cash: $140.0 million

            Deal Type: Agreement April 24, 2023

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            With the financing, CTx will continue the development and complete a Phase Ib clinical proof of concept of its lead product CTx001. CTx001 is a highly innovative AAV gene therapy for the treatment of Geograpic Atrophy (GA) secondary to dry age-related macular degeneration.

            Lead Product(s): CTX001

            Therapeutic Area: Ophthalmology Product Name: CTx001

            Highest Development Status: Preclinical Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Gimv

            Deal Size: $78.9 million Upfront Cash: Undisclosed

            Deal Type: Series A Financing April 17, 2023

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