A liquid filling machine for bottles, which can facilitate for filling of nearly 5000 to 14400 bottles per hour are high speed pharmaceutical packaging equipments. Filling rate may varies according to the shape and size of bottles. Bottling lines uses electronic filling systems for solid dose products such as tablets, capsules, caplets, soft gels, liquid gels or gel cap forms. These bottling lines are capable of handling a wide variety of bottle shapes and sizes, Child-resistant (push and turn or snap cap) and twist-off closures with induction seals, Cotton or polyester coil, Desiccants (canister or sachet), Labeling with in-line printing and print verification, Topserts and sideserts, In-line cartoning and trays, Bundling etc. Packaged bottles are then serialized through serialization equipment.
In a contract packaging of bottles, pharma packaging companies provides the efficiency of bottling lines with quick changeovers, online validated fill accuracy and the flexibility to accommodate small lots to commercial runs for the bottling of tablets, capsules and powders. All shapes and sizes of bottles and tubs can be accommodated, including in-line front and back labelling and exact filling of HDPE and PET bottles, Glass bottles, Flip-Top Vial, 50 ml to 500 ml bottles, Induction seals and permaseals, Safety seal with body band, Rayon coil, cotton or desiccant. Filling processes are completed with coding and cartoning, and also include the insertion of patient information leaflets (PIL).
For the bottle filling contract packagin of tablet, bottle filling of capsule, bottle filling of caplet, bottle filling of softgel capsule bottle lines caters in any pack size with a multitude of bottle and cap combinations, with the addition of neck wool and/or silica gel sachets / canisters. Tamper sealing as well as induction sealed aluminium wads can be applied with our bottling services. Pharma bottling companies also packages liquids into a wide range of glass or plastic bottles and jars.
In a bottle filling contract packaging, liquid oral dose pediatric products such as syrups, solutions, and suspensions are commonly packaged in glass bottle presentations. Glass containers are considered to be the most inert and impermeable containers when compared with other conventional materials of construction such as plastics. A glass container manufacturing by pharma grade bottle manufacturer is a complex process with a wide range of glass formulations utilized by individual contract bottling manufactures and contract bottling fillers. Two main categories of pharmaceutical glass are borosilicate based and soda lime based. Careful thought and consideration should be given when selecting a glass container for oral liquid pharmaceutical products. Guidance on the suitability of pharmaceutical glass can be found in USP <660> (Containers-Glass) and EP 3.2.1 (Glass Container for Pharmaceutical Use). Plastic bottles for oral pharmaceutical products can be an inexpensive alternative to glass containers. Plastic bottles can be manufactured by GMP contract manufacturing packaging companies from a wide range of polymer materials including polyethylene in both high density and low density (HDPE and LDPE), polypropylene (PP), polycarbonate, and polyethylene terephalate each being developed to have unique performance properties.
Multiple-use oral liquids and syrups are filled into bottle presentations through a variety of filling technologies. Volumetric piston filling equipment is well suited for products with a low to-medium viscosity. Vacuum filling technology is commonly employed for products that can become foamy in nature when conveyed with pressure. In all cases, product temperature is carefully monitored as it will affect the viscosity and flow properties of the liquid; constant stirring for suspension formulations is required. Companies provide pharmaceutical contract packaging and solutions deals in filling of bottles made of polyethylene terephthalate (PET) and high-density polyethylene (HDPE). We also make select bottles from polypropylene (PP), polyvinyl chloride (PVC) and PLA (polylactic acid).