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            Lead Product(s): Undisclosed

            Therapeutic Area: Immunology

            Highest Development Status: Discovery Product Type: Small molecule

            Partner/Sponsor/Collaborator: S.R. One

            Deal Size: $65.0 million Upfront Cash: Undisclosed

            Deal Type: Series B Financing May 21, 2020

            Details:

            The Series B financing will support the advancement of HotSpot’s lead programs to the clinic, including protein kinase C (PKC-theta) antagonists for Th2 and T-reg driven autoimmune disease and S6 kinase (S6K) antagonists for rare metabolic disease.

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            Lead Product(s): Synthetic AAV capsids Proteins

            Therapeutic Area: Immunology

            Highest Development Status: Discovery Product Type: Gene therapy

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable May 12, 2020

            Details:

            The presentation will highlight results from Dyno's study on Artificial intelligence powered design of synthetic AAV capsids without pre-existing immunity for the universal treatment of all patients.

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            Lead Product(s): Antibodies

            Therapeutic Area: Immunology

            Highest Development Status: Discovery Product Type: Large molecule

            Partner/Sponsor/Collaborator: Inotrem S.A

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Collaboration May 07, 2020

            Details:

            As part of the agreement, IONTAS will apply its Mammalian Display technology to identify antibodies involved in the TREM-1 pathway.

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            Lead Product(s): Undisclosed

            Therapeutic Area: Immunology

            Highest Development Status: Discovery Product Type: Undisclosed

            Partner/Sponsor/Collaborator: Versant Ventures

            Deal Size: $60.0 million Upfront Cash: Undisclosed

            Deal Type: Series A Financing May 06, 2020

            Details:

            Proceeds will be used to advance three pipeline programs and to expand the company’s structural immunology platform to pursue previously intractable drug targets.

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            Lead Product(s): Undisclosed

            Therapeutic Area: Immunology

            Highest Development Status: Discovery Product Type: Small molecule

            Partner/Sponsor/Collaborator: Galapagos

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Licensing Agreement April 16, 2020

            Details:

            In this joint reaserch collaboration, Ryvu is responsible for early drug discovery. Galapagos will have an exclusive option to license IP developed by Ryvu.

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            Lead Product(s): Undisclosed

            Therapeutic Area: Immunology

            Highest Development Status: Discovery Product Type: Small molecule

            Partner/Sponsor/Collaborator: Bayer HealthCare

            Deal Size: $270.4 million Upfront Cash: Undisclosed

            Deal Type: Licensing Agreement March 23, 2020

            Details:

            The collaboration aims to discover new drug candidates for the treatment of lung diseases, cardiovascular diseases and other inflammatory diseases.