Find Neurology Drugs in Phase I Clinical Development

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            Lead Product(s): PF-05251749

            Therapeutic Area: Neurology Product Name: Undisclosed

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Biogen

            Deal Size: $710.0 million Upfront Cash: $75.0 million

            Deal Type: Acquisition January 13, 2020

            Details:

            With this purchase, Biogen plans to develop the Phase 1 asset for the treatment of Sundowning in Alzheimer’s disease (AD) and Irregular Sleep Wake Rhythm Disorder in Parkinson’s disease.

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            Lead Product(s): BIIB078

            Therapeutic Area: Neurology Product Name: BIIB078

            Highest Development Status: Phase I Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable September 04, 2020

            Details:

            Sponsored by Biogen, the trial involves a new gene therapy, called BIIB078, that targets a mutation in the ALS-associated gene C90rf72. Known as an expansion, this mutation occurs when a sequence of DNA “letters” is repeated within the gene.

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            Lead Product(s): ATA188

            Therapeutic Area: Neurology Product Name: ATA188

            Highest Development Status: Phase I Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable September 01, 2020

            Details:

            Company will present for the first time 12-month data from all four cohorts in the Phase 1a study of ATA188 for the treatment of progressive forms of multiple sclerosis (MS) at MSVirtual2020: 8th Joint ACTRIMS-ECTRIMS Meeting, held September 11-13, 2020.

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            Lead Product(s): EI1071

            Therapeutic Area: Neurology Product Name: EI1071

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Alzheimer's Association

            Deal Size: $1.0 million Upfront Cash: Undisclosed

            Deal Type: Funding August 26, 2020

            Details:

            Grant Program will support a U.S. FDA-approved first-in-human phase 1 clinical trial of its lead drug candidate, EI1071, an orally available, highly potent Colony-Stimulating Factor 1 Receptor (CSF1R) inhibitor.

            CerSci Therapeutics

            • Deals

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            Lead Product(s): ACP-044

            Therapeutic Area: Neurology Product Name: ACP-044

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Acadia Pharmaceuticals

            Deal Size: $939.5 million Upfront Cash: Undisclosed

            Deal Type: Acquisition August 25, 2020

            Details:

            This acquisition strengthens ACADIA’s clinical pipeline to include non-opioid pain therapies that have potential non-addictive properties and reduced side effects typically seen with current opioid treatments.

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            Lead Product(s): YTX-7739

            Therapeutic Area: Neurology Product Name: YTX-7739

            Highest Development Status: Phase I Product Type: Undisclosed

            Partner/Sponsor/Collaborator: Proteostasis Therapeutics

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Merger August 24, 2020

            Details:

            The combined company will leverage their common scientific expertise in protein misfolding, and will work to advance Yumanity’s lead candidate YTX-7739, currently in Phase 1 clinical development for the treatment and disease modification of Parkinson’s disease.

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            Lead Product(s): XPro1595

            Therapeutic Area: Neurology Product Name: XPro1595

            Highest Development Status: Phase I Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable August 13, 2020

            Details:

            European Patent Office granted patent covers XPro1595 and Algernon's peripheral administration for treating Alzheimer’s Disease and other diseases of the CNS.

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            Lead Product(s): KCP506

            Therapeutic Area: Neurology Product Name: KCP506

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable August 12, 2020

            Details:

            A double-blind, placebo-controlled, single ascending dose and multiple ascending dose study will be conducted in healthy subjects to evaluate the safety, tolerability, and pharmacokinetics of KCP506.

            India Globalization Capital

            • Development Update

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            Lead Product(s): Cannabinoids

            Therapeutic Area: Neurology Product Name: IGC-AD1

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable August 11, 2020

            Details:

            U.S. FDA has notified IGC that it has authorized the Company to initiate a Phase 1 human trial study for the Company’s investigational cannabinoid formulation for the treatment of patients suffering from mild to severe dementia due to Alzheimer’s disease.

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            Lead Product(s): DNL151

            Therapeutic Area: Neurology Product Name: DNL151

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Biogen

            Deal Size: $2,150.0 million Upfront Cash: $560.0 million

            Deal Type: Collaboration August 06, 2020

            Details:

            Biogen will collaborate with Denali to co-develop and co-commercialize Denali’s small molecule inhibitors of LRRK2 for Parkinson’s disease. Biogen and Denali will co-commercialize the LRRK2 product in the U.S. and China, and Biogen will commercialize in all other markets.

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