Neurology | Phase I Developments | Pipeline Prospector

Pfizer Inc

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Biogen to buy early-stage potential Alzheimer's, Parkinson's treatment from Pfizer

Lead Product(s): PF-05251749

Therapeutic Area: Neurology Product Name: Undisclosed

Highest Development Status: Phase I Product Type: Small molecule

Partner/Sponsor/Collaborator: Biogen

Deal Size: $710.0 million Upfront Cash: $75.0 million

Deal Type: Acquisition January 13, 2020

Details:

With this purchase, Biogen plans to develop the Phase 1 asset for the treatment of Sundowning in Alzheimer’s disease (AD) and Irregular Sleep Wake Rhythm Disorder in Parkinson’s disease.

Biogen

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First Patient Enrolled in Phase 1 Gene Therapy Study in Ireland

Lead Product(s): BIIB078

Therapeutic Area: Neurology Product Name: BIIB078

Highest Development Status: Phase I Product Type: Cell and Gene therapy

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable September 04, 2020

Details:

Sponsored by Biogen, the trial involves a new gene therapy, called BIIB078, that targets a mutation in the ALS-associated gene C90rf72. Known as an expansion, this mutation occurs when a sequence of DNA “letters” is repeated within the gene.

Atara Biotherapeutics

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Atara Biotherapeutics to Present 12-Month Data from All Four Cohorts in the Phase 1a Study of ATA188 in Progressive MS at MSVirtual2020

Lead Product(s): ATA188

Therapeutic Area: Neurology Product Name: ATA188

Highest Development Status: Phase I Product Type: Cell and Gene therapy

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable September 01, 2020

Details:

Company will present for the first time 12-month data from all four cohorts in the Phase 1a study of ATA188 for the treatment of progressive forms of multiple sclerosis (MS) at MSVirtual2020: 8th Joint ACTRIMS-ECTRIMS Meeting, held September 11-13, 2020.

Elixiron Immunotherapeutics

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TAIWAN Taiwan

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Elixiron Immunotherapeutics Awarded Alzheimer's Association Grant to Target Microglia in Alzheimer's Disease

Lead Product(s): EI1071

Therapeutic Area: Neurology Product Name: EI1071

Highest Development Status: Phase I Product Type: Small molecule

Partner/Sponsor/Collaborator: Alzheimer's Association

Deal Size: $1.0 million Upfront Cash: Undisclosed

Deal Type: Funding August 26, 2020

Details:

Grant Program will support a U.S. FDA-approved first-in-human phase 1 clinical trial of its lead drug candidate, EI1071, an orally available, highly potent Colony-Stimulating Factor 1 Receptor (CSF1R) inhibitor.

CerSci Therapeutics

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ACADIA Pharmaceuticals Acquires CerSci Therapeutics, Adds Novel Pain Program to Portfolio

Lead Product(s): ACP-044

Therapeutic Area: Neurology Product Name: ACP-044

Highest Development Status: Phase I Product Type: Small molecule

Partner/Sponsor/Collaborator: Acadia Pharmaceuticals

Deal Size: $939.5 million Upfront Cash: Undisclosed

Deal Type: Acquisition August 25, 2020

Details:

This acquisition strengthens ACADIA’s clinical pipeline to include non-opioid pain therapies that have potential non-addictive properties and reduced side effects typically seen with current opioid treatments.

Yumanity Therapeutics

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Yumanity Therapeutics and Proteostasis Therapeutics Announce Merger Agreement

Lead Product(s): YTX-7739

Therapeutic Area: Neurology Product Name: YTX-7739

Highest Development Status: Phase I Product Type: Undisclosed

Partner/Sponsor/Collaborator: Proteostasis Therapeutics

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Merger August 24, 2020

Details:

The combined company will leverage their common scientific expertise in protein misfolding, and will work to advance Yumanity’s lead candidate YTX-7739, currently in Phase 1 clinical development for the treatment and disease modification of Parkinson’s disease.

INmune Bio

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European Patent Granted Covering INmune Bio’s XPro1595

Lead Product(s): XPro1595

Therapeutic Area: Neurology Product Name: XPro1595

Highest Development Status: Phase I Product Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable August 13, 2020

Details:

European Patent Office granted patent covers XPro1595 and Algernon's peripheral administration for treating Alzheimer’s Disease and other diseases of the CNS.

Kineta

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Kineta Receives Regulatory Approval for Initiation of Phase 1 Clinical Trials of KCP506

Lead Product(s): KCP506

Therapeutic Area: Neurology Product Name: KCP506

Highest Development Status: Phase I Product Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable August 12, 2020

Details:

A double-blind, placebo-controlled, single ascending dose and multiple ascending dose study will be conducted in healthy subjects to evaluate the safety, tolerability, and pharmacokinetics of KCP506.

India Globalization Capital

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FDA Approves Initiation of IGC’s Cannabinoid Trial on Alzheimer’s Patients

Lead Product(s): Cannabinoids

Therapeutic Area: Neurology Product Name: IGC-AD1

Highest Development Status: Phase I Product Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable August 11, 2020

Details:

U.S. FDA has notified IGC that it has authorized the Company to initiate a Phase 1 human trial study for the Company’s investigational cannabinoid formulation for the treatment of patients suffering from mild to severe dementia due to Alzheimer’s disease.

Denali Therapeutics

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Biogen and Denali to Collaborate on LRRK2 Program for Parkinson’s Disease and TV Platform-Enabled Programs for Neurodegenerative Diseases

Lead Product(s): DNL151

Therapeutic Area: Neurology Product Name: DNL151

Highest Development Status: Phase I Product Type: Small molecule

Partner/Sponsor/Collaborator: Biogen

Deal Size: $2,150.0 million Upfront Cash: $560.0 million

Deal Type: Collaboration August 06, 2020

Details:

Biogen will collaborate with Denali to co-develop and co-commercialize Denali’s small molecule inhibitors of LRRK2 for Parkinson’s disease. Biogen and Denali will co-commercialize the LRRK2 product in the U.S. and China, and Biogen will commercialize in all other markets.

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Pfizer Inc

Biogen to buy early-stage potential Alzheimer's, Parkinson's treatment from Pfizer

Biogen

First Patient Enrolled in Phase 1 Gene Therapy Study in Ireland

Atara Biotherapeutics

Atara Biotherapeutics to Present 12-Month Data from All Four Cohorts in the Phase 1a Study of ATA188 in Progressive MS at MSVirtual2020

Elixiron Immunotherapeutics

Elixiron Immunotherapeutics Awarded Alzheimer's Association Grant to Target Microglia in Alzheimer's Disease

CerSci Therapeutics

ACADIA Pharmaceuticals Acquires CerSci Therapeutics, Adds Novel Pain Program to Portfolio

Yumanity Therapeutics

Yumanity Therapeutics and Proteostasis Therapeutics Announce Merger Agreement

INmune Bio

European Patent Granted Covering INmune Bio’s XPro1595

Kineta

Kineta Receives Regulatory Approval for Initiation of Phase 1 Clinical Trials of KCP506

India Globalization Capital

FDA Approves Initiation of IGC’s Cannabinoid Trial on Alzheimer’s Patients

Denali Therapeutics

Biogen and Denali to Collaborate on LRRK2 Program for Parkinson’s Disease and TV Platform-Enabled Programs for Neurodegenerative Diseases