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We offer cGMP custom manufacturing cryogenic reaction at -70°C at 3000L scale. This industrial capability combined with know-how in organometallic chemistry & asymmetric reactions is a valuable tool into the multistep synthesis industrial platform.

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Minakem is a leader in certain technologies including flow reactions, hazardous chemistry, HPAPIs, including cytotoxic molecules, and low-temperature chemistry.

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Biondustria L.I.M has temperature capabilities from -100°C to +170°C.

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FARMAK, a.s. utilizes these standard types of reactions with Full GMP conditions, temperature range -15°C to 140°C, Grignard reactions (organometallic compounds, ether handling), high-temperature reactions (high-temperature reactor up to 300°C), etc

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Four multi-purpose cGMP manufacturing plants have reaction capacity of 214 KL with 72 reactors - 34 Stainless Steel reactors, 37 Glass Lined reactors. Our cryogenic reaction is carried out by one Cryogenic reactor, ranging from 100 L to 8,000 L.

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In addition to the classical chemical reactions, MINAKEM has developed a strong expertise in field of low temperature reactions at an industrial scale.

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ScinoPharm's core competency will be to specialize in producing international cGMP-quality Active Pharmaceutical Ingredients through organic synthesis.

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Large-scale production capacities (upto 4’500 L, with a temperature range from -80°C to +250 °C) allow the efficient production of early-phase APIs and large-scale intermediates under nonGMP conditions at the CARBOGEN AMCIS Swiss’ facilities.

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Zach System's technologies include cryogenic chemistry (-80°/-90°C).

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We manufacture and supply APIs through our sites in North America, Europe, and Asia. Our API facilities have been inspected and approved by several global regulatory bodies including the US FDA, Japan PMDA, UK MHRA and meet the cGMP compliance standards.

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Alven's facility has all relevant infrastructure to perform a variability of reactions and production conditions, including Temperature range -50 °C to 200 °C.

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DOTTIKON has know-how and low-temperature equipment (glass and Hastelloy) on all scales for batch-wise as well as continuous processing: Research & Development up to 0.5 l and down to –80 °C, Small-scale & Pilot up to 160 l and down to –80 °C, Production

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Uetikon offers an extensive expertise to its pharmaceutical and biotechnology partners.

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The company has expertise in handling cryogenic reactions and can perform cross-coupling reactions and carbonylation reactions on a large scale

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Manufacturing facility of Neuland can handles the reactions like cryogenic reactions on a continuous basis.

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Fermion develop, manufacture and market APIs for generic, specialty and branded pharmaceutical companies and offer fully integrated contract development and manufacturing services from phase I to commercial scale.

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PCI Synthesis is equipped to run low temperature chemical reaction at research, development, pilot, and commercial scale (4,000 Liter). All of our equipment is ready to carry out reactions to as low as -80°C.

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Synthetic Labs are supported by expert team of scientist in handling mg to Kg scale Reactions, adequate Utility Services, hygienic Environment, cryogenic & High pressure Reaction Facilities and separate Laboratories for CRAMS and Generic Research.

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Farmhispania Groups equipment includes: vessels from 5 to 1000 L, temperature range from -70 to 200 ºC, filtration equipment, centrifuges and a wide range of handling equipment to mill, dry and lyophilise the bulk product.

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Grace Albany Fine Chemicals' site is designed to meet customers' highest quality, regulatory, and confidentiality expectations for the manufacture of fine chemicals and intermediates.

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Cryogenic reactors up to 1200 L

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Special technologies and manufacturing processes including full scale cryogenics, phosgenation, hazardous reactions, isolation technology, micro-reactors, and spray drying, and having 800 liters hastelloy C22 reactor for cryogenic reactions, and temperature range -100°C to 250°C.