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PHARMACOMPASS

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Generic physiologically-based models of pharmacokinetics were evaluated for early drug discovery. Plasma profiles after intravenous and oral dosing were simulated in rat for 68 compounds from six chemical classes. Input data consisted of structure based predictions of lipophilicity, ionization, and protein binding plus intrinsic clearance measured in rat hepatocytes, single measured values of aqueous solubility, and artificial membrane permeability. LogP of compounds was high with a mean of 3.9

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PROTEIN ISOLATION, IDENTIFICATION AND CHARACTERIZATION
QUANTITATIVE BIOANALYSIS
RADIOMETRIC DETECTION
PROTEOMICS
STRUCTURAL CHARACTERIZATION
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CALCULATION AND MODELING OF PHARMACOKINETIC PARAMETERS
METHOD DEVELOPMENT AND VALIDATION
IMMUNOASSAY & CELL BASED ASSAY
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BIOANALYTICAL & BIOMARKER TESTING SERVICES
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Cambridge Biomedical Inc

Comparative Biosciences, Inc

QUINTA-ANALYTICA s.r.o

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CZECH REPUBLIC

UNITED STATES

QUINTA-ANALYTICA s.r.o

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Pharmacokinetics & Statistical Evaluation

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Specialized software is used for pharmacokinetic and statistical evaluation of study results: SAS® (SAS Institute Inc.,www.sas.com); WinNonlin® Professional (Pharsight Corporation, www.pharsight.com)

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Pharma Service: Analytical

Category: BioAnalytical Services

Sub Category: Calculation and Modeling of Pharmacokinetic Parameters

Comparative Biosciences, Inc

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Pharmacokinetics

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CBI provides a range of pharmacology and pharmacokinetics capabilities across a spectrum of indications that ensure reliable results in the drug discovery and translation process.

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Pharma Service: Analytical

Category: BioAnalytical Services

Sub Category: Calculation and Modeling of Pharmacokinetic Parameters

Comparative Biosciences, Inc

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Ophthalmic Pharmacokinetics

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CBI offers a variety of preclinical ophthalmic pharmacokinetic, pharmacodynamic and biodistribution study capabilities. Our assessment and analysis modalities are fine-tuned to meet the specific requirements demanded in each targeted area of ophthalmologic pharmacokinetic investigation.

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Pharma Service: Analytical

Category: BioAnalytical Services

Sub Category: Calculation and Modeling of Pharmacokinetic Parameters

Cambridge Biomedical Inc

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Pharmacokinetics / Pharmacodynamics

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Cambridge Biomedical utilizes selective and sensitive immunoassays such as ELISA, MSD and Luminex to implement your PK studies. High performance liquid chromatography, various ligand-binding assays (LBA), cell based assays, and biomarker detection methods to assess pharmacodynamic profiles.

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Pharma Service: Analytical

Category: BioAnalytical Services

Sub Category: Calculation and Modeling of Pharmacokinetic Parameters

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