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    Generic physiologically-based models of pharmacokinetics were evaluated for early drug discovery. Plasma profiles after intravenous and oral dosing were simulated in rat for 68 compounds from six chemical classes. Input data consisted of structure based predictions of lipophilicity, ionization, and protein binding plus intrinsic clearance measured in rat hepatocytes, single measured values of aqueous solubility, and artificial membrane permeability. LogP of compounds was high with a mean of 3.9

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    Ardena

    Cambridge Biomedical Inc

    Comparative Biosciences, Inc

    QUINTA-ANALYTICA s.r.o

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    Comparative Biosciences, Inc

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      Pharmacokinetics

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      - Service Details

      CBI provides a range of pharmacology and pharmacokinetics capabilities across a spectrum of indications that ensure reliable results in the drug discovery and translation process.

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      Pharma Service: Analytical

      Category: BioAnalytical Services

      Sub Category: Calculation and Modeling of Pharmacokinetic Parameters

      Comparative Biosciences, Inc

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        Ophthalmic Pharmacokinetics

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        CBI offers a variety of preclinical ophthalmic pharmacokinetic, pharmacodynamic and biodistribution study capabilities. Our assessment and analysis modalities are fine-tuned to meet the specific requirements demanded in each targeted area of ophthalmologic pharmacokinetic investigation.

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        Pharma Service: Analytical

        Category: BioAnalytical Services

        Sub Category: Calculation and Modeling of Pharmacokinetic Parameters

        QUINTA-ANALYTICA s.r.o

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        CZECH REPUBLIC Czech Republic

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        Pharmacokinetics & Statistical Evaluation

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        Specialized software is used for pharmacokinetic and statistical evaluation of study results: SAS® (SAS Institute Inc.,www.sas.com); WinNonlin® Professional (Pharsight Corporation, www.pharsight.com)

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        Pharma Service: Analytical

        Category: BioAnalytical Services

        Sub Category: Calculation and Modeling of Pharmacokinetic Parameters

        Cambridge Biomedical Inc

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          Pharmacokinetics / Pharmacodynamics

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