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    Generic physiologically-based models of pharmacokinetics were evaluated for early drug discovery. Plasma profiles after intravenous and oral dosing were simulated in rat for 68 compounds from six chemical classes. Input data consisted of structure based predictions of lipophilicity, ionization, and protein binding plus intrinsic clearance measured in rat hepatocytes, single measured values of aqueous solubility, and artificial membrane permeability. LogP of compounds was high with a mean of 3.9

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    Comparative Biosciences, Inc

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      PHARMACOKINETICS BIOANALYTICAL SERVICES

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      CBI is a CRO for bioanalytical services offering clinical bioanalysis & bioanalytical testing services. It provides contract bioanalytical services for PK/PD, preclinical toxicology, pharmacology & has experience in research & drug development.

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      Sub Category: Calculation and Modeling of Pharmacokinetic Parameters
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      Comparative Biosciences, Inc

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        BIOANALYTICAL - OPHTHALMIC PHARMACOKINETICS

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        CBI offers bioanalytical CRO services for ophthalmic PK, PD & biodistribution studies. It provides contract bioanalytical services such as contract research & development, bioanalytical development, & bioanalytical testing services for large molecules.

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        QUINTA-ANALYTICA s.r.o

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        BIOANALYTICAL - PHARMACOKINETIC EVALUATION

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        Quinta is a bioanalytical CRO offering pharmaceutical analysis & bioanalytical contract services. It offers bioanalytical testing services for biosimilars, peptides, proteins & large molecules followed by their pharmacokinetic & statistical evaluation.

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        Cambridge Biomedical Inc

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          BIOANALYTICAL ASSAY (PHARMACOKINETICS)

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          Cambridge is a bioanalytical CRO offering bioanalytical contract services such as ELISA & Luminex for biomarkers & bioanalytical assays (PK, PD). It offers contract bioanalytical solutions & bioanalytical development services for large molecules.

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          Ardena

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            PHARMACOKINETICS SERVICES

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            Ardena provides assay based in-vitro pharmacology & PK services, ADME studies like absorption, distribution to identify potential drug-drug interactions (e.g. solubility, metabolic stability, membrane permeability, CYP interaction, etc).

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