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Generic physiologically-based models of pharmacokinetics were evaluated for early drug discovery. Plasma profiles after intravenous and oral dosing were simulated in rat for 68 compounds from six chemical classes. Input data consisted of structure based predictions of lipophilicity, ionization, and protein binding plus intrinsic clearance measured in rat hepatocytes, single measured values of aqueous solubility, and artificial membrane permeability. LogP of compounds was high with a mean of 3.9

PROTEIN ISOLATION, IDENTIFICATION AND CHARACTERIZATION
QUANTITATIVE BIOANALYSIS
RADIOMETRIC DETECTION
PROTEOMICS
STRUCTURAL CHARACTERIZATION
OVERVIEW
METHOD DEVELOPMENT AND VALIDATION
IMMUNOASSAY & CELL BASED ASSAY
BIOEQUIVALENCE / CLINICAL / PRE-CLINICAL TESTING
BIOANALYTICAL & BIOMARKER TESTING SERVICES
CALCULATION AND MODELING OF PHARMACOKINETIC PARAMETERS
CAPILLARY ELECTROPHORESIS

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Comparative Biosciences, Inc

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PHARMACOKINETICS

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CBI provides a range of pharmacology and pharmacokinetics capabilities across a spectrum of indications that ensure reliable results in the drug discovery and translation process.

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Comparative Biosciences, Inc

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OPHTHALMIC PHARMACOKINETICS

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CBI offers a variety of preclinical ophthalmic pharmacokinetic, pharmacodynamic and biodistribution study capabilities. Our assessment and analysis modalities are fine-tuned to meet the specific requirements demanded in each targeted area of ophthalmologic pharmacokinetic investigation.

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QUINTA-ANALYTICA s.r.o

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PHARMACOKINETICS & STATISTICAL EVALUATION

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Specialized software is used for pharmacokinetic and statistical evaluation of study results: SAS® (SAS Institute Inc.,www.sas.com); WinNonlin® Professional (Pharsight Corporation, www.pharsight.com)

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Cambridge Biomedical Inc

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PHARMACOKINETICS / PHARMACODYNAMICS

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Cambridge Biomedical utilizes selective and sensitive immunoassays such as ELISA, MSD and Luminex to implement your PK studies. High performance liquid chromatography, various ligand-binding assays (LBA), cell based assays, and biomarker detection methods to assess pharmacodynamic profiles.

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Ardena

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Ardena provides assay based in-vitro pharmacology & PK services, ADME studies like absorption, distribution to identify potential drug-drug interactions (e.g. solubility, metabolic stability, membrane permeability, CYP interaction, etc).

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