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            JADENU (deferasirox) tablets for oral use and JADENU® Sprinkle (deferasirox) granules are indicated for the treatment of chronic iron overload due to blood transfusions (transfusional hemosiderosis) in patients 2 years of age and older.

            Lead Product(s): Deferasirox

            Therapeutic Area: Hematology Product Name: Jadenu

            Highest Development Status: Phase IV Product Type: Small molecule

            Partner/Sponsor/Collaborator: Oakrum Pharma, LLC

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable March 22, 2021

            Details:

            Ethypharm acquired Mitsubishi Tanabe's selective antithrombin agent Arganova (argatroban monohydrate) in Europe. It is indicated for the treatment of heparin-induced thrombocytopenia type II.

            Lead Product(s): Argatroban Monohydrate

            Therapeutic Area: Hematology Product Name: Arganova

            Highest Development Status: Phase IV Product Type: Small molecule

            Partner/Sponsor/Collaborator: Ethypharm

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Acquisition June 17, 2024

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            Niopeg (pegfilgrastim) is a USFDA-approved protein that acts as a G-CSF agonist for the treatment of patients with non-myeloid malignancies receiving myelosuppressive anti‑cancer drugs associated with a clinically significant incidence of febrile neutropenia.

            Lead Product(s): Pegfilgrastim

            Therapeutic Area: Hematology Product Name: Niopeg

            Highest Development Status: Phase IV Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable April 19, 2024

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            Ferinject (ferric carboxymaltose) is an Fe modulator, small molecule drug candidate. It is approved for the treatment of iron deficiency anemia in adult and pediatric patients one year of age and older when oral iron preparations are not tolerated.

            Lead Product(s): Ferric Carboxymaltose

            Therapeutic Area: Hematology Product Name: Ferinject

            Highest Development Status: Phase IV Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable March 19, 2024

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            The proceeds will fund commercial launches of FDA-approved gene therapies, Lyfgenia (lovotibeglogene autotemcel) for sickle cell disease, Zynteglo (betibeglogene autotemcel) for beta-thalassemia and Skysona (elivaldogene autotemcel) for cerebral adrenoleukodystrophy.

            Lead Product(s): Lovotibeglogene Autotemcel

            Therapeutic Area: Hematology Product Name: Lyfgenia

            Highest Development Status: Phase IV Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Hercules Capital

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Financing March 18, 2024

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            Through the agreement, Bluebird Bio will commercialize Lyfgenia (lovotibeglogene autotemcelsickle). It is approved for the treatment of patients 12 years of age or older with sickle cell disease and a history of vaso-occlusive events.

            Lead Product(s): Lovotibeglogene Autotemcel

            Therapeutic Area: Hematology Product Name: Lyfgenia

            Highest Development Status: Phase IV Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Medicaid

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Agreement March 11, 2024

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            Udenyca Onbody, the company's on-body injector (OBI) presentation of Udenyca® (pegfilgrastim-cbqv), a CSF-3R agonist. It is indicated for the treatment of decrease the incidence of infection, as manifested by febrile neutropenia, in patients with non-myeloid malignancies.

            Lead Product(s): Pegfilgrastim

            Therapeutic Area: Hematology Product Name: Udenyca Onbody

            Highest Development Status: Phase IV Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable February 21, 2024

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            Casgevy (exagamglogene autotemcel) is an investigational, autologous, ex vivo CRISPR/Cas9 gene-edited therapy that is indicated for patients with Sickle Cell Disease and Transfusion-Dependent Beta Thalassemia.

            Lead Product(s): Exagamglogene Autotemcel

            Therapeutic Area: Hematology Product Name: Casgevy

            Highest Development Status: Phase IV Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable February 13, 2024

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            Angiomax-Generic (bivalirudin) is a direct thrombin inhibitor, which is now launched in the US market. It is indicated for treatment of patients with heparin-induced thrombocytopenia and heparin-induced thrombocytopenia and thrombosis syndrome.

            Lead Product(s): Bivalirudin

            Therapeutic Area: Hematology Product Name: Angiomax-Generic

            Highest Development Status: Phase IV Product Type: Peptide

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable January 29, 2024

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            Omjjara (momelotinib) is a once-a-day, oral JAK1/JAK2 and activin A receptor type 1 (ACVR1) inhibitor. It is indicated for the treatment of splenomegaly (enlarged spleen) or symptoms in adult myelofibrosis patients with moderate to severe anaemia.

            Lead Product(s): Momelotinib

            Therapeutic Area: Hematology Product Name: Omjjara

            Highest Development Status: Phase IV Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable January 29, 2024

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