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            Details:

            YCT-529 is a retinoic acid receptor-alpha (RAR-alpha) inhibitor that prevents sperm production by blocking access to vitamin A. It is under phase 1 clinical development for male contraception.

            Lead Product(s): YCT529

            Therapeutic Area: Obstetrics/Gynecology (Women’s Health) Product Name: YCT-529

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable December 20, 2023

            Details:

            YCT-529 is a retinoic acid receptor-alpha (RAR-alpha) inhibitor that prevents sperm production by blocking access to vitamin A. It is under phase 1 clinical development for male contraception.

            Lead Product(s): YCT529

            Therapeutic Area: Obstetrics/Gynecology (Women’s Health) Product Name: YCT-529

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 03, 2024

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            IntraVag technology enables controlled release and direct delivery of APIs to target organs. This technology along with Cannabinoid-based drug candidates S-301 and S-302 will be evaluated for the treament of Endometriosis-associated pain.

            Lead Product(s): Cannabinoid-based Drug

            Therapeutic Area: Obstetrics/Gynecology (Women’s Health) Product Name: S-301

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable March 14, 2024

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            Details:

            Comanche will initiate a clinical study of CBP-4888, a fixed-dose combination of two small interfering ribonucleic acid (siRNAs) duplex oligonucleotides targeting soluble fms-like tyrosine kinase–1 (sFLT1) mRNA isoformse, in pregnant preeclamptic patients.

            Lead Product(s): CBP-4888

            Therapeutic Area: Obstetrics/Gynecology (Women’s Health) Product Name: CBP-4888

            Highest Development Status: Phase I Product Type: Large molecule

            Partner/Sponsor/Collaborator: Google Ventures

            Deal Size: $75.0 million Upfront Cash: Undisclosed

            Deal Type: Series B Financing January 17, 2024

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            DARE-PDM1 (diclofenac) is a vaginal hydrogel which inhibits Cox-1 and Cox-2. It is being evaluated in phase 1 clinical trials for the treatment of primary dysmenorrhea.

            Lead Product(s): Diclofenac

            Therapeutic Area: Obstetrics/Gynecology (Women’s Health) Product Name: DARE-PDM1

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable December 20, 2023

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            Details:

            Freya will advance the clinical development of its lead drug candidate, FB101, an investigational vaginal microbial immunotherapeutic, for the treatment of infertility in women with dysbiotic vaginal microbiota who are undergoing assisted reproductive technology (ART).

            Lead Product(s): FB101

            Therapeutic Area: Obstetrics/Gynecology (Women’s Health) Product Name: FB101

            Highest Development Status: Phase I Product Type: Large molecule

            Partner/Sponsor/Collaborator: Sofinnova Partners

            Deal Size: $38.0 million Upfront Cash: Undisclosed

            Deal Type: Series A Financing December 12, 2023

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            Details:

            CBP-4888 is a fixed-dose combination of siRNA-2283 and siRNA-2519 targeting two soluble fms-like tyrosine kinase–1 (sFLT1) mRNA isoforms, which is investigated for the treatment of sFlt-1 mediated pre-term preeclampsia.

            Lead Product(s): siRNA-2283,siRNA-2519

            Therapeutic Area: Obstetrics/Gynecology (Women’s Health) Product Name: CBP-4888

            Highest Development Status: Phase I Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable August 23, 2023

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            Details:

            Sildenafil citrate cream is applied locally to the vaginal tissue prior to sexual activity to facilitate vasodilation and increase blood flow directly to the genital tissue to improve the physical arousal responsein womens with FSAD.

            Lead Product(s): Sildenafil Citrate

            Therapeutic Area: Obstetrics/Gynecology (Women’s Health) Product Name: Undisclosed

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable April 20, 2023

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            Details:

            DARE-PDM1 is a novel delivery of the diclofenac sodium, a NSAID drug which inhibits COX-1 and COX-2 responsible for producing PGs which contributes in inflammation and pain signalling. It uses Daré’s proprietary hydrogel technology targeted at treating primary dysmenorrhea.

            Lead Product(s): Diclofenac Sodium

            Therapeutic Area: Obstetrics/Gynecology (Women’s Health) Product Name: DARE-PDM1

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable February 22, 2023

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            Details:

            Through the acquisition, Organon will also acquire Forendo’s pipeline including it's lead candidate, FOR-6219, an investigational, potentially first-in-class oral 17beta-hydroxysteroid dehydrogenase type 1 inhibitor entering Phase 2 clinical development for endometriosis.

            Lead Product(s): FOR-6219

            Therapeutic Area: Obstetrics/Gynecology (Women’s Health) Product Name: FOR-6219

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Organon

            Deal Size: $945.0 million Upfront Cash: $75.0 million

            Deal Type: Acquisition December 13, 2021

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