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Find Drugs for Pulmonary/Respiratory Diseases in Phase I Clinical Development
Under the agreement, BioCina will manufacture large-scale cGMP batches for proprietary engineered whole-cell vaccine called Gamma-PN3 against Streptococcus pneumoniae.
The acquisition includes multiple clinical stage, orphan pulmonary disease candidates, including LTI-03, a Caveolin-1-related peptide in development for the treatment of idiopathic pulmonary fibrosis (IPF).
Aileron intends to use the proceeds primarily to complete the ongoing Phase 1b clinical study of LTI-03, a Caveolin-1-related peptide in development for the treatment of idiopathic pulmonary fibrosis.
UPB-101 is a novel recombinant fully human immunoglobulin G1 (IgG1) monoclonal antibody (mAb) that binds to the human thymic stromal lymphopoietin (TSLP) receptor (TSLPR) to inhibit signaling. UPB-101 is designed to address allergic and inflammatory diseases including asthma.
The collaboration aims to advance GRI Bio's leading NKT regulation technology and its lead program, GRI-0621, a small molecule RAR-beta gamma dual agonist that inhibits the activity of human type 1, iNKT cells.to treat inflammatory, fibrotic and autoimmune diseases.
GT1708F is a highly active and specific inhibitor of SMO protein, which inhibits the activity of SMO protein to affect the activity of the Hedgehog pathway and the expression of its downstream related proteins, thereby treating IPF.
EXOB-001 is a novel investigational medical product, consisting of a sterile suspension of allogeneic extracellular vesicles derived from cultured human umbilical cord mesenchymal stromal cells and is being investigated for the treatment of Broncho Pulmonary Dysplasia.
9MW3811 is an innovative humanized monoclonal antibody against IL-11, which can bind IL-11 through high affinity and effectively block the activation of IL-11 downstream signal pathway being developed for fibrosis and oncology.
The net financing will be used to support the future development of UPB-101, a monoclonal antibody targeting the TSLP receptor, in asthma and chronic rhinosinusitis with nasal polyps (CRSwNP).
AT-100 (zelpultide alfa) is a recombinant version of the endogenous human SP-D, a protein essential to the lung’s immune defense in reducing inflammation and infection while modulating immune responses for the patients of Bronchopulmonary Dysplasia.
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