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Find Ophthalmology Drugs in Phase I/II Clinical Development
CLS-AX (axitinib injectable suspension) is a proprietary suspension of axitinib for suprachoroidal injection. Axitinib is a tyrosine kinase inhibitor (TKI), currently investigate for neovascular age-related macular degeneration.
The net proceeds of the offering will be used to fund the company's pre-clinical and clinical development of its product candidates, including 4D-150, is a dual-transgene, intravitreal gene therapy designed for the treatment of wet AMD.
The proceeds will fund the ongoing and planned clinical and preclinical development of company's candidates, including ongoing trials for 4D-150, 4D-710, 4D-310, 4D-125 and 4D-110. 4D-150 is a dual-transgene, intravitreal gene therapy for the treatment of wet AMD.
CLS-AX (axitinib) is a tyrosine kinase inhibitor currently approved to treat renal cell cancer that achieves pan-VEGF blockade, directly inhibiting VEGF receptors-1, -2, and -3 with high potency and specificity. It is being investigated for the treatment if wet AMD.
LEV102 (oxymetazoline) is an adrenergic α1- and α2-agonist and a direct-acting sympathomimetic, causing vasoconstriction of dilated arterioles and reduces blood flow. It is currently being investigated in phase I/II clinical trial for acquired blepharoptosis.
CLS-AX (axitinib) is a tyrosine kinase inhibitor currently approved to treat renal cell cancer that achieves pan-VEGF blockade, directly inhibiting VEGF receptors-1, -2, and -3 with high potency and specificity. It is being developed for retinal diseases.
CLS-AX (axitinib) is a tyrosine kinase inhibitor approved to treat renal cell cancer that achieves pan-VEGF blockade, directly inhibiting VEGF receptors-1, -2, and -3 with high potency and specificity. It is being developed as a long-acting therapy for retinal diseases.
4D-150 is comprised of our targeted and evolved intravitreal vector, R100, and a payload that expresses aflibercept and a VEGF-C RNAi. This dual transgene payload inhibits 4 angiogenic factors: VEGF A, B, C and PlGF. 4D-150 is designed for low dose intravitreal delivery.
CLS-AX (axitinib injectable suspension) is proprietary suspension of axitinib tyrosine kinase inhibitor for suprachoroidal injection approved to treat renal cell cancer that achieves pan-VEGF blockade, inhibit VEGF receptors-1, -2, and -3 with high potency and specificity.
Under the licensing agreement with Glaukos Corporation that grants Glaukos an exclusive global license to develop and commercialize IVMED-80 (copper sulfate), a pharmacologic treatment for keratoconus.
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