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Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Eyevensys \/ Undisclosed"},{"orgOrder":0,"company":"FELIQS","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"JAPAN","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"FLQ-101","moa":"ADRA2","graph1":"Ophthalmology","graph2":"Phase I","graph3":"FELIQS","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"FELIQS \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"FELIQS \/ Undisclosed"},{"orgOrder":0,"company":"AbbVie Inc","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Undisclosed","year":"2025","type":"Inapplicable","leadProduct":"ABBV-319","moa":"Undisclosed","graph1":"Ophthalmology","graph2":"Phase I","graph3":"AbbVie Inc","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"AbbVie Inc \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"AbbVie Inc \/ Undisclosed"},{"orgOrder":0,"company":"Qilu Pharmaceutical","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"CHINA","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Lifitegrast","moa":"Integrin alpha-L\/beta-2 (LFA-1)","graph1":"Ophthalmology","graph2":"Phase I","graph3":"Qilu Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Qilu Pharmaceutical \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Qilu Pharmaceutical \/ Undisclosed"},{"orgOrder":0,"company":"Shanghai General Hospital","sponsor":"Innostellar Biotherapeutics","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"","productType":"Cell and Gene therapy","year":"2025","type":"Inapplicable","leadProduct":"LX111","moa":"Undisclosed","graph1":"Ophthalmology","graph2":"Phase I","graph3":"Shanghai General Hospital","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Shanghai General Hospital \/ Innostellar Biotherapeutics","highestDevelopmentStatusID":"6","companyTruncated":"Shanghai General Hospital \/ Innostellar Biotherapeutics"},{"orgOrder":0,"company":"Bausch & Lomb Incorporated","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"CANADA","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"BL1332","moa":"Undisclosed","graph1":"Ophthalmology","graph2":"Phase I","graph3":"Bausch & Lomb Incorporated","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Solution","sponsorNew":"Bausch & Lomb Incorporated \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Bausch & Lomb Incorporated \/ Undisclosed"},{"orgOrder":0,"company":"Shanghai General Hospital","sponsor":"Innostellar Biotherapeutics","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"","productType":"Cell and Gene therapy","year":"2025","type":"Inapplicable","leadProduct":"LX107","moa":"Undisclosed","graph1":"Ophthalmology","graph2":"Phase I","graph3":"Shanghai General Hospital","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Shanghai General Hospital \/ Innostellar Biotherapeutics","highestDevelopmentStatusID":"6","companyTruncated":"Shanghai General Hospital \/ Innostellar Biotherapeutics"},{"orgOrder":0,"company":"FELIQS","sponsor":"Beyond Next Ventures","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"JAPAN","productType":"Other Small Molecule","year":"2025","type":"Series A Financing","leadProduct":"FLQ-101","moa":"Adrenergic-alpha-2 receptor","graph1":"Ophthalmology","graph2":"Phase I","graph3":"FELIQS","amount2":0.01,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Ophthalmology","amount2New":0.01,"dosageForm":"Undisclosed","sponsorNew":"FELIQS \/ Beyond Next Ventures","highestDevelopmentStatusID":"6","companyTruncated":"FELIQS \/ Beyond Next Ventures"},{"orgOrder":0,"company":"Breye Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Danegaptide","moa":"GJs","graph1":"Ophthalmology","graph2":"Phase I","graph3":"Breye Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Breye Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Breye Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Raytone Biotech","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"CHINA","productType":"Antibiotic","year":"2025","type":"Inapplicable","leadProduct":"Tacrolimus","moa":"FK506-binding protein 1A","graph1":"Ophthalmology","graph2":"Phase I","graph3":"Raytone Biotech","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Insert","sponsorNew":"Raytone Biotech \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Raytone Biotech \/ Undisclosed"}]

Find Ophthalmology Drugs in Phase I Clinical Development

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                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : Laquinimod

                          Therapeutic Area : Ophthalmology

                          Study Phase : Phase I

                          Sponsor : Active Biotech

                          Deal Size : Undisclosed

                          Deal Type : Agreement

                          Details : Through the agreement, Active Biotech will get the material for the clinical development of the eye-drop formulation of ABR-215062 (laquinimod), which is used for the treatment of non-infectious non-anterior uveitis.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          April 02, 2021

                          Lead Product(s) : Laquinimod

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase I

                          Sponsor : Active Biotech

                          Deal Size : Undisclosed

                          Deal Type : Agreement

                          Famar

                          02

                          Details : ABBV-319 is a drug candidate, which is currently being evaluated in Phase I clinical studies for the treatment of Dry Eye Syndromes.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          May 18, 2025

                          Lead Product(s) : ABBV-319

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Abbvie Company Banner

                          03

                          Lead Product(s) : OC134

                          Therapeutic Area : Ophthalmology

                          Study Phase : Phase I

                          Sponsor : Nanomerics

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : OC134 is an eye drop medicine candidate indicated for the topical treatment of moderate to severe allergic conjunctivitis, a condition for which a suitable non-steroidal topical ocular treatment.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          December 11, 2024

                          Lead Product(s) : OC134

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase I

                          Sponsor : Nanomerics

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Quotient

                          04

                          Lead Product(s) : TAB014

                          Therapeutic Area : Ophthalmology

                          Study Phase : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          September 18, 2018

                          Lead Product(s) : TAB014

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Company Banner

                          05

                          Lead Product(s) : SAR366234

                          Therapeutic Area : Ophthalmology

                          Study Phase : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          August 24, 2015

                          Lead Product(s) : SAR366234

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          06

                          CAMX
                          Not Confirmed
                          CAMX
                          Not Confirmed

                          Details : ZKY001 is a drug candidate, which is currently being evaluated in Phase I clinical studies for the treatment of Corneal Diseases.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          August 20, 2025

                          Lead Product(s) : ZKY001

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          CAMX
                          Not Confirmed
                          CAMX
                          Not Confirmed

                          Details : PST-611 is a Cell and Gene Therapy drug candidate, which is currently being evaluated in Phase I clinical studies for the treatment of Macular Degeneration.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          June 17, 2025

                          Lead Product(s) : PST-611

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          CAMX
                          Not Confirmed
                          CAMX
                          Not Confirmed

                          Details : GAL-101, is an oral amyloid beta aggregation modulator, small molecule drug candidate. It is being evaluated for the treatment of dry age-related macular degeneration glaucoma & Alzheimer’s disease.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          May 06, 2025

                          Lead Product(s) : GAL-101

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          CAMX
                          Not Confirmed
                          CAMX
                          Not Confirmed

                          Details : DT-168 is a novel GeneTAC® small molecule, is designed to selectively target and reduce the expression of the mutant TCF4 gene that causes Fuchs endothelial corneal dystrophy.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          May 01, 2025

                          Lead Product(s) : DT-168

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          CAMX
                          Not Confirmed
                          CAMX
                          Not Confirmed

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          April 04, 2025

                          Lead Product(s) : STN1013800

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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