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Michigan","pharmaFlowCategory":"D","therapeuticArea":"Nephrology","country":"U.S.A","productType":"Other Large Molecule","year":"2024","type":"Expanded Collaboration","leadProduct":"WAL0921","moa":"Undisclosed","graph1":"Nephrology","graph2":"Phase II","graph3":"Walden Biosciences","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Walden Biosciences \/ University of Michigan","highestDevelopmentStatusID":"8","companyTruncated":"Walden Biosciences \/ University of Michigan"},{"orgOrder":0,"company":"Walden Biosciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"U.S.A","productType":"Other Large Molecule","year":"2024","type":"Inapplicable","leadProduct":"WAL0921","moa":"Undisclosed","graph1":"Nephrology","graph2":"Phase II","graph3":"Walden Biosciences","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Walden Biosciences \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Walden Biosciences \/ Inapplicable"},{"orgOrder":0,"company":"Galera Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Avasopasem manganese","moa":"SOD","graph1":"Nephrology","graph2":"Phase II","graph3":"Galera Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Galera Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Galera Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"DiaMedica Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"U.S.A","productType":"Enzyme","year":"2021","type":"Inapplicable","leadProduct":"Rinvecalinase Alpha","moa":"KLK1","graph1":"Nephrology","graph2":"Phase II","graph3":"DiaMedica Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Intravenous Injection","sponsorNew":"DiaMedica Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"DiaMedica Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Catalent Pharma Solutions","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"U.S.A","productType":"Enzyme","year":"2020","type":"Inapplicable","leadProduct":"Rinvecalinase Alpha","moa":"KLK1","graph1":"Nephrology","graph2":"Phase II","graph3":"Catalent Pharma Solutions","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Intravenous Injection","sponsorNew":"Catalent Pharma Solutions \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Catalent Pharma Solutions \/ Inapplicable"},{"orgOrder":0,"company":"AstraZeneca","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"UNITED KINGDOM","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"Zibotentan","moa":"||SGLT2","graph1":"Nephrology","graph2":"Phase II","graph3":"AstraZeneca","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"AstraZeneca \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"AstraZeneca \/ Inapplicable"},{"orgOrder":0,"company":"CinCor Pharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"Baxdrostat","moa":"Aldosterone synthase","graph1":"Nephrology","graph2":"Phase II","graph3":"CinCor Pharma","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"CinCor Pharma \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"CinCor Pharma \/ Inapplicable"},{"orgOrder":0,"company":"Mineralys Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"U.S.A","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"Lorundrostat","moa":"Aldosterone synthase","graph1":"Nephrology","graph2":"Phase II","graph3":"Mineralys Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Mineralys Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Mineralys Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Boehringer Ingelheim GmbH","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"GERMANY","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"BI 690517","moa":"||Aldosterone synthase","graph1":"Nephrology","graph2":"Phase II","graph3":"Boehringer Ingelheim GmbH","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Boehringer Ingelheim GmbH \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Boehringer Ingelheim GmbH \/ Inapplicable"},{"orgOrder":0,"company":"Novo Nordisk","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"DENMARK","productType":"Antibody","year":"2021","type":"Inapplicable","leadProduct":"Ziltivekimab","moa":"IL-6 receptor","graph1":"Nephrology","graph2":"Phase II","graph3":"Novo Nordisk","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"Novo Nordisk \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Novo Nordisk \/ Inapplicable"},{"orgOrder":0,"company":"Bayer AG","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"GERMANY","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"BAY 3283142","moa":"Undisclosed","graph1":"Nephrology","graph2":"Phase II","graph3":"Bayer AG","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Bayer AG \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Bayer AG \/ Inapplicable"},{"orgOrder":0,"company":"Eli Lilly","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"U.S.A","productType":"Protein","year":"2025","type":"Inapplicable","leadProduct":"Volenrelaxin","moa":"RXFP1","graph1":"Nephrology","graph2":"Phase II","graph3":"Eli Lilly","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"Eli Lilly \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Eli Lilly \/ Inapplicable"},{"orgOrder":0,"company":"Arch Biopartners","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"CANADA","productType":"Peptide","year":"2025","type":"Inapplicable","leadProduct":"LSALT Peptide","moa":"DPEP1","graph1":"Nephrology","graph2":"Phase II","graph3":"Arch Biopartners","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Arch Biopartners \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Arch Biopartners \/ Inapplicable"}]

    Find Nephrology Drugs in Phase II Clinical Development

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                            01

                            Arch Biopartners

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                            Arch Biopartners

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                            Lead Product(s) : LSALT Peptide

                            Therapeutic Area : Nephrology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Arch Biopartners Joins LSALT Peptide Trial for CS-AKI After Ethics Approval

                            Details : Metablok (LSALT peptide) is the Company’s lead drug candidate for preventing and treating inflammation injury in the kidneys, lungs, and liver. The drug targets the dipeptidase-1 (DPEP1) pathway.

                            Product Name : Metablok

                            Product Type : Peptide

                            Upfront Cash : Inapplicable

                            April 22, 2025

                            Lead Product(s) : LSALT Peptide

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            BioCity Biopharma

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                            BioCity Biopharma

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                            Lead Product(s) : SC0062

                            Therapeutic Area : Nephrology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            BioCity’s SC0062 Meets Phase 2 Primary Endpoint in Diabetic Kidney Disease

                            Details : SC0062 is one of the most unique, oral endothelin A (ETA)-receptor selective antagonist, small molecule drug. It is being evaluated for the treatment of diabetic kidney disease.

                            Product Name : SC0062

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            February 25, 2025

                            Lead Product(s) : SC0062

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Conduit Pharma

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                            Conduit Pharma

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                            Lead Product(s) : AZD1656

                            Therapeutic Area : Nephrology

                            Study Phase : Phase II

                            Sponsor : Sarborg Limited

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Conduit Progresses Phase II of its AI Initiative with Sarborg

                            Details : AZD1656 is a glucokinase activator small molecule drug candidate, which is currently being evaluated for the treatment of patients with lupus nephritis.

                            Product Name : AZD1656

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            February 20, 2025

                            Lead Product(s) : AZD1656

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase II

                            Sponsor : Sarborg Limited

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Conduit Pharma

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                            Conduit Pharma

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                            Lead Product(s) : AZD1656

                            Therapeutic Area : Nephrology

                            Study Phase : Phase II

                            Sponsor : Charles River Laboratories, Inc

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Conduit Pharma, Charles River Partner on Systemic Lupus Erythematosus Model

                            Details : Conduit will leverage Charles River’s expertise in immunology and preclinical research to help in development of AZD1656 for Lupus Nephritis.

                            Product Name : AZD1656

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            February 13, 2025

                            Lead Product(s) : AZD1656

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase II

                            Sponsor : Charles River Laboratories, Inc

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            05

                            Maze Therapeutics

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                            India Med Expo
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                            Maze Therapeutics

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                            Lead Product(s) : MZE829

                            Therapeutic Area : Nephrology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Maze Doses First Patient in Phase 2 HORIZON Trial for APOL1 Kidney Disease

                            Details : MZE829 is an oral, small molecule inhibitor of APOL1, which is currently being evaluated for the treatment of APOL1 kidney disease.

                            Product Name : MZE829

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            February 07, 2025

                            Lead Product(s) : MZE829

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Sarborg

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                            Sarborg

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                            Lead Product(s) : AZD1656

                            Therapeutic Area : Nephrology

                            Study Phase : Phase II

                            Sponsor : Conduit Pharma

                            Deal Size : $2.2 million

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Conduit Transitions to Phase II of Sarborg Collaboration to Support AI Drug Development

                            Details : Conduit and Sarborg worked closely to align AI-driven processes with Conduit’s portfolio needs, enhancing the potential of key assets, including AZD1656 is being evaluated for Lupus Nephritis.

                            Product Name : AZD1656

                            Product Type : Other Small Molecule

                            Upfront Cash : $0.4 million

                            February 07, 2025

                            Lead Product(s) : AZD1656

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase II

                            Sponsor : Conduit Pharma

                            Deal Size : $2.2 million

                            Deal Type : Agreement

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                            07

                            Maze Therapeutics

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                            Maze Therapeutics

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                            Lead Product(s) : MZE829

                            Therapeutic Area : Nephrology

                            Study Phase : Phase II

                            Sponsor : J.P. Morgan

                            Deal Size : $140.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Maze Therapeutics Announces Pricing of Upsized Initial Public Offering

                            Details : The proceeds from the offering will used to fund the clinical development of company's lead product MZE829, which is being evaluated for the treatment of APOL1-mediated kidney disease.

                            Product Name : MZE829

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            January 30, 2025

                            Lead Product(s) : MZE829

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase II

                            Sponsor : J.P. Morgan

                            Deal Size : $140.0 million

                            Deal Type : Public Offering

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                            08

                            Eli Lilly

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                            India Med Expo
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                            Eli Lilly

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                            Lead Product(s) : Volenrelaxin

                            Therapeutic Area : Nephrology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Lilly Ends Relaxin Study in CKD for Lack of Clinical Benefit

                            Details : LY3540378 (volenrelaxin) is a RXFP1 agonist, fusion protein drug candidate, which was being evaluated for the treatment of chronic kidney disease in adults.

                            Product Name : LY3540378

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            January 29, 2025

                            Lead Product(s) : Volenrelaxin

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Maze Therapeutics

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                            India Med Expo
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                            Maze Therapeutics

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                            Lead Product(s) : MZE829

                            Therapeutic Area : Nephrology

                            Study Phase : Phase II

                            Sponsor : J.P. Morgan

                            Deal Size : Undisclosed

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Maze Charts Path Through Clinical Development with Planned IPO

                            Details : The proceeds will be used to fund the clinical development of MZE829, an oral APOL1 inhibitor, MZE782, an oral SCL6A19 inhibitor, and other discovery and preclinical programs.

                            Product Name : MZE829

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            January 08, 2025

                            Lead Product(s) : MZE829

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase II

                            Sponsor : J.P. Morgan

                            Deal Size : Undisclosed

                            Deal Type : Public Offering

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                            10

                            Arch Biopartners

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                            Arch Biopartners

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                            Lead Product(s) : LSALT Peptide

                            Therapeutic Area : Nephrology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Arch Biopartners Doses First Patient in Canada for Phase II LSALT Trial

                            Details : Metablok (LSALT peptide) targets the dipeptidase-1 (DPEP-1) pathway. It is under clinical development for the treatment of cardiac surgery-associated acute kidney injury.

                            Product Name : MetaBlok

                            Product Type : Peptide

                            Upfront Cash : Inapplicable

                            November 13, 2024

                            Lead Product(s) : LSALT Peptide

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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