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Agreement","leadProduct":"MDI-0151","moa":"","graph1":"Immunology","graph2":"IND Enabling","graph3":"Alivexis","amount2":0.28000000000000003,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Immunology","amount2New":0.28000000000000003,"dosageForm":"","sponsorNew":"Alivexis \/ Melodia Therapeutics","highestDevelopmentStatusID":"5","companyTruncated":"Alivexis \/ Melodia Therapeutics"},{"orgOrder":0,"company":"JJP Biologics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","upfrontCash":"Not Applicable","therapeuticArea":"Immunology","country":"","productType":"Large molecule","date":"May 2024","year":"2024","type":"Not Applicable","leadProduct":"JJP-1212","moa":"","graph1":"Immunology","graph2":"IND Enabling","graph3":"JJP Biologics","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"","sponsorNew":"JJP Biologics \/ Not Applicable","highestDevelopmentStatusID":"5","companyTruncated":"JJP Biologics \/ Not Applicable"},{"orgOrder":0,"company":"Monte Rosa Therapeutics","sponsor":"TD Cowen","pharmaFlowCategory":"D","upfrontCash":"Undisclosed","therapeuticArea":"Immunology","country":"","productType":"Small molecule","date":"May 2024","year":"2024","type":"Public Offering","leadProduct":"MRT-6160","moa":"","graph1":"Immunology","graph2":"IND Enabling","graph3":"Monte Rosa Therapeutics","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"","sponsorNew":"Monte Rosa Therapeutics \/ TD Cowen","highestDevelopmentStatusID":"5","companyTruncated":"Monte Rosa Therapeutics \/ TD Cowen"}]

Find Clinical Drug Development Pipelines & Deals | PipelineProspector

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                          Top Deals by Deal Size (USD bn)

                          01

                          Aquaexpo 2024
                          Not Confirmed
                          Aquaexpo 2024
                          Not Confirmed

                          Details : CLN-978 is a novel, highly potent, half-life extended CD19xCD3 bispecific T cell engager construct. It is being evaluated for systemic lupus erythematosus.

                          Brand Name : CLN-978

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          September 17, 2024

                          Lead Product(s) : CLN-978

                          Therapeutic Area : Immunology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          Aquaexpo 2024
                          Not Confirmed
                          Aquaexpo 2024
                          Not Confirmed

                          Details : CLN-978 is a novel, highly potent, half-life extended CD19xCD3 bispecific T cell engager construct. It is being evaluated for systemic lupus erythematosus.

                          Brand Name : CLN-978

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          September 16, 2024

                          Lead Product(s) : CLN-978

                          Therapeutic Area : Immunology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          Aquaexpo 2024
                          Not Confirmed
                          Aquaexpo 2024
                          Not Confirmed

                          Details : IMSB301 is a novel, orally available small molecule cGAS inhibitor drug candidate, that is being developed for the treatment of inflammatory and autoimmune diseases.

                          Brand Name : IMSB301

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          August 19, 2024

                          Lead Product(s) : IMSB301

                          Therapeutic Area : Immunology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          Aquaexpo 2024
                          Not Confirmed
                          Aquaexpo 2024
                          Not Confirmed

                          Details : MSRD will finance key non-human primate studies for the pre-clinical development of BITT’s CD40 antagonist, BITD401412, in autoimmune diseases, including autoimmune thyroiditis, T1D & IBD.

                          Brand Name : BITD401412

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          August 16, 2024

                          Lead Product(s) : BITD401412

                          Therapeutic Area : Immunology

                          Highest Development Status : IND Enabling

                          Sponsor : MSRD

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          05

                          Aquaexpo 2024
                          Not Confirmed
                          Aquaexpo 2024
                          Not Confirmed

                          Details : IASO-782 Injection is a fully human monoclonal antibody targeting human CD19, with Fc mutations to enhance ADCC function for treatment of Systemic Lupus Erythematosus.

                          Brand Name : IASO-782

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          July 25, 2024

                          Lead Product(s) : IASO-782

                          Therapeutic Area : Immunology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          Aquaexpo 2024
                          Not Confirmed
                          Aquaexpo 2024
                          Not Confirmed

                          Details : Enlivex will initiate a Phase I clinical trial to evaluate the safety and tolerability of Allocetra following injection into an affected joint in patients with psoriatic arthritis.

                          Brand Name : Allocetra

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          July 23, 2024

                          Lead Product(s) : Allocetra-OTS

                          Therapeutic Area : Immunology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          Aquaexpo 2024
                          Not Confirmed
                          Aquaexpo 2024
                          Not Confirmed

                          Details : IMP761 is the world’s first therapeutic LAG-3 agonist antibody, which is being evaluated i the early-stage clinical rial studies for the treatment of autoimmune diseases.

                          Brand Name : IMP761

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          July 17, 2024

                          Lead Product(s) : IMP761

                          Therapeutic Area : Immunology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Aquaexpo 2024
                          Not Confirmed
                          Aquaexpo 2024
                          Not Confirmed

                          Details : The financing round will be used to drive the lead development program SR-878, which is being evaluated in the early-stage clinical trial studies for the treatment of autoimmune disease.

                          Brand Name : SR-878

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          July 09, 2024

                          Lead Product(s) : SR-878

                          Therapeutic Area : Immunology

                          Highest Development Status : IND Enabling

                          Sponsor : Andera Partners

                          Deal Size : $70.0 million

                          Deal Type : Series A Financing

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                          09

                          Aquaexpo 2024
                          Not Confirmed
                          Aquaexpo 2024
                          Not Confirmed

                          Details : Under the terms of the agreement, Alivexis grants Melodia worldwide rights to develop, manufacture, and commercialize MDI-0151 for the treatment of inflammatory diseases.

                          Brand Name : MDI-0151

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          June 21, 2024

                          Lead Product(s) : MDI-0151

                          Therapeutic Area : Immunology

                          Highest Development Status : IND Enabling

                          Sponsor : Melodia Therapeutics

                          Deal Size : $275.0 million

                          Deal Type : Licensing Agreement

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                          10

                          Aquaexpo 2024
                          Not Confirmed
                          Aquaexpo 2024
                          Not Confirmed

                          Details : JJP-1212, their potential first-in-class CD89 inhibitor, which is being evaluated in the early-stage clinical trial studies for the treatment of various IgA-mediated autoimmune- and fibrotic diseases.

                          Brand Name : JJP-1212

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          May 29, 2024

                          Lead Product(s) : JJP-1212

                          Therapeutic Area : Immunology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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