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Lispro","moa":"Insulin receptor","graph1":"Endocrinology","graph2":"Preclinical","graph3":"Sigilon Therapeutics","amount2":0.34000000000000002,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Endocrinology","amount2New":0.34000000000000002,"dosageForm":"Undisclosed","sponsorNew":"Sigilon Therapeutics \/ Eli Lilly","highestDevelopmentStatusID":"4","companyTruncated":"Sigilon Therapeutics \/ Eli Lilly"},{"orgOrder":0,"company":"Aeterna Zentaris","sponsor":"University of Sheffield","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Peptide","year":"2022","type":"Inapplicable","leadProduct":"Delayed Clearance Parathyroid Hormone","moa":"PTH receptor","graph1":"Endocrinology","graph2":"Preclinical","graph3":"Aeterna Zentaris","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Aeterna Zentaris \/ University of Sheffield","highestDevelopmentStatusID":"4","companyTruncated":"Aeterna Zentaris \/ University of Sheffield"},{"orgOrder":0,"company":"ProLynx","sponsor":"National Institutes of Health","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Peptide","year":"2020","type":"Funding","leadProduct":"Teriparatide","moa":"Parathyroid hormone receptor","graph1":"Endocrinology","graph2":"Preclinical","graph3":"ProLynx","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"ProLynx \/ National Institutes of Health","highestDevelopmentStatusID":"4","companyTruncated":"ProLynx \/ National Institutes of Health"},{"orgOrder":0,"company":"Sentia Medical Science","sponsor":"Neurocrine Biosciences","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Peptide","year":"2021","type":"Collaboration","leadProduct":"Astressin B","moa":"CRF1\/CRF2 receptor","graph1":"Endocrinology","graph2":"Preclinical","graph3":"Sentia Medical Science","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Sentia Medical Science \/ Neurocrine Biosciences","highestDevelopmentStatusID":"4","companyTruncated":"Sentia Medical Science \/ Neurocrine Biosciences"},{"orgOrder":0,"company":"Biosplice","sponsor":"Novo Nordisk","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Undisclosed","year":"2024","type":"Collaboration","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Endocrinology","graph2":"Preclinical","graph3":"Biosplice","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Biosplice \/ Novo Nordisk","highestDevelopmentStatusID":"4","companyTruncated":"Biosplice \/ Novo 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Inapplicable"},{"orgOrder":0,"company":"iTolerance","sponsor":"Kadimastem","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2025","type":"Inapplicable","leadProduct":"Allogenic Pancreatic Islet Cell","moa":"Insulin\/Glucagon","graph1":"Endocrinology","graph2":"Preclinical","graph3":"iTolerance","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Implant","sponsorNew":"iTolerance \/ Kadimastem","highestDevelopmentStatusID":"4","companyTruncated":"iTolerance \/ Kadimastem"},{"orgOrder":0,"company":"Sigilon Therapeutics","sponsor":"Eli Lilly","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Peptide","year":"2023","type":"Acquisition","leadProduct":"Insulin Lispro","moa":"Insulin receptor","graph1":"Endocrinology","graph2":"Preclinical","graph3":"Sigilon 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Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2025","type":"Agreement","leadProduct":"Nimvec AM510","moa":"Undisclosed","graph1":"Endocrinology","graph2":"Preclinical","graph3":"NorthX Biologics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"NorthX Biologics \/ Amarna Therapeutics","highestDevelopmentStatusID":"4","companyTruncated":"NorthX Biologics \/ Amarna Therapeutics"}]

Find Clinical Drug Development Pipelines & Deals | PipelineProspector

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : MKP10241

                          Therapeutic Area : Endocrinology

                          Study Phase : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : MKP10241, a new class of anti-diabetic molecules, is designed and developed at the Mankind Research Centre. It is a potent and orally administered small molecule, GPR119 agonist. GPR 119 is highly expressed in pancreatic beta cells and intestinal enteroe...

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          June 19, 2021

                          Lead Product(s) : MKP10241

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Company Banner

                          02

                          Biotech Week Boston
                          Not Confirmed
                          Biotech Week Boston
                          Not Confirmed

                          Details : The milestone is based on the progress in the development of iTOL-102, a novel cell therapy targeting a potential cure for Type 1 diabetes without the need for life-long immunosuppression.

                          Product Name : iTOL-102

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          July 17, 2025

                          Lead Product(s) : iTOL-102

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Preclinical

                          Sponsor : Bird Foundation

                          Deal Size : $0.8 million

                          Deal Type : Funding

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                          03

                          Biotech Week Boston
                          Not Confirmed
                          Biotech Week Boston
                          Not Confirmed

                          Details : Under the terms of the agreement, Amarna enables the transfer & optimization of Amarna’s research-scale production process for Nimvec AM510 to NorthX. It is being evaluated for Type 1 Diabetes.

                          Product Name : Nimvec AM510

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          July 08, 2025

                          Lead Product(s) : Nimvec AM510

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Preclinical

                          Sponsor : Amarna Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          04

                          Biotech Week Boston
                          Not Confirmed
                          Biotech Week Boston
                          Not Confirmed

                          Details : The collaboration validates the use of Nxera’s NxWave platform to identify small molecule binders to GPCR targets and to solve the structure of the receptor in the presence of the small molecule.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : $37.0 million

                          June 01, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Preclinical

                          Sponsor : Eli Lilly

                          Deal Size : $731.0 million

                          Deal Type : Collaboration

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                          05

                          Biotech Week Boston
                          Not Confirmed
                          Biotech Week Boston
                          Not Confirmed

                          Details : The financing aims to advance the clinical development of theTelomir-1, which is being evaluated for the treatment of type 2 diabetes.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          May 21, 2025

                          Lead Product(s) : Telomir-1

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Preclinical

                          Sponsor : The Bayshore Trust

                          Deal Size : $3.0 million

                          Deal Type : Financing

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                          06

                          Biotech Week Boston
                          Not Confirmed
                          Biotech Week Boston
                          Not Confirmed

                          Details : ADI-100 is designed to reprogram, downregulate pro-inflammatory cytokines while upregulating anti-inflammatory cytokines in an antigen-specific manner. it is being investigated for Type 1 Diabetes.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          March 06, 2025

                          Lead Product(s) : ADI-100

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Biotech Week Boston
                          Not Confirmed
                          Biotech Week Boston
                          Not Confirmed

                          Details : The seed funding will enhance the RESET platform and develop company's first therapeutic candidates in Type 2 diabetes, obesity and frailty.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          February 13, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Preclinical

                          Sponsor : Goldcrest Capital

                          Deal Size : $10.0 million

                          Deal Type : Financing

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                          08

                          Biotech Week Boston
                          Not Confirmed
                          Biotech Week Boston
                          Not Confirmed

                          Details : The partnership aims to support the development of cellular therapies by using gene editing of PluriBank cells for Humacyte’s use in developing its investigational BioVascular Pancreas (BVP).

                          Product Name : BVP

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          January 28, 2025

                          Lead Product(s) : BioVascular Pancreas

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Preclinical

                          Sponsor : Humacyte

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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                          09

                          Biotech Week Boston
                          Not Confirmed
                          Biotech Week Boston
                          Not Confirmed

                          Details : LXM.2 is an once-daily oral, first-in-class GLP-1 agonist, currently being investigated for diabetes, metabolic syndrome and weight loss.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          January 15, 2025

                          Lead Product(s) : LXM.2

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          Biotech Week Boston
                          Not Confirmed
                          Biotech Week Boston
                          Not Confirmed

                          Details : BMF-219 (icovamenib) is an oral, Menin inhibitor small molecule drug, being investigated in combination of semaglutide for the treatment of Diabetes Mellitus and obesity.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          January 07, 2025

                          Lead Product(s) : BMF-219,Semaglutide

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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