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Greenspan"},{"orgOrder":0,"company":"Eli Lilly","sponsor":"Christopher Ritchlin","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Peptide, Unconjugated","year":"2017","type":"Inapplicable","leadProduct":"Teriparatide","moa":"Parathyroid hormone receptor","graph1":"Musculoskeletal","graph2":"Phase II","graph3":"Eli Lilly","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Eli Lilly \/ Christopher Ritchlin","highestDevelopmentStatusID":"8","companyTruncated":"Eli Lilly \/ Christopher Ritchlin"},{"orgOrder":0,"company":"Amgen Inc","sponsor":"Nitin Agarwal","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2025","type":"Inapplicable","leadProduct":"Romosozumab","moa":"Sclerostin","graph1":"Musculoskeletal","graph2":"Phase IV","graph3":"Amgen Inc","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Injection","sponsorNew":"Amgen Inc \/ Nitin Agarwal","highestDevelopmentStatusID":"11","companyTruncated":"Amgen Inc \/ Nitin Agarwal"},{"orgOrder":0,"company":"Amgen Inc","sponsor":"Karen Klahr Miller","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2021","type":"Inapplicable","leadProduct":"Romosozumab","moa":"Sclerostin","graph1":"Musculoskeletal","graph2":"Phase III","graph3":"Amgen Inc","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Injection","sponsorNew":"Amgen Inc \/ Karen Klahr Miller","highestDevelopmentStatusID":"10","companyTruncated":"Amgen Inc \/ Karen Klahr Miller"},{"orgOrder":0,"company":"Pacira BioSciences","sponsor":"Casey Stondell","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Miscellaneous","year":"2023","type":"Inapplicable","leadProduct":"Bupivacaine","moa":"Sodium channel protein type IV alpha subunit","graph1":"Musculoskeletal","graph2":"Phase IV","graph3":"Pacira BioSciences","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Pacira BioSciences \/ Casey Stondell","highestDevelopmentStatusID":"11","companyTruncated":"Pacira BioSciences \/ Casey Stondell"},{"orgOrder":0,"company":"Pacira BioSciences","sponsor":"Catherine Vandepitte","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Miscellaneous","year":"2017","type":"Inapplicable","leadProduct":"Bupivacaine","moa":"Sodium channel protein type IV alpha subunit","graph1":"Musculoskeletal","graph2":"Phase II","graph3":"Pacira BioSciences","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Pacira BioSciences \/ Catherine Vandepitte","highestDevelopmentStatusID":"8","companyTruncated":"Pacira BioSciences \/ Catherine Vandepitte"},{"orgOrder":0,"company":"Centocor","sponsor":"Herbert Lindsley","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2010","type":"Inapplicable","leadProduct":"Infliximab","moa":"TNF-alpha","graph1":"Musculoskeletal","graph2":"Phase IV","graph3":"Centocor","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Centocor \/ Herbert Lindsley","highestDevelopmentStatusID":"11","companyTruncated":"Centocor \/ Herbert Lindsley"},{"orgOrder":0,"company":"BioMarin Pharmaceutical","sponsor":"Louis Messina","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Miscellaneous","year":"2021","type":"Inapplicable","leadProduct":"Sapropterin Hydrochloride","moa":"Tyrosine 3-monooxygenase (TH)","graph1":"Musculoskeletal","graph2":"Phase I","graph3":"BioMarin Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"BioMarin Pharmaceutical \/ Louis Messina","highestDevelopmentStatusID":"6","companyTruncated":"BioMarin Pharmaceutical \/ Louis Messina"},{"orgOrder":0,"company":"Novartis Pharmaceuticals Corporation","sponsor":"Andrew J. Wagner","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"SWITZERLAND","productType":"Miscellaneous","year":"2010","type":"Inapplicable","leadProduct":"Nilotinib","moa":"Tyrosine-protein kinase ABL","graph1":"Musculoskeletal","graph2":"Phase II","graph3":"Novartis Pharmaceuticals Corporation","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Novartis Pharmaceuticals Corporation \/ Andrew J. Wagner","highestDevelopmentStatusID":"8","companyTruncated":"Novartis Pharmaceuticals Corporation \/ Andrew J. Wagner"},{"orgOrder":0,"company":"Immunotec Inc.","sponsor":"William Black","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"CANADA","productType":"Dietary Supplement","year":"2011","type":"Inapplicable","leadProduct":"DGB-01","moa":"Undisclosed","graph1":"Musculoskeletal","graph2":"Undisclosed","graph3":"Immunotec Inc.","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Immunotec Inc. \/ William Black","highestDevelopmentStatusID":"1","companyTruncated":"Immunotec Inc. \/ William Black"},{"orgOrder":0,"company":"Rousselot BVBA","sponsor":"ARH van Zanten","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"BELGIUM","productType":"Protein","year":"2022","type":"Inapplicable","leadProduct":"Porcine Protein","moa":"Undisclosed","graph1":"Musculoskeletal","graph2":"Undisclosed","graph3":"Rousselot BVBA","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Rousselot BVBA \/ ARH van Zanten","highestDevelopmentStatusID":"1","companyTruncated":"Rousselot BVBA \/ ARH van Zanten"},{"orgOrder":0,"company":"Bened Biomedical","sponsor":"Chi-Chang Huang","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"CHINA","productType":"Probiotic","year":"2022","type":"Inapplicable","leadProduct":"PS23","moa":"Undisclosed","graph1":"Musculoskeletal","graph2":"Undisclosed","graph3":"Bened Biomedical","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Bened Biomedical \/ Chi-Chang Huang","highestDevelopmentStatusID":"1","companyTruncated":"Bened Biomedical \/ Chi-Chang Huang"},{"orgOrder":0,"company":"Heel","sponsor":"Prof. Dr. med. Frank Christoph Mooren","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"GERMANY","productType":"Plant Extract\/Herbal","year":"2013","type":"Inapplicable","leadProduct":"Traumeel","moa":"Undisclosed","graph1":"Musculoskeletal","graph2":"Phase I","graph3":"Heel","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Heel \/ Prof. Dr. med. Frank Christoph Mooren","highestDevelopmentStatusID":"6","companyTruncated":"Heel \/ Prof. Dr. med. Frank Christoph Mooren"},{"orgOrder":0,"company":"Heel","sponsor":"Prof. Dr. med. Frank Christoph Mooren","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"GERMANY","productType":"Plant Extract\/Herbal","year":"2013","type":"Inapplicable","leadProduct":"Traumeel","moa":"Undisclosed","graph1":"Musculoskeletal","graph2":"Phase I","graph3":"Heel","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Heel \/ Prof. Dr. med. Frank Christoph Mooren","highestDevelopmentStatusID":"6","companyTruncated":"Heel \/ Prof. Dr. med. Frank Christoph Mooren"},{"orgOrder":0,"company":"Yangtze River Pharmaceutical Group","sponsor":"Qiang Fu","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"CHINA","productType":"Plant Extract\/Herbal","year":"2024","type":"Inapplicable","leadProduct":"Zhengyuan","moa":"Undisclosed","graph1":"Musculoskeletal","graph2":"Phase IV","graph3":"Yangtze River Pharmaceutical Group","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Yangtze River Pharmaceutical Group \/ Qiang Fu","highestDevelopmentStatusID":"11","companyTruncated":"Yangtze River Pharmaceutical Group \/ Qiang Fu"},{"orgOrder":0,"company":"Doron Therapeutics","sponsor":"Novotech","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Peptide-drug Conjugate","year":"2025","type":"Inapplicable","leadProduct":"PTP-01","moa":"SPECT","graph1":"Musculoskeletal","graph2":"Phase III","graph3":"Doron Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Injection","sponsorNew":"Doron Therapeutics \/ Novotech","highestDevelopmentStatusID":"10","companyTruncated":"Doron Therapeutics \/ Novotech"},{"orgOrder":0,"company":"LISCure Biosciences","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"SOUTH KOREA","productType":"Probiotic","year":"2025","type":"Inapplicable","leadProduct":"JointWorks","moa":"Undisclosed","graph1":"Musculoskeletal","graph2":"Approved FDF","graph3":"LISCure Biosciences","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"LISCure Biosciences \/ Undisclosed","highestDevelopmentStatusID":"15","companyTruncated":"LISCure Biosciences \/ Undisclosed"}]

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : Celecoxib

                          Therapeutic Area : Musculoskeletal

                          Study Phase : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Celebrex-Generic (celecoxib) is a COX-2 inhibitor, small molecule drug candidate. It is indicated for the treatment of osteoarthritis & rheumatoid arthritis in adults.

                          Product Name : Celebrex-Generic

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          April 30, 2025

                          Lead Product(s) : Celecoxib

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Strides Pharma Science

                          02

                          Lead Product(s) : SAR446959

                          Therapeutic Area : Musculoskeletal

                          Study Phase : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : SAR446959 is a drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Osteoarthritis.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          November 26, 2024

                          Lead Product(s) : SAR446959

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          03

                          Lead Product(s) : Loxoprofen Sodium

                          Therapeutic Area : Musculoskeletal

                          Study Phase : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Loxoprofen Sodium is a generic version of loxonin tape, which is indicated for the treatment of rheumatoid arthritis and osteoarthritis.

                          Product Name : Loxoprofen Sodium Tape

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          August 15, 2024

                          Lead Product(s) : Loxoprofen Sodium

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Towa Pharmaceutical

                          04

                          Lead Product(s) : Sugammadex Sodium

                          Therapeutic Area : Musculoskeletal

                          Study Phase : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Sugammadex is a generic version of bridion which is indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide in adults undergoing surgery.

                          Product Name : Sugammadex Intravenous Solution

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          August 15, 2024

                          Lead Product(s) : Sugammadex Sodium

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Towa Pharmaceutical

                          05

                          Lead Product(s) : Pregabalin

                          Therapeutic Area : Musculoskeletal

                          Study Phase : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : USFDA approved generic version of Pregabalin treatment of fibromyalgia. It binds to the alpha2-delta subunit which is involved in anti-nociceptive and antiseizure effects.

                          Product Name : Lyrica-Generic

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          January 25, 2024

                          Lead Product(s) : Pregabalin

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Strides Pharma Science

                          06

                          Details : Through the acquisition, Corona Remedies gains right for the leading muscle relaxant brand Myoril (thiocolchicoside) and its extensions such as Myoril Plus (ketoprofen and thiocolchicoside) to treat muscular pain.

                          Product Name : Myoril

                          Product Type : Miscellaneous

                          Upfront Cash : Undisclosed

                          June 28, 2023

                          Lead Product(s) : Thiocolchicoside

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Approved FDF

                          Sponsor : Corona Remedies

                          Deal Size : $28.5 million

                          Deal Type : Acquisition

                          Sanofi Company Banner

                          07

                          Lead Product(s) : Teriparatide

                          Therapeutic Area : Musculoskeletal

                          Study Phase : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : USFDA approved biosimilar, Kauliv (human teriparatide hormone), for the treatment of both men and postmenopausal women with osteoporosis who are at high risk for having broken bones or fractures.

                          Product Name : Kauliv

                          Product Type : Peptide, Unconjugated

                          Upfront Cash : Inapplicable

                          November 14, 2022

                          Lead Product(s) : Teriparatide

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Strides Pharma Science

                          08

                          Lead Product(s) : Native Type Ii Collagen

                          Therapeutic Area : Musculoskeletal

                          Study Phase : Undisclosed

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Native Type Ii Collagen is a Protein drug candidate, which is currently being evaluated in clinical studies for the treatment of Arthralgia.

                          Product Name : Undisclosed

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          March 16, 2022

                          Lead Product(s) : Native Type Ii Collagen

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Undisclosed

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Bioiberica Company Banner

                          09

                          Lead Product(s) : Undenatured Type II Collagen

                          Therapeutic Area : Musculoskeletal

                          Study Phase : Approved FDF

                          Sponsor : ByHealth

                          Deal Size : Undisclosed

                          Deal Type : Partnership

                          Details : By partnering with Bioiberica, ByHealth aims to capitalise on the untapped potential of new product development with native type II collagen and respond to the growing number of consumers looking to support their mobility with effective, convenient produ...

                          Product Name : Undisclosed

                          Product Type : Protein

                          Upfront Cash : Undisclosed

                          March 11, 2022

                          Lead Product(s) : Undenatured Type II Collagen

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Approved FDF

                          Sponsor : ByHealth

                          Deal Size : Undisclosed

                          Deal Type : Partnership

                          Bioiberica Company Banner

                          10

                          Lead Product(s) : Eldecalcitol

                          Therapeutic Area : Musculoskeletal

                          Study Phase : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Edirol-Generic (eldecalcitol) is a vitamin D receptor agonist, which is indicated for the treatment of osteoporosis.

                          Product Name : Edirol-Generic

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          December 03, 2021

                          Lead Product(s) : Eldecalcitol

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Towa Pharmaceutical