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Wainwright & Co"},{"orgOrder":0,"company":"Fairhaven Pharmaceuticals","sponsor":"Liminal BioSciences","pharmaFlowCategory":"D","therapeuticArea":"Pulmonary\/Respiratory Diseases","country":"U.S.A","productType":"Undisclosed","year":"2020","type":"Acquisition","leadProduct":"Undisclosed","moa":"OXE receptor","graph1":"Pulmonary\/Respiratory Diseases","graph2":"Preclinical","graph3":"Fairhaven Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Respiratory Diseases","amount2New":0,"dosageForm":"Oral","sponsorNew":"Fairhaven Pharmaceuticals \/ Liminal BioSciences","highestDevelopmentStatusID":"4","companyTruncated":"Fairhaven Pharmaceuticals \/ Liminal BioSciences"},{"orgOrder":0,"company":"Lay Sciences","sponsor":"Statera Biopharma","pharmaFlowCategory":"D","therapeuticArea":"Pulmonary\/Respiratory Diseases","country":"U.S.A","productType":"Antibody","year":"2022","type":"Partnership","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Pulmonary\/Respiratory Diseases","graph2":"Preclinical","graph3":"Lay Sciences","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Respiratory Diseases","amount2New":0,"dosageForm":"Oral Inhalation","sponsorNew":"Lay Sciences \/ Statera Biopharma","highestDevelopmentStatusID":"4","companyTruncated":"Lay Sciences \/ Statera Biopharma"},{"orgOrder":0,"company":"Rein Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Pulmonary\/Respiratory Diseases","country":"U.S.A","productType":"Peptide","year":"2025","type":"Inapplicable","leadProduct":"LTI-2355","moa":"Caveolin-1","graph1":"Pulmonary\/Respiratory Diseases","graph2":"Preclinical","graph3":"Rein Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Respiratory Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Rein Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Rein Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Honeywell","sponsor":"DevPro Biopharma","pharmaFlowCategory":"D","therapeuticArea":"Pulmonary\/Respiratory Diseases","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Agreement","leadProduct":"Salbutamol Sulphate","moa":"Adrenergic receptor beta-2","graph1":"Pulmonary\/Respiratory Diseases","graph2":"Preclinical","graph3":"Honeywell","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Respiratory Diseases","amount2New":0,"dosageForm":"Oral Aerosol (PMDI)","sponsorNew":"Honeywell \/ DevPro Biopharma","highestDevelopmentStatusID":"4","companyTruncated":"Honeywell \/ DevPro Biopharma"},{"orgOrder":0,"company":"DevPro Biopharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Pulmonary\/Respiratory Diseases","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"Salbutamol Sulphate","moa":"Adrenergic receptor beta-2","graph1":"Pulmonary\/Respiratory Diseases","graph2":"Preclinical","graph3":"DevPro Biopharma","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Respiratory Diseases","amount2New":0,"dosageForm":"Oral Aerosol (PMDI)","sponsorNew":"DevPro Biopharma \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"DevPro Biopharma \/ Inapplicable"},{"orgOrder":0,"company":"Etcembly","sponsor":"DJS Antibodies","pharmaFlowCategory":"D","therapeuticArea":"Pulmonary\/Respiratory Diseases","country":"UNITED KINGDOM","productType":"Antibody","year":"2025","type":"Partnership","leadProduct":"DJS 002","moa":"GPCR","graph1":"Pulmonary\/Respiratory Diseases","graph2":"Preclinical","graph3":"Etcembly","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Respiratory Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Etcembly \/ DJS Antibodies","highestDevelopmentStatusID":"4","companyTruncated":"Etcembly \/ DJS Antibodies"},{"orgOrder":0,"company":"Recludix Pharma","sponsor":"Sanofi","pharmaFlowCategory":"D","therapeuticArea":"Pulmonary\/Respiratory Diseases","country":"UNITED KINGDOM","productType":"Other Small Molecule","year":"2025","type":"Collaboration","leadProduct":"REX-8756","moa":"STAT6","graph1":"Pulmonary\/Respiratory Diseases","graph2":"Preclinical","graph3":"Recludix Pharma","amount2":1.3300000000000001,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Respiratory Diseases","amount2New":1.3300000000000001,"dosageForm":"Oral","sponsorNew":"Recludix Pharma \/ Sanofi","highestDevelopmentStatusID":"4","companyTruncated":"Recludix Pharma \/ Sanofi"}]

Find Drugs for Pulmonary/Respiratory Diseases in Preclinical Development

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                          Top Deals by Deal Size (USD bn)

                          01

                          Peptide Forum
                          Not Confirmed
                          Peptide Forum
                          Not Confirmed

                          Details : The collaboration aims to advance preclinical studies, REX-8756, an oral, selective and reversible small molecule inhibitor of STAT6. It is being evaluated for asthma, COPD etc.

                          Product Name : REX-8756

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          June 02, 2025

                          Lead Product(s) : REX-8756

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Sanofi

                          Deal Size : $1,325.0 million

                          Deal Type : Collaboration

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                          02

                          Peptide Forum
                          Not Confirmed
                          Peptide Forum
                          Not Confirmed

                          Details : The partnership aims to advance DSJ’s antibody pipeline, including DJS-002, which targets a well-validated GPCR for treating fibrotic diseases such as IPF.

                          Product Name : DJS 002

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          May 12, 2025

                          Lead Product(s) : DJS 002

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Preclinical

                          Sponsor : DJS Antibodies

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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                          03

                          Peptide Forum
                          Not Confirmed
                          Peptide Forum
                          Not Confirmed

                          Details : Caveolin scaffolding domain (CSD) peptide LTI-2355 modulates the phagocytic and synthetic activity of lung derived myeloid cells in Idiopathic pulmonary disease.

                          Product Name : LTI-2355

                          Product Type : Peptide

                          Upfront Cash : Inapplicable

                          April 15, 2025

                          Lead Product(s) : LTI-2355

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          Peptide Forum
                          Not Confirmed
                          Peptide Forum
                          Not Confirmed

                          Details : The collaboration aims to validate RC-0315, which is being evaluated for treating patients suffering from idiopathic pulmonary fibrosis.

                          Product Name : RC-0315

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          March 12, 2025

                          Lead Product(s) : RC-0315

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Qureight

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          05

                          Peptide Forum
                          Not Confirmed
                          Peptide Forum
                          Not Confirmed

                          Details : ENV-294 is a first-in-class, oral small molecule, with JAK-inhibitor-like efficacy and IL4/IL13-like safety, targeting asthma and other inflammatory conditions.

                          Product Name : ENV-294

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          February 05, 2025

                          Lead Product(s) : ENV-294

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Peptide Forum
                          Not Confirmed
                          Peptide Forum
                          Not Confirmed

                          Details : The KIAT grant will fund the development of first-in-class biologic therapies to treat lung diseases, including asthma and idiopathic pulmonary fibrosis

                          Product Name : Undisclosed

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          January 22, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Korea Institute of Advanced Technology

                          Deal Size : $4.5 million

                          Deal Type : Funding

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                          07

                          Peptide Forum
                          Not Confirmed
                          Peptide Forum
                          Not Confirmed

                          Details : RSBT-001 demonstrated statistically significant reduction of IL-6, IL-8, TNF-α, and IL-1β, which are key inflammatory biomarkers known to play a role in the pathophysiology of COPD.

                          Product Name : RSBT-001

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          January 21, 2025

                          Lead Product(s) : RSBT-001

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Peptide Forum
                          Not Confirmed
                          Peptide Forum
                          Not Confirmed

                          Details : The Company intends to use the proceeds for pre-clinical and clinical development of its product candidates, including stem cell therapy for the treatment of ARDS.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          January 08, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Preclinical

                          Sponsor : H.C. Wainwright & Co

                          Deal Size : $3.0 million

                          Deal Type : Public Offering

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                          09

                          Peptide Forum
                          Not Confirmed
                          Peptide Forum
                          Not Confirmed

                          Details : The agreement will support development of DP007 (albuterol) inhalation aerosol indicated for bronchospasm in patients 4 years of age & older with reversible obstructive airway disease.

                          Product Name : DP007

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          October 10, 2024

                          Lead Product(s) : Salbutamol Sulphate

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Preclinical

                          Sponsor : DevPro Biopharma

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          10

                          Peptide Forum
                          Not Confirmed
                          Peptide Forum
                          Not Confirmed

                          Details : The collaboration aims to advance the clinical development of RSBT-001, which is being evaluated in the early-stage clinical trial studies for the treatment of COPD and IPF.

                          Product Name : RSBT-001

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          August 07, 2024

                          Lead Product(s) : RSBT-001

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Preclinical

                          Sponsor : University of Colorado

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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