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Disorders","country":"FRANCE","productType":"Enzyme","year":"2012","type":"Inapplicable","leadProduct":"Alglucosidase Alfa","moa":"Starch","graph1":"Rare Diseases and Disorders","graph2":"Phase IV","graph3":"Sanofi","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Rare Diseases","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Sanofi \/ Undisclosed","highestDevelopmentStatusID":"11","companyTruncated":"Sanofi \/ Undisclosed"},{"orgOrder":0,"company":"Sanofi","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Rare Diseases and Disorders","country":"FRANCE","productType":"Enzyme","year":"2020","type":"Inapplicable","leadProduct":"Alglucosidase Alfa","moa":"Starch","graph1":"Rare Diseases and Disorders","graph2":"Phase IV","graph3":"Sanofi","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Rare Diseases","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Sanofi \/ Undisclosed","highestDevelopmentStatusID":"11","companyTruncated":"Sanofi \/ Undisclosed"},{"orgOrder":0,"company":"Sanofi","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Rare Diseases and Disorders","country":"FRANCE","productType":"Enzyme","year":"2018","type":"Inapplicable","leadProduct":"Alglucosidase Alfa","moa":"Starch","graph1":"Rare Diseases and Disorders","graph2":"Phase IV","graph3":"Sanofi","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Rare Diseases","amount2New":0,"dosageForm":"Injection, Powder","sponsorNew":"Sanofi \/ Undisclosed","highestDevelopmentStatusID":"11","companyTruncated":"Sanofi \/ Undisclosed"},{"orgOrder":0,"company":"Chinese SLE Treatment And Research Group","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Rare Diseases and Disorders","country":"CHINA","productType":"Antibody, Unconjugated","year":"2021","type":"Inapplicable","leadProduct":"Adalimumab","moa":"TNF-alpha","graph1":"Rare Diseases and Disorders","graph2":"Phase IV","graph3":"Chinese SLE Treatment And Research Group","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Rare Diseases","amount2New":0,"dosageForm":"Injection","sponsorNew":"Chinese SLE Treatment And Research Group \/ Undisclosed","highestDevelopmentStatusID":"11","companyTruncated":"Chinese SLE Treatment And Research Group \/ Undisclosed"},{"orgOrder":0,"company":"Chinese SLE Treatment And Research Group","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Rare Diseases and Disorders","country":"CHINA","productType":"Miscellaneous","year":"2025","type":"Inapplicable","leadProduct":"Deucravacitinib","moa":"Tyrosine-protein kinase TYK2","graph1":"Rare Diseases and Disorders","graph2":"Phase IV","graph3":"Chinese SLE Treatment And Research Group","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Rare Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Chinese SLE Treatment And Research Group \/ Undisclosed","highestDevelopmentStatusID":"11","companyTruncated":"Chinese SLE Treatment And Research Group \/ Undisclosed"},{"orgOrder":0,"company":"Green Cross Lab Cell","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Rare Diseases and Disorders","country":"SOUTH KOREA","productType":"Antibody, Unconjugated","year":"2012","type":"Inapplicable","leadProduct":"Immunoglobulin G","moa":"Immunoglobulin G (IgG)","graph1":"Rare Diseases and Disorders","graph2":"Phase IV","graph3":"Green Cross Lab Cell","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Rare Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Green Cross Lab Cell \/ Undisclosed","highestDevelopmentStatusID":"11","companyTruncated":"Green Cross Lab Cell \/ Undisclosed"},{"orgOrder":0,"company":"Green Cross Lab Cell","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Rare Diseases and Disorders","country":"SOUTH KOREA","productType":"Antibody, Unconjugated","year":"2019","type":"Inapplicable","leadProduct":"Immunoglobulin G","moa":"Immunoglobulin G (IgG)","graph1":"Rare Diseases and Disorders","graph2":"Phase IV","graph3":"Green Cross Lab Cell","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Rare Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Green Cross Lab Cell \/ Undisclosed","highestDevelopmentStatusID":"11","companyTruncated":"Green Cross Lab Cell \/ Undisclosed"},{"orgOrder":0,"company":"ATS Clinical Research","sponsor":"Allergan","pharmaFlowCategory":"DU","therapeuticArea":"Rare Diseases and Disorders","country":"U.S.A","productType":"Undisclosed","year":"2013","type":"Inapplicable","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Rare Diseases and Disorders","graph2":"Phase IV","graph3":"ATS Clinical Research","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Rare Diseases","amount2New":0,"dosageForm":"Solution","sponsorNew":"ATS Clinical Research \/ Allergan","highestDevelopmentStatusID":"11","companyTruncated":"ATS Clinical Research \/ Allergan"}]

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : Avalglucosidase Alfa

                          Therapeutic Area : Rare Diseases and Disorders

                          Study Phase : Phase IV

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Avalglucosidase Alfa is a Enzyme drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Glycogen Storage Disease Type II.

                          Product Name : Undisclosed

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          October 30, 2024

                          Lead Product(s) : Avalglucosidase Alfa

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase IV

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          02

                          Lead Product(s) : Avalglucosidase Alfa

                          Therapeutic Area : Rare Diseases and Disorders

                          Study Phase : Phase IV

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Avalglucosidase Alfa is a Enzyme drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Glycogen Storage Disease Type II.

                          Product Name : Undisclosed

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          December 20, 2021

                          Lead Product(s) : Avalglucosidase Alfa

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase IV

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          03

                          Lead Product(s) : Alglucosidase Alfa

                          Therapeutic Area : Rare Diseases and Disorders

                          Study Phase : Phase IV

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Alglucosidase Alfa is a Enzyme drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Glycogen Storage Disease Type II.

                          Product Name : Undisclosed

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          December 21, 2020

                          Lead Product(s) : Alglucosidase Alfa

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase IV

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          04

                          Lead Product(s) : Alglucosidase Alfa

                          Therapeutic Area : Rare Diseases and Disorders

                          Study Phase : Phase IV

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Myozyme (Alglucosidase Alfa) is a Enzyme drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Glycogen Storage Disease Type II.

                          Product Name : Myozyme

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          September 27, 2018

                          Lead Product(s) : Alglucosidase Alfa

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase IV

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          05

                          Lead Product(s) : Alglucosidase Alfa

                          Therapeutic Area : Rare Diseases and Disorders

                          Study Phase : Phase IV

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Alglucosidase Alfa is a Enzyme drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Glycogen Storage Disease Type II.

                          Product Name : Undisclosed

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          May 14, 2012

                          Lead Product(s) : Alglucosidase Alfa

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase IV

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          06

                          Lead Product(s) : Alglucosidase Alfa

                          Therapeutic Area : Rare Diseases and Disorders

                          Study Phase : Phase IV

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Alglucosidase Alfa is a Enzyme drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Glycogen Storage Disease Type II.

                          Product Name : Undisclosed

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          February 06, 2012

                          Lead Product(s) : Alglucosidase Alfa

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase IV

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          07

                          Lead Product(s) : Alglucosidase Alfa

                          Therapeutic Area : Rare Diseases and Disorders

                          Study Phase : Phase IV

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Alglucosidase Alfa is a Enzyme drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Glycogen Storage Disease Type II.

                          Product Name : Undisclosed

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          August 05, 2011

                          Lead Product(s) : Alglucosidase Alfa

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase IV

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          08

                          Lead Product(s) : Alglucosidase Alfa

                          Therapeutic Area : Rare Diseases and Disorders

                          Study Phase : Phase IV

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Alglucosidase Alfa is a Enzyme drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Glycogen Storage Disease Type II.

                          Product Name : Undisclosed

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          February 02, 2011

                          Lead Product(s) : Alglucosidase Alfa

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase IV

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          09

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Pozelimab is a Antibody drug candidate, which is currently being evaluated in Phase IV clinical studies for the treatment of Chaple Disease.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          August 26, 2025

                          Lead Product(s) : Pozelimab

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase IV

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          Chinese SLE Treatment And Research Group

                          Country arrow
                          OTS 2025
                          Not Confirmed

                          Chinese SLE Treatment And Research Group

                          Country arrow
                          OTS 2025
                          Not Confirmed

                          Details : Deucravacitinib is a Other Small Molecule drug candidate, which is currently being evaluated in Phase IV clinical studies for the treatment of Takayasu Arteritis.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          June 10, 2025

                          Lead Product(s) : Deucravacitinib

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase IV

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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