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TBB is a well established, albeit dated, method for target identification, and validation. This method relies on enriching target proteins of a ‘bait-molecule’ by preparing ’bait-molecule’ specific affinity matrix.
Proteome Sciences has developed an analytical proteomic pipeline to provide broad biological context of targets and drug mechanisms based on unbiased analysis of protein expression and phosphorylation (SysQuant®), statistical data modeling (FeaST) and a novel functional analysis tool (FAT).
Shantani's portfolio of services based on chemical-proteomics technologies helps you identify & validate drug targets; thus de-risking molecules and supporting crucial GO / NO-GO decisions throughout the drug discovery process.
Targeted proteomics screens for peptides from proteins expected to be present based on prior knowledge, such as literature, genomic studies, or pathway analysis. Agilent offers solutions that enable you to screen large numbers of proteins simultaneously.
Successful proteomics experiments start with excellent sample preparation and a well-designed analytical workflow, which may include fractionation or enrichment. Agilent offers a full range of instruments, columns, and supplies for proteomics, from trypsin to full automation of peptide sample
COMP is Shantani's proprietary method for target identification using mining of historical ligand-target data sets.
SCLS is Shantani's proprietary and most comprehensive method for target identification, validation and for determination of the mechanism of action.