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    [{"orgOrder":0,"company":"Kexing Biopharm","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"CHINA","productType":"Antibody, Unconjugated","year":"2025","type":"Inapplicable","leadProduct":"GB18","moa":"GDF-15","graph1":"Nutrition and Weight Loss","graph2":"IND Enabling","graph3":"Kexing Biopharm","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Kexing Biopharm \/ Undisclosed","highestDevelopmentStatusID":"5","companyTruncated":"Kexing Biopharm \/ Undisclosed"},{"orgOrder":0,"company":"9 Meters Biopharma","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2023","type":"Inapplicable","leadProduct":"NM-136","moa":"GIP","graph1":"Nutrition and Weight Loss","graph2":"IND Enabling","graph3":"9 Meters Biopharma","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Injection","sponsorNew":"9 Meters Biopharma \/ Undisclosed","highestDevelopmentStatusID":"5","companyTruncated":"9 Meters Biopharma \/ Undisclosed"},{"orgOrder":0,"company":"9 Meters Biopharma","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2022","type":"Inapplicable","leadProduct":"NM-136","moa":"GIP","graph1":"Nutrition and Weight Loss","graph2":"IND Enabling","graph3":"9 Meters Biopharma","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Injection","sponsorNew":"9 Meters Biopharma \/ Undisclosed","highestDevelopmentStatusID":"5","companyTruncated":"9 Meters Biopharma \/ Undisclosed"},{"orgOrder":0,"company":"Fractyl Health","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2024","type":"Inapplicable","leadProduct":"RJVA-001","moa":"Undisclosed","graph1":"Nutrition and Weight Loss","graph2":"IND Enabling","graph3":"Fractyl Health","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Fractyl Health \/ Undisclosed","highestDevelopmentStatusID":"5","companyTruncated":"Fractyl Health \/ Undisclosed"},{"orgOrder":0,"company":"Fractyl Health","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2025","type":"Inapplicable","leadProduct":"RJVA-001","moa":"Undisclosed","graph1":"Nutrition and Weight Loss","graph2":"IND Enabling","graph3":"Fractyl Health","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Fractyl Health \/ Undisclosed","highestDevelopmentStatusID":"5","companyTruncated":"Fractyl Health \/ Undisclosed"},{"orgOrder":0,"company":"Fractyl Health","sponsor":"Nantahala Capital","pharmaFlowCategory":"D","therapeuticArea":"Nutrition and Weight Loss","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2025","type":"Public Offering","leadProduct":"RJVA-001","moa":"GLP-1 receptor","graph1":"Nutrition and Weight Loss","graph2":"IND Enabling","graph3":"Fractyl Health","amount2":0.02,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0.02,"dosageForm":"Undisclosed","sponsorNew":"Fractyl Health \/ Nantahala Capital","highestDevelopmentStatusID":"5","companyTruncated":"Fractyl Health \/ Nantahala Capital"},{"orgOrder":0,"company":"Fractyl Health","sponsor":"Nantahala Capital","pharmaFlowCategory":"D","therapeuticArea":"Nutrition and Weight Loss","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2025","type":"Public Offering","leadProduct":"RJVA-001","moa":"GLP-1 receptor","graph1":"Nutrition and Weight Loss","graph2":"IND Enabling","graph3":"Fractyl Health","amount2":0.02,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0.02,"dosageForm":"Undisclosed","sponsorNew":"Fractyl Health \/ Nantahala Capital","highestDevelopmentStatusID":"5","companyTruncated":"Fractyl Health \/ Nantahala Capital"},{"orgOrder":0,"company":"Vivani Medical","sponsor":"Undisclosed","pharmaFlowCategory":"D","therapeuticArea":"Nutrition and Weight Loss","country":"U.S.A","productType":"Peptide, Unconjugated","year":"2025","type":"Private Placement","leadProduct":"Semaglutide","moa":"Glucagon-like peptide 1 receptor","graph1":"Nutrition and Weight Loss","graph2":"IND Enabling","graph3":"Vivani Medical","amount2":0.01,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0.01,"dosageForm":"Implant","sponsorNew":"Vivani Medical \/ Undisclosed","highestDevelopmentStatusID":"5","companyTruncated":"Vivani Medical \/ Undisclosed"},{"orgOrder":0,"company":"Vivani Medical","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"U.S.A","productType":"Peptide, Unconjugated","year":"2025","type":"Inapplicable","leadProduct":"Semaglutide","moa":"Glucagon-like peptide 1 receptor","graph1":"Nutrition and Weight Loss","graph2":"IND Enabling","graph3":"Vivani Medical","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Implant","sponsorNew":"Vivani Medical \/ Undisclosed","highestDevelopmentStatusID":"5","companyTruncated":"Vivani Medical \/ Undisclosed"},{"orgOrder":0,"company":"Vivani Medical","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"U.S.A","productType":"Peptide, Unconjugated","year":"2025","type":"Inapplicable","leadProduct":"Semaglutide","moa":"Glucagon-like peptide 1 receptor","graph1":"Nutrition and Weight Loss","graph2":"IND Enabling","graph3":"Vivani Medical","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Implant","sponsorNew":"Vivani Medical \/ Undisclosed","highestDevelopmentStatusID":"5","companyTruncated":"Vivani Medical \/ Undisclosed"},{"orgOrder":0,"company":"Biolexis Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"U.S.A","productType":"Miscellaneous","year":"2024","type":"Inapplicable","leadProduct":"BLX 0871","moa":"Undisclosed","graph1":"Nutrition and Weight Loss","graph2":"IND Enabling","graph3":"Biolexis Therapeutics","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Biolexis Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"5","companyTruncated":"Biolexis Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Kintai Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"U.S.A","productType":"Miscellaneous","year":"2020","type":"Inapplicable","leadProduct":"KTX-0200","moa":"Undisclosed","graph1":"Nutrition and Weight Loss","graph2":"IND Enabling","graph3":"Kintai Therapeutics","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Kintai Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"5","companyTruncated":"Kintai Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"TransThera Biosciences","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"CHINA","productType":"Miscellaneous","year":"2024","type":"Inapplicable","leadProduct":"TT-02332","moa":"Undisclosed","graph1":"Nutrition and Weight Loss","graph2":"IND Enabling","graph3":"TransThera Biosciences","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"TransThera Biosciences \/ Undisclosed","highestDevelopmentStatusID":"5","companyTruncated":"TransThera Biosciences \/ Undisclosed"},{"orgOrder":0,"company":"Superluminal Medicines","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"U.S.A","productType":"Miscellaneous","year":"2025","type":"Inapplicable","leadProduct":"Undisclosed","moa":"MC4 receptor","graph1":"Nutrition and Weight Loss","graph2":"IND Enabling","graph3":"Superluminal Medicines","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Superluminal Medicines \/ Undisclosed","highestDevelopmentStatusID":"5","companyTruncated":"Superluminal Medicines \/ Undisclosed"},{"orgOrder":0,"company":"Rona Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"CHINA","productType":"Oligonucleotide","year":"2025","type":"Inapplicable","leadProduct":"RN3161","moa":"INHBE","graph1":"Nutrition and Weight Loss","graph2":"IND Enabling","graph3":"Rona Therapeutics","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Rona Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"5","companyTruncated":"Rona Therapeutics \/ Undisclosed"}]

    Find FDA Investigational New Drug (IND) Submissions for Nutrition and Weight Loss

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                            01

                            Rona Therapeutics

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                            Rona Therapeutics

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                            Lead Product(s) : RN3161

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Rona Therapeutics Announces IND Filing of RN3161

                            Details : RN3161 is a highly potent and durable INHBE siRNA which is being evaluated fpr the treatment of obesity.

                            Product Name : RN3161

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            September 15, 2025

                            Lead Product(s) : RN3161

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Vivani Medical

                            U.S.A arrow
                            FNCE
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                            Vivani Medical

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                            FNCE
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                            Lead Product(s) : Semaglutide

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Vivani Medical Provides Update on Clinical Development Plans for NPM-139 Semaglutide

                            Details : NPM-139 (semaglutide) is a small molecule drug candidate which is being evaluated for the treatment of obesity.

                            Product Name : Undisclosed

                            Product Type : Peptide, Unconjugated

                            Upfront Cash : Inapplicable

                            September 04, 2025

                            Lead Product(s) : Semaglutide

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Fractyl Health

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                            Fractyl Health

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                            Lead Product(s) : RJVA-001

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : IND Enabling

                            Sponsor : Nantahala Capital

                            Deal Size : $23.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Fractyl Health Announces Closing of $23 Million Underwritten Public Offering

                            Details : Fractyl intends to use net proceeds to support development of its Revita and Rejuva platforms, including RJVA-001, designed to express glucagon-like peptide-1 (GLP-1) locally in pancreatic beta cells.

                            Product Name : RJVA-001

                            Product Type : Cell & Gene Therapy

                            Upfront Cash : Undisclosed

                            August 07, 2025

                            Lead Product(s) : RJVA-001

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : IND Enabling

                            Sponsor : Nantahala Capital

                            Deal Size : $23.0 million

                            Deal Type : Public Offering

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                            04

                            Fractyl Health

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                            FNCE
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                            Fractyl Health

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                            Lead Product(s) : RJVA-001

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : IND Enabling

                            Sponsor : Nantahala Capital

                            Deal Size : $20.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Fractyl Health Announces Pricing of $20 Million Underwritten Public Offering

                            Details : Fractyl intends to use net proceeds to support development of its Revita and Rejuva platforms, including RJVA-001, designed to express glucagon-like peptide-1 (GLP-1) locally in pancreatic beta cells.

                            Product Name : RJVA-001

                            Product Type : Cell & Gene Therapy

                            Upfront Cash : Undisclosed

                            August 06, 2025

                            Lead Product(s) : RJVA-001

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : IND Enabling

                            Sponsor : Nantahala Capital

                            Deal Size : $20.0 million

                            Deal Type : Public Offering

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                            05

                            Superluminal Medicines

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                            FNCE
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                            Superluminal Medicines

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Superluminal Advances Selective MC4R Agonist To IND Studies For Obesity

                            Details : Superluminal's compound is an orally administered, highly selective, biased MC4R agonist initially targeting rare genetic forms of obesity and hypothalamic obesity.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            July 22, 2025

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            MBX Biosciences

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                            MBX Biosciences

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                            Lead Product(s) : MBX 4291

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            MBX Biosciences Submits IND for MBX 4291 to Treat Obesity with GLP1/GIP Co-Agonist

                            Details : MBX 4291 is a long-acting GLP1/GIP Receptor co-agonist prodrug, which is currently being evaluated for the treatment of obesity.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            June 16, 2025

                            Lead Product(s) : MBX 4291

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Kexing Biopharm

                            China arrow
                            FNCE
                            Not Confirmed

                            Kexing Biopharm

                            China arrow
                            FNCE
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                            Lead Product(s) : GB18

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Kexing Biopharm's GB18 project received clearance of IND application from NMPA and FDA

                            Details : GB18 is an innovative biologic product and a nanobody targeting GDF-15 developed for the treatment of cancer cachexia.

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Inapplicable

                            May 28, 2025

                            Lead Product(s) : GB18

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Zealand Pharma

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                            FNCE
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                            Zealand Pharma

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                            Lead Product(s) : Petrelintide,CT-388

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : IND Enabling

                            Sponsor : F. Hoffmann-La Roche

                            Deal Size : $5,300.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Roche & Zealand Partner to Develop Petrelintide for Obesity & Overweight Therapy

                            Details : The two companies will collaborate to co-develop and co-commercialise ZP8396 (petrelintide) in combination with CT-388 for the treatment of obesity.

                            Product Name : Undisclosed

                            Product Type : Peptide, Unconjugated

                            Upfront Cash : $1,650.0 million

                            March 12, 2025

                            Lead Product(s) : Petrelintide,CT-388

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : IND Enabling

                            Sponsor : F. Hoffmann-La Roche

                            Deal Size : $5,300.0 million

                            Deal Type : Collaboration

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                            09

                            Arrowhead Pharmaceuticals

                            U.S.A arrow
                            FNCE
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                            Arrowhead Pharmaceuticals

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                            Lead Product(s) : ARO-ALK7

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Arrowhead Pharmaceuticals Presents Preclinical Data on ARO-ALK7 for Treatment of Obesity

                            Details : ARO-ALK7 is the first RNAi-based therapy to directly target a gene expressed in adipose tissue. It is being evaluated for the treatment of obesity.

                            Product Name : Undisclosed

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            February 25, 2025

                            Lead Product(s) : ARO-ALK7

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Antag Therapeutic

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                            Antag Therapeutic

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                            Lead Product(s) : AT-7687

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : IND Enabling

                            Sponsor : Versant Ventures

                            Deal Size : $84.0 million

                            Deal Type : Series A Financing

                            DEALS_DEV arrow-down

                            Antag Therapeutics Announces €80 Million Series A Financing

                            Details : The proceeds from the financing will be used for the development of Antag's lead molecule AT-7687. It is a peptide designed to be co-administrated with current or future obesity therapies.

                            Product Name : Undisclosed

                            Product Type : Peptide, Unconjugated

                            Upfront Cash : Undisclosed

                            December 04, 2024

                            Lead Product(s) : AT-7687

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : IND Enabling

                            Sponsor : Versant Ventures

                            Deal Size : $84.0 million

                            Deal Type : Series A Financing

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