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    [{"orgOrder":0,"company":"Palacky University","sponsor":"CB21 Pharma","pharmaFlowCategory":"DU","therapeuticArea":"Dental and Oral Health","country":"","productType":"Controlled Substance","year":"2022","type":"Inapplicable","leadProduct":"Cannabidiol","moa":"Cannabinoid CB1 receptor","graph1":"Dental and Oral Health","graph2":"Phase I\/ Phase II","graph3":"Palacky University","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Dental & Oral Health","amount2New":0,"dosageForm":"Paste","sponsorNew":"Palacky University \/ CB21 Pharma","highestDevelopmentStatusID":"7","companyTruncated":"Palacky University \/ CB21 Pharma"},{"orgOrder":0,"company":"RiboX Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dental and Oral Health","country":"CHINA","productType":"Oligonucleotide","year":"2024","type":"Inapplicable","leadProduct":"RXRG001","moa":"hAQP1 overexpression","graph1":"Dental and Oral Health","graph2":"Phase I\/ Phase II","graph3":"RiboX Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Dental & Oral Health","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"RiboX Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"RiboX Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"RiboX Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dental and Oral Health","country":"CHINA","productType":"Oligonucleotide","year":"2025","type":"Inapplicable","leadProduct":"RXRG001","moa":"hAQP1 overexpression","graph1":"Dental and Oral Health","graph2":"Phase I\/ Phase II","graph3":"RiboX Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Dental & Oral Health","amount2New":0,"dosageForm":"Injection","sponsorNew":"RiboX Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"RiboX Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"MeiraGTx","sponsor":"Sanofi","pharmaFlowCategory":"D","therapeuticArea":"Dental and Oral Health","country":"U.S.A","productType":"Other Large Molecule","year":"2023","type":"Financing","leadProduct":"AAV-AQP1","moa":"Aquaporin-1 (AQP1)","graph1":"Dental and Oral Health","graph2":"Phase I\/ Phase II","graph3":"MeiraGTx","amount2":0.029999999999999999,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Dental & Oral Health","amount2New":0.029999999999999999,"dosageForm":"Undisclosed","sponsorNew":"MeiraGTx \/ Sanofi","highestDevelopmentStatusID":"7","companyTruncated":"MeiraGTx \/ Sanofi"},{"orgOrder":0,"company":"RiboX Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dental and Oral Health","country":"CHINA","productType":"Oligonucleotide","year":"2024","type":"Inapplicable","leadProduct":"RXRG001","moa":"hAQP1 overexpression","graph1":"Dental and Oral Health","graph2":"Phase I\/ Phase II","graph3":"RiboX Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Dental & Oral Health","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"RiboX Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"RiboX Therapeutics \/ Inapplicable"}]

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                            01

                            RiboX Therapeutics

                            China arrow
                            BioProcess International
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                            RiboX Therapeutics

                            China arrow
                            BioProcess International
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                            Lead Product(s) : RXRG001

                            Therapeutic Area : Dental and Oral Health

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            RiboX Announces First Patient Dosed in Phase I/IIa Clinical Trial of RXRG001

                            Details : RXRG001 is an AQP1 modulator, circular RNA, which is currently being evaluated for the treatment of patients with radiation-induced-xerostomia (RIX) and hyposalivation.

                            Product Name : Undisclosed

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            March 09, 2025

                            Lead Product(s) : RXRG001

                            Therapeutic Area : Dental and Oral Health

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            RiboX Therapeutics

                            China arrow
                            BioProcess International
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                            RiboX Therapeutics

                            China arrow
                            BioProcess International
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                            Lead Product(s) : RXRG001

                            Therapeutic Area : Dental and Oral Health

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Study of Circular RNA Treatment in Patients With Radiation Induced Xerostomia-1

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            December 03, 2024

                            Lead Product(s) : RXRG001

                            Therapeutic Area : Dental and Oral Health

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            MeiraGTx

                            U.S.A arrow
                            BioProcess International
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                            MeiraGTx

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                            BioProcess International
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                            Lead Product(s) : AAV-AQP1

                            Therapeutic Area : Dental and Oral Health

                            Study Phase : Phase I/ Phase II

                            Sponsor : Sanofi

                            Deal Size : $30.0 million

                            Deal Type : Financing

                            DEALS_DEV arrow-down

                            MeiraGTx Announces $30 Million Strategic Investment from Sanofi; Company Pursuing Multiple Additional Strategi...

                            Details : Sanofi will receive a right of first negotiation for the use of MeiraGTx’s Riboswitch gene regulation technology for certain Immunology and Inflammation and CNS targets, including AAV-AQP1, a gene therapy for xerostomia caused by Sjogren's syndrome.

                            Product Name : Undisclosed

                            Product Type : Other Large Molecule

                            Upfront Cash : Undisclosed

                            October 30, 2023

                            Lead Product(s) : AAV-AQP1

                            Therapeutic Area : Dental and Oral Health

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Sanofi

                            Deal Size : $30.0 million

                            Deal Type : Financing

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                            04

                            Palacky University

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                            BioProcess International
                            Not Confirmed

                            Palacky University

                            Country arrow
                            BioProcess International
                            Not Confirmed
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                            Lead Product(s) : Cannabidiol

                            Therapeutic Area : Dental and Oral Health

                            Study Phase : Phase I/ Phase II

                            Sponsor : CB21 Pharma

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            CBD Effects on Periodontal Health of Patients With Chronic Periodontitis

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Controlled Substance

                            Upfront Cash : Inapplicable

                            August 11, 2022

                            Lead Product(s) : Cannabidiol

                            Therapeutic Area : Dental and Oral Health

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : CB21 Pharma

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            HysensBio

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                            BioProcess International
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                            HysensBio

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                            BioProcess International
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                            Lead Product(s) : KH001

                            Therapeutic Area : Dental and Oral Health

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Evaluation of the Safety and Tolerability of KH001 in Dentin Hypersensitivity Patients

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            March 18, 2021

                            Lead Product(s) : KH001

                            Therapeutic Area : Dental and Oral Health

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Amyndas Pharmaceuticals

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                            BioProcess International
                            Not Confirmed

                            Amyndas Pharmaceuticals

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                            BioProcess International
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                            Lead Product(s) : AMY-101

                            Therapeutic Area : Dental and Oral Health

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Study of the C3 Complement Inhibitor AMY-101 in Adults With Gingivitis

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Peptide

                            Upfront Cash : Inapplicable

                            October 03, 2018

                            Lead Product(s) : AMY-101

                            Therapeutic Area : Dental and Oral Health

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Geistlich Pharma

                            Switzerland arrow
                            BioProcess International
                            Not Confirmed

                            Geistlich Pharma

                            Switzerland arrow
                            BioProcess International
                            Not Confirmed
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                            Lead Product(s) : Taurolidine

                            Therapeutic Area : Dental and Oral Health

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Phase I/II Study to Evaluate the Safety and Efficacy of PerioSept® as Adjunct to SRP in Subjects With Per...

                            Details : Undisclosed

                            Product Name : PerioSept

                            Product Type : Antibiotic

                            Upfront Cash : Inapplicable

                            December 10, 2014

                            Lead Product(s) : Taurolidine

                            Therapeutic Area : Dental and Oral Health

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Augusta University

                            Country arrow
                            BioProcess International
                            Not Confirmed

                            Augusta University

                            Country arrow
                            BioProcess International
                            Not Confirmed
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                            Lead Product(s) : Mighteaflow

                            Therapeutic Area : Dental and Oral Health

                            Study Phase : Phase I/ Phase II

                            Sponsor : GSK

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Green Tea Lozenges for the Management of Dry Mouth

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            July 24, 2012

                            Lead Product(s) : Mighteaflow

                            Therapeutic Area : Dental and Oral Health

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : GSK

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Red de Terapia Celular

                            Country arrow
                            BioProcess International
                            Not Confirmed

                            Red de Terapia Celular

                            Country arrow
                            BioProcess International
                            Not Confirmed
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                            Lead Product(s) : Autologous Bone Mesenchymal Stem Cell

                            Therapeutic Area : Dental and Oral Health

                            Study Phase : Phase I/ Phase II

                            Sponsor : Sanidad de Castilla y León | University of Valladolid | CRMR Castilla y León | Citospin

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Treatment Of Maxillary Bone Cysts With Autologous Bone Mesenchymal Stem Cells (MSV-H)

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            July 08, 2011

                            Lead Product(s) : Autologous Bone Mesenchymal Stem Cell

                            Therapeutic Area : Dental and Oral Health

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Sanidad de Castilla y León | University of Valladolid | CRMR Castilla y León | Citospin

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Parion Sciences

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                            BioProcess International
                            Not Confirmed

                            Parion Sciences

                            U.S.A arrow
                            BioProcess International
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                            Lead Product(s) : P-552

                            Therapeutic Area : Dental and Oral Health

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            An Evaluation of the Impact of a Single Dose of P-552 on Oral Mucosal Wetness

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            June 09, 2011

                            Lead Product(s) : P-552

                            Therapeutic Area : Dental and Oral Health

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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