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\/ OrganoTherapeutics","highestDevelopmentStatusID":"2","companyTruncated":"Vyant Bio \/ OrganoTherapeutics"},{"orgOrder":0,"company":"Biolexis Therapeutics","sponsor":"Halia Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Undisclosed","year":"2024","type":"Collaboration","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Neurology","graph2":"Discovery","graph3":"Biolexis Therapeutics","amount2":0,"highestDevelopmentShortName":"Discovery","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Biolexis Therapeutics \/ Halia Therapeutics","highestDevelopmentStatusID":"2","companyTruncated":"Biolexis Therapeutics \/ Halia Therapeutics"},{"orgOrder":0,"company":"Cajal Neuroscience","sponsor":"The Column Group","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Undisclosed","year":"2022","type":"Series A 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                          Top Deals by Deal Size (USD bn)

                          01

                          Pharma MES 2025
                          Not Confirmed
                          Pharma MES 2025
                          Not Confirmed

                          Details : The collaboration will leverage ADARx's RNA discovery expertise and proprietary siRNA technology to develop siRNA therapeutics across multiple disease areas, including immunology and oncology.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : $335.0 million

                          May 14, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Discovery

                          Sponsor : AbbVie Inc

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          02

                          Pharma MES 2025
                          Not Confirmed
                          Pharma MES 2025
                          Not Confirmed

                          Details : Lundbeck expects that Gefion will contribute to advancing research by providing AI-driven insights into molecule discovery and drug optimization in the development of therapies.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          May 06, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Discovery

                          Sponsor : DCAI

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          03

                          Pharma MES 2025
                          Not Confirmed
                          Pharma MES 2025
                          Not Confirmed

                          Details : The companies signed a collaboration agreement to discover new therapies for the treatment of myotrophic lateral sclerosis .

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : $50.0 million

                          December 18, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Discovery

                          Sponsor : Bristol Myers Squibb

                          Deal Size : $2,075.0 million

                          Deal Type : Collaboration

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                          04

                          Pharma MES 2025
                          Not Confirmed
                          Pharma MES 2025
                          Not Confirmed

                          Details : The collaboration of Dewpoint with MTPC to advance Dewpoint’s novel TDP-43 small molecule condensate modulator (c-mod) for the treatment of amyotrophic lateral sclerosis.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          December 04, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Discovery

                          Sponsor : Mitsubishi Tanabe Pharma

                          Deal Size : $480.0 million

                          Deal Type : Collaboration

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                          05

                          Pharma MES 2025
                          Not Confirmed
                          Pharma MES 2025
                          Not Confirmed

                          Details : Under the collaboration, targets were identified and validated by Verge’s AI-enabled CONVERGE platform, for the tretment of amyotrophic lateral sclerosis.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : $25.0 million

                          November 20, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Discovery

                          Sponsor : Eli Lilly

                          Deal Size : $719.0 million

                          Deal Type : Collaboration

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                          06

                          Alleo

                          Country arrow
                          Pharma MES 2025
                          Not Confirmed

                          Alleo

                          Country arrow
                          Pharma MES 2025
                          Not Confirmed

                          Details : The partnership will combine Alleo’s AI-based approach to developing novel therapeutics with Ubiquigent’s platform and expertise in the field of DUB focused drug discovery.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          October 15, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Discovery

                          Sponsor : Ubiquigent

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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                          07

                          Pharma MES 2025
                          Not Confirmed
                          Pharma MES 2025
                          Not Confirmed

                          Details : Charles River and CEBINA will accelerate innovative approaches to treating neurodegenerative diseases using Charles' extensive expertise in drug discovery and development in the CNS field.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          September 17, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Discovery

                          Sponsor : Cebina

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          08

                          Pharma MES 2025
                          Not Confirmed
                          Pharma MES 2025
                          Not Confirmed

                          Details : The collaboration aims to investigate the use of C4T’s novel protein degradation platform to discover and develop potential new treatments for Alzheimer’s & Parkinson’s disease.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          September 10, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Discovery

                          Sponsor : Biogen

                          Deal Size : $415.0 million

                          Deal Type : Collaboration

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                          09

                          Pharma MES 2025
                          Not Confirmed
                          Pharma MES 2025
                          Not Confirmed

                          Details : The SEED-Eisai Research Collaboration leverages Eisai’s expertise to advance the SEED early-stage product RBM39 for treating neurodegeneration and cancer.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : $1,500.0 million

                          August 06, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Discovery

                          Sponsor : Eisai

                          Deal Size : $1,500.0 million

                          Deal Type : Collaboration

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                          10

                          Pharma MES 2025
                          Not Confirmed
                          Pharma MES 2025
                          Not Confirmed

                          Details : The collaboration successfully identified a novel brain-penetrant small molecule candidate targeting NLRP3-driven neuroinflammation by leveraging Biolexis' MolecuLern™ AI-enabled approach.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          July 31, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Discovery

                          Sponsor : Halia Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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