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Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Miscellaneous","year":"2022","type":"Inapplicable","leadProduct":"Nesvategrast","moa":"?v?3","graph1":"Ophthalmology","graph2":"Phase II","graph3":"OcuTerra Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Solution","sponsorNew":"OcuTerra Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"OcuTerra Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"OcuTerra Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Miscellaneous","year":"2021","type":"Series B Financing","leadProduct":"Nesvategrast","moa":"?v?3","graph1":"Ophthalmology","graph2":"Phase II","graph3":"OcuTerra Therapeutics","amount2":0.040000000000000001,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0.040000000000000001,"dosageForm":"Solution","sponsorNew":"OcuTerra Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"OcuTerra Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"OcuTerra Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Miscellaneous","year":"2024","type":"Inapplicable","leadProduct":"Nesvategrast","moa":"?v?3","graph1":"Ophthalmology","graph2":"Phase II","graph3":"OcuTerra Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Solution","sponsorNew":"OcuTerra Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"OcuTerra Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"OcuTerra 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II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Solution","sponsorNew":"OcuTerra Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"OcuTerra Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Marinomed Biotech","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"AUSTRIA","productType":"Undisclosed","year":"2020","type":"Inapplicable","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Marinomed Biotech","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Solution","sponsorNew":"Marinomed Biotech \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"Marinomed Biotech \/ Undisclosed"}]

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                            Evergreen Therapeutics

                            Country
                            BioJapan
                            Not Confirmed
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                            Lead Product(s) : EG-301

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Study to Evaluate Safety and Efficacy of EG-301 in Patients with Nonfocal Geographic Atrophy Secondary to DAMD

                            Details : EG-301 is a drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Macular Degeneration.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            December 27, 2021

                            Lead Product(s) : EG-301

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            AbbVie Inc

                            U.S.A
                            BioJapan
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                            Lead Product(s) : RGX-314

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            RGX-314 Gene Therapy Pharmacodynamic Study for Neovascular Age-related Macular Degeneration (nAMD)

                            Details : RGX-314 is a Cell and Gene Therapy drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Wet Macular Degeneration.

                            Product Name : Undisclosed

                            Product Type : Cell & Gene Therapy

                            Upfront Cash : Inapplicable

                            April 06, 2021

                            Lead Product(s) : RGX-314

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            AbbVie Inc

                            U.S.A
                            BioJapan
                            Not Confirmed
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                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : ABBV-RGX-314

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Regenxbio

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Diabetic Retinopathy (DR) ...

                            Details : ABBV-RGX-314 is a drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Diabetic Retinopathy.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            September 28, 2020

                            Lead Product(s) : ABBV-RGX-314

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Regenxbio

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            AbbVie Inc

                            U.S.A
                            BioJapan
                            Not Confirmed
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                            • EDQM
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                            Lead Product(s) : RGX-314

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Neovascular Age-Related Ma...

                            Details : RGX-314 is a Cell and Gene Therapy drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Wet Macular Degeneration.

                            Product Name : Undisclosed

                            Product Type : Cell & Gene Therapy

                            Upfront Cash : Inapplicable

                            August 17, 2020

                            Lead Product(s) : RGX-314

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Zhaoke Ophthalmology

                            China arrow
                            BioJapan
                            Not Confirmed

                            Zhaoke Ophthalmology

                            China arrow
                            BioJapan
                            Not Confirmed
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                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : ZKY001

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            ZKY001 Eye Drops Safety and Efficacy In Neurotrophic Keratitis

                            Details : ZKY001 is a drug candidate, which is currently being evaluated in Phase II clinical studies for the treatment of Corneal Epithelial Defect.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            August 13, 2025

                            Lead Product(s) : ZKY001

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Cognition Therapeutics

                            U.S.A arrow
                            BioJapan
                            Not Confirmed

                            Cognition Therapeutics

                            U.S.A arrow
                            BioJapan
                            Not Confirmed
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                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : CT1812

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Cognition Says Oral CT1812 Reduced Lesion Growth in GA Phase 2 Trial

                            Details : CT1812 (zervimesine) is a sigma-2 receptor binder, being investigated as a potential oral treatment for adults with geographic atrophy (GA) secondary to dry age-related macular degeneration (dry AMD).

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            May 08, 2025

                            Lead Product(s) : CT1812

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Boehringer Ingelheim GmbH

                            Germany arrow
                            BioJapan
                            Not Confirmed

                            Boehringer Ingelheim GmbH

                            Germany arrow
                            BioJapan
                            Not Confirmed
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                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : BI 1584862

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Boehringer Starts Phase II Trial of Oral Compound for Geographic Atrophy

                            Details : BI 1584862, a phospholipid modulator developed by Boehringer Ingelheim, is an investigational compound with the potential to be a first-in-class oral treatment for Geographic Atrophy.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            May 06, 2025

                            Lead Product(s) : BI 1584862

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Unity Biotechnology

                            U.S.A arrow
                            BioJapan
                            Not Confirmed

                            Unity Biotechnology

                            U.S.A arrow
                            BioJapan
                            Not Confirmed
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                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Foselutoclax,Aflibercept

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            UNITY Shares Final 36-Week Results from UBX1325 Study in Macular Edema

                            Details : UBX1325 (foselutoclax) is a novel BCL-xL inhibitor, small molecule drug candidate, which is being evaluated for the treatment of diabetic macular edema.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            May 05, 2025

                            Lead Product(s) : Foselutoclax,Aflibercept

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            OKYO Pharma

                            United Kingdom arrow
                            BioJapan
                            Not Confirmed

                            OKYO Pharma

                            United Kingdom arrow
                            BioJapan
                            Not Confirmed
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                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Urcosimod

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            FDA Grants OKYO Pharma Fast Track Designation to Urcosimod for Neuropathic Corneal Pain

                            Details : OK-101 (urcosimod) is a novel, non-opioid therapeutic candidate, is designed to target and alleviate the debilitating pain associated with corneal nerve damage.

                            Product Name : Undisclosed

                            Product Type : Peptide, Unconjugated

                            Upfront Cash : Inapplicable

                            May 01, 2025

                            Lead Product(s) : Urcosimod

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            OKYO Pharma

                            United Kingdom arrow
                            BioJapan
                            Not Confirmed

                            OKYO Pharma

                            United Kingdom arrow
                            BioJapan
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Urcosimod

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            OKYO To Accelerate Clinical Development of Urcosimod for Corneal Pain

                            Details : OK-101 (urcosimod) is a novel, non-opioid therapeutic candidate, is designed to target and alleviate the debilitating pain associated with corneal nerve damage.

                            Product Name : Undisclosed

                            Product Type : Peptide, Unconjugated

                            Upfront Cash : Inapplicable

                            April 30, 2025

                            Lead Product(s) : Urcosimod

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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