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Find Ophthalmology Drugs in Phase II Clinical Development
APX3330 is a first-in-class, small molecule, oral inhibitor of transcription factor regulator Ref-1, including those involving angiogenesis (VEGF) and inflammation (NFkB) to decrease their abnormal activation that are implicated across several ocular diseases.
iDose TR contains a novel formulation of travoprost, a prostaglandin analog used to lower intraocular pressure. Once all the travoprost is released, the iDose TR is then removed and replaced with a new iDose TR, thus offers a dropless alternative to daily eye drop treatment.
ST-100 is part of Stuart's PolyCol™ (PolyCol) platform of synthesized collagen mimetics, which target and treat disease damaged extracellular matrix (ECM) collagen.
RZ402 is a selective and potent PKI being developed as a potential once-daily oral therapy for the chronic treatment of DME. By inhibiting the formation of kallikrein, RZ402 is designed to block downstream bradykinin production.
THR-149 is a bicyclic peptide that selectively inhibits human plasma kallikrein with an inhibition constant of 0.22 nM. Through the inhibition of the kallikrein-kinin system, THR-149 prevents the induction of retinal vascular permeability, neurodegeneration, and inflammation.
In Phase 1/2a clinical trial, RG6501 (OpRegen) demonstrated the potential to slow, stop, or reverse the progression of GA in patients with GA. These results can be maintained beyond one year following a one-time, approximately 30-minute outpatient procedure.
THR-149 is a bicyclic peptide that selectively inhibits human plasma kallikrein (PKal) with an inhibition constant of 0.22 nM. THR-149 prevents the induction of retinal vascular permeability, neurodegeneration, and inflammation.
SYL1801 is an RNAi-based drug administered as eye drops that selectively inhibits NRARP receptor production. NRARP, by regulating Notch and Wnt signaling pathways in endothelial cells, plays an important role in the control of choroidal neovascularization.
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