Pharmaceutical analysis plays an important role in both the development process and GMP manufacturing. Concerns about drug safety, costly development programs, complex manufacturing, market demands for evidence-based data and increased regulatory requirements are all issues that can be addressed through a better understanding of your drug substance, drug product or manufacturing process which, in turn, can only be achieved through experienced analytical studies and robust analytical data. Contract pharmaceutical analysis services are focused on supporting product development, GMP manufacturing and distribution, from an early phase of development through to manufacturing and post-marketing analytical support.
Thermogravimetric, or thermal analysis (TGA or TG) measures changes in sample weight in a controlled thermal environment as a function of temperature or time. The changes in sample weight (mass) can be a result of alterations in chemical or physical properties and can be detected to a fraction of a microgram. TGA is useful for investigating thermal stability of solid or liquid materials under conditions of ramping temperature in an inert gas atmosphere or in an oxidative gas atmosphere. TGA can also be conducted at constant temperature to evaluate thermal stability of materials over a specific time period. For example, potential VOC emission from pesticides can be measured at constant temperature for determining the amount and rate of mass loss over a specified time period.
Coupling the TGA to a spectrophotometer allows the study of volatile species and pyrolysis products, which can lead to discovering how a compound or formulation degrades and what components it contains. For example, TGA coupled with mass spectroscopy (MS) can provide specific information on chemical structure for identifying additives, contaminants and composition of blends and copolymers (TGA-EGA.)
Contract Thermal Analysis Laboratories are proficient partners for nearly all thermal analysis issues. Their involvement in Pharmaceutical companies’ projects begins with painstaking sample preparation and continues through meticulous examination and interpretation of the measurement results.
Within the realm of thermal analysis and the measurement of thermophysical properties, Contract TGA service providers offer a comprehensive line of the most diverse analysis techniques for the characterization of materials (solids, powders and liquids). Measurements can be carried out on samples of the most varied of geometries and configurations.