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[{"orgOrder":0,"company":"Elevar Therapeutics","sponsor":"Zukunftsfonds Heilbronn","pharmaFlowCategory":"D","amount":"$72.2 million","upfrontCash":"Undisclosed","newsHeadline":"Eleva Secures up to EUR 60 million to Advance a Drug Candidate, Appoints New Board Member","therapeuticArea":"Nephrology","highestDevelopmentStatus":"Preclinical","country":"U.S.A","productType":"Undisclosed","productStatus":"New Molecular Entity","date":"January 2021","url1":"","url2":"","graph1":"Undisclosed","graph2":"Elevar Therapeutics"},{"orgOrder":0,"company":"Creative Medical Technology","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Creative Medical Technology Holdings Files Patent based on Positive Data on Renal Failure using ImmCelz\u00ae Regenerative Immunotherapy","therapeuticArea":"Nephrology","highestDevelopmentStatus":"Preclinical","country":"U.S.A","productType":"Cell and Gene therapy","productStatus":"New Molecular 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            Details:

            The net proceeds will be used for the clinical development of the Auxora (zegocractin), which is a small molecule CRAC channel inhibitor and are also planning for Phase 2 for the treatment of acute kidney injury.

            Lead Product(s): Zegocractin

            Therapeutic Area: Nephrology Product Name: Auxora

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Deerfield Management

            Deal Size: $55.0 million Upfront Cash: $20.4 million

            Deal Type: Private Placement January 22, 2024

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            Miromatrix Medical

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            Details:

            The acquisition of Miromatrix will expand United Therapeutics’ platform of organ manufacturing programs and regenerative medicine and upon the achievement of clinical development milestone to Miromatrix’s development-stage, manufactured kidney product known as mirokidney™.

            Lead Product(s): Undisclosed

            Therapeutic Area: Nephrology Product Name: Mirokidney

            Highest Development Status: Preclinical Product Type: Undisclosed

            Partner/Sponsor/Collaborator: United Therapeutics

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Acquisition December 13, 2023

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            The acquisition of Miromatrix will expand United Therapeutics’ platform of organ manufacturing programs and regenerative medicine and upon the achievement of clinical development milestone to Miromatrix’s development-stage, manufactured kidney product known as mirokidney™.

            Lead Product(s): Undisclosed

            Therapeutic Area: Nephrology Product Name: Mirokidney

            Highest Development Status: Preclinical Product Type: Undisclosed

            Partner/Sponsor/Collaborator: United Therapeutics

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Acquisition October 30, 2023

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            Through the acquisition, United Therapeutics gains access to Miromatrix’s development-stage, fully-implantable manufactured kidney product known as mirokidney.

            Lead Product(s): Undisclosed

            Therapeutic Area: Nephrology Product Name: Mirokidney

            Highest Development Status: Preclinical Product Type: Undisclosed

            Partner/Sponsor/Collaborator: United Therapeutics

            Deal Size: $91.0 million Upfront Cash: $91.0 million

            Deal Type: Acquisition October 30, 2023

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            Details:

            NP-251 (repirinast), company’s lead candidate for the treatment of chronic kidney disease, binds to receptors on mast cell and prevents their degranulation. Repirinast originally developed by Mitsubishi was sold in Japan under the brand name Romet™ for the treatment of Asthma.

            Lead Product(s): Repirinast

            Therapeutic Area: Nephrology Product Name: NP-251

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable May 31, 2023

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            Details:

            Lupkynis (voclosporin) is a calcineurin-inhibitor of calcineurin. The immunosuppressant activity results in inhibition of lymphocyte proliferation, T-cell cytokine production, and expression of T-cell activation surface antigens. Currently being developed for lupus nephritis.

            Lead Product(s): Voclosporin,Mycophenolate Mofetil,Undisclosed

            Therapeutic Area: Nephrology Product Name: Lupkynis

            Highest Development Status: Preclinical Product Type: Peptide

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable April 11, 2023

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            Details:

            The agreement is for the comprehensive strategic cooperation with Guangdong Academy of Medical Sciences in renal disease research, scientific innovation and translational studies.

            Lead Product(s): Undisclosed

            Therapeutic Area: Nephrology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Guangdong Academy of Medical Sciences

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Agreement March 23, 2023

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            Details:

            Teijin will grant Novartis exclusive worldwide rights to research, develop, manufacture and commercialize an investigational small molecule candidate for proteinuric kidney diseases. The candidate is believed to impact the pathogenesis of multiple kidney diseases.

            Lead Product(s): Undisclosed

            Therapeutic Area: Nephrology Product Name: Undislcosed

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Novartis Pharmaceuticals Corporation

            Deal Size: $230.0 million Upfront Cash: $30.0 million

            Deal Type: Licensing Agreement March 06, 2023

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            Details:

            Purespring’s Adeno Associated Virus (AAV) based gene therapy presents a lower-dose, local delivery approach which maximizes both safety and efficacy, as well as lowering the cost of goods.

            Lead Product(s): AAV-based Gene Therapy

            Therapeutic Area: Nephrology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Charles River Laboratories International

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Collaboration February 15, 2023

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            Details:

            REVTx-300 is a inhibitor of TGF-b, formulated for systemic administration of PHAD and is being developed as a potential therapy for CKD, AKI, myocarditis and NASH.

            Lead Product(s): REVTx-300

            Therapeutic Area: Nephrology Product Name: REVTx-300

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable February 07, 2023

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