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Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Gastroenterology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Werewolf Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Werewolf Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Hoth Therapeutics","sponsor":"Reprocell","pharmaFlowCategory":"D","therapeuticArea":"Gastroenterology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Partnership","leadProduct":"HT-003","moa":"Toll-like-2 receptor","graph1":"Gastroenterology","graph2":"Preclinical","graph3":"Hoth Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Gastroenterology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Hoth Therapeutics \/ Reprocell","highestDevelopmentStatusID":"4","companyTruncated":"Hoth Therapeutics \/ Reprocell"},{"orgOrder":0,"company":"Hoth Therapeutics","sponsor":"Isoprene Pharmaceuticals","pharmaFlowCategory":"DU","therapeuticArea":"Gastroenterology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"HT-003","moa":"Toll-like-2 receptor","graph1":"Gastroenterology","graph2":"Preclinical","graph3":"Hoth Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Gastroenterology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Hoth Therapeutics \/ Isoprene Pharmaceuticals","highestDevelopmentStatusID":"4","companyTruncated":"Hoth Therapeutics \/ Isoprene Pharmaceuticals"},{"orgOrder":0,"company":"Aeglea BioTherapeutics","sponsor":"Fairmount Funds Management LLC","pharmaFlowCategory":"D","therapeuticArea":"Gastroenterology","country":"U.S.A","productType":"Other Large Molecule","year":"2023","type":"Private Placement","leadProduct":"SPY001","moa":"Alpha-4-beta-7 integrin","graph1":"Gastroenterology","graph2":"Preclinical","graph3":"Aeglea BioTherapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Gastroenterology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Aeglea BioTherapeutics \/ Fairmount Funds Management LLC","highestDevelopmentStatusID":"4","companyTruncated":"Aeglea BioTherapeutics \/ Fairmount Funds Management LLC"},{"orgOrder":0,"company":"N-Zyme Biomedical","sponsor":"LGM Pharma","pharmaFlowCategory":"D","therapeuticArea":"Gastroenterology","country":"CANADA","productType":"Other Small Molecule","year":"2024","type":"Collaboration","leadProduct":"Fosamprenavir Sodium Alginate","moa":"Undisclosed","graph1":"Gastroenterology","graph2":"Preclinical","graph3":"N-Zyme Biomedical","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Gastroenterology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"N-Zyme Biomedical \/ LGM Pharma","highestDevelopmentStatusID":"4","companyTruncated":"N-Zyme Biomedical \/ LGM Pharma"},{"orgOrder":0,"company":"EnteraBio Ltd","sponsor":"OPKO Health","pharmaFlowCategory":"DU","therapeuticArea":"Gastroenterology","country":"ISRAEL","productType":"Undisclosed","year":"2024","type":"Inapplicable","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Gastroenterology","graph2":"Preclinical","graph3":"EnteraBio Ltd","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Gastroenterology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"EnteraBio Ltd \/ OPKO Health","highestDevelopmentStatusID":"4","companyTruncated":"EnteraBio Ltd \/ OPKO Health"},{"orgOrder":0,"company":"ThirtyFiveBio","sponsor":"Mayewell Capital","pharmaFlowCategory":"D","therapeuticArea":"Gastroenterology","country":"UNITED KINGDOM","productType":"Other Small Molecule","year":"2025","type":"Financing","leadProduct":"Undisclosed","moa":"GPR35","graph1":"Gastroenterology","graph2":"Preclinical","graph3":"ThirtyFiveBio","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Gastroenterology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"ThirtyFiveBio \/ Mayewell Capital","highestDevelopmentStatusID":"4","companyTruncated":"ThirtyFiveBio \/ Mayewell Capital"},{"orgOrder":0,"company":"Earendil Labs","sponsor":"Sanofi","pharmaFlowCategory":"D","therapeuticArea":"Gastroenterology","country":"U.S.A","productType":"Antibody","year":"2025","type":"Licensing Agreement","leadProduct":"HXN-1002","moa":"Alpha-4-beta-7\/TL1A","graph1":"Gastroenterology","graph2":"Preclinical","graph3":"Earendil Labs","amount2":1.8500000000000001,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Gastroenterology","amount2New":1.8500000000000001,"dosageForm":"Undisclosed","sponsorNew":"Earendil Labs \/ Sanofi","highestDevelopmentStatusID":"4","companyTruncated":"Earendil Labs \/ Sanofi"}]

Find Novel Gastroenterology Drugs in Preclinical Development

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                          Top Deals by Deal Size (USD bn)

                          01

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : Under the licensing agreement, Sanofi will obtain exclusive worldwide rights to antibody, HXN-1002. It is designed to provide a treatment option for patients with ulcerative colitis.

                          Product Name : HXN-1002

                          Product Type : Antibody

                          Upfront Cash : $125.0 million

                          April 17, 2025

                          Lead Product(s) : HXN-1002

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Preclinical

                          Sponsor : Sanofi

                          Deal Size : $1,845.0 million

                          Deal Type : Licensing Agreement

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                          02

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : The funds will support the continued development of the company's first-in-class GPR35 inhibitor program, which is currently advancing through preclinical development of Ulcerative Colitis.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          April 15, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Preclinical

                          Sponsor : Mayewell Capital

                          Deal Size : Undisclosed

                          Deal Type : Financing

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                          03

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : Through the acquisition, Alvotech leverages R&D operations and a biosimilar candidate of Xbrane XB003 (certolizumab pegol). It is being evluated for treating crohn disease.

                          Product Name : XB003

                          Product Type : Antibody-drug Conjugate

                          Upfront Cash : $10.1 million

                          March 20, 2025

                          Lead Product(s) : Certolizumab Pegol

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Preclinical

                          Sponsor : Alvotech

                          Deal Size : $10.1 million

                          Deal Type : Acquisition

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                          04

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : The combination vaccine will utilize Zydus' WHO-prequalified Typhoid Conjugate Vaccine (ZyVac TCV) and a Shigella vaccine from an undisclosed partner.

                          Product Name : Undisclosed

                          Product Type : Vaccine

                          Upfront Cash : Inapplicable

                          March 03, 2025

                          Lead Product(s) : Typhoid Vi Conjugate Vaccine,Undisclosed

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : CJRB-201 is a microbiome-based drug candidate identified through Ez-Mx®, platform, and is being developed for the treatment of inflammatory bowel disease.

                          Product Name : CJRB-201

                          Product Type : Microorganism

                          Upfront Cash : Inapplicable

                          February 18, 2025

                          Lead Product(s) : CJRB-201

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : The partnership aims to support the development and manufacturing of Parvus novel autoimmune drug candidate, PVT401, targeting Inflammatory Bowel Disease.

                          Product Name : PVT401

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          January 08, 2025

                          Lead Product(s) : PVT401

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Preclinical

                          Sponsor : Parvus Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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                          07

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : The collaboration aims to bring to market a first-in-class, pepsin inhibitor, fosamprenavir that is safe and effective for patients with LPR and/or persistent GERD symptoms.

                          Product Name : NZYM-001

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          November 18, 2024

                          Lead Product(s) : Fosamprenavir Sodium Alginate

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Preclinical

                          Sponsor : LGM Pharma

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          08

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : The collaboration aims to develop ND081, a potential first-in-class multi-specific antibody for the treatment of inflammatory bowel disease (IBD).

                          Product Name : ND081

                          Product Type : Other Large Molecule

                          Upfront Cash : $14.6 million

                          November 15, 2024

                          Lead Product(s) : ND081

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Preclinical

                          Sponsor : Kaken Pharmaceuticals

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          09

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : WTX-921 is a novel IL-10 indukine development candidate for Inflammatory Bowel Disease (IBD) and potentially other inflammatory diseases.

                          Product Name : WTX-921

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          October 31, 2024

                          Lead Product(s) : WTX-921

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : PSX-514 (epigallocatechin gallate) is a small molecule, amyloid precursor protein (APP) inhibitor indicated for the treatment of inflammatory bowel disease pouchitis.

                          Product Name : PSX-514

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          October 07, 2024

                          Lead Product(s) : Green Tea Extract

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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