All Data
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Lead Product(s): Adalimumab
Therapeutic Area: Gastroenterology Product Name: PGN-001
Highest Development Status: Preclinical Product Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable November 06, 2020
Details:
Progenity has two lead drug-device candidates utilizing the DDS technology, PGN-001, a high-concentration formulation of adalimumab, and PGN-600 a liquid formulation of tofacitinib, both under development for the treatment of ulcerative colitis.
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Lead Product(s): Allocetra
Therapeutic Area: Gastroenterology Product Name: Allocetra
Highest Development Status: Preclinical Product Type: Cell and Gene therapy
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable November 05, 2020
Details:
Upon issuance, the new patent will provide added intellectual property protection for methods of treating autoimmune and inflammatory diseases comprising gout, inflammatory bowel disease, Crohn's disease, and ulcerative colitis.
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Lead Product(s): PN-235
Therapeutic Area: Gastroenterology Product Name: JNJ-77242113
Highest Development Status: Preclinical Product Type: Peptide
Partner/Sponsor/Collaborator: Janssen Pharmaceutical
Deal Size: Undisclosed Upfront Cash: Undisclosed
Deal Type: Collaboration October 29, 2020
Details:
The two new candidates, PN-235 (JNJ-77242113) and PN-232 (JNJ-75105186), are being developed as part of a portfolio strategy of discovering and developing oral IL-23 receptor antagonists.
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Lead Product(s): BX002
Therapeutic Area: Gastroenterology Product Name: BX002
Highest Development Status: Preclinical Product Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable October 21, 2020
Details:
The poster presentation details a phage therapy panel, comprised of phage directed against Klebsiella pneumoniae, showing a broad target host range and the potential to address carbapenem-resistant and extended spectrum beta-lactamase (ESBL)-producing bacteria.
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Lead Product(s): SNSP003
Therapeutic Area: Gastroenterology Product Name: SNSP003
Highest Development Status: Preclinical Product Type: Large molecule
Partner/Sponsor/Collaborator: CF Foundation
Deal Size: $22.5 Million Upfront Cash: $14.0 million
Deal Type: Funding October 20, 2020
Details:
The new funding will be used to advance preclinical development and early stage clinical trials for Synspira’s non-porcine enzyme replacement therapy, SNSP003.
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Lead Product(s): ALV-304
Therapeutic Area: Gastroenterology Product Name: ALV-304
Highest Development Status: Preclinical Product Type: Undisclosed
Partner/Sponsor/Collaborator: U.S. Department of Defense
Deal Size: $3.3 million Upfront Cash: Undisclosed
Deal Type: Funding October 05, 2020
Details:
The funds will support Alivio’s preclinical research and development activities to potentially enable the filing of an investigational new drug (IND) application for ALV-304.
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Lead Product(s): RTX-1688
Therapeutic Area: Gastroenterology Product Name: RTX-1688
Highest Development Status: Preclinical Product Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable August 31, 2020
Details:
Rodeo Therapeutics nominates Candidate RTX-1688, a first-in-class oral small molecule therapy for tissue regeneration and repair, with inflammatory bowel disease as the initial indication and platform potential in other disease settings .
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Lead Product(s): PR600
Therapeutic Area: Gastroenterology Product Name: PR600
Highest Development Status: Preclinical Product Type: Large molecule
Partner/Sponsor/Collaborator: Dr. Falk Pharma
Deal Size: Undisclosed Upfront Cash: Undisclosed
Deal Type: Collaboration August 13, 2020
Details:
Under the terms of the agreement, Prometheus and Falk will share responsibility for the global development of PR600, with Falk contributing one-quarter of the costs associated with developing PR600.
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Lead Product(s): MORF-057
Therapeutic Area: Gastroenterology Product Name: MORF-057
Highest Development Status: Preclinical Product Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable June 29, 2020
Details:
The data presented at DDW demonstrate that MORF-057 successfully targets the integrin α4β7 with high potency and selectivity.
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Lead Product(s): Synthetic Biotic medicines
Therapeutic Area: Gastroenterology Product Name: Undisclosed
Highest Development Status: Preclinical Product Type: Undisclosed
Partner/Sponsor/Collaborator: AbbVie Inc
Deal Size: Undisclosed Upfront Cash: Undisclosed
Deal Type: Termination May 21, 2020
Details:
Upon termination, Synlogic regains all rights to develop Synthetic Biotic medicines for the potential treatment of inflammatory bowel disease (IBD).
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