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Find Novel Gastroenterology Drugs in Preclinical Development

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            Lead Product(s): Adalimumab

            Therapeutic Area: Gastroenterology Product Name: PGN-001

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable November 06, 2020

            Details:

            Progenity has two lead drug-device candidates utilizing the DDS technology, PGN-001, a high-concentration formulation of adalimumab, and PGN-600 a liquid formulation of tofacitinib, both under development for the treatment of ulcerative colitis.

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            Lead Product(s): Allocetra

            Therapeutic Area: Gastroenterology Product Name: Allocetra

            Highest Development Status: Preclinical Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable November 05, 2020

            Details:

            Upon issuance, the new patent will provide added intellectual property protection for methods of treating autoimmune and inflammatory diseases comprising gout, inflammatory bowel disease, Crohn's disease, and ulcerative colitis.

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            Lead Product(s): PN-235

            Therapeutic Area: Gastroenterology Product Name: JNJ-77242113

            Highest Development Status: Preclinical Product Type: Peptide

            Partner/Sponsor/Collaborator: Janssen Pharmaceutical

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Collaboration October 29, 2020

            Details:

            The two new candidates, PN-235 (JNJ-77242113) and PN-232 (JNJ-75105186), are being developed as part of a portfolio strategy of discovering and developing oral IL-23 receptor antagonists.

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            Lead Product(s): BX002

            Therapeutic Area: Gastroenterology Product Name: BX002

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable October 21, 2020

            Details:

            The poster presentation details a phage therapy panel, comprised of phage directed against Klebsiella pneumoniae, showing a broad target host range and the potential to address carbapenem-resistant and extended spectrum beta-lactamase (ESBL)-producing bacteria.

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            Lead Product(s): SNSP003

            Therapeutic Area: Gastroenterology Product Name: SNSP003

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: CF Foundation

            Deal Size: $22.5 Million Upfront Cash: $14.0 million

            Deal Type: Funding October 20, 2020

            Details:

            The new funding will be used to advance preclinical development and early stage clinical trials for Synspira’s non-porcine enzyme replacement therapy, SNSP003.

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            Lead Product(s): ALV-304

            Therapeutic Area: Gastroenterology Product Name: ALV-304

            Highest Development Status: Preclinical Product Type: Undisclosed

            Partner/Sponsor/Collaborator: U.S. Department of Defense

            Deal Size: $3.3 million Upfront Cash: Undisclosed

            Deal Type: Funding October 05, 2020

            Details:

            The funds will support Alivio’s preclinical research and development activities to potentially enable the filing of an investigational new drug (IND) application for ALV-304.

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            Lead Product(s): RTX-1688

            Therapeutic Area: Gastroenterology Product Name: RTX-1688

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable August 31, 2020

            Details:

            Rodeo Therapeutics nominates Candidate RTX-1688, a first-in-class oral small molecule therapy for tissue regeneration and repair, with inflammatory bowel disease as the initial indication and platform potential in other disease settings .

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            Lead Product(s): PR600

            Therapeutic Area: Gastroenterology Product Name: PR600

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Dr. Falk Pharma

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Collaboration August 13, 2020

            Details:

            Under the terms of the agreement, Prometheus and Falk will share responsibility for the global development of PR600, with Falk contributing one-quarter of the costs associated with developing PR600.

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            Lead Product(s): MORF-057

            Therapeutic Area: Gastroenterology Product Name: MORF-057

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 29, 2020

            Details:

            The data presented at DDW demonstrate that MORF-057 successfully targets the integrin α4β7 with high potency and selectivity.

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            Lead Product(s): Synthetic Biotic medicines

            Therapeutic Area: Gastroenterology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Undisclosed

            Partner/Sponsor/Collaborator: AbbVie Inc

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Termination May 21, 2020

            Details:

            Upon termination, Synlogic regains all rights to develop Synthetic Biotic medicines for the potential treatment of inflammatory bowel disease (IBD).

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